Role of phosphatidylcholine saturation in preventing bile salt toxicity to gastrointestinal epithelia and membranes

Journal of Gastroenterology and Hepatology (Australia)

Volumn 23, Issue 3, 2008, Pages 430-436

  Dial, Elizabeth J ^a   Rooijakkers, Suzan H M ^a   Darling, Rebecca L ^a   Romero, Jim J ^a   Lichtenberger, Lenard M ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Bile salt; Caco 2 cells; Liposomes; Peptic ulcer; Phosphatidylcholine

Indexed keywords

BILE ACID; BILE SALT; DEOXYCHOLATE SODIUM; DIPALMITOYLPHOSPHATIDYLCHOLINE; LIPOSOME; PHOSPHATIDYLCHOLINE;

ARTICLE; CELL LINE; CELL MEMBRANE; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; ELECTRIC RESISTANCE; EPITHELIUM; ERYTHROCYTE; GASTROINTESTINAL TRACT; HEMOLYSIS; HEPATOBILIARY SYSTEM; HUMAN; HUMAN CELL; IN VITRO STUDY; INTESTINE CELL; INTESTINE MUCOSA; MICELLE; PEPTIC ULCER; PRIORITY JOURNAL;

EID: 40349096749     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2007.05153.x     Document Type: Article

References (34)

1. 1 Coleman R, Iqbal S, Godfrey PP, Billington D. Membranes and bile formation: composition of several mammalian biles and their membrane‐damaging properties. Biochem. J. 1979 ; 178: 201–8.
2. 2 Scholmerich J, Becher MS, Schmidt K et al. Influence of hydroxylation and conjugation of bile salts on their membrane‐damaging properties‐ studies on isolated hepatocytes and lipid membrane vesicles. Hepatology 1984 ; 4: 661–6.
3. 3 Duane WC, Wiegand DM, Sievert CE. Bile acids and bile salts disrupt gastric mucosal barrier in the dog by different mechanisms. Am. J. Physiol. 1982 ; 242: G95–9.
4. 4 Duane WC, Wiegand DM. Mechanisms by which bile salt disrupts the gastric mucosal barrier in the dog. J. Clin. Invest. 1980 ; 66: 1044–9.
5. 5 El‐Hariri LM, Martin GP, Marriott C. The effect of pH on human membrane perturbation by bile salts found in man. J. Pharm. Pharmacol. 1988 ; 40: 13.
6. 6 Allen A, Flemstrong G, Garner A, Kivilaasko E. Gastroduodenal mucosal protection. Physiol. Rev. 1993 ; 73: 823–57.
7. 7 Martin GP, El‐Hariri LM, Marriott C. Bile salt‐ and lysophosphatidylcholine‐induced membrane damage in human erythrocytes. J. Pharm. Pharmacol. 1992 ; 44: 646–50.
8. 8 Harmon JW, Doong T, Gadacz TR. Bile acids are not equally damaging to the gastric mucosa. Surgery 1978 ; 84: 79–86.
9. 9 Balint JA, Kyriakides EC, Spitzer HL, Morrison ES. Lecithin fatty acid composition in bile and plasma of man, dogs, rats and oxen. J. Lipid Res. 1965 ; 6: 96.
10. 10 Martin GP, Marriott C. Membrane damage by bile salts: the protective function of phospholipids. J. Pharm. Pharmacol. 1981 ; 33: 754–9.
11. 11 El‐Hariri LM, Marriott C, Martin GP. The mitigating effects of phosphatidylcholines on bile salt‐ and lysophosphatidylcholine‐induced membrane damage. J. Pharm. Pharmacol. 1992 ; 44: 651–4.
12. 12 Newberry RS, Turner NC, Martin GP, Marriott C. Gastric ulceration: the effects of bile salt and biliary phospholipid in the rat. J. Pharm. Pharmacol. 1984 ; 36: 44P.
13. 13 Martin GP, Newberry RS, Turner NC, Marriott C. Gastric mucosal injury by bile acids. The influence of phospholipids. Gastroenterol. Clin. Biol. 1985 ; 9: 80–3.
14. 14 Marriott C, Martin GP, Newberry RS, Turner NC. The effect of phosphatidylcholine on bile‐salt‐induced gastric ulceration in the rat. J. Physiol. 1984 ; 354: 84.
15. 15 Newberry RS, Martin GP, Marriott C. The effect of bile salt and phosphatidylcholine on the rheological properties of pig purified gastric mucus. J. Pharm. Pharmacol. 1986 ; 38: 55.
16. 16 Newberry RS, Martin GP, Turner NC, Marriott C. Mucosal injury: the combined effects of lysophosphatidylcholine and sodium taurodeoxycholate on the rat stomach. J. Pharm. Pharmacol. 1985 ; 37: 144P.
17. 17 Newberry RS, Martin GP, Turner NC, Marriott C. The effects of lysophosphatidylcholine on the rat gastric mucosa at acid and neutral pH. J. Pharm. Pharmacol. 1985 ; 37: 101.
18. 18 Martin GP, Marriott C, Kellaway IW. Direct effect of bile salts and phospholipids on the physical properties of mucus. Gut 1978 ; 19: 103–7.
19. 19 Balint JA, Beeler DA, Kyriakides EC, Treble DH. The effect of bile salts upon lecithin synthesis. J. Lab. Clin. Med. 1971 ; 77: 122–33.
20. 20 Narain PK, DeMaria EJ, Heuman DM. Lecithin protects against plasma membrane disruption by bile salts. J. Surg. Res. 1998 ; 78: 131–6.
21. 21 Barrios JM, Lichtenberger LM. Role of biliary phosphatidylcholine in bile acid protection and NSAID injury of the ileal mucosa in rats. Gastroenterology 2000 ; 118: 1179–86.
22. 22 Pinto M, Robine‐Leon S, Appay M et al. Enterocyte‐like differentiation and polarization of the human colon carcinoma cell line Caco‐2 in culture. Biol. Cell 1983 ; 47: 323–30.
23. 23 Cantafora A, Di Biase A, Alvaro D, Angelico M, Marin M, Attili AF. High performance liquid chromatographic analysis of molecular species of phosphatidylcholine development of quantitative assay and its application to human bile. Clin. Chim. Acta 1983 ; 134: 281–95.
24. 24 Mingeot‐Leclercq M‐P, Gallet X, Flore C, Van Bambeke F, Peuvot J, Brasseur R. Experimental and conformational analyses of interactions between butenafine and lipids. Antimicrob. Agents Chemother. 2001 ; 45: 3347–54.
25. 25 Smit JJ, Schinkel AH, Oude ERP et al. Homozygous disruption of the murine mdr2 P‐glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell 1993 ; 75: 451–62.
26. 26 Jacquemin E, De Vree JM, Cresteil D et al. The wide spectrum of multidrug resistance 3 deficiency: from neonatal cholestasis to cirrhosis of adulthood. Gastroenterology 2001 ; 120: 1448–58.
27. 27 Rosmorduc O, Hermelin B, Poupon R. MDR3 gene defect in adults with symptomatic intrahepatic and gallbladder cholesterol cholelithiasis. Gastroenterology 2001 ; 120: 1459–87.
28. 28 Elferink RPJO, Paulusma CC. Function and pathophysiological importance of ABCB4 (MDR3 P‐glycoprotein). Pflugers Arch. Eur. J. Physiol. 2007 ; 453: 601–10.
29. 29 Puglielli L, Amigo L, Arrese M et al. Protective role of biliary cholesterol and phospholipid lamellae against bile acid‐induced cell damage. Gastroenterology 1994 ; 107: 244–54.
30. 30 Amigo L, Mendoza H, Zanlungo S et al. Enrichment of canalicular membrane with cholesterol and sphingomyelin prevents bile salt‐induced hepatic damage. J. Lipid Res. 1999 ; 40: 533–42.
31. 31 Quist RG, Ton‐Nu HT, Lillienau J, Hofmann AF, Barrett KE. Activation of mast cells by bile acids. Gastroenterology 1991 ; 101: 446–56.
32. 32 Heuman DM, Bajaj RS, Lin Q. Adsorption of mixtures of bile salt taurine conjugates to lecithin‐cholesterol membranes: implications for bile salt toxicity and cytoprotection. J. Lipid Res. 1996 ; 37: 562–73.
33. 33 Lacroix P, Simon‐Assmann K, Haffen J, Schmitz MGJ, Renooij W. Phospholipids from rat, human, and canine gastric mucosa. Gastroenterology 1990 ; 99: 1292–6.
34. 34 Cohen E, Carey MC. Acyl chain unsaturation modulates distribution of lecithin molecular species between mixed micelles and vesicles in model bile. Implications for particle structure and metastable cholesterol solubilities. J. Lipid Res. 1991 ; 32: 1291–302.