The synthesis and evaluation of flavone and isoflavone chimeras of novobiocin and derrubone

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 1, 2010, Pages 249-266

  Mays, Jared R ^a   Hill, Stephanie A ^a   Moyers, Justin T ^a   Blagg, Brian S J ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

Anticancer; Derrubone; Hsp90; Novobiocin

Indexed keywords

1 (2,4 DIHYDROXY 3 METHYLPHENYL) 2 (2 ISOINDOLINE 1,3 DIONE)ETHANONE; 1 (2,4 DIHYDROXYPHENYL) 2 (2 ISOINDOLINE 1,3 DIONE)ETHANONE; 1 (2,4,6 TRIHYDROXYPHENYL) 2 (2 ISOINDOLINE 1,3 DIONE)ETHANONE; 1 (5 (BENZYLOXY) 2 HYDROXYPHENYL)ETHANONE; 2 (1,3 DIOXOISOINDOLIN 2 YL)ACETONITRILE; 2 (4 METHOXY 3 (3 METHOXYPHENYL)BENZAMIDO) 4 OXO 4H CHROMEN 6 YL ACETATE; 2 (5,7 DIHYDROXY 4 OXO 4H CHROMEN 3 YL)ISOINDOLINE 1,3 DIONE; 2 (7 HYDROXY 4 OXO 4H CHROMEN 3 YL)ISOINDOLINE 1,3 DIONE; 2 (7 HYDROXY 8 METHYL 4 OXO 4H CHROMEN 3 YL)ISOINDOLINE 1,3 DIONE; 2 ACETAMIDO 4 OXO 4H CHROMEN 6 YL ACETATE; 2 AMINO 6 (BENZYLOXY) 4H CHROMEN 4 ONE; 3 ACETAMIDO 4 OXO 4H CHROMEN 7 YL ACETATE; 4 (BENZYLOXY) 2 (ISOXAZOL 5 YL)PHENOL; DERRUBONE; FLAVONE; ISOFLAVONE; N(5,7 DIHYDROXY 4 OXO 4H CHROMEN 3 YL) 4 METHOXY 3 (3 METHOXYPHENYL)BENZAMIDE; N(5,7 DIHYDROXY 4 OXO 4H CHROMEN 3 YL)ACETAMIDE; N(6 (3,4 DIHYDROXY 5 METHOXY 6,6 DIMETHYLTETRAHYDRO 2H PYRAN 2 YLOXY) 4 OXO 4H CHROMEN 2 YL) 4 METHOXY 3 (3 METHOXYPHENYL)BENZAMIDE; N(6 (3,4 DIHYDROXY 5 METHOXY 6,6 DIMETHYLTETRAHYDRO 2H PYRAN 2 YLOXY) 4 OXO 4H CHROMEN 2 YL)ACETAMIDE; N(6 (BENZYLOXY) 4 OXO 4H CHROMEN 2 YL) 4 METHOXY 3 (3 METHOXYPHENYL)BENZAMIDE; N(6 (BENZYLOXY) 4 OXO 4H CHROMEN 2 YL)ACETAMIDE; N(6 HYDROXY 4 OXO 4H CHROMEN 2 YL) 4 METHOXY 3 (3 METHOXYPHENYL)BENZAMIDE; N(6 HYDROXY 4 OXO 4H CHROMEN 2 YL)ACETAMIDE; N(7 HYDROXY 4 OXO 4H CHROMEN 3 YL) 4 METHOXY 3 (3 METHOXYPHENYL)BENZAMIDE; N(7 HYDROXY 4 OXO 4H CHROMEN 3 YL)ACETAMIDE; N(7 HYDROXY 8 METHYL 4 OXO 4H CHROMEN 3 YL) 4 METHOXY 3 (3 METHOXYPHENYL)BENZAMIDE; N(7 HYDROXY 8 METHYL 4 OXO 4H CHROMEN 3 YL)ACETAMIDE; NOVOBIOCIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ACYLATION; ARTICLE; CONTROLLED STUDY; CYCLIZATION; DRUG ACTIVITY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROLYSIS; POLYMERIZATION;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; FLAVONES; HSP90 HEAT-SHOCK PROTEINS; HUMANS; ISOFLAVONES; MOLECULAR STRUCTURE; NOVOBIOCIN;

EID: 72149097346     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.10.061     Document Type: Article

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