Synthesis, structure-activity relationship of novel substituted 4H-chromen-1,2,3,4-tetrahydropyrimidine-5-carboxylates as potential anti-mycobacterial and anticancer agents

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 10, 2011, Pages 2855-2859

  China Raju, B ^a   Nageswara Rao, R ^a   Suman, P ^a   Yogeeswari, P ^b   Sriram, D ^b   Shaik, Thokhir Basha ^a   Kalivendi, Shasi Vardhan ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

4 Oxo 4H chromene 3 carbaldehydes; Anti mycobacterial activity; Anticancer activity; Biginelli reaction; Substituted 4H chromen 1,2,3,4 tetrahydropyrimidine 5 carboxylates; Suzuki coupling; Vilsmeier reaction

Indexed keywords

1,2,3,4 TETRAHYDROPYRIMIDINE DERIVATIVE; 4H CHROMEN 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLIC ACID DERIVATIVE; ANTIMYCOBACTERIAL AGENT; ANTINEOPLASTIC AGENT; CARBOXYLIC ACID DERIVATIVE; CIPROFLOXACIN; DOXORUBICIN; ETHAMBUTOL; ISONIAZID; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MYCOBACTERIUM TUBERCULOSIS; NEUROBLASTOMA CELL; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; CARBOXYLIC ACIDS; CELL LINE, TUMOR; CELL SURVIVAL; CHROMANS; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

MYCOBACTERIUM TUBERCULOSIS;

EID: 79955566862     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.03.079     Document Type: Article

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