Mass spectrometric determination of disulfide linkages in recombinant therapeutic proteins using online LC-MS with electron-transfer dissociation

Analytical Chemistry

Volumn 81, Issue 1, 2009, Pages 112-122

  Wu, Shiaw Lin ^a   Jiang, Haitao ^a   Lu, Qiaozhen ^a   Dai, Shujia ^a   Hancock, William S ^a   Karger, Barry L ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOTECHNOLOGY INDUSTRIES; CHEMICAL REDUCTIONS; CHO CELL LINES; CONVENTIONAL APPROACHES; DISULFIDE BONDS; DISULFIDE BRIDGES; DISULFIDE LINKAGES; DRUG QUALITIES; EXPRESSION SYSTEMS; FINAL PRODUCTS; HIGH CONFIDENCES; INDUCED DISSOCIATIONS; MS APPROACHES; PEPTIDE BACKBONES; PEPTIDE IONS; POWERFUL APPROACHES; RECOMBINANT HUMAN GROWTH HORMONES; RECOMBINANT PROTEINS; SIMULTANEOUS OBSERVATIONS; THERAPEUTIC MONOCLONAL ANTIBODIES; TISSUE PLASMINOGEN ACTIVATORS;

ANTIBODIES; CELL CULTURE; CHAINS; DISSOCIATION; IONS; MONOCLONAL ANTIBODIES; PROTEIN FOLDING; PROTEINS;

AMINES;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, LIQUID; CYSTEINE; DISULFIDES; HUMAN GROWTH HORMONE; HUMANS; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS; TANDEM MASS SPECTROMETRY; TISSUE PLASMINOGEN ACTIVATOR;

EID: 58149510241     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac801560k     Document Type: Article

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