Chromone 3-phenylcarboxamides as potent and selective MAO-B inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 2, 2011, Pages 707-709

  Gaspar, Alexandra ^a   Reis, Joana ^a   Fonseca, André ^a   Milhazes, Nuno ^a,b   Viña, Dolores ^c   Uriarte, Eugenio ^c   Borges, Fernanda ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY INSTITUTE OF HEALTH SCIENCES IUCS   (Portugal)

^c UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Chromone; IMAO B; Neurodegenerative diseases

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; CHROMONE 3 PHENYLCARBOXAMIDE DERIVATIVE; CHROMONE DERIVATIVE; IPRONIAZID; MONOAMINE OXIDASE INHIBITOR; SELEGILINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; INSECT; NONHUMAN; ONE POT SYNTHESIS; POLYMERIZATION;

ANIMALS; CELL LINE; CHROMONES; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; NEURODEGENERATIVE DISEASES; PROTEIN ISOFORMS; STRUCTURE-ACTIVITY RELATIONSHIP;

MAMMALIA;

EID: 78651257725     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.11.128     Document Type: Article

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11. 2 (6 mL) was added and the mixture was stirred for 30 min. After, the corresponding amine was added in equimolar amount and the temperature was let to gradually increase to room temperature. The reaction was stirred for additional 4-6 h.
12. 50 values shown in the table are expressed as means ± SEM from five experiments.