Ferritin gene expression and transferrin receptor activity in intestine of rats with varying iron stores

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 273, Issue 3 36-3, 1997, Pages

  Oates, Phillip S ^a   Morgan, Evan H ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Enterocytes; Excretion; In situ hybridization; Light and heavy ferritin; Macrophages; Regulation

Indexed keywords

FERRITIN; TRANSFERRIN RECEPTOR;

ANIMAL TISSUE; ARTICLE; GENE EXPRESSION; INTESTINE; INTESTINE CELL; IRON METABOLISM; IRON STORAGE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT;

EID: 0030870217     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1997.273.3.g636     Document Type: Article

References (38)

1. Anderson, G. J., L. W. Powell, and J. W. Halliday. Transferrin receptor distribution and regulation in the rat small intestine. Effect of iron stores and erythropoiesis. Gastroenterology 98: 576-585, 1990.
2. Astaldi, G., G. Meardi, and T. Lisino. The iron content of jejunal mucosa obtained by Crosby's biopsy in hemochromatosis and hemosiderosis. Blood 28: 70-82, 1966.
3. Bannerjee, D., P. R. Flanagan, J. Cluett, and L. S. Valberg. Transferrin receptors in the human gastrointestinal tract: relationship to body stores. Gastroenterology 91: 861-869, 1986.
4. Bieri, J. G., G. S. Stoewsand, G. M. Briggs, R. W. Phillips, J. C. Woodard, and J. J. Knapka. Report of the American Institute of Nutrition ad hoc committee on standards for nutritional studies. J. Nutr. 107: 1340-1348, 1977.
5. Bomford, A. B., and H. N. Munro. Transferrin and its receptor: their roles in cell function. Hepatology 5: 870-875, 1985.
6. Bothwell, T. H., R. W. Charlton, J. D. Cook, and C. A. Finch. Iron Metabolism in Man. Oxford, UK: Blackwell, 1979, p. 416-424.
7. Bothwell, T. H., G. Pirzio-Biroli, and C. A. Finch. Iron absorption. I. Factors affecting absorption. J. Lab. Clin. Med. 51: 24-36, 1958.
8. Canale, V., and P. Lanzkowsky. Cellular growth in specific nutritional deficiency states in rats. I. Iron deficiency anaemia in post-weanling period. Br. J. Haematol. 19: 579-586, 1970.
9. Cazzola, M., H. A. Huebers, M. H. Sayers, A. P. MacPhail, M. Eng, and C. A. Finch. Transferrin saturation, plasma iron turnover, and transferrin uptake in normal humans. Blood 66: 935-939, 1985.
10. Christensen, A. C., H. Huebers, and C. A. Finch. Effect of transferrin saturation on iron delivery in rats. Am. J. Physiol. 235 (Regulatory Integrative Comp. Physiol. 4): R18-R22, 1978.
11. Clark, G. Staining Procedures. Baltimore, MD: Williams and Wilkins, 1981, p. 402-406.
12. Conrad, M. E., and W. H. Crosby. Intestinal mucosal mechanisms controlling iron absorption. Blood 22: 406-415, 1963.
13. Conrad, M. E., L. R. Weintraub, and W. H. Crosby. The role of the intestine in iron kinetics. J. Clin. Invest. 43: 963-974, 1963.
14. Crosby, W. H. The control of iron balance by the intestinal mucosa. Blood 22: 441-449, 1963.
15. Hahn, P. F., W. F. Bale, J. F. Ross, W. F. Balfour, and G. F. Whipple. Radioactive iron absorption by the gastro-intestinal tract. Influence of anemia, anoxia and antecedent feeding distribution in growing dogs. J. Exp. Med. 78: 169-188, 1943.
16. Hall, P. A., P. J. Coates, B. Ansari, and D. Hopwood. Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis. J. Cell Sci. 104: 3569-3577, 1994.
17. Harford, J. B., and R. D. Klausner. Coordinate post-transcriptional regulation of ferritin and transferrin receptor expression: the role of regulated RNA-binding protein interaction. Enzymes 44: 28-36, 1990.
18. Hemmaplardh, D., and E. H. Morgan. The mechanism of iron exchange between synthetic non chelators and rabbit reticulocytes. Biochim. Biophys. Acta 373: 84-99, 1974.
19. Huebers, H., W. Bauer, E. Huebers, E. Csiba, and C. Finch. The behavior of transferrin iron in the rat. Blood 57: 218-228.
20. Huebers, H., E. Csiba, E. Huebers, and C. Finch. Molecular advantage of diferric transferrin in delivering iron to reticulocytes: a comparative study. Proc. Soc. Exp. Biol. Med. 179: 222-226, 1985.
21. Huebers, H., E. Huebers, W. Rummel, and R. R. Crichton. Isolation and characterization of iron binding proteins from rat intestinal mucosa. Eur. J. Biochem. 66: 447-455, 1976.
22. Kornfeld, S. The effect of metal attachment to human apotransferrin on its binding to reticulocytes. Biochim. Biophys. Acta 194: 25-33, 1969.
23. Legget, B. A., L. M. Fletcher, G. A. Ramm, L. W. Powell, and J. W. Halliday. Differential regulation of ferritin H and L subunit mRNA during inflammation and long-term iron overload. J. Gastroenterol. Hepatol. 8: 21-27, 1993.
24. Leibold, E. A., and H. N. Munro. Characterization and evolution of the expressed rat ferritin light gene and its pseudogene family. J. Biol. Chem. 262: 7335-7341, 1987.
25. Madara, J. L., and J. S. Trier. The functional morphology of the mucosa of the small intestine. In: Physiology of the Gastrointestinal Tract, edited by L. R. Johnson. New York: Raven, 1994, vol. 2, p. 1577-1622.
26. 3 into male rats and mice. Am. J. Anat. 106: 247-285, 1960.
27. Morgan, E. H. Iron metabolism. In: Hepatology (3rd ed.), edited by D. Zakin and T. D. Boyer. Philadelphia, PA: Saunders, 1995, p. 526-536.
28. Munro, H. N., Z. Kikinis, and R. S. Eisenstein. Iron dependent regulation of ferritin synthesis. In: Nutrition and Gene Expression, edited by C. D. Berdanier and J. L. Hargrove. London: CRC, 1993, p. 526-545.
29. Murray, M. T., K. White, and H. N. Munro. Conservation of ferritin heavy subunit gene structure: implications for the regulation of ferritin gene expression. Proc. Natl. Acad. Sci. USA 84: 7438-7442, 1987.
30. Oates, P. S., and E. H. Morgan. Defective iron uptake by the duodenum of Belgrade rats fed diets of different iron contents. Am. J. Physiol. 270 (Gastrointest. Liver Physiol. 33): G826-G832, 1996.
31. Oates, P. S., and E. H. Morgan. Effects of dietary iron loading with carbonyl iron, and iron depletion, on intestinal growth, morphology and expression of transferrin receptor in the rat. Anat. Rec. 246: 364-371, 1996.
32. Pietrangelo, A., G. Casalgrandi, D. Quaglino, R. Gualdi, D. Conte, S. Milani, G. Montosi, L. Cesarini, E. Ventura, and G. Cairo. Duodenal ferritin synthesis in genetic hemochromatosis. Gastroenterology 108: 208-217, 1995.
33. Pietrangelo, A., E. Rocchi, G. Casalgrandi, G. Rigo, A. Ferrari, M. Perini, E. Ventura, and G. Cairo. Regulation of transferrin, transferrin receptor, and ferritin genes in human duodenum. Gastroenterology 102: 802-809, 1992.
34. Refsum, S. B., and B. Schreiner. Iron excretion from the goblet cells in the small intestine in man. An additional regulatory mechanism in iron homeostasis? Scand. J. Gastroenterol. 15: 1013-1020, 1980.
35. Trinder, D., R. G. Batey, E. H. Morgan, and E. Baker. Effects of cellular iron concentration on iron uptake by hepatocytes. Am. J. Physiol. 259 (Gastrointest. Liver Physiol. 22): G611-G617, 1990.
36. Weintraub, L. R., M. E. Conrad, and W. H. Crosby. Regulation of the intestinal absorption of iron by the rate of erythropoiesis. Br. J. Haematol. 11: 432-438, 1965.
37. Wheby, M. S., and W. H. Crosby. The gastrointestinal tract and iron absorption. Blood 22: 416-428, 1964.
38. White, K., and H. N. Munro. Induction of ferritin subunit synthesis by iron is regulated at both the transcriptional and translational levels. J. Biol. Chem. 263: 8938-8942, 1988.