Arginine 186 in the extracellular N-terminal region of the human parathyroid hormone I receptor is essential for contact with position 13 of the hormone

Molecular Endocrinology

Volumn 12, Issue 11, 1998, Pages 1673-1683

  Adams, Amy E ^a,b,c   Bisello, Alessandro ^a   Chorev, Michael ^a   Rosenblatt, Michael ^a   Suva, Larry J ^a,d  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b Israel Deaconess Medical Center   (United States)

^c HARVARD UNIVERSITY   (United States)

^d GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; PARATHYROID HORMONE RECEPTOR;

AMINO TERMINAL SEQUENCE; ARTICLE; CALCIUM BLOOD LEVEL; CROSS LINKING; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; PARATHYROID HORMONE RELEASE; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

EID: 0031724680     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.12.11.0198     Document Type: Article

References (43)

1. Fitzpatrick LA, Bilezikian JP 1996 Actions of parathyroid hormone. In: Bilezikian JP, Raisz LG, Rodan GA (eds) Principles of Bone Biology. Academic Press, San Diego, CA, pp 339-346
2. Jüppner H 1994 Molecular cloning and characterization of a parathyroid hormone/parathyroid hormone-related peptide receptor: a member of an ancient family of G protein-coupled receptors. Curr Opin Nephrol Hypertens 3:371-378
3. Abou-Samra A-B, Jüppner H, Force T, Freeman MW, Kong X-F, Schipani E, Urena P, Richards J, Bonventre JV, Potts Jr JT, Kronenberg HM, Segre GV 1992 Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol triphosphates and increases intracellular free calcium. Proc Natl Acad Sci USA 89:2732-2736
4. Chorev M, Rosenblatt M 1996 Parathyroid hormone: structure-function relations and analog design. In: Bilezikian JP, Raisz LG, Rodan GA (eds) Principles of Bone Biology. Academic Press, San Diego, CA, pp 305-324
5. 2+ signaling by the recombinant human PTH/PTHrP receptor stably expressed in a human kidney cell line. Bone 18:381-389
6. Hock JM, Gera I, Fonseca J, Raisz LG 1988 Human parathyroid hormone-(1-34) increases bone mass in ovariectomized and orchidectomized rats. Endocrinology 122:2899-2904
7. Dempster DW, Cosman F, Parisien M, Shen V, Lindsay R 1993 Anabolic actions of parathyroid hormone on bone. Endocr Rev 14:690-709
8. Wronski TJ, Yen C-F, Qi H, Dann LM 1993 Parathyroid hormone is more effective than estrogen or bisphosphonates for restoration of lost bone mass in ovariectomized rats. Endocrinology 132:823-831
9. Finkelstein JS, Klibanski A, Schaefer EH, Hornstein MD, Schiff I, Neer E 1994 Parathyroid hormone for the prevention of bone loss induced by estrogen deficiency. N Engl J Med 331:1618-1623
10. 2]PTH-(1-34) binding and signaling in the transmembrane region of the parathyroid hormone receptor. Endocrinology 135:1186-1194
11. Huang Z, Chen Y, Pratt S, Chen TH, Bambino T, Shoback DM, Nissenson RA 1995 Mutational analysis of the cytoplasmic tail of the G protein-coupled receptor for parathyroid hormone (PTH) and PTH-related protein: effects on receptor expression and signaling. Mol Endocrinol 9:1240-1249
12. Lee C, Luck MD, Juppner H, Potts Jr JT, Kronenberg HM, Gardella TJ 1995 Homolog-scanning mutagenesis of the parathyroid hormone (PTH) receptor reveals PTH-(1-34) binding determinants in the third extracellular loop. Mol Endocrinol 9:1269-1278
13. Bergwitz C, Gardella TJ, Flannery MR, Potts Jr JT, Kronenberg HM, Goldring SR, Jüppner H 1996 Full activation of chimeric receptors by hybrids between parathyroid hormone and calcitonin. Evidence for a common pattern of ligand-receptor interaction. J Biol Chem 271:26469-26472
14. Gardella TJ, Luck MD, Fan MH, Lee C 1996 Transmembrane residues of the parathyroid hormone (PTH)/PTH-related peptide receptor that specifically affect binding and signaling by agonist ligands. J Biol Chem 271:12820-12825
15. Zhou AT, Besalle R, Bisello A, Nakamoto C, Rosenblatt M, Suva LJ, Chorev M 1997 Direct mapping of an agonist-binding domain within the parathyroid hormone/parathyroid hormone-related protein receptor by photoaffinity crosslinking. Proc Natl Acad Sci USA 94:3644-3649
16. Chowdhry V, Westheimer FH 1979 Photoaffinity labeling of biological systems. Annu Rev Biochem 48:293-325
17. Adams AE, Pines M, Nakamoto C, Behar V, Yang QM, Besalle R, Chorev M, Rosenblatt M, Levine MA, Suva LJ 1995 Probing the bimolecular interactions of parathyroid hormone and the human parathyroid hormone/parathyroid hormone-related protein receptor. 2. Cloning, characterization, and photoaffinity labeling of the recombinant human receptor. Biochemistry 34:10553-10559
18. Bisello A, Greenberg Z, Behar V, Rosenblatt M, Suva LJ, Chorev M 1997 Direct mapping of interactions between PTH and the PTH/PTHrP receptor by photoaffinity crosslinking: identification of two distinct contact domains. J Bone Miner Res 12 [Suppl]:S363 [Abstract]
19. Bisello A, Adams AE, Mierke DF, Pellegrini M, Rosenblatt M, Suva LJ, Chorev M 1998 Parathyroid hormone-receptor interactions identified directly by photocrosslinking and molecular modeling studies. J Biol Chem 273:22498-22505
20. Dorman G, Prestwich GD 1994 Benzophenone photophores in biochemistry. Biochemistry 33:5661-5673
21. Nakamoto C, Behar V, Chin KR, Adams AE, Suva LJ, Rosenblatt M, Chorev M 1995 Probing the bimolecular interactions of parathyroid hormone with the human parathyroid hormone/parathyroid hormone-related protein receptor. 1. Design, synthesis and characterization of photoreactive benzophenone-containing analogs of parathyroid hormone. Biochemistry 34:10546-10552
22. Schipani E, Karga H, Karaplis AC, Potts Jr JT, Kronenberg HM, Segre GV, Abou-Samra A-B, Jüppner H 1993 Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor. Endocrinology 132: 2157-2165
23. Adams AE, Chorev M, Rosenblatt M, Suva LJ 1993 Cloning and characterization of the human PTH/PTHrP receptor. J Bone Miner Res 8[Suppl 1]:S195 (Abstract)
24. Pines M, Adams AE, Stueckle S, Bessalle R, Rashti-Behar V, Chorev M, Rosenblatt M, Suva LJ 1994 Generation and characterization of human kidney cell lines stably expressing recombinant human PTH/PTHrP receptor: lack of interaction with a C-terminal human PTH peptide. Endocrinology 135:1713-1716
25. Behar V, Nakamoto C, Greenberg Z, Bisello A, Suva LJ, Rosenblatt M, Chorev M 1996 Histidine at position 5 is the specificity "switch" between two parathyroid hormone receptor subtypes. Endocrinology 137:4217-4224
26. Behar V, Pines M, Nakamoto C, Greenberg Z, Bisello A, Stueckle SM, Bessalle R, Usdin TB, Chorev M, Rosenblatt M, Suva LJ 1996 The human PTH2 receptor: binding and signal transduction properties of the stably expressed recombinant receptor. Endocrinology 137: 2748-2757
27. Shigeno C, Hiraki Y, Westerberg DP, Potts JT, Segre GV 1988 Parathyroid hormone receptors are plasma membrane glycoproteins with asparagine-linked oligosaccharides. J Biol Chem 263:3872-3878
28. Bisello A, Greenberg Z, Behar V, Rosenblatt M, Suva LJ, Chorev M 1996 Role of glycosylation in expression and function of the human parathyroid hormone/parathyroid hormone-related protein receptor. Biochemistry 35: 15890-15895
29. Leung AT, Oi LJ, Abou-Samra AB 1996 Role of glycosylation in PTH/PTHrP receptor function. J Bone Miner Res 11[Suppl]:S306 (Abstract)
30. 1 kidney cells. Endocrinology 132:2090-2098
31. Cunningham BC, Wells JA 1989 High-resolution mapping of hGH-receptor interactions by alanine-scanning mutagenesis. Science 244:1081-1085
32. Williams PF, Mynarcik DC, Yu GQ, Whittaker J 1995 Mapping of an NH2-terminal ligand binding site of the insulin receptor by alanine scanning mutagenesis. J Biol Chem 270:3012-3016
33. Spalding TA, Burstein ES, Wells JW, Brann MR 1997 Constitutive activation of the m5 muscarinic receptor by a series of mutations at the extracellular end of transmembrane 6. Biochemistry 36:10109-10116
34. Konopka JB, Margarit SM, Dube P 1996 Mutation of Pro-258 in transmembrane domain 6 constitutively activates the G protein-coupled alpha-factor receptor. Proc Natl Acad Sci USA 93:6764-6769
35. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ 1990 Basic local alignment search tool. J Mol Biol 215:403-410
36. Horiuchi N, Holick MF, Potts Jr JT, Rosenblatt M 1983 A parathyroid hormone inhibitor in vivo: design and biological evaluation of a hormone analog. Science 220:1053-1055
37. McGowan JA, Chen TC, Fragola J, Puschett JB, Rosenblatt M 1983 Parathyroid hormone: effects of the 3-34 fragment in vivo and in vitro. Science 219:67-69
38. McKee RL, Goldman ME, Caulfield MP, DeHaven PA, Levy JJ, Nutt RF, Rosenblatt M 1988 The 7-34-fragment of human hypercalcemia factor is a partial agonist/antagonist for parathyroid hormone-stimulated cAMP production. Endocrinology 122:3008-3010
39. Chorev M, Goldman ME, McKee RL, Roubini E, Levy JJ, Gay CT, Reagan JE, Fisher JE, Caporale LH, Golub EE, Caulfield MP, Nutt RF, Rosenblatt M 1990 Modifications of position 12 in parathyroid hormone and parathyroid hormone-related protein: toward the design of highly potent antagonists. Biochemistry 29:1580-1586
40. Chorev M, Roubini E, McKee RL, Gibbons SW, Reagan JE, Goldman ME, Caulfield MP, Rosenblatt M 1991 Biological activity of parathyroid hormone antagonists substituted at position 13. Peptides 12:57-62
41. Goldman ME, Chorev M, Regan JE, Nutt RF, Levy JJ, Rosenblatt M 1988 Evaluation of novel parathyroid hormone analogs using a bovine renal membrane receptor binding assay. Endocrinology 123:1468-1475
42. Roubini E, Duong LT, Gibbons SW, Leu CT, Caulfield MP, Chorev M, Rosenblatt M 1992 Synthesis of fully active biotinylated analogues of parathyroid hormone and parathyroid hormone-related protein as tools for the characterization of parathyroid hormone receptors. Biochemistry 31:4026-4033
43. Laemmli UK 1970 Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685