Development of different analysis platforms with LC-MS for pharmacokinetic studies of protein drugs

Analytical Chemistry

Volumn 81, Issue 21, 2009, Pages 8715-8723

  Qiaozhen, Lu ^a   Xiaoyang, Zheng ^a,d   McIntosh, Thomas ^b   Davis, Hugh ^b   Nemeth, Jennifer F ^c   Pendley, Chuck ^b   Wu, Shiaw Lin ^a   Hancock, William S ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

^b Clin Pharmacol   (United States)

^c Antibody Drug Discovery   (United States)

^d Genzyme   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN DEPLETION; ANTIBODY DRUGS; DEVELOPMENT TIME; ENZYME LINKED IMMUNOSORBENT ASSAY; GENERIC METHOD; HIGH-THROUGHPUT; INGEL DIGESTION; LINEAR DYNAMIC RANGES; PHARMACOKINETIC STUDIES; PROTEIN A; PROTEIN DRUGS; SAMPLE PREPARATION; SDS-PAGE; SODIUM DODECYL SULFATE-POLYACRYLAMIDE GEL ELECTROPHORESIS;

BODY FLUIDS; DIFFUSERS (OPTICAL); ELECTROPHORESIS; GELATION; GELS; PHARMACOKINETICS; SODIUM; SODIUM SULFATE;

ANTIBODIES;

ALBUMIN; ANTIBODY; CNTO 736; DRUG ANTIBODY; PROTEIN A; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; ENRICHMENT CULTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; INTERMETHOD COMPARISON; MASS FRAGMENTOGRAPHY; MOLECULAR MIMICRY; MONKEY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN DEPLETION; SENSITIVITY ANALYSIS; SERUM;

ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MACACA FASCICULARIS; MASS SPECTROMETRY; RECOMBINANT FUSION PROTEINS; SERUM ALBUMIN; STAPHYLOCOCCAL PROTEIN A;

EID: 70350637466     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac901991x     Document Type: Article

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