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Volumn 57, Issue 2, 2011, Pages 115-128

Physiological significance of lysophospholipids that act on the lumen side of mammalian lower digestive tracts

Author keywords

Gastric ulcer; Lysophosphatidic acid; Lysophospholipid mediator; Mucosa protection

Indexed keywords

ALKALINE PHOSPHATASE; ARACHIDONIC ACID; AUTOTAXIN; GLYCEROLIPID; GLYCOSYLPHOSPHATIDYLINOSITOL; HERBACEOUS AGENT; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHATIDIC ACID RECEPTOR; LYSOPHOSPHATIDIC ACID RECEPTOR 2; LYSOPHOSPHATIDYLCHOLINE; LYSOPHOSPHOLIPID; MESSENGER RNA; PHOSPHATIDIC ACID; PHOSPHATIDYLCHOLINE; PHOSPHOLIPASE A2; SPHINGOLIPID; SPHINGOMYELIN; UNCLASSIFIED DRUG;

EID: 79954505527     PISSN: 13449702     EISSN: 13475207     Source Type: Journal    
DOI: 10.1248/jhs.57.115     Document Type: Review
Times cited : (24)

References (112)
  • 1
    • 70350509805 scopus 로고    scopus 로고
    • Intestinal mucosal barrier function in health and disease
    • Turner, J. R. (2009) Intestinal mucosal barrier function in health and disease. Nat. Rev. Immunol., 9, 799-809.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 799-809
    • Turner, J.R.1
  • 3
    • 33847734027 scopus 로고    scopus 로고
    • Food intake regulates oleoylethanolamine formation and degradation in the proximal small intestine
    • Fu, J., Astarita, G., Gaetani, S., Kim, J., Cravatt, B. F., Mackie, K. and Piomelli, D. (2007) Food intake regulates oleoylethanolamine formation and degradation in the proximal small intestine. J. Biol. Chem., 282, 1518-1528.
    • (2007) J. Biol. Chem. , vol.282 , pp. 1518-1528
    • Fu, J.1    Astarita, G.2    Gaetani, S.3    Kim, J.4    Cravatt, B.F.5    Mackie, K.6    Piomelli, D.7
  • 4
    • 0037162027 scopus 로고    scopus 로고
    • Modulation of gastrointestinal wound repair and inflammation by phospholipids
    • Sturm, A. and Dignass, A. U. (2002) Modulation of gastrointestinal wound repair and inflammation by phospholipids. Biochim. Biophys. Acta, 1582, 282-288.
    • (2002) Biochim. Biophys. Acta. , vol.1582 , pp. 282-288
    • Sturm, A.1    Dignass, A.U.2
  • 5
    • 0029077406 scopus 로고
    • A family of phospholipid autaocoids: Occurrence, metabolism and bioactions
    • Tokumura, A. (1995) A family of phospholipid autaocoids: occurrence, metabolism and bioactions. Prog. Lipid Res., 34, 151-184.
    • (1995) Prog. Lipid Res. , vol.34 , pp. 151-184
    • Tokumura, A.1
  • 7
    • 77953288970 scopus 로고    scopus 로고
    • Biological roles of lysophosphatidic acid signaling through its production by autotoxin
    • Okudaira, S., Yukiura, H. and Aoki, J. (2010) Biological roles of lysophosphatidic acid signaling through its production by autotoxin. Biochimie, 92, 698-702.
    • (2010) Biochimie , vol.92 , pp. 698-702
    • Okudaira, S.1    Yukiura, H.2    Aoki, J.3
  • 9
    • 1642445349 scopus 로고    scopus 로고
    • Cloning of a G-protein-coupled receptor that shows an activity to transform NIH3T3 cells and is expressed in gastric cancer cells
    • Okumura, S., Baba, H., Kumada, T., Nanmoku, K., Nakajima, H., Nakane, Y., Hioki, K. and Ikenaka, K. (2004) Cloning of a G-protein-coupled receptor that shows an activity to transform NIH3T3 cells and is expressed in gastric cancer cells. Cancer Sci., 95, 131-135.
    • (2004) Cancer Sci , vol.95 , pp. 131-135
    • Okumura, S.1    Baba, H.2    Kumada, T.3    Nanmoku, K.4    Nakajima, H.5    Nakane, Y.6    Hioki, K.7    Ikenaka, K.8
  • 11
    • 69549103075 scopus 로고    scopus 로고
    • Emerging lysophospholipid mediators, lysophosphatidylserine, lysophosphatidylthreonine, lysophosphatidylethanolamine and lysophosphatidylglycerol
    • Makide, K., Kitamura, H., Sato, Y., Okutani, M. and Aoki, J. (2008) Emerging lysophospholipid mediators, lysophosphatidylserine, lysophosphatidylthreonine, lysophosphatidylethanolamine and lysophosphatidylglycerol. Prostaglandins Other Lipid Mediat., 89, 135-139.
    • (2008) Prostaglandins Other Lipid Mediat , vol.89 , pp. 135-139
    • Makide, K.1    Kitamura, H.2    Sato, Y.3    Okutani, M.4    Aoki, J.5
  • 12
    • 34347389492 scopus 로고    scopus 로고
    • GPR93 activation by protein hydrolysate induces CCK transcription and secretion in STC-1 cells
    • Choi, S., Lee, M., Shiu, A. L., Yo, S. J., Hallden, G. and Aponte, G. W. (2007) GPR93 activation by protein hydrolysate induces CCK transcription and secretion in STC-1 cells. Am. J. Physiol., 292, G1366-G1375.
    • (2007) Am. J. Physiol. , vol.292
    • Choi, S.1    Lee, M.2    Shiu, A.L.3    Yo, S.J.4    Hallden, G.5    Aponte, G.W.6
  • 13
    • 24344474845 scopus 로고    scopus 로고
    • Proton-sensing and lysolipid-sensitive Gprotein- coupled receptors: A novel type of multifunctional receptors
    • Tomura, H., Mogi, C., Sato, K. and Okajima, F. (2005) Proton-sensing and lysolipid-sensitive Gprotein- coupled receptors: A novel type of multifunctional receptors. Cell. Signal., 17, 1466-1476.
    • (2005) Cell. Signal. , vol.17 , pp. 1466-1476
    • Tomura, H.1    Mogi, C.2    Sato, K.3    Okajima, F.4
  • 16
    • 70350290230 scopus 로고    scopus 로고
    • Analysis of sphingomyelin in meat based on hydrophilic interaction liquid chromatography coupled to electrospray ionization-tandem mass spectrometry (HILIC-HPLC-ESI-MS/MS)
    • Fischbeck A., Krüger, M., Blaas, N. and Humpf, H.-U. (2009) Analysis of sphingomyelin in meat based on hydrophilic interaction liquid chromatography coupled to electrospray ionization-tandem mass spectrometry (HILIC-HPLC-ESI-MS/MS). J. Agric. Food Chem., 57, 9469-9474.
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 9469-9474
    • Fischbeck, A.1    Krüger, M.2    Blaas, N.3    Humpf, H.-U.4
  • 17
    • 33646146401 scopus 로고    scopus 로고
    • Alkaline sphingomyelinase: An old enzyme with novel implications
    • Duan, R. D. (2006) Alkaline sphingomyelinase: An old enzyme with novel implications. Biochim. Biophys. Acta, 1761, 281-291.
    • (2006) Biochim. Biophys. Acta. , vol.1761 , pp. 281-291
    • Duan, R.D.1
  • 18
    • 57649188727 scopus 로고    scopus 로고
    • Metabolism of sphingolipids in the gut and its relation to inflammation and cancer development
    • Duan, R. D. and Nilsson, A. (2009) Metabolism of sphingolipids in the gut and its relation to inflammation and cancer development. Prog. Lipid Res., 48, 62-72.
    • (2009) Prog. Lipid Res. , vol.48 , pp. 62-72
    • Duan, R.D.1    Nilsson, A.2
  • 19
    • 0035529575 scopus 로고    scopus 로고
    • Phospholipids for functional food
    • Schneider, M. (2001) Phospholipids for functional food. Eur. J. Lipid Sci. Technol., 103, 98-101.
    • (2001) Eur. J. Lipid Sci. Technol. , vol.103 , pp. 98-101
    • Schneider, M.1
  • 20
    • 15044345701 scopus 로고    scopus 로고
    • Analysis of phospho- and sphingolipids in dairy products by new HPLC method
    • Rombaut, R., Camp, J. V. and Dewettinck, K. (2005) Analysis of phospho- and sphingolipids in dairy products by new HPLC method. J. Dairy Sci., 88, 482-488.
    • (2005) J. Dairy Sci. , vol.88 , pp. 482-488
    • Rombaut, R.1    Camp, J.V.2    Dewettinck, K.3
  • 21
    • 14844304777 scopus 로고    scopus 로고
    • Enzymatic modification of phospholipids for functional applications and human nutrition
    • Guo, Z., Vikbjerg, A. F. and Xu, X. (2005) Enzymatic modification of phospholipids for functional applications and human nutrition. Biotechnol. Adv., 23, 203-259.
    • (2005) Biotechnol. Adv. , vol.23 , pp. 203-259
    • Guo, Z.1    Vikbjerg, A.F.2    Xu, X.3
  • 22
    • 66849122202 scopus 로고    scopus 로고
    • Intestinal lipid absorption
    • Iqbal, J. and Hussain, M. M. (2009) Intestinal lipid absorption. Am J. Physiol., 296, E1183-E1194.
    • (2009) Am J. Physiol. , vol.296
    • Iqbal, J.1    Hussain, M.M.2
  • 23
    • 0023782582 scopus 로고
    • A method for separation and quantification of phospholipid classes in human milk
    • Hundrieser, K. and Clark, R. M. (1988) A method for separation and quantification of phospholipid classes in human milk. J. Dairy Sci., 71, 61-67.
    • (1988) J. Dairy Sci. , vol.71 , pp. 61-67
    • Hundrieser, K.1    Clark, R.M.2
  • 24
    • 0242299620 scopus 로고    scopus 로고
    • LCMS/ MS analysis of lysophospholipids associated with soy protein isolate
    • Fang, N., Yu, S. and Badger, T. M. (2003) LCMS/ MS analysis of lysophospholipids associated with soy protein isolate. J. Agric. Food Chem., 51, 6676-6682.
    • (2003) J. Agric. Food Chem. , vol.51 , pp. 6676-6682
    • Fang, N.1    Yu, S.2    Badger, T.M.3
  • 26
    • 0035036305 scopus 로고    scopus 로고
    • Hen egg yolk and white contain high amounts of lysophosphatidic acids, growth factorlike lipids: Distinct molecular species compositions
    • Nakane, S., Tokumura, A., Waku, K. and Sugiura, T. (2001) Hen egg yolk and white contain high amounts of lysophosphatidic acids, growth factorlike lipids: distinct molecular species compositions. Lipids, 36, 413-419.
    • (2001) Lipids , vol.36 , pp. 413-419
    • Nakane, S.1    Tokumura, A.2    Waku, K.3    Sugiura, T.4
  • 29
    • 0035079697 scopus 로고    scopus 로고
    • Compensatory phospholipid digestion is required for cholesterol absorption in pancreatic phospholipase A2-deficient mice
    • Richmond, B. L., Boileau, A. C., Zheng, S., Huggins, K. W., Granholm, N. A., Tso, P. and Hui, D. Y. (2001) Compensatory phospholipid digestion is required for cholesterol absorption in pancreatic phospholipase A2-deficient mice. Gastroenterology, 120, 1193-1202.
    • (2001) Gastroenterology , vol.120 , pp. 1193-1202
    • Richmond, B.L.1    Boileau, A.C.2    Zheng, S.3    Huggins, K.W.4    Granholm, N.A.5    Tso, P.6    Hui, D.Y.7
  • 30
    • 0031940847 scopus 로고    scopus 로고
    • Identification of functional domains of rat intestinal phospholipase B/lipase. Its cDNA cloning, expression, and tissue distribution
    • Takemori, H., Zolotaryov, F. N., Ting, L., Urbain, T., Komatsubara, T., Hatano, O., Okamoto, M. and Tojo, H. (1998) Identification of functional domains of rat intestinal phospholipase B/lipase. Its cDNA cloning, expression, and tissue distribution. J. Biol. Chem., 273, 2222-2231.
    • (1998) J. Biol. Chem. , vol.273 , pp. 2222-2231
    • Takemori, H.1    Zolotaryov, F.N.2    Ting, L.3    Urbain, T.4    Komatsubara, T.5    Hatano, O.6    Okamoto, M.7    Tojo, H.8
  • 31
    • 0036838450 scopus 로고    scopus 로고
    • Protection against diet-induced obesity and obesity-related insulin resistance in Group 1B PLA2-deficient mice
    • Huggins, K. W., Boileau, A. C. and Hui, A. D. (2002) Protection against diet-induced obesity and obesity-related insulin resistance in Group 1B PLA2-deficient mice. Am. J. Physiol., 283, E994- E1001.
    • (2002) Am. J. Physiol. , vol.283
    • Huggins, K.W.1    Boileau, A.C.2    Hui, A.D.3
  • 32
    • 33745309628 scopus 로고    scopus 로고
    • Group 1B phospholipase A2-mediated lysophospholipid absorption directly contributes to postprandial hyperglycemia
    • Labonte, E. D., Kirby, R. J., Schildmeyer, N. M., Cannon, A. M., Huggins, K. W. and Hui, D. Y. (2006) Group 1B phospholipase A2-mediated lysophospholipid absorption directly contributes to postprandial hyperglycemia. Diabetes, 55, 935-941.
    • (2006) Diabetes , vol.55 , pp. 935-941
    • Labonte, E.D.1    Kirby, R.J.2    Schildmeyer, N.M.3    Cannon, A.M.4    Huggins, K.W.5    Hui, D.Y.6
  • 34
    • 1642580968 scopus 로고    scopus 로고
    • Ingestion of plasmalogen markedly increased plasmalogen levels of blood plasma in rats
    • Nishimukai, M., Wakisaka, T. and Hara, H. (2003) Ingestion of plasmalogen markedly increased plasmalogen levels of blood plasma in rats. Lipids, 38, 1227-1235.
    • (2003) Lipids , vol.38 , pp. 1227-1235
    • Nishimukai, M.1    Wakisaka, T.2    Hara, H.3
  • 35
    • 33646154333 scopus 로고    scopus 로고
    • Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids
    • M., Dreier, J. L., Ellis, J.M., Allende, M. L., Kalkofen, D. N., Sanders, K. M., Bielawski, J., Bielawska, A., Hannun, Y. A. and Proia, R. L. (2006) Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids. J. Biol. Chem., 281, 7324-7331.
    • (2006) J. Biol. Chem. , vol.281 , pp. 7324-7331
  • 36
    • 48749099833 scopus 로고    scopus 로고
    • Dietary sphingomyelin alleviates experimental inflammatory bowel disease in mice
    • Furuya, H., Ohkawara, S., Nagashima, K., Asanuma, N. and Hino, T. (2008) Dietary sphingomyelin alleviates experimental inflammatory bowel disease in mice. Int. J. Vitam. Nutr. Res., 78, 41-49.
    • (2008) Int. J. Vitam. Nutr. Res. , vol.78 , pp. 41-49
    • Furuya, H.1    Ohkawara, S.2    Nagashima, K.3    Asanuma, N.4    Hino, T.5
  • 40
    • 0026503808 scopus 로고
    • Helicobacter pylori associated phospholipase A2 activity: A factor in pepticulcer production
    • Langton, S. R. and Cesareo, S. D. (1992) Helicobacter pylori associated phospholipase A2 activity: a factor in peptic ulcer production? J. Clin. Pathol., 45, 221-224.
    • (1992) J. Clin. Pathol. , vol.45 , pp. 221-224
    • Langton, S.R.1    Cesareo, S.D.2
  • 41
    • 0346401737 scopus 로고    scopus 로고
    • Protective effect of polyunsaturated phosphatidylcholine pretreatment on stress ulcer formation in rats
    • Demirbilek, S., Gürses, I., Sezgin, N., Karaman, A. and Gürbüz, N. (2004) Protective effect of polyunsaturated phosphatidylcholine pretreatment on stress ulcer formation in rats. J. Pediatr. Surg., 39, 57-62.
    • (2004) J. Pediatr. Surg. , vol.39 , pp. 57-62
    • Demirbilek, S.1    Gürses, I.2    Sezgin, N.3    Karaman, A.4    Gürbüz, N.5
  • 42
    • 0027398144 scopus 로고
    • Gastroprotective capability of exogenous phosphatidylcholine in experimentally induced chronic gastric ulcers in rats
    • Dunjic, B. S., Axelson, J., Ar'Rajab, A., Larsson, K. and Bengmark, S. (1993) Gastroprotective capability of exogenous phosphatidylcholine in experimentally induced chronic gastric ulcers in rats. Scand. J. Gastroenterol., 28, 89-94.
    • (1993) Scand. J. Gastroenterol. , vol.28 , pp. 89-94
    • Dunjic, B.S.1    Axelson, J.2    Ar'Rajab, A.3    Larsson, K.4    Bengmark, S.5
  • 43
    • 0027080645 scopus 로고
    • Effects of phosphatidylcholines and phosphatidylinositols on acetic acid-induced colitis in the rat
    • Fabia, R., Ar'Rajab, A.,Willen, R., Andersson, R., Ahren, B., Larsson, K. and Bengmark, S. (1992) Effects of phosphatidylcholines and phosphatidylinositols on acetic acid-induced colitis in the rat. Digestion, 53, 35-44.
    • (1992) Digestion , vol.53 , pp. 35-44
    • Fabia, R.1    Ar'Rajab, A.2    Willen, R.3    Andersson, R.4    Ahren, B.5    Larsson, K.6    Bengmark, S.7
  • 44
    • 40349096749 scopus 로고    scopus 로고
    • Role of phosphatidylcholine saturation in preventing bile salt toxicity to gastrointestinal epithelia and membranes
    • Dial, E. J., Rooijakkers, S. H. M., Darling, R. L., Romero, J. J. and Lichtenberger, L. M. (2007) Role of phosphatidylcholine saturation in preventing bile salt toxicity to gastrointestinal epithelia and membranes. Gastroenterology, 23, 430-436.
    • (2007) Gastroenterology , vol.23 , pp. 430-436
    • Dial, E.J.1    Rooijakkers, S.H.M.2    Darling, R.L.3    Romero, J.J.4    Lichtenberger, L.M.5
  • 45
    • 0029863104 scopus 로고    scopus 로고
    • Polyunsaturated phosphatidylcholine prevents stricture formation in a rat model of colitis
    • Mourelle, M., Guarner, F. and Malagelada, J. R. (1996) Polyunsaturated phosphatidylcholine prevents stricture formation in a rat model of colitis. Gastroenterology, 110, 1093-1097.
    • (1996) Gastroenterology , vol.110 , pp. 1093-1097
    • Mourelle, M.1    Guarner, F.2    Malagelada, J.R.3
  • 46
    • 3242706202 scopus 로고    scopus 로고
    • The effects of aspirin on gastric mucosal integrity, surface hydrophobicity and prostaglandin metabolism in cycloxygenase knockout mice
    • Darling, R. L., Romero, J. J., Dial, E. J., Akunda, J. K., Langenbach, R. and Lichtenberger, L. M. (2004) The effects of aspirin on gastric mucosal integrity, surface hydrophobicity and prostaglandin metabolism in cycloxygenase knockout mice. Gastroenterology, 127, 94-104.
    • (2004) Gastroenterology , vol.127 , pp. 94-104
    • Darling, R.L.1    Romero, J.J.2    Dial, E.J.3    Akunda, J.K.4    Langenbach, R.5    Lichtenberger, L.M.6
  • 47
    • 4143054569 scopus 로고    scopus 로고
    • Phosphatidylcholine and lysophosphatidylcholine in intestinal mucus of ulcerative colitis patients. A quantitative approach by nanoelectrospray-tandem mass spectrometry
    • Ehehalt, R., Wagenblast, J., Erben, G., Lehmann, W. D., Hinz, U., Merle, U. and Stremmel, W. (2004) Phosphatidylcholine and lysophosphatidylcholine in intestinal mucus of ulcerative colitis patients. A quantitative approach by nanoelectrospray-tandem mass spectrometry. Scand. J. Gastroenterol., 39, 737-742.
    • (2004) Scand. J. Gastroenterol. , vol.39 , pp. 737-742
    • Ehehalt, R.1    Wagenblast, J.2    Erben, G.3    Lehmann, W.D.4    Hinz, U.5    Merle, U.6    Stremmel, W.7
  • 48
    • 21044457089 scopus 로고    scopus 로고
    • Retarded release phosphatidylcholine benefits patients with chronic active ulcerative colitis
    • Stremmel, W.,Merle, U., Zahn, A., Autschbach, F., Hinz, U. and Ehehalt, R. (2005) Retarded release phosphatidylcholine benefits patients with chronic active ulcerative colitis. Gut, 54, 966-971.
    • (2005) Gut , vol.54 , pp. 966-971
    • Stremmel, W.1    Merle, U.2    Zahn, A.3    Autschbach, F.4    Hinz, U.5    Ehehalt, R.6
  • 50
    • 34748913670 scopus 로고    scopus 로고
    • Conjugated primary bile salts reduce permeability of endotoxin through intestinal epithelial cells and synergize with phosphatidylcholine in intestinal epithelial cells, Crit
    • Parlesak, A., Schaeckeler, S., Moser, L. and Bode, C. (2007) Conjugated primary bile salts reduce permeability of endotoxin through intestinal epithelial cells and synergize with phosphatidylcholine in intestinal epithelial cells, Crit. Care Med., 35, 2367-2374.
    • (2007) Care Med , vol.35 , pp. 2367-2374
    • Parlesak, A.1    Schaeckeler, S.2    Moser, L.3    Bode, C.4
  • 51
    • 33646433407 scopus 로고    scopus 로고
    • A clinical single-pass perfusion investigation of the dynamics in vivo secretory response to dietary meal in human proximal small intestine
    • Persson, E. M., Nilsson, R. G., Hansson, G. I., Löfgren, L. J., Liback, F., Knutson, L., Abrahamsson, B. and Lennernäs, H. (2006) A clinical single-pass perfusion investigation of the dynamics in vivo secretory response to dietary meal in human proximal small intestine. Pharm. Res., 23, 742-751.
    • (2006) Pharm. Res. , vol.23 , pp. 742-751
    • Persson, E.M.1    Nilsson, R.G.2    Hansson, G.I.3    Löfgren, L.J.4    Liback, F.5    Knutson, L.6    Abrahamsson, B.7    Lennernäs, H.8
  • 52
    • 52149122500 scopus 로고    scopus 로고
    • Pathophysiology of LPS-induced gastrointestinal injury in the rat: Role of secretory phospholipase A2
    • Zayat, M., Lichtenberger, L. M. and Dial, E. J. (2008) Pathophysiology of LPS-induced gastrointestinal injury in the rat: role of secretory phospholipase A2. Shock, 30, 206-211.
    • (2008) Shock , vol.30 , pp. 206-211
    • Zayat, M.1    Lichtenberger, L.M.2    Dial, E.J.3
  • 54
    • 0021353180 scopus 로고
    • Lysophosphatidylcholine-induced gastric injury and ulceration in the guinea pig
    • Maksem, J., Jacbson, N. and Neiderhiser, D. H. (1984) Lysophosphatidylcholine-induced gastric injury and ulceration in the guinea pig. Am. J. Pathol., 115, 288-295.
    • (1984) Am. J. Pathol. , vol.115 , pp. 288-295
    • Maksem, J.1    Jacbson, N.2    Neiderhiser, D.H.3
  • 55
    • 0023277792 scopus 로고
    • Gastric mucosal damage induced by combination of ethanol and lysophosphatidylcholine
    • Neiderhiser, D. H. and Maksem, J. (1987) Gastric mucosal damage induced by combination of ethanol and lysophosphatidylcholine. Dig. Dis. Sci., 32, 628-640.
    • (1987) Dig. Dis. Sci. , vol.32 , pp. 628-640
    • Neiderhiser, D.H.1    Maksem, J.2
  • 56
    • 77952398305 scopus 로고    scopus 로고
    • A direct role for secretory phospholipase A2 and lysophosphatidylcholine in the mediation of LPS-induced gastric injury
    • Dial, E. J., Tran, D. M., Romero, J. J., Zayat, M. and Lichtenberger, L. M. (2009) A direct role for secretory phospholipase A2 and lysophosphatidylcholine in the mediation of LPS-induced gastric injury. Shock, 33, 634-638.
    • (2009) Shock , vol.33 , pp. 634-638
    • Dial, E.J.1    Tran, D.M.2    Romero, J.J.3    Zayat, M.4    Lichtenberger, L.M.5
  • 57
    • 75349109603 scopus 로고    scopus 로고
    • Elevated pro-inflammatory and lipotoxic mucosal lipids characterize irritable bowel syndrome
    • Kajander, K., Myllyluoma, E., Kyrönpalo, S., Rasmussen, M., Sipponen, P., Mattila, I., Seppönen-Laakso, T., Vapaatalo, H., Oresic, M. and Korpela, R. (2009) Elevated pro-inflammatory and lipotoxic mucosal lipids characterize irritable bowel syndrome. World J. Gastroenterol., 15, 6068-6074.
    • (2009) World J. Gastroenterol. , vol.15 , pp. 6068-6074
    • Kajander, K.1    Myllyluoma, E.2
  • 59
    • 76549096530 scopus 로고    scopus 로고
    • Intestinal lipid alterations occur prior to antibody-induced prostaglandin E2 production in a mouse model of ischemic/reperfusion
    • Sparkes, B. L., Slone, E. E. A., Roth, M., Welti, R. and Fleming, S. D. (2010) Intestinal lipid alterations occur prior to antibody-induced prostaglandin E2 production in a mouse model of ischemic/reperfusion. Biochim. Biophys. Acta, 1801, 517-525.
    • (2010) Biochim. Biophys. Acta. , vol.1801 , pp. 517-525
    • Sparkes, B.L.1    Slone, E.E.A.2    Roth, M.3    Welti, R.4    Fleming, S.D.5
  • 60
    • 0021869307 scopus 로고
    • Lysophosphatidylcholine increases rat ileal permeability to macromolecules
    • Tagesson, C., Franzén, L., Dahl, G. and Weström, B. (1985) Lysophosphatidylcholine increases rat ileal permeability to macromolecules. Gut, 26, 369-377.
    • (1985) Gut , vol.26 , pp. 369-377
    • Tagesson, C.1    Franzén, L.2    Dahl, G.3    Weström, B.4
  • 61
    • 0022536406 scopus 로고
    • A study of the permeability of rat stomach to larger molecules. Influence of lysophosphatidylcholine
    • Karlqvist, P. A., Franzen, L., Sjödahl, R. and Tagesson, C. (1986) A study of the permeability of rat stomach to larger molecules. Influence of lysophosphatidylcholine. Acta Chir. Scand, 152, 279-284.
    • (1986) Acta Chir. Scand. , vol.152 , pp. 279-284
    • Karlqvist, P.A.1    Franzen, L.2    Sjödahl, R.3    Tagesson, C.4
  • 62
    • 0023019388 scopus 로고
    • Lysophosphatidylcholine potentiates the increase in mucosal permeability after small-intestinal ischemia
    • Otamiri, T., Sjödahl, R. and Tagesson, C. (1986) Lysophosphatidylcholine potentiates the increase in mucosal permeability after small-intestinal ischemia. Scand. J. Gastroenterol., 21, 1131-1136.
    • (1986) Scand. J. Gastroenterol. , vol.21 , pp. 1131-1136
    • Otamiri, T.1    Sjödahl, R.2    Tagesson, C.3
  • 63
    • 0021688791 scopus 로고
    • Induced mucosal penetration and transfer to portal blood of luminal horseradish peroxidase after exposure of mucosa of guineapig small intestine to ethanol and lysolecithin
    • Talbot, R. W., Foster, J. R., Hermon-Taylor, J. and Grant, D. A. (1984) Induced mucosal penetration and transfer to portal blood of luminal horseradish peroxidase after exposure of mucosa of guineapig small intestine to ethanol and lysolecithin. Dig. Dis. Sci., 29, 1015-1022.
    • (1984) Dig. Dis. Sci. , vol.29 , pp. 1015-1022
    • Talbot, R.W.1    Foster, J.R.2    Hermon-Taylor, J.3    Grant, D.A.4
  • 64
    • 0036821130 scopus 로고    scopus 로고
    • Lysophosphatidylcholine alters enterocyte monolayer permeability via a protein kinase C/Ca2+ mechanism
    • Sawai, T., Lampman, R., Hua, Y., Segura, B., Drongowski, R. A., Coran, A. G. and Harmon, C. M. (2002) Lysophosphatidylcholine alters enterocyte monolayer permeability via a protein kinase C/Ca2+ mechanism. Pediatr. Surg. Int., 18, 591-594.
    • (2002) Pediatr. Surg. Int. , vol.18 , pp. 591-594
    • Sawai, T.1    Lampman, R.2    Hua, Y.3    Segura, B.4    Drongowski, R.A.5    Coran, A.G.6    Harmon, C.M.7
  • 66
    • 0035348393 scopus 로고    scopus 로고
    • Helicobacter infection and phospholipase A2 enzymes: Effect of Helicobacter felis-infection on the expression and activity of sPLA2 enzymes in mouse stomach
    • Ottlecz, A., Romero, J. J. and Lichtenberger, L. M. (2001) Helicobacter infection and phospholipase A2 enzymes: Effect of Helicobacter felis-infection on the expression and activity of sPLA2 enzymes in mouse stomach. Mol. Cell. Biochem., 221, 71-77.
    • (2001) Mol. Cell. Biochem. , vol.221 , pp. 71-77
    • Ottlecz, A.1    Romero, J.J.2    Lichtenberger, L.M.3
  • 68
    • 0026357935 scopus 로고
    • Phospholipase A2 activity of colonic mucosa in patients with ulcerative colitis
    • S., Franzen, L., Olaison, G., Smedh, K. and Strom, M. (1991) Phospholipase A2 activity of colonic mucosa in patients with ulcerative colitis. Digestion, 50, 135-141.
    • (1991) Digestion , vol.50 , pp. 135-141
  • 69
    • 0028081488 scopus 로고
    • Increased group II phospholipase A2 in colonic mucosa of patients with Crohn's disease and ulcerative colitis
    • Minami, T., Tojo, H., Shinomura, Y., Matsuzawa, Y. and Okamoto, M. (1994) Increased group II phospholipase A2 in colonic mucosa of patients with Crohn's disease and ulcerative colitis. Gut, 35, 1593-1598.
    • (1994) Gut , vol.35 , pp. 1593-1598
    • Minami, T.1    Tojo, H.2    Shinomura, Y.3    Matsuzawa, Y.4    Okamoto, M.5
  • 70
    • 0030043297 scopus 로고    scopus 로고
    • Mechanisms for cytoprotection by vitamin U from ethanol-induced gastric mucosal damage in rats
    • Watanabe, T., Ohara, S., Ichikawa, T., Saigenji, K. and Hotta, K. (1996) Mechanisms for cytoprotection by vitamin U from ethanol-induced gastric mucosal damage in rats. Dig. Dis. Sci., 41, 49-54.
    • (1996) Dig. Dis. Sci , vol.41 , pp. 49-54
    • Watanabe, T.1    Ohara, S.2    Ichikawa, T.3    Saigenji, K.4    Hotta, K.5
  • 71
    • 49949098676 scopus 로고    scopus 로고
    • Two pathways for lysophosphatidic acid production
    • Aoki, J., Inoue, A. and Okudaira, S. (2008) Two pathways for lysophosphatidic acid production. Biochim. Biophys. Acta, 1781, 543-548.
    • (2008) Biochim. Biophys. Acta. , vol.1781 , pp. 543-548
    • Aoki, J.1    Inoue, A.2    Okudaira, S.3
  • 72
    • 38949163648 scopus 로고    scopus 로고
    • Distinct expression pattern of the full set of secreted phospholipase A2 in human colorectal adenocarcinomas: SPLA2-III as biomarker candidate
    • Mounier, C. M., Wendum, D., Greenspan, E., Flejou, J. F., Rosenberg, D. W. and Lambeau, G. (2008) Distinct expression pattern of the full set of secreted phospholipase A2 in human colorectal adenocarcinomas: sPLA2-III as biomarker candidate. Br. J. Cancer, 98, 587-595.
    • (2008) Br. J. Cancer. , vol.98 , pp. 587-595
    • Mounier, C.M.1    Wendum, D.2    Greenspan, E.3    Flejou, J.F.4    Rosenberg, D.W.5    Lambeau, G.6
  • 73
    • 0022623355 scopus 로고
    • Involvement of lysophospholipase D in the production of lysophosphatidic in rat plasma
    • Tokumura, A., Harada, K., Fukuzawa, K. and Ttsukatani, H. (1986) Involvement of lysophospholipase D in the production of lysophosphatidic in rat plasma. Biochim. Biophys Acta, 875, 31-38.
    • (1986) Biochim. Biophys Acta. , vol.875 , pp. 31-38
    • Tokumura, A.1    Harada, K.2    Fukuzawa, K.3    Ttsukatani, H.4
  • 74
    • 0037162023 scopus 로고    scopus 로고
    • Physiological and pathophysiological roles of lysophosphatidic acids produced by secretory lysophospholipase D in body fluids
    • Tokumura, A. (2002) Physiological and pathophysiological roles of lysophosphatidic acids produced by secretory lysophospholipase D in body fluids. Biochim. Biophys. Acta, 1582, 18-25.
    • (2002) Biochim. Biophys. Acta. , vol.1582 , pp. 18-25
    • Tokumura, A.1
  • 75
    • 16644392588 scopus 로고    scopus 로고
    • Metabolic pathways and physiological and pathological significance of lysolipid phosphate mediator
    • Tokumura, A. (2004) Metabolic pathways and physiological and pathological significance of lysolipid phosphate mediator. J. Cell. Biochem., 92, 869-881.
    • (2004) J. Cell. Biochem. , vol.92 , pp. 869-881
    • Tokumura, A.1
  • 76
    • 77954391618 scopus 로고    scopus 로고
    • Autotaxin-an LPA producing enzyme with diverse functions
    • Nakanaga, K., Hama, K. and Aoki, J. (2010) Autotaxin-an LPA producing enzyme with diverse functions. J. Biochem. (Tokyo), 148, 13-24.
    • (2010) J. Biochem. (Tokyo). , vol.148 , pp. 13-24
    • Nakanaga, K.1    Hama, K.2    Aoki, J.3
  • 77
    • 0026787698 scopus 로고
    • Identification, purification, and partial sequence analysis of autotoxin, a novel motilitystimulating protein
    • Stracke, M. L., Krutzsch, H. C., Unsworth, E. J., Årestad, A., Cioce, V., Schiffmann, E. and Liotta, L. A. (1992) Identification, purification, and partial sequence analysis of autotoxin, a novel motilitystimulating protein. J. Biol. Chem., 267, 2524-2529.
    • (1992) J. Biol. Chem. , vol.267 , pp. 2524-2529
    • Stracke, M.L.1    Krutzsch, H.C.2    Unsworth, E.J.3    Årestad, A.4    Cioce, V.5    Schiffmann, E.6    Liotta, L.A.7
  • 78
    • 0037131366 scopus 로고    scopus 로고
    • Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotoxin, a multifunctional phosphodiesterase
    • Tokumura, A., Majima, E., Kariya, Y., Tominaga, K., Kogure, K., Yasuda, K. and Fukuzawa, K. (2002) Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotoxin, a multifunctional phosphodiesterase. J. Biol. Chem., 277, 39436-39442.
    • (2002) J. Biol. Chem. , vol.277 , pp. 39436-39442
    • Tokumura, A.1    Majima, E.2    Kariya, Y.3    Tominaga, K.4    Kogure, K.5    Yasuda, K.6    Fukuzawa, K.7
  • 80
    • 38149136440 scopus 로고    scopus 로고
    • Autotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodia
    • Khurana, S., Tomar, A., George, S. P., Wang, Y., Siddiqui, R., Guo, H., Tigyi, G. and Mathew, S. (2008) Autotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodia. Exp. Cell Res., 314, 530-542.
    • (2008) Exp. Cell Res. , vol.314 , pp. 530-542
    • Khurana, S.1    Tomar, A.2    George, S.P.3    Wang, Y.4    Siddiqui, R.5    Guo, H.6    Tigyi, G.7    Mathew, S.8
  • 83
    • 0031414674 scopus 로고    scopus 로고
    • Soy-derived antiapoptotic fraction decreases methotrexate toxicity in the gastrointestinal tract of the rat
    • Funk-Archelta, M. A., Foehr, M. W., Tomei, L. D., Hennebold, K. L. and Bathurst, I. C. (1997) Soy-derived antiapoptotic fraction decreases methotrexate toxicity in the gastrointestinal tract of the rat. Nutr. Cancer, 29, 217-221.
    • (1997) Nutr. Cancer. , vol.29 , pp. 217-221
    • Funk-Archelta, M.A.1    Foehr, M.W.2    Tomei, L.D.3    Hennebold, K.L.4    Bathurst, I.C.5
  • 84
    • 0032801428 scopus 로고    scopus 로고
    • Lysophosphatidic acid modulates intestinal epithelial cell function in vitro by lysophosphatidic acid
    • Sturm, A., Becker, A., Schulte, K. M., Goebell, H. and Dignass, A. U. (1999) Lysophosphatidic acid modulates intestinal epithelial cell function in vitro by lysophosphatidic acid. Gasteroenterology, 117, 368-377.
    • (1999) Gasteroenterology , vol.117 , pp. 368-377
    • Sturm, A.1    Becker, A.2    Schulte, K.M.3    Goebell, H.4    Dignass, A.U.5
  • 85
    • 12244261671 scopus 로고    scopus 로고
    • Lisofylline and lysophospholipids ameliorate experimental colitis in rats
    • Sturm, A., Zeeh, J., Sudermann, T., Rath, H., Gerken, G. and Dignass, A. U. (2002) Lisofylline and lysophospholipids ameliorate experimental colitis in rats. Digestion, 66, 23-29.
    • (2002) Digestion , vol.66 , pp. 23-29
    • Sturm, A.1    Zeeh, J.2    Sudermann, T.3    Rath, H.4    Gerken, G.5    Dignass, A.U.6
  • 86
    • 0030612068 scopus 로고    scopus 로고
    • Phospholipase A2 stimulates rat gastric epithelial cell line (RGM-1) migration
    • Minami, T., Tojo, H., Zushi, S., Shinomura, Y. and Matsuzawa, Y. (1997). Phospholipase A2 stimulates rat gastric epithelial cell line (RGM-1) migration. Inflamm. Res., 46, 103-107.
    • (1997) Inflamm. Res. , vol.46 , pp. 103-107
    • Minami, T.1    Tojo, H.2    Zushi, S.3    Shinomura, Y.4    Matsuzawa, Y.5
  • 87
    • 0035988869 scopus 로고    scopus 로고
    • Roles of cytoskeleton and tyrosine receptor mediated signal transduction in the restitution of isolated guinea-pig gastric mucosa
    • Bhowmik, A., Paimela, H., Mustonen, H. and Kivilaakso, E. (2002) Roles of cytoskeleton and tyrosine receptor mediated signal transduction in the restitution of isolated guinea-pig gastric mucosa. Scand. J. Gastroenterol., 37, 759-764.
    • (2002) Scand. J. Gastroenterol. , vol.37 , pp. 759-764
    • Bhowmik, A.1    Paimela, H.2    Mustonen, H.3    Kivilaakso, E.4
  • 88
    • 79960932906 scopus 로고    scopus 로고
    • Intragastrically administrated lysophosphatidic acids protect against gastric ulcer in rats under water-immersion restraint stress
    • DOI 10.1007/S16620-011-19595-0
    • M., Horiuchi, G., Ikematsu, N., Tanaka, T., Terao, J., Satouchi, K. and Tokumura, A. (2011) Intragastrically administrated lysophosphatidic acids protect against gastric ulcer in rats under water-immersion restraint stress. Dig. Dis. Sci., DOI 10.1007/S16620-011-19595-0
    • (2011) Dig. Dis. Sci.
  • 92
  • 94
    • 34347240776 scopus 로고    scopus 로고
    • Lysophosphatidic acid prevents apoptosis of Caco-2 colon cancer cells via activation of mitogen-activated protein kinase and phosphorylated of Bad
    • Rusovici, R., Ghaleb, A., Shim, H., Yang, V. W. and Yun, C. C. (2007) Lysophosphatidic acid prevents apoptosis of Caco-2 colon cancer cells via activation of mitogen-activated protein kinase and phosphorylated of Bad. Biochim. Biophys. Acta, 1770, 1194-1203.
    • (2007) Biochim. Biophys. Acta. , vol.1770 , pp. 1194-1203
    • Rusovici, R.1    Ghaleb, A.2    Shim, H.3    Yang, V.W.4    Yun, C.C.5
  • 95
    • 78149481269 scopus 로고    scopus 로고
    • The absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine
    • Lin, S., Lee, S. J., Shim, H., Chun, J. and Yun, C. C. (2010) The absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine. Am. J. Physiol., 299, G1128-G1138.
    • (2010) Am. J. Physiol. , vol.299
    • Lin, S.1    Lee, S.J.2    Shim, H.3    Chun, J.4    Yun, C.C.5
  • 97
    • 0037379768 scopus 로고    scopus 로고
    • Lysophosphatidic acid (LPA) enhances the metastatic potentials of human colon carcinoma DLD1 cells through LPA1
    • Shida, D., Kitayama, J., Yamaguchi, H., Okaji, Y., Tsuno, N. H., Watanabe, T., Takuwa, Y. and Nagawa, H. (2003) Lysophosphatidic acid (LPA) enhances the metastatic potentials of human colon carcinoma DLD1 cells through LPA1. Cancer Res., 63, 1706-1711.
    • (2003) Cancer Res , vol.63 , pp. 1706-1711
    • Shida, D.1    Kitayama, J.2    Yamaguchi, H.3    Okaji, Y.4    Tsuno, N.H.5    Watanabe, T.6    Takuwa, Y.7    Nagawa, H.8
  • 98
    • 65249173527 scopus 로고    scopus 로고
    • The absence of LPA2 attenuates tumor formation in an experimental model of colitisassociated cancer
    • Lin, S., Wang, D., Iyer, S., Ghaleb, A. M., Shim, H., Yang, V. W., Chun, J. and Yun, C. C. (2009) The absence of LPA2 attenuates tumor formation in an experimental model of colitisassociated cancer. Gastroenterology, 136, 1711-1720.
    • (2009) Gastroenterology , vol.136 , pp. 1711-1720
    • Lin, S.1    Wang, D.2    Iyer, S.3    Ghaleb, A.M.4    Shim, H.5    Yang, V.W.6    Chun, J.7    Yun, C.C.8
  • 99
    • 33747685338 scopus 로고    scopus 로고
    • GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP; LPA5
    • Lee, C. W., Rivera, R., Gardell, S., Dubin, A. E. and Chun, J. (2006) GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP; LPA5. J. Biol. Chem., 281, 23589-23597.
    • (2006) J. Biol. Chem. , vol.281 , pp. 23589-23597
    • Lee, C.W.1    Rivera, R.2    Gardell, S.3    Dubin, A.E.4    Chun, J.5
  • 101
    • 70349756906 scopus 로고    scopus 로고
    • P2Y5 is Gai, Ga12/13 G protein-coupled receptor activated by lysophosphatidic acid that reduces intestinal cell adhesion
    • Lee, M., Choi, S., Halldén, G., Yo, S. J., Schichnes, D. and Aponte, G. W. (2009) P2Y5 is Gai, Ga12/13 G protein-coupled receptor activated by lysophosphatidic acid that reduces intestinal cell adhesion. Am. J. Physiol., 297, G641- G654.
    • (2009) Am. J. Physiol. , vol.297
    • Lee, M.1    Choi, S.2    Halldén, G.3    Yo, S.J.4    Schichnes, D.5    Aponte, G.W.6
  • 102
    • 13944267080 scopus 로고    scopus 로고
    • Induction by lysophosphatidic acid of peritoneal and pleural metastased of intestinal cancers induced by azoxymethane in Wistar rats
    • Tatsuta, M., Iishi, H., Baba, M., Uedo, N., Ishihara, R., Higashino, K., Mukai, M. and Ishiguro, S. (2005) Induction by lysophosphatidic acid of peritoneal and pleural metastased of intestinal cancers induced by azoxymethane in Wistar rats. Cancer Lett., 219, 137-145.
    • (2005) Cancer Lett , vol.219 , pp. 137-145
    • Tatsuta, M.1    Iishi, H.2    Baba, M.3    Uedo, N.4    Ishihara, R.5    Higashino, K.6    Mukai, M.7    Ishiguro, S.8
  • 104
    • 78149285909 scopus 로고    scopus 로고
    • Colorectal cancer cells-Proliferation, survival and invasion by lysophosphatidic acid
    • Lee, S. J. and Yun, C. C. (2010) Colorectal cancer cells-Proliferation, survival and invasion by lysophosphatidic acid. Int. J. Biochem. Cell Biol., 42, 1907-1911.
    • (2010) Int. J. Biochem. Cell Biol. , vol.42 , pp. 1907-1911
    • Lee, S.J.1    Yun, C.C.2
  • 105
    • 29844437521 scopus 로고    scopus 로고
    • Differential expression of lysophosphatidic acid receptor-2 in intestinal and diffuse type gastric cancer
    • Yamashita, H., Kitayama, J., Shida, D., Ishikawa, M., Hama, K., Aoki, J., Arai, H. and Nagawa, H. (2006) Differential expression of lysophosphatidic acid receptor-2 in intestinal and diffuse type gastric cancer. J. Surg. Oncol., 93, 30-35.
    • (2006) J. Surg. Oncol. , vol.93 , pp. 30-35
    • Yamashita, H.1    Kitayama, J.2    Shida, D.3    Ishikawa, M.4    Hama, K.5    Aoki, J.6    Arai, H.7    Nagawa, H.8
  • 106
    • 45149095189 scopus 로고    scopus 로고
    • Lysophosphatidic acid promotes cell invasion by up-regulation the urokinase-type plasminogen activator in human gastric cancer cells
    • Kim, M. H., Park, J. S., Chang, H. J., Baek, M. K., Kim, H. R., Shin, B. A., Ahn, B. W. and Jung, Y. D. (2008) Lysophosphatidic acid promotes cell invasion by up-regulation the urokinase-type plasminogen activator in human gastric cancer cells. J. Cell. Biochem., 104, 1102-1112.
    • (2008) J. Cell. Biochem. , vol.104 , pp. 1102-1112
    • Kim, M.H.1    Park, J.S.2    Chang, H.J.3    Baek, M.K.4    Kim, H.R.5    Shin, B.A.6    Ahn, B.W.7    Jung, Y.D.8
  • 107
    • 0036547908 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate stimulates human Caco-2 intestinal epithelial proliferation via p38 activation and activates ERK by an independent mechanism
    • Thamilselvan, V., Li, W., Sumpio, B. E. and Basson, M. D. (2002) Sphingosine-1-phosphate stimulates human Caco-2 intestinal epithelial proliferation via p38 activation and activates ERK by an independent mechanism. In Vitro Cell. Dev. Biol. Anim., 38, 246-253.
    • (2002) Vitro Cell. Dev. Biol. Anim. , vol.38 , pp. 246-253
    • Thamilselvan, V.1    Li, W.2    Sumpio, B.E.3    Basson, M.D.4
  • 109
    • 59449090359 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate protects intestinal epithelial cells from apoptosis through the Akt signaling pathway
    • Greenspon, J., Li, R., Xiao, L., Rao, J. N., Marasa, B. S., Strauch, E. D., Wang, J. Y. and Turner, D. J. (2009) Sphingosine-1-phosphate protects intestinal epithelial cells from apoptosis through the Akt signaling pathway. Dig. Dis. Sci., 54, 499-510.
    • (2009) Dig. Dis. Sci. , vol.54 , pp. 499-510
    • Greenspon, J.1    Li, R.2    Xiao, L.3    Rao, J.N.4    Marasa, B.S.5    Strauch, E.D.6    Wang, J.Y.7    Turner, D.J.8
  • 110
    • 49949105271 scopus 로고    scopus 로고
    • Phosphataseresistant analogues of lysophosphatidic acid agonists promote healing antagonists and autotoxin inhibitors treat cancer
    • Prestwich, G. D., Gajewiak, J., Zhang, H., Xu, X., Yang, G. and Serban, M. (2008) Phosphataseresistant analogues of lysophosphatidic acid agonists promote healing antagonists and autotoxin inhibitors treat cancer. Biochim. Biophys. Acta, 1781, 588-594.
    • (2008) Biochim. Biophys. Acta. , vol.1781 , pp. 588-594
    • Prestwich, G.D.1    Gajewiak, J.2    Zhang, H.3    Xu, X.4    Yang, G.5    Serban, M.6
  • 111
    • 60549102676 scopus 로고    scopus 로고
    • Autotaxin inhibitions: Challenges and progress toward novel anti-cancer agents
    • Parrill, A. L. and Baker, D. L. (2008) Autotaxin inhibitions: challenges and progress toward novel anti-cancer agents. Anticancer Agents Med. Chem., 8, 917-923.
    • (2008) Anticancer Agents Med. Chem. , vol.8 , pp. 917-923
    • Parrill, A.L.1    Baker, D.L.2
  • 112
    • 77952643453 scopus 로고    scopus 로고
    • Evaluation of inhibitory action of flavonols and related substances on lysophospholipase D activity of serum autotoxin by a convenient assay using a chromogenic substrate
    • Ueda, K., Yoshioka, M., Yoshihara, M., Nakao, M., Tanaka, T., Sano, S., Fukuzawa, K. and Tokumura, A. (2010) Evaluation of inhibitory action of flavonols and related substances on lysophospholipase D activity of serum autotoxin by a convenient assay using a chromogenic substrate. J. Agric. Food Chem., 58, 6053-6063.
    • (2010) J. Agric. Food Chem. , vol.58 , pp. 6053-6063
    • Ueda, K.1    Yoshioka, M.2    Yoshihara, M.3    Nakao, M.4    Tanaka, T.5    Sano, S.6    Fukuzawa, K.7    Tokumura, A.8


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