Discovery of novel 2-aryl-4-benzoyl-imidazoles targeting the colchicines binding site in tubulin as potential anticancer agents

Journal of Medicinal Chemistry

Volumn 53, Issue 20, 2010, Pages 7414-7427

  Chen, Jianjun ^a   Wang, Zhao ^a   Li, Chien Ming ^b,c   Lu, Yan ^a   Vaddady, Pavan K ^a   Meibohm, Bernd ^a   Dalton, James T ^b,c   Miller, Duane D ^a,c   Li, Wei ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c GTx Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 FLUOROPHENYL[2 PHENYL 1 (PHENYLSULFONYL) 1H IMIDAZO 4 YL]METHANONE; 3 METHOXYPHENYL[2 PHENYL 1 (PHENYLSULFONYL) 1H IMIDAZOL 4 YL)METHANONE; 4 FLUOROPHENYL)[2 (4 METHOXYPHENYL) 1 (PHENYLSULFONYL) 1H IMIDAZO 4 YL]METHANONE; 4 FLUOROPHENYL[1 (PHENYLSULFONYL) 2 (3,4,5 TRIMETHOXYPHENYL) 1H IMIDAZOL 4 YL]METHANONE; 4 FLUOROPHENYL[1 (PHENYLSULFONYL) 2 (4 TOLYL) 1H IMIDAZOL 4 YL]METHANONE; 4 FLUOROPHENYL[2 (4 METHOXYPHENYL) 1 (PHENYLSULFONYL) 1H IMIDAZO 4 YL]METHANONE; 4 FLUOROPHENYL[2 (4 METHOXYPHENYL) 1H IMIDAZOL 4 YL]METHANONE; 4 FLUOROPHENYL[2 PHENYL 1 (PHENYLSULFONYL) 1H IMIDAZOL 4 YL)METHANONE; 4 METHOXYPHENYL[2 PHENYL 1 (PHENYLSULFONYL) 1H IMIDAZOL 4 YL)METHANONE; ANTINEOPLASTIC AGENT; COLCHICINE; COMBRETASTATIN A4; DACARBAZINE; IMIDAZOLE DERIVATIVE; PACLITAXEL; TUBULIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINBLASTINE; [1 (PHENYLSULFONYL) 2 (3,4,5 TRIMETHOXYPHENYL) 1H IMIDAZOL 4 YL](3,4,5 TRIMETHOXYPHENYL)METHANONE; [2 (3,4 DIMETHOXYPHENYL) 1 (PHENYLSULFONYL) 1H IMIDAZOL 4 YL] (3,4,5 TRIMETHOXYPHENYL)METHANONE; [2 (3,4 DIMETHOXYPHENYL) 1 (PHENYLSULFONYL) 1H IMIDAZOL 4 YL] (4 FLUOROPHENYL)METHANONE; [2 (4 CHLOROPHENYL) 1 (PHENYLSULFONYL) 1H IMIDAZOL 4 YL] (4 FLUOROPHENYL)METHANONE; [2 (4 CHLOROPHENYL) 1 (PHENYLSULFONYL) 1H IMIDAZOL 4 YL](4 FLUOROPHENYL)METHANONE; [2 (4 TOLYL) 1H IMIDAZOL 4 YL](3,4,5 TRIMETHOXYPHENYL)METHANONE; [2 PHENYL 1 (PHENYLSULFONYL) 1H IMIDAZOL 4 YL](4 TOLYL)METHANONE; [2 [4 (DIMETHYLAMINO)PHENYL] 1 (PHENYLSULFONYL) 1H IMIDAZOL 4 YL](3,4,5 TRIMETHOXYPHENYL)METHANONE; [2 [4 (DIMETHYLAMINO)PHENYL] 1 (PHENYLSULFONYL) 1H IMIDAZOL 4 YL](4 FLUOROPHENYL)METHANONE; [2 [5 (DIMETHYLAMINO)PHENYL] 1H IMIDAZOL 4 YL](3,4,5 TRIMETHOXYPHENYL)METHANONE; {1 (PHENYLSULFONYL) 2 [2 (TRIFLUOOMETHYL)PHENYL] 1H IMIDAZOL 4 YL}(3,4,5 TRIMETHOXYPHENYL)METHANONE; {1 (PHENYLSULFONYL) 2 [2 (TRIFLUOROMETHYL)PHENYL] 1H IMIDAZOL 4 YL}(3,4,5 TRIMETHOXYPHENYL)METHANONE; PROTEIN BINDING; TUBULIN MODULATOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; AQUEOUS SOLUTION; ARTICLE; BINDING COMPETITION; BINDING SITE; CANCER INHIBITION; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SOLUBILITY; DRUG SYNTHESIS; DRUG TARGETING; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VIVO STUDY; MELANOMA; MELANOMA CELL; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; TUMOR MODEL; ANIMAL; C57BL MOUSE; CANCER TRANSPLANTATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG RESISTANCE; DRUG SCREENING; METABOLISM; PROTEIN MULTIMERIZATION; SOLUBILITY; SYNTHESIS; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; BINDING SITES; CELL LINE, TUMOR; COLCHICINE; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; IMIDAZOLES; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; NEOPLASM TRANSPLANTATION; PROTEIN BINDING; PROTEIN MULTIMERIZATION; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS; TUBULIN; TUBULIN MODULATORS;

EID: 77958501821     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100884b     Document Type: Article

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