Mutant HFE H63D protein is associated with prolonged endoplasmic reticulum stress and increased neuronal vulnerability

Journal of Biological Chemistry

Volumn 286, Issue 15, 2011, Pages 13161-13170

  Liu, Yiting ^a   Lee, Sang Y ^a   Neely, Elizabeth ^a   Nandar, Wint ^a   Moyo, Mthabisi ^c   Simmons, Zachary ^b   Connor, James R ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^c AVE MARIA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; APOPTOSIS; CASPASE-3; CELL MODEL; ENDOPLASMIC RETICULUM STRESS; ER STRESS; IN-CELL; IN-VITRO; INDUCIBLE EXPRESSION; MUTANT PROTEINS; NEURODEGENERATIVE DISORDERS; NEURONAL CELL; SPINAL CORDS; TRANSGENIC MICE; UNFOLDED PROTEIN RESPONSE; UP-REGULATION;

CELL CULTURE; CELL DEATH; CELL PROLIFERATION; GENES; PROTEINS;

NEURODEGENERATIVE DISEASES;

CASPASE 3; HFE PROTEIN; IRON; MUTANT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL LEVEL; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LUMBAR SPINAL CORD; MOUSE; NERVE CELL CULTURE; NERVE CELL DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; UNFOLDED PROTEIN RESPONSE; UPREGULATION;

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; APOPTOSIS; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; IRON; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MUTATION, MISSENSE; NEURONS; UNFOLDED PROTEIN RESPONSE;

MUS MUSCULUS;

EID: 79953894390     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.170944     Document Type: Article

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