The hydrophobic residues phenylalanine 184 and leucine 187 in the type-1 parathyroid hormone (PTH) receptor functionally interact with the amino- terminal portion of PTH-(1-34)

Journal of Biological Chemistry

Volumn 274, Issue 45, 1999, Pages 31955-31960

  Carter, Percy H ^a   Shimizu, Masaru ^a   Luck, Michael D ^a   Gardella, Thomas J ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

LEUCINE; PARATHYROID HORMONE; PARATHYROID HORMONE RECEPTOR; PHENYLALANINE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT; RECEPTOR BINDING; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SUBSTITUTION; ANIMALS; CATTLE; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; LEUCINE; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; PROTEIN STRUCTURE, SECONDARY; RATS; RECEPTORS, PARATHYROID HORMONE; TERIPARATIDE;

EID: 0033527567     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.45.31955     Document Type: Article

References (32)

1. Segre, G. V., and Goldring, S. R. (1993) Trends Endocrinol. Metab. 4, 309-314
2. Kolakowski, L. F. (1994) Receptors Channels 2, 1-7
3. Jüppner, H., Abou-Samra, A.-B., Freeman, M., Kong, X.-F., Schipani, E., Richards, J., Kolakowski, L. F., Jr., Hock, J., Potts, J. T., Jr., Kronenberg, H. M., and Segre, G. V. (1991) Science 254, 1024-1026
4. Kronenberg, H., Abou-Samra A, Bringhurst, F., Gardella, T., Jüppner, H., and Segre, G. (1997) in Genetics of Endocrine and Metabolic Disorders (Thakker, R., ed) pp. 389-420, Chapman & Hall, London
5. Lee, C., Gardella, T., Abou-Samra, A.-B., Nussbaum, S., Segre, G., Potts, J. T., Jr., Kronenberg, H., and Jüppner, H. (1994) Endocrinology 135, 1488-1495
6. Nicole, P., Du, K., Couvineau, A., and Laburthe, M. (1998) J. Pharmacol. Exp. Ther. 284, 744-50
7. Stroop, S., Kuestner, R., Serwold, T., Chen, L., and Moore, E. (1995) Biochemistry 34, 1050-1057
8. Jüppner, H., Schipani, E., Bringhurst, F. R., McClure, I., Keutmann, H. T., Potts J. T., Jr., Kronenberg, H. M., Abou-Samra, A. B., Segre, G. V., and Gardella, T. (1994) Endocrinology 134, 879-884
9. Holtmann, M. H., Hadac, E. M., Ulrich, C. D., and Miller, L. J. (1996) J. Pharmacol. Exp. Ther. 279, 555-560
10. Cao, Y.-J., Gimpl, G., and Fahrenholz, F. (1995) Biochem. Biophys. Res. Commun. 212, 673-680
11. Couvineau, A., Rouyer-Fessard, C., Maoret, J. J., Gaudin, P., Nicole, P., and Laburthe, M. (1996) J. Biol. Chem. 271, 12795-800
12. Turner, P. R., Mefford, S., Bambino, T., and Nissenson, R. A. (1998) J. Biol. Chem. 273, 3830-3837
13. Dautzenberg, F., Wille, S., Lohmann, R., and Spiess, J. (1998) Proc. Natl. Acad. Sci. 95, 4941-4946
14. DeAlmeida, V., and Mayo, K. (1998) Mol. Endocrinol. 12, 750-765
15. Mannstadt, M., Luck, M., Gardella, T., and Jüppner, H. (1998) J. Biol. Chem. 273, 16890-16896
16. Dong, M., Wang, Y., Pinon, D., Hadac, E., and Miller, L. (1999) J. Biol. Chem. 274, 903-909
17. Bergwitz, C., Jusseaume, S., Luck, M., Jüppner, H., and Gardella, T. (1997) J. Biol. Chem. 272, 28861-28868
18. Bergwitz, C., Gardella, T., Flannery, M., Potts, J. T., Jr., Kronenberg, H., Goldring, S., and Jüppner, H. (1996) J. Biol. Chem. 271, 26469-26472
19. Gardella, T. J., Jüppner, H., Wilson, A. K., Keutmann, H. T., Abou-Samra, A. B., Segre, G. V., Bringhurst, F. R., Potts, J. T., Jr., Nussbaum, S. R., and Kronenberg, H. M. (1994) Endocrinology 135, 1186-1194
20. Gardella, T., Luck, M., Fan, M.-H., and Lee, C. (1996) J. Biol. Chem. 271, 12820-12825
21. Bisello, A., Adams, A. E., Mierke, D., Pellegrini, M., Rosenblatt, M., Suva, L., and Chorev, M. (1998) J. Biol. Chem. 273, 22498-22505
22. Luck, M. D, Carter, P. H., and Gardella, T. (1999) Mol. Endocrinol. 13, 670-680
23. Lee, C., Luck, M., Jüppner, H., Potts, J. T., Jr., Kronenberg, H., and Gardella, T. (1995) Mol. Endocrinol 9, 1269-1278
24. Zhou, A., Bessalle, R., Bisello, A., Nakamoto, C., Rosenblatt, M., Suva, L. J., and Chorev, M. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 3644-3649
25. Adams, A., Bisello, A., Chorev, M., Rosenblatt, M., and Suva, L. (1998) Mol. Endocrinol. 12, 1673-1683
26. Kunkel, T. A. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 488-492
27. Nielsen, H., Engelbrecht, J., Brunak, S., and von Heijne, G. (1997) Protein Eng. 10, 1-6
28. Abell, A., Liu, X., and Segaloff, D. (1996) J. Biol. Chem. 271, 4518-4527
29. Bowen, W., and Jerman, J. (1995) Trends Pharmacol. Sci. 16, 413-417
30. Gardella, T., Luck, M., Jensen, G., Usdin, T., and Jüppner, H. (1996) J. Biol. Chem. 271, 19888-19893
31. Pellegrini, M., Bisello, A., Rosenblatt, M., Chorev, M., and Mierke, D. F. (1998) Biochemistry 37, 12737-12743
32. Rost, B., Casadio, R., Fariselli, P., and Sander, C. (1995) Protein Sci. 4, 521-533