Implementation of an FTIR calibration curve for fast and objective determination of changes in protein secondary structure during formulation development

Journal of Pharmaceutical and Biomedical Analysis

Volumn 51, Issue 1, 2010, Pages 39-45

  Vonhoff, Sebastian ^a   Condliffe, Jamie ^b   Schiffter, Heiko ^b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Calibration curve; Circular dichroism; FTIR; Multivariate data analysis; Protein formulation; Secondary structure

Indexed keywords

GLUCAGON; HUMAN SERUM ALBUMIN;

ALPHA HELIX; ARTICLE; BETA SHEET; CALIBRATION; CIRCULAR DICHROISM; CONTROLLED STUDY; GEL PERMEATION CHROMATOGRAPHY; HEAT TREATMENT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFRARED SPECTROSCOPY; PARTIAL LEAST SQUARES REGRESSION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN PROCESSING; PROTEIN SECONDARY STRUCTURE; QUANTITATIVE ANALYSIS; RELIABILITY; STRUCTURE ANALYSIS; TURBIDITY;

ALGORITHMS; CALIBRATION; CIRCULAR DICHROISM; DRUG DESIGN; HUMANS; LEAST-SQUARES ANALYSIS; PROTEIN STRUCTURE, SECONDARY; PROTEINS; REPRODUCIBILITY OF RESULTS; SERUM ALBUMIN; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TEMPERATURE;

EID: 70349314315     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.07.031     Document Type: Article

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