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Volumn 294, Issue 5, 2008, Pages

Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation

Author keywords

Ataxia telangiectasia mutant; Checkpoint

Indexed keywords

ATM PROTEIN; ATR PROTEIN; CHECKPOINT KINASE 1; HISTONE H2AX; PROTEIN P53; ATR PROTEIN, HUMAN; ATRIP PROTEIN, HUMAN; CASEIN KINASE II; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; H2AFX PROTEIN, HUMAN; HISTONE; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; SERINE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TUMOR SUPPRESSOR PROTEIN;

EID: 45849085731     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00004.2008     Document Type: Article
Times cited : (38)

References (52)
  • 1
    • 0035449355 scopus 로고    scopus 로고
    • Cell cycle checkpoint signaling through the ATM and ATR kinases
    • Abraham RT. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 15: 2177-2196, 2001.
    • (2001) Genes Dev , vol.15 , pp. 2177-2196
    • Abraham, R.T.1
  • 2
    • 0036009454 scopus 로고    scopus 로고
    • DNA oxidation or apoptosis: Will the real culprit of DNA damage in hyperoxic lung injury please stand up?
    • Albertine KH, Plopper CG. DNA oxidation or apoptosis: will the real culprit of DNA damage in hyperoxic lung injury please stand up? Am J Respir Cell Mol Biol 26: 381-383, 2002.
    • (2002) Am J Respir Cell Mol Biol , vol.26 , pp. 381-383
    • Albertine, K.H.1    Plopper, C.G.2
  • 3
    • 0031935413 scopus 로고    scopus 로고
    • Glucose modulates cell death due to normobaric hyperoxia by maintaining cellular ATP
    • Allen CB, White CW. Glucose modulates cell death due to normobaric hyperoxia by maintaining cellular ATP. Am J Physiol Lung Cell Mol Physiol 274: L159-L164, 1998.
    • (1998) Am J Physiol Lung Cell Mol Physiol , vol.274
    • Allen, C.B.1    White, C.W.2
  • 4
    • 0034818446 scopus 로고    scopus 로고
    • Post-translational modifications and activation of p53 by genotoxic stresses
    • Appella E, Anderson CW. Post-translational modifications and activation of p53 by genotoxic stresses. Eur J Biochem 268: 2764-2772, 2001.
    • (2001) Eur J Biochem , vol.268 , pp. 2764-2772
    • Appella, E.1    Anderson, C.W.2
  • 5
    • 0034031250 scopus 로고    scopus 로고
    • Signaling to p53: Breaking the posttranslational modification code
    • Appella E, Anderson CW. Signaling to p53: breaking the posttranslational modification code. Pathol Biol (Paris) 48: 227-245, 2000.
    • (2000) Pathol Biol (Paris) , vol.48 , pp. 227-245
    • Appella, E.1    Anderson, C.W.2
  • 6
    • 18244385718 scopus 로고    scopus 로고
    • ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation
    • Ball HL, Myers JS, Cortez D. ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation. Mol Biol Cell 16: 2372-2381, 2005.
    • (2005) Mol Biol Cell , vol.16 , pp. 2372-2381
    • Ball, H.L.1    Myers, J.S.2    Cortez, D.3
  • 9
    • 0024998101 scopus 로고
    • Reactive oxygen species and airway inflammation
    • Barnes PJ. Reactive oxygen species and airway inflammation. Free Radic Biol Med 9: 235-243, 1990.
    • (1990) Free Radic Biol Med , vol.9 , pp. 235-243
    • Barnes, P.J.1
  • 10
    • 0034102337 scopus 로고    scopus 로고
    • ATR disruption leads to chromosomal fragmentation and early embryonic lethality
    • Brown EJ, Baltimore D. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev 14: 397-402, 2000.
    • (2000) Genes Dev , vol.14 , pp. 397-402
    • Brown, E.J.1    Baltimore, D.2
  • 11
    • 1342325422 scopus 로고    scopus 로고
    • Reactive oxygen species are required for hyperoxia-induced Bax activation and cell death in alveolar epithelial cells
    • Buccellato LJ, Tso M, Akinci OI, Chandel NS, Budinger GR. Reactive oxygen species are required for hyperoxia-induced Bax activation and cell death in alveolar epithelial cells. J Biol Chem 279: 6753-6760, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 6753-6760
    • Buccellato, L.J.1    Tso, M.2    Akinci, O.I.3    Chandel, N.S.4    Budinger, G.R.5
  • 13
    • 0032427628 scopus 로고    scopus 로고
    • The role of ATM in DNA damage responses and cancer
    • Canman CE, Lim DS. The role of ATM in DNA damage responses and cancer. Oncogene 17: 3301-3308, 1998.
    • (1998) Oncogene , vol.17 , pp. 3301-3308
    • Canman, C.E.1    Lim, D.S.2
  • 15
    • 0034710870 scopus 로고    scopus 로고
    • Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage
    • Chao C, Saito S, Anderson CW, Appella E, Xu Y. Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage. Proc Natl Acad Sci USA 97: 11936-11941, 2000.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 11936-11941
    • Chao, C.1    Saito, S.2    Anderson, C.W.3    Appella, E.4    Xu, Y.5
  • 16
    • 0034665461 scopus 로고    scopus 로고
    • p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage
    • Chao C, Saito S, Kang J, Anderson CW, Appella E, Xu Y. p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage. EMBO J 19: 4967-4975, 2000.
    • (2000) EMBO J , vol.19 , pp. 4967-4975
    • Chao, C.1    Saito, S.2    Kang, J.3    Anderson, C.W.4    Appella, E.5    Xu, Y.6
  • 17
    • 0032472330 scopus 로고    scopus 로고
    • Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints
    • Cliby WA, Roberts CJ, Cimprich KA, Stringer CM, Lamb JR, Schreiber SL, Friend SH. Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO J 17: 159-169, 1998.
    • (1998) EMBO J , vol.17 , pp. 159-169
    • Cliby, W.A.1    Roberts, C.J.2    Cimprich, K.A.3    Stringer, C.M.4    Lamb, J.R.5    Schreiber, S.L.6    Friend, S.H.7
  • 19
    • 0035941021 scopus 로고    scopus 로고
    • ATR and ATRIP: Partners in checkpoint signaling
    • Cortez D, Guntuku S, Qin J, Elledge SJ. ATR and ATRIP: partners in checkpoint signaling. Science 294: 1713-1716, 2001.
    • (2001) Science , vol.294 , pp. 1713-1716
    • Cortez, D.1    Guntuku, S.2    Qin, J.3    Elledge, S.J.4
  • 21
    • 0347357996 scopus 로고    scopus 로고
    • Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites
    • Das KC, Dashnamoorthy R. Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites. Am J Physiol Lung Cell Mol Physiol 286: L87-L97, 2004.
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.286
    • Das, K.C.1    Dashnamoorthy, R.2
  • 24
    • 0019848340 scopus 로고
    • Hyperoxia increases oxygen radical production in rat lungs and lung mitochondria
    • Freeman BA, Crapo JD. Hyperoxia increases oxygen radical production in rat lungs and lung mitochondria. J Biol Chem 256: 10986-10992, 1981.
    • (1981) J Biol Chem , vol.256 , pp. 10986-10992
    • Freeman, B.A.1    Crapo, J.D.2
  • 25
    • 0029736434 scopus 로고    scopus 로고
    • Role of reactive oxygen metabolites in DNA damage and cell death in chemical hypoxic injury to LLC-PK1 cells
    • Hagar H, Ueda N, Shah SV. Role of reactive oxygen metabolites in DNA damage and cell death in chemical hypoxic injury to LLC-PK1 cells. Am J Physiol Renal Fluid Electrolyte Physiol 271: F209-F215, 1996.
    • (1996) Am J Physiol Renal Fluid Electrolyte Physiol , vol.271
    • Hagar, H.1    Ueda, N.2    Shah, S.V.3
  • 26
    • 12544250589 scopus 로고    scopus 로고
    • Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage
    • Helt CE, Cliby WA, Keng PC, Bambara RA, O'Reilly MA. Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage. J Biol Chem 280: 1186-1192, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 1186-1192
    • Helt, C.E.1    Cliby, W.A.2    Keng, P.C.3    Bambara, R.A.4    O'Reilly, M.A.5
  • 30
    • 34247483506 scopus 로고    scopus 로고
    • ATM activation and DNA damage response
    • Lavin MF, Kozlov S. ATM activation and DNA damage response. Cell Cycle 6: 931-942, 2007.
    • (2007) Cell Cycle , vol.6 , pp. 931-942
    • Lavin, M.F.1    Kozlov, S.2
  • 31
    • 0034644220 scopus 로고    scopus 로고
    • Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response
    • Li S, Ting NS, Zheng L, Chen PL, Ziv Y, Shiloh Y, Lee EY, Lee WH. Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Nature 406: 210-215, 2000.
    • (2000) Nature , vol.406 , pp. 210-215
    • Li, S.1    Ting, N.S.2    Zheng, L.3    Chen, P.L.4    Ziv, Y.5    Shiloh, Y.6    Lee, E.Y.7    Lee, W.H.8
  • 34
    • 33646777679 scopus 로고    scopus 로고
    • Rapid activation of ATR by ionizing radiation requires ATM and Mre11
    • Myers JS, Cortez D. Rapid activation of ATR by ionizing radiation requires ATM and Mre11. J Biol Chem 281: 9346-9350, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 9346-9350
    • Myers, J.S.1    Cortez, D.2
  • 36
    • 30944435091 scopus 로고    scopus 로고
    • Unleashing the power of p53: Lessons from mice and men
    • Poyurovsky MV, Prives C. Unleashing the power of p53: lessons from mice and men. Genes Dev 20: 125-131, 2006.
    • (2006) Genes Dev , vol.20 , pp. 125-131
    • Poyurovsky, M.V.1    Prives, C.2
  • 40
    • 0035877581 scopus 로고    scopus 로고
    • The Ataxia telangiectasia gene product is required for oxidative stress-induced G1 and G2 checkpoint function in human fibroblasts
    • Shackelford RE, Innes CL, Sieber SO, Heinloth AN, Leadon SA, Paules RS. The Ataxia telangiectasia gene product is required for oxidative stress-induced G1 and G2 checkpoint function in human fibroblasts. J Biol Chem 276: 21951-21959, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 21951-21959
    • Shackelford, R.E.1    Innes, C.L.2    Sieber, S.O.3    Heinloth, A.N.4    Leadon, S.A.5    Paules, R.S.6
  • 41
    • 0034142034 scopus 로고    scopus 로고
    • The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
    • Shieh SY, Ahn J, Tamai K, Taya Y, Prives C. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev 14: 289-300, 2000.
    • (2000) Genes Dev , vol.14 , pp. 289-300
    • Shieh, S.Y.1    Ahn, J.2    Tamai, K.3    Taya, Y.4    Prives, C.5
  • 42
    • 0033118933 scopus 로고    scopus 로고
    • DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization
    • Shieh SY, Taya Y, Prives C. DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization. EMBO J 18: 1815-1823, 1999.
    • (1999) EMBO J , vol.18 , pp. 1815-1823
    • Shieh, S.Y.1    Taya, Y.2    Prives, C.3
  • 43
    • 33745823159 scopus 로고    scopus 로고
    • The ATM-mediated DNA-damage response: Taking shape
    • Shiloh Y. The ATM-mediated DNA-damage response: taking shape. Trends Biochem Sci 31: 402-410, 2006.
    • (2006) Trends Biochem Sci , vol.31 , pp. 402-410
    • Shiloh, Y.1
  • 45
    • 26244435498 scopus 로고    scopus 로고
    • Molecular pathology of ataxia telangiectasia
    • Taylor AM, Byrd PJ. Molecular pathology of ataxia telangiectasia. J Clin Pathol 58: 1009-1015, 2005.
    • (2005) J Clin Pathol , vol.58 , pp. 1009-1015
    • Taylor, A.M.1    Byrd, P.J.2
  • 46
    • 0026669469 scopus 로고
    • p53 function and dysfunction
    • Vogelstein B, Kinzler KW. p53 function and dysfunction. Cell 70: 523-526, 1992.
    • (1992) Cell , vol.70 , pp. 523-526
    • Vogelstein, B.1    Kinzler, K.W.2
  • 47
    • 0042707655 scopus 로고    scopus 로고
    • Necrotic cell death in response to oxidant stress involves the activation of the apoptogenic caspase-8/bid pathway
    • Wang X, Ryter SW, Dai C, Tang ZL, Watkins SC, Yin XM, Song R, Choi AM. Necrotic cell death in response to oxidant stress involves the activation of the apoptogenic caspase-8/bid pathway. J Biol Chem 278: 29184-29191, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 29184-29191
    • Wang, X.1    Ryter, S.W.2    Dai, C.3    Tang, Z.L.4    Watkins, S.C.5    Yin, X.M.6    Song, R.7    Choi, A.M.8
  • 48
    • 0035930537 scopus 로고    scopus 로고
    • Histone H2AX is phosphorylated in an ATRdependent manner in response to replicational stress
    • Ward IM, Chen J. Histone H2AX is phosphorylated in an ATRdependent manner in response to replicational stress. J Biol Chem 276: 47759-47762, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 47759-47762
    • Ward, I.M.1    Chen, J.2
  • 49
    • 0037099404 scopus 로고    scopus 로고
    • Protection of human lung cells against hyperoxia using the DNA base excision repair genes hOgg1 and Fpg
    • Wu M, He YH, Kobune M, Xu Y, Kelley MR, Martin WJ 2nd. Protection of human lung cells against hyperoxia using the DNA base excision repair genes hOgg1 and Fpg. Am J Respir Crit Care Med 166: 192-199, 2002.
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 192-199
    • Wu, M.1    He, Y.H.2    Kobune, M.3    Xu, Y.4    Kelley, M.R.5    Martin 2nd, W.J.6
  • 50
    • 34547115962 scopus 로고    scopus 로고
    • Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM
    • Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG. Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM. J Biol Chem 282: 17501-17506, 2007.
    • (2007) J Biol Chem , vol.282 , pp. 17501-17506
    • Yoo, H.Y.1    Kumagai, A.2    Shevchenko, A.3    Shevchenko, A.4    Dunphy, W.G.5
  • 51
    • 0034967556 scopus 로고    scopus 로고
    • ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
    • Zhao H, Piwnica-Worms H. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol 21: 4129-4139, 2001.
    • (2001) Mol Cell Biol , vol.21 , pp. 4129-4139
    • Zhao, H.1    Piwnica-Worms, H.2
  • 52
    • 0024364839 scopus 로고
    • Electron paramagnetic resonance evidence that cellular oxygen toxicity is caused by the generation of superoxide and hydroxyl free radicals
    • Zweier JL, Duke SS, Kuppusamy P, Sylvester JT, Gabrielson EW. Electron paramagnetic resonance evidence that cellular oxygen toxicity is caused by the generation of superoxide and hydroxyl free radicals. FEBS Lett 252: 12-16, 1989.
    • (1989) FEBS Lett , vol.252 , pp. 12-16
    • Zweier, J.L.1    Duke, S.S.2    Kuppusamy, P.3    Sylvester, J.T.4    Gabrielson, E.W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.