AAV-mediated expression of wild-type and ALS-linked mutant VAPB selectively triggers death of motoneurons through a Ca2+-dependent ER-associated pathway

Journal of Neurochemistry

Volumn 114, Issue 3, 2010, Pages 795-809

  Langou, Karine ^a,b   Moumen, Anice ^a,b   Pellegrino, Christophe ^a,b   Aebischer, Julianne ^a,b   Medina, Igor ^a,b   Aebischer, Patrick ^c   Raoul, Cédric ^a,b  

^a Turing Center for Living Systems CENTURI Aix Marseille University   (France)

^b AIX MARSEILLE UNIVERSITY   (France)

^c EPFL   (Switzerland)

Author keywords

adeno associated virus; amyotrophic lateral sclerosis; calcium; endoplasmic reticulum stress; motoneuron culture; vesicle associated membrane protein associated protein B

Indexed keywords

CALCIUM; CALPAIN; CASPASE 12; CASPASE 3; SYNAPTOBREVIN; THAPSIGARGIN; UNCLASSIFIED DRUG; VESICLE ASSOCIATED MEMBRANE PROTEIN ASSOCIATED PROTEIN B; MEMBRANE PROTEIN; VAPB PROTEIN, MOUSE;

ADENO ASSOCIATED VIRUS; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ARTICLE; CALCIUM HOMEOSTASIS; CALCIUM SIGNALING; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GENE DOSAGE; GENE MUTATION; GENE OVEREXPRESSION; IMMUNOCYTOCHEMISTRY; MOTONEURON; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WILD TYPE; ANIMAL; BIOSYNTHESIS; CELL CULTURE; DEPENDOPARVOVIRUS; ENDOPLASMIC RETICULUM; GENETIC TRANSDUCTION; GENETICS; HUMAN; METABOLISM; MUTATION; NERVE DEGENERATION; PATHOLOGY; PHYSIOLOGY; PROCEDURES;

ADENO-ASSOCIATED VIRUS;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CALCIUM SIGNALING; CELL DEATH; CELLS, CULTURED; DEPENDOVIRUS; ENDOPLASMIC RETICULUM; HUMANS; MEMBRANE PROTEINS; MICE; MOTOR NEURONS; MUTATION; NERVE DEGENERATION; TRANSDUCTION, GENETIC;

EID: 77954324616     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.06806.x     Document Type: Article

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