Glycaemic variability and complications in patients with diabetes mellitus: Evidence from a systematic review of the literature

Diabetes, Obesity and Metabolism

Volumn 12, Issue 4, 2010, Pages 288-298

  Nalysnyk, L ^a   Hernandez Medina, M ^a   Krishnarajah, G ^b  

^a UNITED BIOSOURCE CORPORATION   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

Diabetes mellitus; Diabetic complications; Glycaemic variability

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C;

ARTICLE; BLOOD GLUCOSE MONITORING; CARDIOVASCULAR DISEASE; DIABETIC NEPHROPATHY; DIABETIC NEUROPATHY; DIABETIC RETINOPATHY; DISEASE COURSE; GLUCOSE BLOOD LEVEL; GLYCEMIC VARIABILITY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; METABOLIC REGULATION; MICROANGIOPATHY; MORTALITY; NON INSULIN DEPENDENT DIABETES MELLITUS; OXIDATIVE STRESS; SYSTEMATIC REVIEW; VASCULAR DISEASE;

EID: 77953637843     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2009.01160.x     Document Type: Article

References (32)

1. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin dependent diabetes mellitus. N Engl J Med 1993, 329:977-986. The Diabetes Control and Complications Trial (DCCT) Research Group
2. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998, 352:837-853. UK Prospective Diabetes Study (UKPDS) Group
3. Duckworth W, Abraira C., Moritz T. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med 2009, 360:129-139.
4. Patel A, MacMahon S, Chalmers J. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 2008, 358:2560-2572.
5. White NH, Sun W, Cleary PA. Prolonged effect of intensive therapy on the risk of retinopathy complications in patients with type 1 diabetes mellitus: 10 years after the Diabetes Control and Complications Trial. Arch Ophthalmol 2008, 126:1707-1715.
6. Hirsch IB, Brownlee M. Should minimal blood glucose variability become the gold standard of glycemic control? J Diabetes Complications 2005, 19:178-181.
7. Hanefeld M. Postprandial hyperglycaemia: noxious effects on the vessel wall. Int J Clin Pract Suppl 2002, 129:45-50.
8. Brownlee M, Hirsch IB. Glycemic variability: a hemoglobin A1c-independent risk factor for diabetic complications. JAMA 2006, 295:1707-1708.
9. Hanefeld M, Temelkova-Kurktschiev T. Control of postprandial hyperglycemia-an essential part of good diabetes treatment and prevention of cardiovascular complications. Nutr Metab Cardiovasc Dis 2002, 12:98-107.
10. The relationship of glycemic exposure (HbA1c) to the risk of development and progression of retinopathy in the Diabetes Control and Complications Trial. Diabetes 1995, 44:968-983. The Diabetes Control and Complications Trial (DCCT) Research Group
11. Monnier L, Mas E, Ginet C. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA 2006, 295:1681-1687.
12. Guerci B. Asymptomatic glycemic instability: how to measure it and which clinical applications? Diabetes Metab 2003, 29:179-188.
13. Cochrane Collaboration Handbook 4.2.1 2004, Alderson PGreen SHiggins JPT. eds., The Cochrane Library, Issue 1., Chichester, John Wiley & Sons, Ltd., [updated December 2003].
14. Cook D, Mulrow CD, Haynes RB. Systematic reviews: synthesis of best evidence for clinical decisions. Ann Intern Med 1997, 126:376-380.
15. Cook D, Guyatt GH, Laupacis A. Rules of evidence and clinical recommendations on the use of antithrombotic agents. Chest 1992, 102:5S-311S.
16. Cavalot F, Petrelli A, Traversa M. Postprandial blood glucose is a stronger predictor of cardiovascular events than fasting blood glucose in type 2 diabetes mellitus, particularly in women: lessons from the San Luigi Gonzaga Diabetes Study. J Clin Endocrinol Metab 2006, 91:813-819.
17. Esposito K, Giugliano D, Nappo F, Marfella R. Regression of carotid atherosclerosis by control of postprandial hyperglycemia in type 2 diabetes mellitus. Circulation 2004, 110:214-219.
18. Gimeno-Orna JA, Castro-Alonso FJ, Boned-Juliani B, Lou-Arnal LM. Fasting plasma glucose variability as a risk factor of retinopathy in type 2 diabetic patients. J Diabetes Complications 2003, 17:78-81.
19. Muggeo M, Verlato G, Bonora E. Long-term instability of fasting plasma glucose predicts mortality in elderly NIDDM patients: the Verona Diabetes Study. Diabetologia 1995, 38:672-679.
20. Muggeo M, Verlato G, Bonora E, Zoppini G, Corbellini M, de Marco R. Long-term instability of fasting plasma glucose, a novel predictor of cardiovascular mortality in elderly patients with non-insulin-dependent diabetes mellitus: the Verona Diabetes Study. Circulation 1997, 96:1750-1754.
21. Muggeo M, Zoppini G, Bonora E. Fasting plasma glucose variability predicts 10-year survival of type 2 diabetic patients: the Verona Diabetes Study. Diabetes Care 2000, 23:45-50.
22. Zoppini G, Verlato G, Targher G, Bonora E, Trombetta M, Muggeo M. Variability of body weight, pulse pressure and glycaemia strongly predict total mortality in elderly type 2 diabetic patients. Diabetes Metab Res Rev 2008, 24:624-628. The Verona Diabetes Study
23. Zoppini G, Verlato G, Targher G. Is fasting glucose variability a risk factor for retinopathy in people with type 2 diabetes? Nutr Metab Cardiovasc Dis 2008, 19:334-339.
24. Bragd J, Adamson U, Backlund LB, Lins PE, Moberg E, Oskarsson P. Can glycemic variability, as calculated from blood glucose self-monitoring, predict the development of complications in type 1 diabetes over a decade? Diabetes Metab 2008, 34:612-616.
25. Gordin D, Ronnback M, Forsblom C, Makinen V, Saraheimo M, Groop PH. Glucose variability, blood pressure and arterial stiffness in type 1 diabetes. Diabetes Res Clin Pract 2008, 80:e4-e7.
26. Kilpatrick ES, Rigby AS, Atkin SL. The effect of glucose variability on the risk of microvascular complications in type 1 diabetes. Diabetes Care 2006, 29:1486-1490.
27. Kilpatrick ES, Rigby AS, Atkin SL. Mean blood glucose compared with HbA1c in the prediction of cardiovascular disease in patients with type 1 diabetes. Diabetologia 2008, 51:365-371.
28. Moberg EA, Lins PE, Adamson UK. Variability of blood glucose levels in patients with type 1 diabetes mellitus on intensified insulin regimens. Diabetes Metab 1994, 20:546-552.
29. Oyibo SO, Prasad YD, Jackson NJ, Jude EB, Boulton AJ. The relationship between blood glucose excursions and painful diabetic peripheral neuropathy: a pilot study. Diabet Med 2002, 19:870-873.
30. Wentholt IM, Kulik W, Michels RP, Hoekstra JB, DeVries JH. Glucose fluctuations and activation of oxidative stress in patients with type 1 diabetes. Diabetologia 2008, 51:183-190.
31. Service F, O'Brien PC. The relation of glycaemsia to the risk of development and progression of retinopathy in the Diabetic Control and Complications Trial. Diabetologia 2001, 44:1215-1220.
32. Ceriello A, Esposito K, Piconi L. Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients. Diabetes 2008, 57:1349-1354.