Synthesis and biological evaluation of polyenylpyrrole derivatives as anticancer agents acting through caspases-dependent apoptosis

Journal of Medicinal Chemistry

Volumn 53, Issue 22, 2010, Pages 7967-7978

  Fang, Zhanxiong ^a   Liao, Pei Chun ^b   Yang, Yu Liang ^c   Yang, Feng Ling ^c   Chen, Yi Lin ^b   Lam, Yulin ^a   Hua, Kuo Feng ^b,d   Wu, Shih Hsiung ^c  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL ILAN UNIVERSITY   (Taiwan)

^c INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

3 BUTYL 6 [9 (3 CHLORO PYRROL 2 YL) NONA 2,4,6,8 TETRAEN 2 YL) 4 METHOXY PYRAN 2 ONE; ANTINEOPLASTIC AGENT; AUXARCONJUGATIN B; CASPASE; CYTOCHROME C; POLYENYLPYRROLE DERIVATIVE; PROTEIN BAX; PROTEIN BCL 2; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CARCINOMA CELL; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LUNG CARCINOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CASPASES; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; LUNG NEOPLASMS; MICE; MICE, NUDE; MITOCHONDRIA; NEOPLASM TRANSPLANTATION; POLYENES; PYRROLES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS;

EID: 78649528654     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100619x     Document Type: Article

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