Setdb1-mediated histone H3K9 hypermethylation in neurons worsens the neurological phenotype of Mecp2-deficient mice

Neuropharmacology

Volumn 60, Issue 7-8, 2011, Pages 1088-1097

  Jiang, Yan ^a   Matevossian, Anouch ^a   Guo, Yin ^a   Akbarian, Schahram ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Epigenetic; Heterochromatin; Histone methylation; Major satellite; Neurodevelopment; Nucleosome; Repeat DNA

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; COMPLEMENTARY DNA; HISTONE H3; HISTONE H3 LYSINE 9; METHYLTRANSFERASE; PROTEIN ESET; PROTEIN KMT1E; PROTEIN SETB1; UNCLASSIFIED DRUG; HISTONE LYSINE METHYLTRANSFERASE; LYSINE; MESSENGER RNA; METHYL CPG BINDING PROTEIN 2; PROTEIN SETDB1; TAU PROTEIN;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CK SETB1 GENE; CONTROLLED STUDY; ENZYME SPECIFICITY; FOREBRAIN; GENE; GENE DELETION; GENE EXPRESSION; GENE LOCUS; LIFESPAN; MECP2 GENE; MITOSIS; MOUSE; NERVE CELL; NERVE CELL DIFFERENTIATION; NERVE CELL NECROSIS; NEUROLOGIC DISEASE; NONHUMAN; PHENOTYPE; PRENATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METHYLATION; RETT SYNDROME; SETB1 GENE; TAU GENE; TAUSETB1 GENE; TRANSGENE; UPREGULATION; WILD TYPE; BRAIN DEVELOPMENT; DISEASE EXACERBATION; FEMALE; GENE EXPRESSION REGULATION; GENE TARGETING; HISTONE HYPERMETHYLATION; HISTONE METHYLATION; MALE; NEUROTOXICITY; SETDB1 GENE;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN; CEREBRAL CORTEX; FEMALE; GENES, MYC; HISTONES; LOCOMOTION; MALE; METHYL-CPG-BINDING PROTEIN 2; METHYLATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, NEUROLOGIC MUTANTS; MICE, TRANSGENIC; NEURONS; PHENOTYPE; PROTEIN METHYLTRANSFERASES; TAU PROTEINS;

EID: 79954575054     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2010.09.020     Document Type: Article

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