Recombinant clotting factor VIII concentrates: Heterogeneity and high-purity evaluation

Electrophoresis

Volumn 31, Issue 16, 2010, Pages 2730-2739

  D'Amici, Gian Maria ^a   Timperio, Anna Maria ^a   Gevi, Federica ^a   Grazzini, Giuliano ^b   Zolla, Lello ^a  

^a UNIVERSITY OF TUSCIA   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

2 DE; Hemophilia A; Proteomics; Recombinant factor VIII

Indexed keywords

CELL CULTURE; CONTAMINATION; ENZYMES; IMPURITIES; MOLECULAR BIOLOGY; QUALITY ASSURANCE; RECOMBINANT PROTEINS;

2-DE; B DOMAINS; CDNA SEQUENCE; EXPRESSION VECTORS; FACTOR VIII; HAEMOSTASIS; HEMOPHILIA A; HIGH PURITY; PROTEOMICS; RECOMBINANT FACTOR VIII;

MAMMALS;

AMINO ACID; APOLIPOPROTEIN; BETA LACTAMASE; GLUTATHIONE TRANSFERASE; HAPTOGLOBIN; HEAT SHOCK PROTEIN 70; PROAPOLIPOPROTEIN; RECOMBINANT BLOOD CLOTTING FACTOR 8; UNCLASSIFIED DRUG;

ARTICLE; DRUG CONTAMINATION; DRUG MANUFACTURE; DRUG QUALITY; EXPRESSION VECTOR; GENETIC HETEROGENEITY; GENETIC RECOMBINATION; GOOD MANUFACTURING PRACTICE; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN PURIFICATION; PROTEOMICS; QUALITY CONTROL; TWO DIMENSIONAL ELECTROPHORESIS; TWO DIMENSIONAL GEL ELECTROPHORESIS;

EID: 77955891554     PISSN: 01730835     EISSN: 15222683     Source Type: Journal    
DOI: 10.1002/elps.201000216     Document Type: Article

References (39)

1. Vehar, G. A., Keyt, B., Eaton, D., Rodriguez, H., O'Brien, D. P., Rotblat, F., Oppermann, H., Keck, R., Wood, W. I., Harkins, R. N., Tuddenham, E. G. D., Lawn, R. M., Capon, D. J., Nature 1984, 312, 337-342.
2. Cawthern, K. M., van't Veer, C., Lock, J. B., di Lorenzo, M. E., Branda, R. F., Mann, K. G., Blood 1998, 91, 4581-4592.
3. Andersson, L. O., Forsman, N., Huang, K., Larsen, K., Lundin, A., Pavlu, B., Sandberg, H., Sewerin, K., Smart, J., Proc. Natl. Acad. Sci. USA 1986, 83, 2979-2983.
4. Fulcher, C. A., Roberts, J. R., Zimmerman, T. S., Blood 1983, 4, 807-811.
5. Fay, P. J., Anderson, M. T., Chavin, S. I., Marder, V. J., Biochim Biophys. Acta 1986, 871, 268-278.
6. Fay, P. J., Blood 2004, 1, 1-15.
7. Lenting, P. J., van Mourik, J. A., Mertens, K., Blood 1998, 11, 3983-3996.
8. Wood, W. I., Capon, D. J., Simonsen, C. C., Eaton, D. L., Gitschier, J., Keyt, B., Seeburg, P. H., Smith, D. H., Hollingshead, P., Wion, K. L., Delwart, E., Tuddenham, E. G. D., Vehar, G. A., Lawn, R. M., Nature 1984, 312, 330-337.
9. Eaton, D. L., Hass, P. E., Riddle, L., Mather, J., Wiebe, M., Gregory, T., Vehar, G. A., J. Biol. Chem. 1987, 262, 3285-3290.
10. Musso, R., Drugs Today 2008, 44, 735-750.
11. Cumming, D. A., Glycobiology 1991, 1, 115-130.
12. Gomperts, E., Lundblad, R., Adamson, R., Transfus. Med. Rev. 1992, 6, 247-251.
13. Jiang, R., Monroe, T., McRogers, R., Larson, P. J., Haemophilia 2002, 8, 1-5.
14. Eriksson, R. K., Fenge, C., Lindner-Olsson, E., Liungggvist, C., Rosenguist, J., Smeds, A. L., Ostlin, A., Charlebois, T., Leonard, M., Kelley, B. D., Ljungqvist, A., Semin. Hematol. 2001, 38, 24-31.
15. Pipe, S. W., Morris, J. A., Shah, J., Kaufman, R. J., J. Biol. Chem. 1998, 273, 8537-8544.
16. Dorner, A. J., Bole, D. G., Kaufman, R. J., J. Cell Biol. 1987, 105, 2665-2674.
17. Kim, M. R., Kim, C. W., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2007, 849, 203-210.
18. Clifton, J. G., Huang, F., Kovac, S., Yang, X., Hixson, D. C., Josic, C., Electrophoresis 2009, 30, 3636-3646.
19. Laemmli, U. K., Nature 1970, 227, 680-686.
20. Shevchenko, A., Wilm, M., Vorm, O., Mann, M., Anal. Chem. 1996, 68, 850-858.
21. Shen, B. W., Spiegel, P. C., Chang, C.H., Huh, J. W., Lee, J. S., Kim, J., Stoddard, B. L., Blood 2008, 111, 1240-1247.
22. Gorg, A., Weiss, W., Dunn, M. J., Proteomics 2004, 4, 3665-3685.
23. Pock, K., Jungbauer, A., Kannicht, C., Loster, K., Buchacher, A., Josic, D., Anal. Chim. Acta 1998, 372, 219-229.
24. Brigulla, M , Thiele, T., Scharf, C., Ruddock, S. B., Venz, S., Völker, U., Greinacher, A., Transfution 2006, 46, 377-385.
25. Jankowski, M. A., Patel, H., Rouse, J. C., Marzilli, L. A., Weston, S. B., Sharpe, P. J., Haemophilia 2007, 13, 30-37.
26. Josic, D., Brown, M. K., Huang, F., Lim, Y. P., Rucevic, M., Clifton, J. G., Hixson, D. C., Proteomics 2006, 6, 2874-2885.
27. Hansen, K., Kjalke, M., Rasmussen, P. B., Kongerslev, P., Ezban, M., Cytotechnology 1997, 24, 227-234.
28. Lenting, P. J., van Mourik, J. A., Mertens, K., Blood 1998, 92, 3983-3996.
29. Pittman, D. D., Marquette, K. A., Kaufman, R. J., Blood 1994, 84, 4214-4225.
30. Toole, J. J., Pittman, D. D., Orr, E. C., Murtha, P., Wasley, L. C., Kaufman, R. J., Proc. Natl. Acad. Sci. USA 1986, 83, 5939-5942.
31. Kjale, M., Hending, A., Talbo, G., Persson, E., Thomsen, J., Ezban, M., Eur. J. Biochem. 1995, 234, 73-779.
32. Basilico, F., Nardini, I., Mori, F., Brambilla, E., Benazzi, L., De Palma, A., Rosti, E. et al., J. Pharm. Biomed. Anal. 2010, 1, 50-57.
33. Al-Rubeai, M., Singh, R. P., Curr. Opin. Biotechnol. 1998, 2, 152-156.
34. Arden, N., Betenbaugh, M. J., Trends Biotechnol. 2004, 22, 174-180.
35. Lynch, C. M., Israel, D. I., Kaufman, R. J., Miller, A. D., Hum. Gene Ther. 1993, 4, 259-272.
36. Soukharev, S., Hammond, D., Ananyeva, N. M., Anderson, J. A., Hauser, C. A., Pepe, S., Saenko, E. L., Blood Cells Mol. Dis. 2002, 28, 234-248.
37. Samali, A., Cotter, T. G., Exp. Cell. Res. 1996, 223, 163-170.
38. Creagh, E. M., Carmody, R. J., Cotter, T. G., Cell. Res. 2000, 257, 58-66.
39. Jiang, R., Monroe, T., Mcrogers, R., Larson, P. J., Haemophilia 2002, 2, 1-5.