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Volumn 93, Issue 5, 2008, Pages 1563-1572

Generalized glucocorticoid resistance: Clinical aspects, molecular mechanisms, and implications of a rare genetic disorder

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; DEXAMETHASONE; GLUCOCORTICOID;

EID: 43249102598     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2008-0040     Document Type: Review
Times cited : (162)

References (71)
  • 1
    • 77956681311 scopus 로고    scopus 로고
    • Glucocorticoid effects on gene expression
    • T Kino GP Chrousos Glucocorticoid effects on gene expression T Steckler NH Kalin JMHM Reul Handbook of stress and the brain 2005 Elsevier Amsterdam 295 311
    • (2005) , pp. 295-311
    • Kino, T1    Chrousos, GP2
  • 2
    • 1642416888 scopus 로고    scopus 로고
    • Glucocorticoid action networks-an introduction to systems biology
    • GP Chrousos E Charmandari T Kino Glucocorticoid action networks-an introduction to systems biology J Clin Endocrinol Metab 89 2004 563 564
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 563-564
    • Chrousos, GP1    Charmandari, E2    Kino, T3
  • 3
    • 3843071883 scopus 로고    scopus 로고
    • The glucocorticoid receptor gene, longevity, and the complex disorders of Western societies
    • GP Chrousos The glucocorticoid receptor gene, longevity, and the complex disorders of Western societies Am J Med 117 2004 204 207
    • (2004) Am J Med , vol.117 , pp. 204-207
    • Chrousos, GP1
  • 5
    • 18144399332 scopus 로고    scopus 로고
    • The human glucocorticoid receptor: one gene, multiple proteins and diverse responses
    • J Zhou JA Cidlowski The human glucocorticoid receptor: one gene, multiple proteins and diverse responses Steroids 70 2005 407 417
    • (2005) Steroids , vol.70 , pp. 407-417
    • Zhou, J1    Cidlowski, JA2
  • 6
    • 33751000477 scopus 로고    scopus 로고
    • Multiple glucocorticoid receptor isoforms and mechanisms of post-translational modification
    • D Duma CM Jewell JA Cidlowski Multiple glucocorticoid receptor isoforms and mechanisms of post-translational modification J Steroid Biochem Mol Biol 102 2006 11 21
    • (2006) J Steroid Biochem Mol Biol , vol.102 , pp. 11-21
    • Duma, D1    Jewell, CM2    Cidlowski, JA3
  • 7
    • 0027451956 scopus 로고
    • The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor
    • WB Pratt The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor J Biol Chem 268 1993 21455 21458
    • (1993) J Biol Chem , vol.268 , pp. 21455-21458
    • Pratt, WB1
  • 8
    • 36749081534 scopus 로고    scopus 로고
    • Crossing the nuclear envelope: hierarchical regulation of nucleocytoplasmic transport
    • LJ Terry EB Shows SR Wente Crossing the nuclear envelope: hierarchical regulation of nucleocytoplasmic transport Science 318 2007 1412 1416
    • (2007) Science , vol.318 , pp. 1412-1416
    • Terry, LJ1    Shows, EB2    Wente, SR3
  • 9
    • 0030026713 scopus 로고    scopus 로고
    • Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids
    • CM Bamberger HM Schulte GP Chrousos Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids Endocr Rev 17 1996 245 261
    • (1996) Endocr Rev , vol.17 , pp. 245-261
    • Bamberger, CM1    Schulte, HM2    Chrousos, GP3
  • 10
    • 0037643416 scopus 로고    scopus 로고
    • Molecular mechanisms of glucocorticoid action and resistance
    • MJ Schaaf JA Cidlowski Molecular mechanisms of glucocorticoid action and resistance J Steroid Biochem Mol Biol 83 2002 37 48
    • (2002) J Steroid Biochem Mol Biol , vol.83 , pp. 37-48
    • Schaaf, MJ1    Cidlowski, JA2
  • 11
    • 0025015647 scopus 로고
    • Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone
    • C Jonat HJ Rahmsdorf KK Park AC Cato S Gebel H Ponta P Herrlich Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone Cell 62 1990 1189 1204
    • (1990) Cell , vol.62 , pp. 1189-1204
    • Jonat, C1    Rahmsdorf, HJ2    Park, KK3    Cato, AC4    Gebel, S5    Ponta, H6    Herrlich, P7
  • 12
    • 0028831128 scopus 로고
    • Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors
    • RI Scheinman A Gualberto CM Jewell JA Cidlowski Baldwin AS Jr Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors Mol Cell Biol 15 1995 943 953
    • (1995) Mol Cell Biol , vol.15 , pp. 943-953
    • Scheinman, RI1    Gualberto, A2    Jewell, CM3    Cidlowski, JA4    Baldwin, AS5
  • 13
    • 33644875471 scopus 로고    scopus 로고
    • Intracellular glucocorticoid signaling: a formerly simple system turns stochastic
    • GP Chrousos T Kino Intracellular glucocorticoid signaling: a formerly simple system turns stochastic Sci STKE 2005 2005 pe48
    • (2005) Sci STKE , vol.2005 , pp. pe48
    • Chrousos, GP1    Kino, T2
  • 14
    • 0036226710 scopus 로고    scopus 로고
    • Tissue-specific glucocorticoid resistance-hypersensitivity syndromes: multifactorial states of clinical importance
    • T Kino GP Chrousos Tissue-specific glucocorticoid resistance-hypersensitivity syndromes: multifactorial states of clinical importance J Allergy Clin Immunol 109 2002 609 613
    • (2002) J Allergy Clin Immunol , vol.109 , pp. 609-613
    • Kino, T1    Chrousos, GP2
  • 15
    • 0034463835 scopus 로고    scopus 로고
    • Protracted nuclear export of glucocorticoid receptor limits its turnover and does not require the exportin 1/CRM1-directed nuclear export pathway
    • J Liu DB DeFranco Protracted nuclear export of glucocorticoid receptor limits its turnover and does not require the exportin 1/CRM1-directed nuclear export pathway Mol Endocrinol 14 2000 40 51
    • (2000) Mol Endocrinol , vol.14 , pp. 40-51
    • Liu, J1    DeFranco, DB2
  • 16
    • 0033305547 scopus 로고    scopus 로고
    • Nuclear receptor coregulators: cellular and molecular biology
    • NJ McKenna RB Lanz BW O'Malley Nuclear receptor coregulators: cellular and molecular biology Endocr Rev 20 1999 321 344
    • (1999) Endocr Rev , vol.20 , pp. 321-344
    • McKenna, NJ1    Lanz, RB2    O'Malley, BW3
  • 17
  • 18
    • 0037154974 scopus 로고    scopus 로고
    • Combinatorial control of gene expression by nuclear receptors and coregulators
    • NJ McKenna BW O'Malley Combinatorial control of gene expression by nuclear receptors and coregulators Cell 108 2002 465 474
    • (2002) Cell , vol.108 , pp. 465-474
    • McKenna, NJ1    O'Malley, BW2
  • 19
    • 0037064150 scopus 로고    scopus 로고
    • Coordinate regulation of transcription and splicing by steroid receptor coregulators
    • D Auboeuf A Honig SM Berget BW O'Malley Coordinate regulation of transcription and splicing by steroid receptor coregulators Science 298 2002 416 419
    • (2002) Science , vol.298 , pp. 416-419
    • Auboeuf, D1    Honig, A2    Berget, SM3    O'Malley, BW4
  • 20
    • 0033214780 scopus 로고    scopus 로고
    • Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins
    • AB Hittelman D Burakov JA Iniguez-Lluhi LP Freedman MJ Garabedian Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins EMBO J 18 1999 5380 5388
    • (1999) EMBO J , vol.18 , pp. 5380-5388
    • Hittelman, AB1    Burakov, D2    Iniguez-Lluhi, JA3    Freedman, LP4    Garabedian, MJ5
  • 21
    • 0030986236 scopus 로고    scopus 로고
    • A signature motif in transcriptional co-activators mediates binding to nuclear receptors
    • DM Heery E Kalkhoven S Hoare MG Parker A signature motif in transcriptional co-activators mediates binding to nuclear receptors Nature 387 1997 733 736
    • (1997) Nature , vol.387 , pp. 733-736
    • Heery, DM1    Kalkhoven, E2    Hoare, S3    Parker, MG4
  • 22
    • 0034965716 scopus 로고    scopus 로고
    • Glucocorticoid and mineralocorticoid resistance/hypersensitivity syndromes
    • T Kino GP Chrousos Glucocorticoid and mineralocorticoid resistance/hypersensitivity syndromes J Endocrinol 169 2001 437 445
    • (2001) J Endocrinol , vol.169 , pp. 437-445
    • Kino, T1    Chrousos, GP2
  • 23
    • 43249104061 scopus 로고    scopus 로고
    • Modern endocrinology series
    • GP Chrousos Modern endocrinology series GP Chrousos JM Olefsky E Samols Hormone resistance and hypersensitivity states 2002 Lippincott Williams & Wilkins Philadelphia 542
    • (2002) , pp. 542
    • Chrousos, GP1
  • 25
    • 34249002259 scopus 로고    scopus 로고
    • Glucocorticoid action networks and complex psychiatric and/or somatic disorders
    • GP Chrousos T Kino Glucocorticoid action networks and complex psychiatric and/or somatic disorders Stress 10 2007 213 219
    • (2007) Stress , vol.10 , pp. 213-219
    • Chrousos, GP1    Kino, T2
  • 29
    • 0037024524 scopus 로고    scopus 로고
    • Familial/sporadic glucocorticoid resistance syndrome and hypertension
    • T Kino A Vottero E Charmandari GP Chrousos Familial/sporadic glucocorticoid resistance syndrome and hypertension Ann NY Acad Sci 970 2002 101 111
    • (2002) Ann NY Acad Sci , vol.970 , pp. 101-111
    • Kino, T1    Vottero, A2    Charmandari, E3    Chrousos, GP4
  • 30
    • 3042754450 scopus 로고    scopus 로고
    • Familial/sporadic glucocorticoid resistance: clinical phenotype and molecular mechanisms
    • E Charmandari T Kino GP Chrousos Familial/sporadic glucocorticoid resistance: clinical phenotype and molecular mechanisms Ann NY Acad Sci 1024 2004 168 181
    • (2004) Ann NY Acad Sci , vol.1024 , pp. 168-181
    • Charmandari, E1    Kino, T2    Chrousos, GP3
  • 31
    • 0030179298 scopus 로고    scopus 로고
    • Cushing's disease preceded by generalized glucocorticoid resistance: clinical consequences of a novel, dominant-negative glucocorticoid receptor mutation
    • M Karl SW Lamberts JW Koper DA Katz NE Huizenga T Kino BR Haddad MR Hughes GP Chrousos Cushing's disease preceded by generalized glucocorticoid resistance: clinical consequences of a novel, dominant-negative glucocorticoid receptor mutation Proc Assoc Am Physicians 108 1996 296 307
    • (1996) Proc Assoc Am Physicians , vol.108 , pp. 296-307
    • Karl, M1    Lamberts, SW2    Koper, JW3    Katz, DA4    Huizenga, NE5    Kino, T6    Haddad, BR7    Hughes, MR8    Chrousos, GP9
  • 32
    • 0026026319 scopus 로고
    • Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance
    • DM Hurley D Accili CA Stratakis M Karl N Vamvakopoulos E Rorer K Constantine SI Taylor GP Chrousos Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance J Clin Invest 87 1991 680 686
    • (1991) J Clin Invest , vol.87 , pp. 680-686
    • Hurley, DM1    Accili, D2    Stratakis, CA3    Karl, M4    Vamvakopoulos, N5    Rorer, E6    Constantine, K7    Taylor, SI8    Chrousos, GP9
  • 35
    • 0035187441 scopus 로고    scopus 로고
    • Pathologic human GR mutant has a transdominant negative effect on the wild-type GR by inhibiting its translocation into the nucleus: importance of the ligand-binding domain for intracellular GR trafficking
    • T Kino RH Stauber JH Resau GN Pavlakis GP Chrousos Pathologic human GR mutant has a transdominant negative effect on the wild-type GR by inhibiting its translocation into the nucleus: importance of the ligand-binding domain for intracellular GR trafficking J Clin Endocrinol Metab 86 2001 5600 5608
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5600-5608
    • Kino, T1    Stauber, RH2    Resau, JH3    Pavlakis, GN4    Chrousos, GP5
  • 38
    • 0036075596 scopus 로고    scopus 로고
    • A novel, C-terminal dominant negative mutation of the GR causes familial glucocorticoid resistance through abnormal interactions with p160 steroid receptor coactivators
    • A Vottero T Kino H Combe P Lecomte GP Chrousos A novel, C-terminal dominant negative mutation of the GR causes familial glucocorticoid resistance through abnormal interactions with p160 steroid receptor coactivators J Clin Endocrinol Metab 87 2002 2658 2667
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 2658-2667
    • Vottero, A1    Kino, T2    Combe, H3    Lecomte, P4    Chrousos, GP5
  • 39
    • 1942536210 scopus 로고    scopus 로고
    • Natural glucocorticoid receptor mutants causing generalized glucocorticoid resistance: molecular genotype, genetic transmission and clinical phenotype
    • E Charmandari T Kino A Vottero E Souvatzoglou N Bhattacharyya GP Chrousos Natural glucocorticoid receptor mutants causing generalized glucocorticoid resistance: molecular genotype, genetic transmission and clinical phenotype J Clin Endocrinol Metab 89 2004 1939 1949
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 1939-1949
    • Charmandari, E1    Kino, T2    Vottero, A3    Souvatzoglou, E4    Bhattacharyya, N5    Chrousos, GP6
  • 40
    • 21244432841 scopus 로고    scopus 로고
    • A novel point mutation in the ligand-binding domain (LBD) of the human glucocorticoid receptor (hGR) causing generalized glucocorticoid resistance: the importance of the C terminus of hGR LBD in conferring transactivational activity
    • E Charmandari A Raji T Kino T Ichijo A Tiulpakov K Zachman GP Chrousos A novel point mutation in the ligand-binding domain (LBD) of the human glucocorticoid receptor (hGR) causing generalized glucocorticoid resistance: the importance of the C terminus of hGR LBD in conferring transactivational activity J Clin Endocrinol Metab 90 2005 3696 3705
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 3696-3705
    • Charmandari, E1    Raji, A2    Kino, T3    Ichijo, T4    Tiulpakov, A5    Zachman, K6    Chrousos, GP7
  • 41
    • 33646040431 scopus 로고    scopus 로고
    • Functional characterization of the natural human glucocorticoid receptor (hGR) mutants hGRαR477H and hGRαG679S associated with generalized glucocorticoid resistance
    • E Charmandari T Kino T Ichijo K Zachman A Alatsatianos GP Chrousos Functional characterization of the natural human glucocorticoid receptor (hGR) mutants hGRαR477H and hGRαG679S associated with generalized glucocorticoid resistance J Clin Endocrinol Metab 91 2006 1535 1543
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 1535-1543
    • Charmandari, E1    Kino, T2    Ichijo, T3    Zachman, K4    Alatsatianos, A5    Chrousos, GP6
  • 42
    • 35349002759 scopus 로고    scopus 로고
    • A novel point mutation in helix 11 of the ligand-binding domain of the human glucocorticoid receptor gene causing generalized glucocorticoid resistance
    • E Charmandari T Kino T Ichijo W Jubiz L Mejia K Zachman GP Chrousos A novel point mutation in helix 11 of the ligand-binding domain of the human glucocorticoid receptor gene causing generalized glucocorticoid resistance J Clin Endocrinol Metab 92 2007 3986 3990
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 3986-3990
    • Charmandari, E1    Kino, T2    Ichijo, T3    Jubiz, W4    Mejia, L5    Zachman, K6    Chrousos, GP7
  • 44
    • 0027330978 scopus 로고
    • Steroid 5α-reductase 2 deficiency
    • JD Wilson JE Griffin DW Russell Steroid 5α-reductase 2 deficiency Endocr Rev 14 1993 577 593
    • (1993) Endocr Rev , vol.14 , pp. 577-593
    • Wilson, JD1    Griffin, JE2    Russell, DW3
  • 45
    • 0034455751 scopus 로고    scopus 로고
    • Five patients with biochemical and/or clinical generalized glucocorticoid resistance without alterations in the glucocorticoid receptor gene
    • NA Huizenga P de Lange JW Koper WW de Herder R Abs JH Kasteren FH de Jong SW Lamberts Five patients with biochemical and/or clinical generalized glucocorticoid resistance without alterations in the glucocorticoid receptor gene J Clin Endocrinol Metab 85 2000 2076 2081
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 2076-2081
    • Huizenga, NA1    de Lange, P2    Koper, JW3    de Herder, WW4    Abs, R5    Kasteren, JH6    de Jong, FH7    Lamberts, SW8
  • 46
    • 0037233685 scopus 로고    scopus 로고
    • Pediatric stress: hormonal mediators and human development
    • E Charmandari T Kino E Souvatzoglou GP Chrousos Pediatric stress: hormonal mediators and human development Horm Res 59 2003 161 179
    • (2003) Horm Res , vol.59 , pp. 161-179
    • Charmandari, E1    Kino, T2    Souvatzoglou, E3    Chrousos, GP4
  • 51
    • 0030024586 scopus 로고    scopus 로고
    • Role of the C terminus of the glucocorticoid receptor in hormone binding and agonist/antagonist discrimination
    • S Zhang X Liang M Danielsen Role of the C terminus of the glucocorticoid receptor in hormone binding and agonist/antagonist discrimination Mol Endocrinol 10 1996 24 34
    • (1996) Mol Endocrinol , vol.10 , pp. 24-34
    • Zhang, S1    Liang, X2    Danielsen, M3
  • 52
    • 0032929622 scopus 로고    scopus 로고
    • Discrimination between NL1- and NL2-mediated nuclear localization of the glucocorticoid receptor
    • JG Savory B Hsu IR Laquian W Giffin T Reich RJ Hache YA Lefebvre Discrimination between NL1- and NL2-mediated nuclear localization of the glucocorticoid receptor Mol Cell Biol 19 1999 1025 1037
    • (1999) Mol Cell Biol , vol.19 , pp. 1025-1037
    • Savory, JG1    Hsu, B2    Laquian, IR3    Giffin, W4    Reich, T5    Hache, RJ6    Lefebvre, YA7
  • 53
    • 0023441954 scopus 로고
    • Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor
    • D Picard KR Yamamoto Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor EMBO J 6 1987 3333 3340
    • (1987) EMBO J , vol.6 , pp. 3333-3340
    • Picard, D1    Yamamoto, KR2
  • 54
    • 0024360979 scopus 로고
    • v-mos oncoproteins affect the nuclear retention and reutilization of glucocorticoid receptors
    • M Qi BJ Hamilton D DeFranco v-mos oncoproteins affect the nuclear retention and reutilization of glucocorticoid receptors Mol Endocrinol 3 1989 1279 1288
    • (1989) Mol Endocrinol , vol.3 , pp. 1279-1288
    • Qi, M1    Hamilton, BJ2    DeFranco, D3
  • 55
    • 0023146969 scopus 로고
    • Intracellular localization of the glucocorticoid receptor: evidence for cytoplasmic and nuclear localization
    • AC Wikstrom O Bakke S Okret M Bronnegard JA Gustafsson Intracellular localization of the glucocorticoid receptor: evidence for cytoplasmic and nuclear localization Endocrinology 120 1987 1232 1242
    • (1987) Endocrinology , vol.120 , pp. 1232-1242
    • Wikstrom, AC1    Bakke, O2    Okret, S3    Bronnegard, M4    Gustafsson, JA5
  • 56
    • 0035984194 scopus 로고    scopus 로고
    • Ca2+-dependent nuclear export mediated by calreticulin
    • JM Holaska BE Black F Rastinejad BM Paschal Ca2+-dependent nuclear export mediated by calreticulin Mol Cell Biol 22 2002 6286 6297
    • (2002) Mol Cell Biol , vol.22 , pp. 6286-6297
    • Holaska, JM1    Black, BE2    Rastinejad, F3    Paschal, BM4
  • 57
    • 0035856514 scopus 로고    scopus 로고
    • DNA binding domains in diverse nuclear receptors function as nuclear export signals
    • BE Black JM Holaska F Rastinejad BM Paschal DNA binding domains in diverse nuclear receptors function as nuclear export signals Curr Biol 11 2001 1749 1758
    • (2001) Curr Biol , vol.11 , pp. 1749-1758
    • Black, BE1    Holaska, JM2    Rastinejad, F3    Paschal, BM4
  • 58
    • 0025759019 scopus 로고
    • Interaction of the glucocorticoid receptor DNA-binding domain with DNA as a dimer is mediated by a short segment of five amino acids
    • K Dahlman-Wright A Wright JA Gustafsson J Carlstedt-Duke Interaction of the glucocorticoid receptor DNA-binding domain with DNA as a dimer is mediated by a short segment of five amino acids J Biol Chem 266 1991 3107 3112
    • (1991) J Biol Chem , vol.266 , pp. 3107-3112
    • Dahlman-Wright, K1    Wright, A2    Gustafsson, JA3    Carlstedt-Duke, J4
  • 59
    • 0024337858 scopus 로고
    • Determinants of target gene specificity for steroid/thyroid hormone receptors
    • K Umesono RM Evans Determinants of target gene specificity for steroid/thyroid hormone receptors Cell 57 1989 1139 1146
    • (1989) Cell , vol.57 , pp. 1139-1146
    • Umesono, K1    Evans, RM2
  • 60
    • 0030824266 scopus 로고    scopus 로고
    • A new function for the C-terminal zinc finger of the glucocorticoid receptor. Repression of RelA transactivation
    • J Liden F Delaunay I Rafter J Gustafsson S Okret A new function for the C-terminal zinc finger of the glucocorticoid receptor. Repression of RelA transactivation J Biol Chem 272 1997 21467 21472
    • (1997) J Biol Chem , vol.272 , pp. 21467-21472
    • Liden, J1    Delaunay, F2    Rafter, I3    Gustafsson, J4    Okret, S5
  • 62
    • 0035951781 scopus 로고    scopus 로고
    • Mapping of glucocorticoid receptor DNA binding domain surfaces contributing to transrepression of NF-kappa B and induction of apoptosis
    • Y Tao C Williams-Skipp RI Scheinman Mapping of glucocorticoid receptor DNA binding domain surfaces contributing to transrepression of NF-kappa B and induction of apoptosis J Biol Chem 276 2001 2329 2332
    • (2001) J Biol Chem , vol.276 , pp. 2329-2332
    • Tao, Y1    Williams-Skipp, C2    Scheinman, RI3
  • 63
    • 0032230231 scopus 로고    scopus 로고
    • Nuclear receptor-binding sites of coactivators glucocorticoid receptor interacting protein 1 (GRIP1) and steroid receptor coactivator 1 (SRC-1): multiple motifs with different binding specificities
    • XF Ding CM Anderson H Ma H Hong RM Uht PJ Kushner MR Stallcup Nuclear receptor-binding sites of coactivators glucocorticoid receptor interacting protein 1 (GRIP1) and steroid receptor coactivator 1 (SRC-1): multiple motifs with different binding specificities Mol Endocrinol 12 1998 302 313
    • (1998) Mol Endocrinol , vol.12 , pp. 302-313
    • Ding, XF1    Anderson, CM2    Ma, H3    Hong, H4    Uht, RM5    Kushner, PJ6    Stallcup, MR7
  • 64
    • 0030949836 scopus 로고    scopus 로고
    • GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors
    • H Hong K Kohli MJ Garabedian MR Stallcup GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors Mol Cell Biol 17 1997 2735 2744
    • (1997) Mol Cell Biol , vol.17 , pp. 2735-2744
    • Hong, H1    Kohli, K2    Garabedian, MJ3    Stallcup, MR4
  • 65
    • 0029978605 scopus 로고    scopus 로고
    • GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors
    • H Hong K Kohli A Trivedi DL Johnson MR Stallcup GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors Proc Natl Acad Sci USA 93 1996 4948 4952
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 4948-4952
    • Hong, H1    Kohli, K2    Trivedi, A3    Johnson, DL4    Stallcup, MR5
  • 66
    • 0026600841 scopus 로고
    • Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors
    • PS Danielian R White JA Lees MG Parker Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors EMBO J 11 1992 1025 1033
    • (1992) EMBO J , vol.11 , pp. 1025-1033
    • Danielian, PS1    White, R2    Lees, JA3    Parker, MG4
  • 67
    • 0034984748 scopus 로고    scopus 로고
    • Binding of ligands and activation of transcription by nuclear receptors
    • AC Steinmetz JP Renaud D Moras Binding of ligands and activation of transcription by nuclear receptors Annu Rev Biophys Biomol Struct 30 2001 329 359
    • (2001) Annu Rev Biophys Biomol Struct , vol.30 , pp. 329-359
    • Steinmetz, AC1    Renaud, JP2    Moras, D3
  • 69
    • 29244464325 scopus 로고    scopus 로고
    • Glucocorticoid receptor mutants demonstrate increased motility inside the nucleus of living cells: time of fluorescence recovery after photobleaching (FRAP) is an integrated measure of receptor function
    • T Kino SH Liou E Charmandari GP Chrousos Glucocorticoid receptor mutants demonstrate increased motility inside the nucleus of living cells: time of fluorescence recovery after photobleaching (FRAP) is an integrated measure of receptor function Mol Med 10 2004 80 88
    • (2004) Mol Med , vol.10 , pp. 80-88
    • Kino, T1    Liou, SH2    Charmandari, E3    Chrousos, GP4
  • 70
    • 0026722231 scopus 로고
    • Glucocorticoid receptor abnormalities in fibroblasts from patients with idiopathic resistance to dexamethasone diagnosed when evaluated for adrenocortical disorders
    • S Werner M Thorén JA Gustafsson M Brönnegård Glucocorticoid receptor abnormalities in fibroblasts from patients with idiopathic resistance to dexamethasone diagnosed when evaluated for adrenocortical disorders J Clin Endocrinol Metab 75 1992 1005 1009
    • (1992) J Clin Endocrinol Metab , vol.75 , pp. 1005-1009
    • Werner, S1    Thorén, M2    Gustafsson, JA3    Brönnegård, M4
  • 71
    • 85119747920 scopus 로고
    • The adrenogenital syndrome
    • F Cassorla GP Chrousos The adrenogenital syndrome KL Becker Principles and practice of endocrinology and metabolism 1990 Lippincott Philadelphia 604 613
    • (1990) , pp. 604-613
    • Cassorla, F1    Chrousos, GP2


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