Studies of the toxicological potential of capsinoids, xi: Pharmacokinetic and tissue distribution study of 14c-dihydrocapsiate and metabolites in rats

International Journal of Toxicology

Volumn 29, Issue 2_suppl, 2010, Pages 3S-14S

  Bernard, Bruce K ^a   Ubukata, Kazuyuki ^b   Mihara, Ryuichi ^b   Sato, Yoshiaki ^c   Nemoto, Hiroyuki ^c  

^a GENERAL DYNAMICS   (United States)

^b AJINOMOTO CO INC   (Japan)

^c DAIICHI PURE CHEMICALS CO LTD   (Japan)

Author keywords

14C dihydrocapsiate; capsinoid; metabolites; pharmacokinetics; rats

Indexed keywords

ALCOHOL; DIHYDROCAPSAICIN; DIHYDROCAPSIATE C 14; ESTERASE; GLUCURONIDE; SULFATE; UNCLASSIFIED DRUG; VANILLIC ACID; CAPSAICIN; CAPSIATE; CARBON; DIAGNOSTIC AGENT; DRUG DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG EXCRETION; DRUG HALF LIFE; DRUG LIVER LEVEL; EXPIRED AIR; FECES; HYDROLYSIS; KIDNEY; MALE; MAXIMUM PLASMA CONCENTRATION; METABOLITE; NONHUMAN; RADIATION EXPOSURE; RADIOACTIVITY; RAT; SINGLE DRUG DOSE; TISSUE DISTRIBUTION; URINE; ANIMAL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALS; CAPSAICIN; CARBON RADIOISOTOPES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MALE; RATS; TISSUE DISTRIBUTION;

EID: 77955066391     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1177/1091581809357082     Document Type: Article

References (21)

1. Kirshbaum-Titze P, Mueller-Seitz E, Petz M. Pungency in paprika (Capsicum annuum), 2: heterogeneity of capsaicinoid content in individual fruits from one plant. J Agric Food Chem. 2002;50: 1264-1226
2. Dib B. Effects of intrathecal capsaicin on autonomic and behavioral heat loss responses in the rat. Pharmacol Biochem Behav. 1987;28:65-70
3. Kawada T, Hagihara K, Iwai K. Effects of capsaicin on lipid metabolism in rats fed a high fat diet. J Nutr. 1986;116: 1272-1278
4. Yazawa S, Yoneda H, Hosokawa M, et al. Novel capsaicinoid-like substances in the fruits of new non-pungent cultivar CH-19 Sweet of pepper (Capsicum annuum). Capsicum and Eggplant Newsletter. 2004;23:17-20
5. Kobata K, Todo T, Yazawa S, Iwai K, Watanabe T. Novel capsaicinoid-like substances, capsiate and dihydrocapsiate, from the fruits of a nonpungent cultivar, CH-19 Sweet, of pepper (Capsicum annuum L.). J Agric Food Chem. 1998;46: 1695-1697
6. Kobata K, Sutoh K, Todo T, Yazawa S, Iwai K, Watanabe T. Nordihydrocapsiate, a new capsinoid from the fruits of nonpungent pepper, Capsicum annuum. J Nat Prod. 1999;62:335-336
7. Ohnuki K, Harumizu S, Oki K, Watanabe T, Yazawa S, Fushiki T. Administration of capsiate, a non-pungent capsaicin analog, promotes energy metabolism and suppresses body fat accumulation in mice. Biosci Biotechnol Biochem. 2001;65:2735-2740
8. Ohnuki K, Niwa S, Maeda S, Inoue N, Yazawa S, Fushiki T. CH-19 Sweet, a non-pungent cultivar of red pepper, increased body temperature and oxygen consumption in humans. Biosci Biotechnol Biochem. 2001;65:2033-2036
9. Bernard BK, Watanabe E, Kodama T, et al. Studies of the toxicological potential of capsinoids, IX: teratology studies of dihydrocapsiate in rats and rabbits. Int J Toxicol. 2008;27(suppl 3):119-136
10. Bernard BK, Watanabe E, Kodama T, et al. Studies of the toxicological potential of capsinoids, V: genotoxicity studies in dihydrocapsiate. Int J Toxicol. 2008;27(suppl 3):59-72
11. Kodama T, Masuyama T, Kayahara T, et al. Studies of the toxicological potential of capsinoids, XIV: a 26-week gavage toxicity study of dihydrocapsiate in rats. Int J Toxicol. 2010;29(suppl 1): 27S-54S
12. Kodama T, Watanabe E, Tsubuku S, et al. Studies of the toxicological potential of capsinoids, VII: a 13-week gavage toxicity study of dihydrocapsiate in rats. Int J Toxicol. 2008;27(suppl 3):79-100
13. Watanabe E, Kodama T, Masuyama T, et al. Studies of the toxicological potential of capsinoids, VIII: a 13-week toxicity study of commercial grade dihydrocapsiate in rats. Int J Toxicol. 2008;27(suppl 3):101-118
14. Watanabe E, Kodama T, Masuyama T, Tsubuku S, Nakajima M, Bernard BK. Studies of the toxicological potential of capsinoids, VI: single dose toxicity study and micronucleus test of commercial grade dihydrocapsiate. Int J Toxicol. 2008;27(suppl 3):73-77
15. Bernard BK, Watanabe E, Kodama T, et al. Studies of the toxicological potential of capsinoids, IV: teratology studies of CH-19 Sweet extract in rats and rabbits. Int J Toxicol. 2008;27(suppl 3):41-57
16. Kodama T, Watanabe E, Masuyama T, et al. Studies of the toxicological potential of capsinoids, II: a 26-week daily gavage toxicity study of CH-19 Sweet extract in rats. Int J Toxicol. 2008;27(suppl 3):11-27
17. Kodama T, Watanabe E, Masuyama T, et al. Studies of the toxicological potential of capsinoids, III: a two-generation reproduction study of CH-19 Sweet extract in rats. Int J Toxicol. 2008; 27(suppl 3):29-39
18. Watanabe E, Kodama T, Masuyama T, et al. Studies of the toxicological potential of capsinoids, I: single dose toxicity study and genotoxicity studies of CH-19 Sweet extract. Int J Toxicol. 2008; 27(suppl 3):1-9
19. Bernard BK, Tsubuku S, Kayahara T, et al. Studies of the toxicological potential of capsinoids, X: safety assessment and pharmacokinetics of capsinoids in healthy male volunteers after a single oral ingestion of CH-19 Sweet extract. Int J Toxicol. 2008; 27(suppl 3):137-147
20. Shirai Y, Ueno S, Nakayama A, et al. Studies of the toxicological potential of capsinoids, XII: a pharmacokinetic study of capsinoid-containing CH-19 Sweet extract in rats. Int J Toxicol. 2010;29(suppl 1):15S-21S
21. Linda PS, Ronald RS. The metabolism of vanillin and isovanillin in the rat. Xenobiotica. 1975;5:49-63.