A soy-derived antiapoptotic fraction decreases methotrexate toxicity in the gastrointestinal tract of the rat

Nutrition and Cancer

Volumn 29, Issue 3, 1997, Pages 217-221

  Funk Archuleta, Martha A ^a   Foehr, Matthew W ^b   Tomei, L David ^b   Hennebold, Karla L ^a   Bathurst, Ian C ^b  

^a UNIVERSITY OF UTAH   (United States)

^b LXR Biotechnology Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHOTREXATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CELL FRACTIONATION; CONTROLLED STUDY; DIARRHEA; DNA DAMAGE; DNA SYNTHESIS INHIBITION; EMBRYO DEVELOPMENT; GASTROINTESTINAL MUCOSA; GASTROINTESTINAL TOXICITY; NONHUMAN; PROTEIN ISOLATION; RADIATION DOSE; RAT; SOYBEAN; WEIGHT REDUCTION;

EID: 0031414674     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1080/01635589709514627     Document Type: Article

References (23)

1. Zeaman, FJ: "Nutrition and cancer." In Clinical Nutrition and Dietetics, 2nd ed. New York: Macmillan, 1991, pp 571-598.
2. Pinkerton, CR, and Milla, PJ: "Methotrexate enterotoxicity: influence of drug dose and timing in the rat." Br J Cancer 49, 97-101, 1984.
3. Craft, JW, Hem, K, Lawson, DN, and MacElwain, TJ: "Methotrexate-induced malabsorption in children with acute lymphoblastic leukemia." Br Med J 2, 1511-1512, 1977.
4. Pinkerton, CR, Cameron, CHS, Sloan, JM, Glasgow, JFT, and Gevarea, NFT: "Jejunal crypt cell abnormalities associated with methotrexate treatment in children with acute lymphoblastic leukemia." J Clin Pathol 35, 1272-1277, 1982.
5. Cunningham, D, Morgan, RJ, Mill, PR, Toukop, M, and McArdle, CS: "Functional and structural changes of the human proximal small intestine after cytotoxic therapy." J Clin Pathol 38, 265-270, 1985.
6. 51Cr-EDTA in rats with experimentally introduced enteropathy." Gut 26, 579-585, 1985.
7. Mitchell, EP, and Schein, PS: "Gastrointestinal toxicity of chemotherapeutic agents." In Toxicity of Chemotherapy. New York: Grune & Stratton, 1984, pp 269-295.
8. Ross, BT: "Cancer's impact on the nutritional status of patients." In Nutrition Management of the Cancer Patient, AS Bloch (ed). Baltimore, MD: Aspen, 1990, pp 11-14.
9. Nahikian-Nelms, ML: "General feeding problems." In Nutrition Management of the Cancer Patient, AS Bloch (ed). Baltimore, MD: Aspen, 1990, pp 41-50.
10. Chevreau, N, and Funk-Archuleta, M: "Effect of enteral formulas on methotrexate toxicity." Nutr Cancer 23, 185-204, 1995.
11. Funk, MA, and Baker, DH: "Effect of soy products on methotrexate toxicity in rats." J Nutr 121, 1684-1692, 1991.
12. Funk, MA, and Baker, DH: "Effect of fiber, protein source and time of feeding on methotrexate toxicity in rats." J Nutr 121, 1673-1683, 1991.
13. Stokstad, EL, and Jukes, TH: "Sulfonamides and folic acid antagonists: an historical review." J Nutr 117, 1334-1341, 1987.
14. Kerr, JF, Wyllie, AH, and Currie, AR: "Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics." Br J Cancer 26, 239-257, 1972.
15. Tomei, LD, and Cope, FO (eds): Apoptosis: The Molecular Basis of Cell Death. Cold Spring Harbor, NY: Cold Spring Harbor Press, 1991.
16. Tomei, LD, Shapiro, JP, and Cope, FO: "Apoptosis in C3H/10T1/2 mouse embryonic cells: evidence for internucleosomal DNA modification in the absence of double-strand cleavage." Proc Natl Acad Sci USA 90, 853-857, 1993.
17. Barry, MA, Behnke, CA, and Eastman, A: "Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia." Biochem Pharmacol 40, 2353-2362, 1990.
18. Vaux, DL, and Strasser, A: "The molecular biology of apoptosis." Proc Natl Acad Sci USA 93, 2239-2244, 1996.
19. Christie, WW: HPLC and Lipids - A Practical Guide. New York: Pergamon, 1987, p 132.
20. Dawson, RM, Elliot, DC, Elliot, WH, and Jones, KM: Data for Biochemical Research. New York: Oxford University Press, 1990, p 541.
21. Cope, FO, Issinger, OG, McArdle, AH, Shapiro, JP, and Tomei, LD: "Enteral peptide formulas inhibit radiation induced enteritis and apoptosis in intestinal epithelial cells and suppress the expression and function of Alzheimer's and cell division control gene products" (abstr). FASEB J 5, A931, 1991.
22. Kennedy, AR: "The evidence for soybean products as cancer protective agents." J Nutr 125, 733S-743S, 1995.
23. Molteni, A, Brizio-Molteni, L, and Perski, V: "In vitro hormonal effects of soybean isoflavones." J Nutr 125, 751S-756S, 1995.