Structural integrity of the γ-carboxyglutamic acid domain of human blood coagulation factor IXa is required for its binding to cofactor VIIIa

Journal of Biological Chemistry

Volumn 271, Issue 7, 1996, Pages 3869-3876

  Larson, Peter J ^a,f   Stanfield Oakley, Sherry A ^b   VanDusen, William J ^c   Kasper, Carol K ^e   Smith, Kenneth J ^d   Monroe, Dougald M ^b   High, Katherine A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 CARBOXYGLUTAMIC ACID; BLOOD CLOTTING FACTOR 8A; BLOOD CLOTTING FACTOR 9A; CALCIUM ION; MUTANT PROTEIN; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; THROMBOPLASTIN;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; BLOOD CLOTTING; CONTROLLED STUDY; DNA SEQUENCE; ENZYME ACTIVATION; HEMOPHILIA B; HUMAN; IMMUNOAFFINITY CHROMATOGRAPHY; MALE; PARTIAL THROMBOPLASTIN TIME; PHOSPHOLIPID VESICLE; POINT MUTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTHROMBIN TIME;

ADENINE; AMINO ACID SEQUENCE; ARGININE; BASE SEQUENCE; BINDING SITES; DNA; DNA MUTATIONAL ANALYSIS; EXONS; FACTOR IX; FACTOR IXA; FACTOR VIIIA; FACTOR X; GLYCINE; GUANINE; HEMOPHILIA B; HUMANS; KINETICS; MATHEMATICS; MODELS, THEORETICAL; MOLECULAR SEQUENCE DATA; POINT MUTATION; PROTHROMBIN TIME; TRIAZINES;

EID: 0029671099     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.7.3869     Document Type: Article

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