Synthesis and anticancer activity of chromone-based analogs of lavendustin A

European Journal of Medicinal Chemistry

Volumn 45, Issue 9, 2010, Pages 4288-4292

  Nam, Dong Hyuk ^a   Lee, Ki Yong ^a   Moon, Chang Sang ^b   Lee, Yong Sup ^a  

^a Kyung Hee University   (South Korea)

^b Korea Institute of Science and Technology   (South Korea)

Author keywords

A 431; Chromone; Growth inhibition; KB; Lavendustin A

Indexed keywords

7 (4 METHOXYBENZYLOXY) 2 METHYL 8 [(PHENETHYLAMINO)METHYL] 4H CHROMEN 4 ONE; 7 (4 METHOXYBENZYLOXY) 8 [(4-METHOXYPHENETHYLAMINO) METHYL] 2 METHYL 4H CHROMEN 4 ONE; 7 HYDROXY 2 METHYL 8 [[(4 NITROBENZYL)(PHENETHYL)AMINO]METHYL] 4H CHROMEN 4 ONE; 7 HYDROXY 8 [[(4 METHOXYBENZYL)(4 NITROBENZYL)AMINO]METHYL] 2 METHYL 4H CHROMEN 4 ONE; 7 HYDROXY 8 [[(4 METHOXYBENZYL)(NAPHTHALEN 2 YLMETHYL)AMINO]METHYL] 2 METHYL 4H CHROMEN 4 ONE; 8 [(3,4 DIMETHOXYPHENETHYLAMINO)METHYL] 7 (4 METHOXMETHOXYBENZYLOXY) 2 METHYL 4H CHROMEN 4 ONE; 8 [(4 METHOXYBENZYLAMINO)METHYL] 7 (4 METHOXYBENZYLOXY) 2 METHYL 4H CHROMEN 4 ONE; 8 [(BENZYLAMINO)METHYL] 7 (4 METHOXYBENZYLOXY) 2 METHYL 4H CHROMEN 4 ONE; 8 [(DIBENZYLAMINO)METHYL] 7 HYDROXY 2 METHYL 4H CHROMEN 4 ONE; 8 [[BENZYL(3,4 DIMETHOXYPHENETHYL)AMINO]METHYL] 7 HYDROXY 2 METHYL 4H CHROMEN 4 ONE; 8 [[BENZYL(4 METHOXYBENZYL)AMINO]METHYL] 7 HYDROXY 2 METHYL 4H CHROMEN 4 ONE; 8 [[BENZYL(4-METHOXYPHENETHYL)AMINO]METHYL] 7 HYDROXY 2 METHYL 4H CHROMEN 4 ONE; 8 [[BENZYL(PHENETHYL)AMINO]METHYL] 7 HYDROXY 2 METHYL 4H CHROMEN 4 ONE; 8 [[BIS(4 METHOXYBENZYL)AMINO]METHYL] 7 HYDROXY 2 METHYL 4H CHROMEN 4 ONE; 8 [[ETHYL(4 METHOXYBENZYL)AMINO]METHYL] 7 HYDROXY 2 METHYL 4H CHROMEN 4 ONE; 8 [[ETHYL(PHENETHYL)AMINO]METHYL] 7 HYDROXY 2 METHYL 4H CHROMEN 4 ONE; ANTINEOPLASTIC AGENT; LAVENDUSTIN A; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CLINICAL EVALUATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG SYNTHESIS;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMONES; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; PHENOLS;

EID: 77955560310     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.06.030     Document Type: Article

References (13)

1. W.H. Gerwik, A. Lopez, G.D. Van Duyne, J. Clardy, W. Ortiz, and A. Baez Tetrahedron Lett. 27 1986 1979 1982
2. W.H. Gerwik J. Nat. Prod. 52 1989 252 256
3. N. Jain, G. Gambhir, and H.G. Krishnamurty Indian J. Chem., Sect. B 40B 2001 278 283
4. L.W. McGarry, and M.R. Detty J. Org. Chem. 55 1990 4349 4356
5. T. Onoda, H. Iinuma, Y. Sasaki, M. Hamada, K. Isshiki, H. Nagawana, T. Takeuchi, K. Tatsuta, and K. Umezawa J. Nat. Prod. 52 1989 1252 1257
6. F. Mu, E. Hamel, D.J. Lee, D.E. Pryor, and M. Cushman J. Med. Chem. 46 2003 1670 1682
7. G. Kaur, V.L. Narayanan, P.A. Risbood, M.G. Hollingshead, S.F. Stinson, R.K. Varmaa, and E.A. Sausville Bioorg. Med. Chem. 13 2005 1749 1761
8. R. Albuschat, W. Loewe, M. Weber, P. Luger, and V. Jendrossek Eur. J. Med. Chem. 39 2004 1001 1011
9. V. Moret, Y. Laras, T. Cresteil, G. Aubert, D.Q. Ping, C. Di, M. Barthélémy-Requin, C. Béclin, V. Peyrot, D. Allegro, A. Rolland, F.D. Angelis, E. Gatti, P. Pierre, L. Pasquini, E. Petrucci, U. Testa, and J.-L. Kraus Eur. J. Med. Chem. 44 2009 558 567
10. C.S. Moon, K.-W. Lee, J.Y. Lee, B.Y. Chung, K.-T. Lee, and Y.S. Lee Yakhak Hoechi 47 2003 376 381
11. K.Y. Lee, D.H. Nam, C.S. Moon, S.H. Seo, J.Y. Lee, and Y.S. Lee Eur. J. Med. Chem. 41 2006 991 996
12. R.F. Borch, M.D. Bernstein, and H.D. Durst J. Am. Chem. Soc. 93 1971 2897 2904
13. P. Skehan, R. Streng, D. Scudiero, A. Monks, J. McMahon, D. Vistica, J.T. Warren, H. Bokesch, S. Kenney, and M.R. Boyd J. Natl. Cancer Inst. 82 1990 1107 1112