Glucose oscillations, more than constant high glucose, induce p53 activation and a metabolic memory in human endothelial cells

Diabetologia

Volumn 54, Issue 5, 2011, Pages 1219-1226

  Schisano, B ^a   Tripathi, G ^a   McGee, K ^a   McTernan, P G ^a   Ceriello, A ^b  

^a UNIVERSITY OF WARWICK   (United Kingdom)

^b INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

Author keywords

Cardiovascular disorders; Endothelial function; HUVECs; Hyperglycaemia; Metabolic memory; Oscillating glucose; p53 activation; Type 2 diabetes

Indexed keywords

GLUCOSE; HISTONE H2AX; PROTEIN KINASE C DELTA; PROTEIN P53;

ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; GENETIC TRANSCRIPTION; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; NEGATIVE FEEDBACK; PRIORITY JOURNAL; UPREGULATION;

BLOTTING, WESTERN; CELLS, CULTURED; DNA DAMAGE; ENDOTHELIAL CELLS; HISTONES; HUMANS; OXIDATIVE STRESS; PROTEIN KINASE C; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 79954631857     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2049-0     Document Type: Article

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