메뉴 건너뛰기




Volumn 15, Issue 48, 2009, Pages 6068-6074

Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome

Author keywords

Functional gastrointestinal diseases; Histopathology; Irritable bowel syndrome

Indexed keywords

CERAMIDE; DIACYLGLYCEROL; GLYCOSPHINGOLIPID; TRIACYLGLYCEROL;

EID: 75349109603     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.15.6068     Document Type: Article
Times cited : (40)

References (45)
  • 11
    • 0036893131 scopus 로고    scopus 로고
    • Full-thickness biopsy of the jejunum reveals inflammation and enteric neuropathy in irritable bowel syndrome
    • Törnblom H, Lindberg G, Nyberg B, Veress B. Full-thickness biopsy of the jejunum reveals inflammation and enteric neuropathy in irritable bowel syndrome. Gastroenterology 2002; 123: 1972-1979
    • (2002) Gastroenterology , vol.123 , pp. 1972-1979
    • Törnblom, H.1    Lindberg, G.2    Nyberg, B.3    Veress, B.4
  • 12
    • 36949037766 scopus 로고    scopus 로고
    • Decreased expression of serotonin in the jejunum and increased numbers of mast cells in the terminal ileum in patients with irritable bowel syndrome
    • Wang SH, Dong L, Luo JY, Gong J, Li L, Lu XL, Han SP. Decreased expression of serotonin in the jejunum and increased numbers of mast cells in the terminal ileum in patients with irritable bowel syndrome. World J Gastroenterol 2007; 13: 6041-6047
    • (2007) World J Gastroenterol , vol.13 , pp. 6041-6047
    • Wang, S.H.1    Dong, L.2    Luo, J.Y.3    Gong, J.4    Li, L.5    Lu, X.L.6    Han, S.P.7
  • 13
    • 0031980886 scopus 로고    scopus 로고
    • Postprandial plasma 5-hydroxytryptamine in diarrhoea predominant irritable bowel syndrome: A pilot study
    • Bearcroft CP, Perrett D, Farthing MJ. Postprandial plasma 5-hydroxytryptamine in diarrhoea predominant irritable bowel syndrome: a pilot study. Gut 1998; 42: 42-46
    • (1998) Gut , vol.42 , pp. 42-46
    • Bearcroft, C.P.1    Perrett, D.2    Farthing, M.J.3
  • 16
    • 33746819836 scopus 로고    scopus 로고
    • Metabolomic approaches to phenotype characterization and applications to complex diseases
    • Orešič M, Vidal-Puig A, Hänninen V. Metabolomic approaches to phenotype characterization and applications to complex diseases. Expert Rev Mol Diagn 2006; 6: 575-585
    • (2006) Expert Rev Mol Diagn , vol.6 , pp. 575-585
    • Orešič, M.1    Vidal-Puig, A.2    Hänninen, V.3
  • 17
    • 33750453370 scopus 로고    scopus 로고
    • Monitoring the health to disease continuum with global metabolic profiling and systems biology
    • Schnackenberg LK, Beger RD. Monitoring the health to disease continuum with global metabolic profiling and systems biology. Pharmacogenomics 2006; 7: 1077-1086
    • (2006) Pharmacogenomics , vol.7 , pp. 1077-1086
    • Schnackenberg, L.K.1    Beger, R.D.2
  • 19
    • 25444526868 scopus 로고    scopus 로고
    • Processing methods for differential analysis of LC/MS profile data
    • Katajamaa M, Orešič M. Processing methods for differential analysis of LC/MS profile data. BMC Bioinformatics 2005; 6: 179
    • (2005) BMC Bioinformatics , vol.6 , pp. 179
    • Katajamaa, M.1    Orešič, M.2
  • 20
    • 21344474748 scopus 로고    scopus 로고
    • Comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry (GC x GC-TOF) for high resolution metabolomics: Biomarker discovery on spleen tissue extracts of obese NZO compared to lean C57BL/6 mice
    • Welthagen W, Shellie RA, Spranger J, Ristow M, Zimmermann R, Fiehn O. Comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry (GC x GC-TOF) for high resolution metabolomics: biomarker discovery on spleen tissue extracts of obese NZO compared to lean C57BL/6 mice. Metabolomics 2005; 1: 65-73
    • (2005) Metabolomics , vol.1 , pp. 65-73
    • Welthagen, W.1    Shellie, R.A.2    Spranger, J.3    Ristow, M.4    Zimmermann, R.5    Fiehn, O.6
  • 21
    • 0042424602 scopus 로고    scopus 로고
    • Statistical significance for genomewide studies
    • Storey JD, Tibshirani R. Statistical significance for genomewide studies. Proc Natl Acad Sci USA 2003; 100: 9440-9445
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 9440-9445
    • Storey, J.D.1    Tibshirani, R.2
  • 23
    • 33750480850 scopus 로고    scopus 로고
    • Metabolic profiling technologies for biomarker discovery in biomedicine and drug development
    • Schlotterbeck G, Ross A, Dieterle F, Senn H. Metabolic profiling technologies for biomarker discovery in biomedicine and drug development. Pharmacogenomics 2006; 7: 1055-1075
    • (2006) Pharmacogenomics , vol.7 , pp. 1055-1075
    • Schlotterbeck, G.1    Ross, A.2    Dieterle, F.3    Senn, H.4
  • 26
    • 33845314350 scopus 로고    scopus 로고
    • Mass spectrometry-based metabolic profiling reveals different metabolite patterns in invasive ovarian carcinomas and ovarian borderline tumors
    • Denkert C, Budczies J, Kind T, Weichert W, Tablack P, Sehouli J, Niesporek S, Konsgen D, Dietel M, Fiehn O. Mass spectrometry-based metabolic profiling reveals different metabolite patterns in invasive ovarian carcinomas and ovarian borderline tumors. Cancer Res 2006; 66: 10795-10804
    • (2006) Cancer Res , vol.66 , pp. 10795-10804
    • Denkert, C.1    Budczies, J.2    Kind, T.3    Weichert, W.4    Tablack, P.5    Sehouli, J.6    Niesporek, S.7    Konsgen, D.8    Dietel, M.9    Fiehn, O.10
  • 27
    • 27144540581 scopus 로고    scopus 로고
    • Lipid mediators of sensitivity in sensory neurons
    • Park KA, Vasko MR. Lipid mediators of sensitivity in sensory neurons. Trends Pharmacol Sci 2005; 26: 571-577
    • (2005) Trends Pharmacol Sci , vol.26 , pp. 571-577
    • Park, K.A.1    Vasko, M.R.2
  • 29
    • 0028081488 scopus 로고
    • Increased group II phospholipase A2 in colonic mucosa of patients with Crohn's disease and ulcerative colitis
    • Minami T, Tojo H, Shinomura Y, Matsuzawa Y, Okamoto M. Increased group II phospholipase A2 in colonic mucosa of patients with Crohn's disease and ulcerative colitis. Gut 1994; 35: 1593-1598
    • (1994) Gut , vol.35 , pp. 1593-1598
    • Minami, T.1    Tojo, H.2    Shinomura, Y.3    Matsuzawa, Y.4    Okamoto, M.5
  • 31
    • 0021869307 scopus 로고
    • Lysophosphatidylcholine increases rat ileal permeability to macromolecules
    • Tagesson C, Franzen L, Dahl G, Weström B. Lysophosphatidylcholine increases rat ileal permeability to macromolecules. Gut 1985; 26: 369-377
    • (1985) Gut , vol.26 , pp. 369-377
    • Tagesson, C.1    Franzen, L.2    Dahl, G.3    Weström, B.4
  • 32
    • 0023019388 scopus 로고
    • Lysophosphatidylcholine potentiates the increase in mucosal permeability after smallintestinal ischaemia
    • Otamiri T, Sjödahl R, Tagesson C. Lysophosphatidylcholine potentiates the increase in mucosal permeability after smallintestinal ischaemia. Scand J Gastroenterol 1986; 21: 1131-1136
    • (1986) Scand J Gastroenterol , vol.21 , pp. 1131-1136
    • Otamiri, T.1    Sjödahl, R.2    Tagesson, C.3
  • 33
    • 0023039417 scopus 로고
    • Lysophosphatidylcholine and taurodeoxycholate increase stomach permeability to different-sized molecules
    • Karlqvist PA, Franzen L, Sjödahl R, Tagesson C. Lysophosphatidylcholine and taurodeoxycholate increase stomach permeability to different-sized molecules. Scand J Gastroenterol 1986; 21: 1039-1045
    • (1986) Scand J Gastroenterol , vol.21 , pp. 1039-1045
    • Karlqvist, P.A.1    Franzen, L.2    Sjödahl, R.3    Tagesson, C.4
  • 34
  • 35
    • 34250877518 scopus 로고    scopus 로고
    • Intestinal permeability and irritable bowel syndrome
    • Camilleri M, Gorman H. Intestinal permeability and irritable bowel syndrome. Neurogastroenterol Motil 2007; 19: 545-552
    • (2007) Neurogastroenterol Motil , vol.19 , pp. 545-552
    • Camilleri, M.1    Gorman, H.2
  • 36
    • 30944447092 scopus 로고    scopus 로고
    • Lysophosphatidylcholine and secretory phospholipase A2 in vascular disease: Mediators of endothelial dysfunction and atherosclerosis
    • Kougias P, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. Lysophosphatidylcholine and secretory phospholipase A2 in vascular disease: mediators of endothelial dysfunction and atherosclerosis. Med Sci Monit 2006; 12: RA5-R16
    • (2006) Med Sci Monit , vol.12
    • Kougias, P.1    Chai, H.2    Lin, P.H.3    Lumsden, A.B.4    Yao, Q.5    Chen, C.6
  • 37
    • 34248666988 scopus 로고    scopus 로고
    • Inhibition of lipopolysaccharide-induced release of interleukin-8 from intestinal epithelial cells by SMA, a novel inhibitor of sphingomyelinase and its therapeutic effect on dextran sulphate sodium-induced colitis in mice
    • Sakata A, Yasuda K, Ochiai T, Shimeno H, Hikishima S, Yokomatsu T, Shibuya S, Soeda S. Inhibition of lipopolysaccharide-induced release of interleukin-8 from intestinal epithelial cells by SMA, a novel inhibitor of sphingomyelinase and its therapeutic effect on dextran sulphate sodium-induced colitis in mice. Cell Immunol 2007; 245: 24-31
    • (2007) Cell Immunol , vol.245 , pp. 24-31
    • Sakata, A.1    Yasuda, K.2    Ochiai, T.3    Shimeno, H.4    Hikishima, S.5    Yokomatsu, T.6    Shibuya, S.7    Soeda, S.8
  • 38
    • 0036201098 scopus 로고    scopus 로고
    • IL-1 stimulates ceramide accumulation without inducing apoptosis in intestinal epithelial cells
    • Homaidan FR, El-Sabban ME, Chakroun I, El-Sibai M, Dbaibo GS. IL-1 stimulates ceramide accumulation without inducing apoptosis in intestinal epithelial cells. Mediators Inflamm 2002; 11: 39-45
    • (2002) Mediators Inflamm , vol.11 , pp. 39-45
    • Homaidan, F.R.1    El-Sabban, M.E.2    Chakroun, I.3    El-Sibai, M.4    Dbaibo, G.S.5
  • 39
    • 31644443192 scopus 로고    scopus 로고
    • Ceramides in insulin resistance and lipotoxicity
    • Summers SA. Ceramides in insulin resistance and lipotoxicity. Prog Lipid Res 2006; 45: 42-72
    • (2006) Prog Lipid Res , vol.45 , pp. 42-72
    • Summers, S.A.1
  • 45
    • 0028136286 scopus 로고
    • The creatine kinase system in smooth muscle
    • Clark JF. The creatine kinase system in smooth muscle. Mol Cell Biochem 1994; 133-134: 221-232
    • (1994) Mol Cell Biochem , vol.133-134 , pp. 221-232
    • Clark, J.F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.