메뉴 건너뛰기




Volumn 72, Issue 2, 2011, Pages 162-177

In silico subtractive genomics for target identification in human bacterial pathogens

Author keywords

bacterial pathogen; drug target; essential genes; subtractive genomics

Indexed keywords

AMIKACIN; AZITHROMYCIN; BCG VACCINE; CEFOPERAZONE; CEFOTAXIME; CEFTAZIDIME; CEFTRIAXONE; CEPHALOSPORIN DERIVATIVE; CHOLERA VACCINE; CIPROFLOXACIN; CLARITHROMYCIN; CLINDAMYCIN; DAPSONE; ERYTHROMYCIN; ETHAMBUTOL; FURAZOLIDONE; ISONIAZID; LATAMOXEF; MEROPENEM; METRONIDAZOLE; MEZLOCILLIN; OFLOXACIN; PIPERACILLIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RIFABUTIN; RIFAMPICIN; STREPTOMYCIN; TETRACYCLINE; UNINDEXED DRUG; VANCOMYCIN;

EID: 79953863902     PISSN: 02724391     EISSN: 10982299     Source Type: Journal    
DOI: 10.1002/ddr.20413     Document Type: Article
Times cited : (129)

References (79)
  • 1
    • 0032403024 scopus 로고    scopus 로고
    • Bacterial genome sequencing and drug discovery
    • DOI 10.1016/S0958-1669(98)80143-2
    • Allsop AE., 1998. Bacterial genome sequencing and drug discovery. Curr Opin Biotechnol 9: 637-642. (Pubitemid 28558496)
    • (1998) Current Opinion in Biotechnology , vol.9 , Issue.6 , pp. 637-642
    • Allsop, A.E.1
  • 4
    • 59449088862 scopus 로고    scopus 로고
    • Antibiotic-resistant bugs in the 21st century-a clinical super-challenge
    • Arias CA, Murray BE., 2009. Antibiotic-resistant bugs in the 21st century-a clinical super-challenge. N Engl J Med 360: 439-443.
    • (2009) N Engl J Med , vol.360 , pp. 439-443
    • Arias, C.A.1    Murray, B.E.2
  • 6
    • 0030861438 scopus 로고    scopus 로고
    • The SWISS-PROT protein sequence data bank and its supplement TrEMBL
    • DOI 10.1093/nar/25.1.31
    • Bairoch A, Apweiler R., 1997. The SWISS-PROT protein sequence data bank and its supplement TrEMBL. Nucleic Acids Res 25: 31-36. (Pubitemid 27303144)
    • (1997) Nucleic Acids Research , vol.25 , Issue.1 , pp. 31-36
    • Bairoch, A.1    Apweiler, R.2
  • 7
    • 61649121489 scopus 로고    scopus 로고
    • The use of genomics in microbial vaccine development
    • Bambini S, Rappuoli R., 2009. The use of genomics in microbial vaccine development. Drug Discov Today 14: 252-260.
    • (2009) Drug Discov Today , vol.14 , pp. 252-260
    • Bambini, S.1    Rappuoli, R.2
  • 8
    • 70449380022 scopus 로고    scopus 로고
    • In silico identification of candidate drug and vaccine targets from various pathways in Neisseria gonorrhoeae
    • Barh D, Kumar A., 2009. In silico identification of candidate drug and vaccine targets from various pathways in Neisseria gonorrhoeae. In Silico Biol 9: 225-231.
    • (2009) Silico Biol , vol.9 , pp. 225-231
    • Barh, D.1    Kumar, A.2
  • 9
    • 67649549976 scopus 로고    scopus 로고
    • In silico identification of membrane associated candidate drug targets in Neisseria gonorrhoeae
    • Barh D, Misra AN., 2009. In silico identification of membrane associated candidate drug targets in Neisseria gonorrhoeae. Int J Integr Biol 6: 65-67.
    • (2009) Int J Integr Biol , vol.6 , pp. 65-67
    • Barh, D.1    Misra, A.N.2
  • 10
    • 78149441034 scopus 로고    scopus 로고
    • Genomic Target Database (GTD): A database of potential targets in human pathogenic bacteria
    • Barh D, Kumar A, Misra AN., 2009. Genomic Target Database (GTD): a database of potential targets in human pathogenic bacteria. Bioinformation 4: 50-51.
    • (2009) Bioinformation , vol.4 , pp. 50-51
    • Barh, D.1    Kumar, A.2    Misra, A.N.3
  • 11
    • 79953886421 scopus 로고    scopus 로고
    • A novel strategy of epitope design in Neisseria gonorrhoeae
    • Barh D, Misra AN, Kumar A, Azevedo V., 2010a. A novel strategy of epitope design in Neisseria gonorrhoeae. Bioinformation 5: 77-85.
    • (2010) Bioinformation , vol.5 , pp. 77-85
    • Barh, D.1    Misra, A.N.2    Kumar, A.3    Azevedo, V.4
  • 12
    • 77950121219 scopus 로고    scopus 로고
    • In silico identification of dual ability of N. gonorrhoeae ddl for developing drug and vaccine against pathogenic Neisseria and other human pathogens
    • 082-090.
    • Barh D, Misra AN, Kumar A., 2010b. In silico identification of dual ability of N. gonorrhoeae ddl for developing drug and vaccine against pathogenic Neisseria and other human pathogens. J Proteomics Bioinform 3:082-090.
    • (2010) J Proteomics Bioinform , vol.3
    • Barh, D.1    Misra, A.N.2    Kumar, A.3
  • 13
    • 59449088232 scopus 로고    scopus 로고
    • Prediction of surface exposed proteins in Streptococcus pyogenes, with a potential application to other Gram-positive bacteria
    • Barinov A, Loux V, Hammani A, Nicolas P, Langella P, Ehrlich D, Maguin E, van de Guchte M., 2009. Prediction of surface exposed proteins in Streptococcus pyogenes, with a potential application to other Gram-positive bacteria. Proteomics 9: 61-73.
    • (2009) Proteomics , vol.9 , pp. 61-73
    • Barinov, A.1    Loux, V.2    Hammani, A.3    Nicolas, P.4    Langella, P.5    Ehrlich, D.6    Maguin, E.7    Van De Guchte, M.8
  • 14
    • 3042521098 scopus 로고    scopus 로고
    • Improved prediction of signal peptides: SignalP 3.0
    • DOI 10.1016/j.jmb.2004.05.028, PII S0022283604005972
    • Bendtsen JD, Nielsen H, von Heijne G, Brunak S., 2004. Improved prediction of signal peptides: SignalP 3.0. J Mol Biol 340: 783-795. (Pubitemid 38829638)
    • (2004) Journal of Molecular Biology , vol.340 , Issue.4 , pp. 783-795
    • Bendtsen, J.D.1    Nielsen, H.2    Von Heijne, G.3    Brunak, S.4
  • 15
    • 0035161543 scopus 로고    scopus 로고
    • Genomes OnLine Database (GOLD): A monitor of genome projects world-wide
    • Bernal A, Ear U, Kyrpides N., 2001. Genomes OnLine Database (GOLD): a monitor of genome projects world-wide. Nucleic Acids Res 29: 126-167.
    • (2001) Nucleic Acids Res , vol.29 , pp. 126-167
    • Bernal, A.1    Ear, U.2    Kyrpides, N.3
  • 16
    • 19544388127 scopus 로고    scopus 로고
    • PSLpred: Prediction of subcellular localization of bacterial proteins
    • DOI 10.1093/bioinformatics/bti309
    • Bhasin M, Garg A, Raghava GPS., 2005. PSLpred: prediction of subcellular localization of bacterial proteins. Bioinformatics 21: 2522-2524. (Pubitemid 40731613)
    • (2005) Bioinformatics , vol.21 , Issue.10 , pp. 2522-2524
    • Bhasin, M.1    Garg, A.2    Raghava, G.P.S.3
  • 17
    • 35348992048 scopus 로고    scopus 로고
    • Manipulation of host-cell pathways by bacterial pathogens
    • DOI 10.1038/nature06247, PII NATURE06247
    • Bhavsar AP, Guttman JA, Finlay BB., 2007. Manipulation of host-cell pathways by bacterial pathogens. Nature 449: 827-834. (Pubitemid 47598623)
    • (2007) Nature , vol.449 , Issue.7164 , pp. 827-834
    • Bhavsar, A.P.1    Guttman, J.A.2    Finlay, B.B.3
  • 18
    • 0032189860 scopus 로고    scopus 로고
    • Concordance analysis of microbial genomes
    • DOI 10.1093/nar/26.19.4482
    • Bruccoleri RE, Dougherty TJ, Davison DB., 1998. Concordance analysis of microbial genomes. Nucleic Acids Res 26: 4482-4486. (Pubitemid 28442143)
    • (1998) Nucleic Acids Research , vol.26 , Issue.19 , pp. 4482-4486
    • Bruccoleri, R.E.1    Dougherty, T.J.2    Davison, D.B.3
  • 19
    • 75149125686 scopus 로고    scopus 로고
    • Recent advances and method development for drug target identification
    • Chan JN, Nislow C, Emili A., 2010. Recent advances and method development for drug target identification. Trends Pharmacol Sci 31: 82-88.
    • (2010) Trends Pharmacol Sci , vol.31 , pp. 82-88
    • Chan, J.N.1    Nislow, C.2    Emili, A.3
  • 21
    • 0034780277 scopus 로고    scopus 로고
    • FindTarget: Software for subtractive genome analysis
    • Chetouani F, Glaser P, Kunst F., 2001. FindTarget: software for subtractive genome analysis. Microbiology 147: 2643-2649. (Pubitemid 32976305)
    • (2001) Microbiology , vol.147 , Issue.10 , pp. 2643-2649
    • Chetouani, F.1    Glaser, P.2    Kunst, F.3
  • 23
    • 33748933062 scopus 로고    scopus 로고
    • In silico analysis of Burkholderia pseudomallei genome sequence for potential drug targets
    • Chong CE, Lim BS, Nathan S, Mohamed R., 2006. In silico analysis of Burkholderia pseudomallei genome sequence for potential drug targets. In Silico Biol 6: 341-346. (Pubitemid 44430622)
    • (2006) Silico Biology , vol.6 , Issue.4 , pp. 341-346
    • Chong, C.-E.1    Lim, B.-S.2    Nathan, S.3    Mohamed, R.4
  • 25
    • 33750290455 scopus 로고    scopus 로고
    • Understanding microbial metabolism
    • DOI 10.1146/annurev.micro.60.080805.142308
    • Downs DM., 2006. Understanding microbial metabolism. Annu Rev Microbiol 60: 533-559. (Pubitemid 44627960)
    • (2006) Annual Review of Microbiology , vol.60 , pp. 533-559
    • Downs, D.M.1
  • 26
    • 33745202607 scopus 로고    scopus 로고
    • In silico identification of potential therapeutic targets in the human pathogen helicobacter pylori
    • Dutta A, Singh SK, Ghosh P, Mukherjee R, Mitter S, Bandyopadhyay D., 2006. In silico identification of potential therapeutic targets in the human pathogen Helicobacter pylori. In Silico Biol 6: 43-47. (Pubitemid 43905155)
    • (2006) Silico Biology , vol.6 , Issue.1-2 , pp. 43-47
    • Dutta, A.1    Singh, S.Kr.2    Ghosh, P.3    Mukherjee, R.4    Mitter, S.5    Bandyopadhyay, D.6
  • 27
    • 69549111337 scopus 로고    scopus 로고
    • Antibiotics for emerging pathogens
    • Fischbach MA, Walsh CT., 2009. Antibiotics for emerging pathogens. Science 28: 1089-1093.
    • (2009) Science , vol.28 , pp. 1089-1093
    • Fischbach, M.A.1    Walsh, C.T.2
  • 28
    • 15844431346 scopus 로고    scopus 로고
    • PSORTb v.2.0: Expanded prediction of bacterial protein subcellular localization and insights gained from comparative proteome analysis
    • DOI 10.1093/bioinformatics/bti057
    • Gardy JL, Laird MR, Chen F, Rey S, Walsh CJ, Ester M, Brinkman FSL., 2005. PSORTb v.2.0: expanded prediction of bacterial protein subcellular localization and insights gained from comparative proteome analysis. Bioinformatics 21: 617-623. (Pubitemid 40424787)
    • (2005) Bioinformatics , vol.21 , Issue.5 , pp. 617-623
    • Gardy, J.L.1    Laird, M.R.2    Chen, F.3    Rey, S.4    Walsh, C.J.5    Ester, M.6    Brinkman, F.S.L.7
  • 29
    • 77954675992 scopus 로고    scopus 로고
    • Identification of potential targets in Mycoplasma pneumoniae through subtractive genome analysis
    • 038-041.
    • Gupta SK, Singh S, Gupta MK, Pant KK, Seth PK., 2010. Identification of potential targets in Mycoplasma pneumoniae through subtractive genome analysis. J Antivir Antiretrovir 2:038-041.
    • (2010) J Antivir Antiretrovir , vol.2
    • Gupta, S.K.1    Singh, S.2    Gupta, M.K.3    Pant, K.K.4    Seth, P.K.5
  • 30
    • 73849107815 scopus 로고    scopus 로고
    • Computational prediction of essential genes in an unculturable endosymbiotic bacterium, Wolbachia of Brugia malayi
    • Holman AG, Davis PJ, Foster JM, Carlow CK, Kumar S., 2009. Computational prediction of essential genes in an unculturable endosymbiotic bacterium, Wolbachia of Brugia malayi. BMC Microbiol 9: 243.
    • (2009) BMC Microbiol , vol.9 , pp. 243
    • Holman, A.G.1    Davis, P.J.2    Foster, J.M.3    Carlow, C.K.4    Kumar, S.5
  • 31
    • 0032772507 scopus 로고    scopus 로고
    • The utility of complete genome sequences in the study of pathogenic bacteria
    • Hood DW., 1999. The utility of complete genome sequences in the study of pathogenic bacteria. Parasitology 118: S3-S9.
    • (1999) Parasitology , vol.118
    • Hood, D.W.1
  • 32
    • 0031253990 scopus 로고    scopus 로고
    • Differential genome display
    • PII S0168952597012559
    • Huynen MA, Diaz-Lazcoz Y, Bork P., 1997. Differential genome display. Trends Genet 13: 389-390. (Pubitemid 127739571)
    • (1997) Trends in Genetics , vol.13 , Issue.10 , pp. 389-390
    • Huynen, M.A.1    Diaz-Lazcoz, Y.2    Bork, P.3
  • 33
    • 0032502899 scopus 로고    scopus 로고
    • Differential genome analysis applied to the species-specific features of Helicobacter pylori
    • DOI 10.1016/S0014-5793(98)00276-2, PII S0014579398002762
    • Huynen M, Dandekar T, Bork P., 1998. Differential genome analysis applied to the species-specific features of Helicobacter pylori. FEBS Lett 426: 1-5. (Pubitemid 28198144)
    • (1998) FEBS Letters , vol.426 , Issue.1 , pp. 1-5
    • Huynen, M.1    Dandekar, T.2    Bork, P.3
  • 34
    • 59449110078 scopus 로고    scopus 로고
    • SOSUI-GramN: High performance prediction for sub-cellular localization of proteins in Gram-negative bacteria
    • Imai K, Asakawa N, Tsuji T, Akazawa F, Ino A, Sonoyama M, Mitaku S., 2008. SOSUI-GramN: high performance prediction for sub-cellular localization of proteins in Gram-negative bacteria. Bioinformation 2: 417-421.
    • (2008) Bioinformation , vol.2 , pp. 417-421
    • Imai, K.1    Asakawa, N.2    Tsuji, T.3    Akazawa, F.4    Ino, A.5    Sonoyama, M.6    Mitaku, S.7
  • 35
    • 4544227574 scopus 로고    scopus 로고
    • Toward large-scale modeling of the microbial cell for computer simulation
    • DOI 10.1016/j.jbiotec.2004.04.038, PII S0168165604003190
    • Ishii N, Robert M, Nakayama Y, Kanai A, Tomita M., 2004. Toward large-scale modeling of the microbial cell for computer simulation. J Biotechnol 113: 281-294. (Pubitemid 39237084)
    • (2004) Journal of Biotechnology , vol.113 , Issue.1-3 , pp. 281-294
    • Ishii, N.1    Robert, M.2    Nakayama, Y.3    Kanai, A.4    Tomita, M.5
  • 36
    • 0028906201 scopus 로고
    • An estimation of minimal genome size required for life
    • Itaya M., 1995. An estimation of minimal genome size required for life. FEBS Lett 362: 257-260.
    • (1995) FEBS Lett , vol.362 , pp. 257-260
    • Itaya, M.1
  • 37
    • 0036262135 scopus 로고    scopus 로고
    • The role of genomics in the discovery of novel targets for antibiotic therapy
    • DOI 10.1517/14622416.3.3.315
    • Ji Y., 2002. The role of genomics in the discovery of novel targets for antibiotic therapy. Pharmacogenomics 3: 315-323. (Pubitemid 34567569)
    • (2002) Pharmacogenomics , vol.3 , Issue.3 , pp. 315-323
    • Ji, Y.1
  • 38
    • 0036078078 scopus 로고    scopus 로고
    • Essential genes are more evolutionarily conserved than are nonessential genes in bacteria
    • DOI 10.1101/gr.87702. Article published online before print in May 2002
    • Jordan IK, Rogozin IB, Wolf YI, Koonin EV., 2002. Essential genes are more evolutionarily conserved than are nonessential genes in bacteria. Genome Res 12: 962-968. (Pubitemid 34662289)
    • (2002) Genome Research , vol.12 , Issue.6 , pp. 962-968
    • King Jordan, I.1    Rogozin, I.B.2    Wolf, Y.I.3    Koonin, E.V.4
  • 42
    • 0036087099 scopus 로고    scopus 로고
    • SYSTERS, GeneNest, SpliceNest: Exploring sequence space from genome to protein
    • Krause A, Haas SA, Coward E, Vingron M., 2002. SYSTERS, GeneNest, SpliceNest: exploring sequence space from genome to protein. Nucleic Acids Res 30: 299-300. (Pubitemid 34679568)
    • (2002) Nucleic Acids Research , vol.30 , Issue.1 , pp. 299-300
    • Krause, A.1    Haas, S.A.2    Coward, E.3    Vingron, M.4
  • 44
    • 0035910270 scopus 로고    scopus 로고
    • Predicting transmembrane protein topology with a hidden Markov model: Application to complete genomes
    • DOI 10.1006/jmbi.2000.4315
    • Krogh A, Larsson B, von Heijne G, Sonnhammer EL., 2001. Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J Mol Biol 305: 567-580. (Pubitemid 33032862)
    • (2001) Journal of Molecular Biology , vol.305 , Issue.3 , pp. 567-580
    • Krogh, A.1    Larsson, B.2    Von Heijne, G.3    Sonnhammer, E.L.L.4
  • 46
    • 33846950455 scopus 로고    scopus 로고
    • Systems biology approach to integrative comparative genomics
    • DOI 10.1586/14789450.4.1.107
    • Lin J, Qian J., 2007. Systems biology approach to integrative comparative genomics. Expert Rev Proteomics 4: 107-119. (Pubitemid 46242106)
    • (2007) Expert Review of Proteomics , vol.4 , Issue.1 , pp. 107-119
    • Lin, J.1    Qian, J.2
  • 47
    • 0035581737 scopus 로고    scopus 로고
    • Exploiting genomics to discover new antibiotics
    • DOI 10.1016/S0966-842X(01)02235-1, PII S0966842X01022351
    • McDevitt D, Rosenberg M., 2001. Exploiting genomics to discover new antibiotics. Trends Microbiol 9: 611-617. (Pubitemid 33135418)
    • (2001) Trends in Microbiology , vol.9 , Issue.12 , pp. 611-617
    • McDevitt, D.1    Rosenberg, M.2
  • 48
    • 2942587063 scopus 로고    scopus 로고
    • Bacterial genomes pave the way to novel vaccines
    • DOI 10.1016/j.mib.2004.04.008, PII S1369527404000463
    • Meinke A, Henics T, Nagy E., 2004. Bacterial genomes pave the way to novel vaccines. Curr Opin Microbiol 7: 314-320. (Pubitemid 38758074)
    • (2004) Current Opinion in Microbiology , vol.7 , Issue.3 , pp. 314-320
    • Meinke, A.1    Henics, T.2    Nagy, E.3
  • 49
    • 33644557421 scopus 로고    scopus 로고
    • When will the genomics investment pay off for antibacterial discovery?
    • Mills SD., 2006. When will the genomics investment pay off for antibacterial discovery? Biochem Pharmacol 30: 1096-1102.
    • (2006) Biochem Pharmacol , vol.30 , pp. 1096-1102
    • Mills, S.D.1
  • 52
    • 38449085447 scopus 로고    scopus 로고
    • Drug target validation and identification of secondary drug target effects using DNA microarrays
    • Owa T., 2007. Drug target validation and identification of secondary drug target effects using DNA microarrays. Tanpakushitsu Kakusan Koso 52: 1808-1809.
    • (2007) Tanpakushitsu Kakusan Koso , vol.52 , pp. 1808-1809
    • Owa, T.1
  • 53
    • 0023989064 scopus 로고
    • Improved tools for biological sequence comparison
    • Pearson WR, Lipman DJ., 1988. Improved tools for biological sequence comparison. Proc Natl Acad Sci USA 85: 2444-2448.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 2444-2448
    • Pearson, W.R.1    Lipman, D.J.2
  • 54
    • 0343618652 scopus 로고    scopus 로고
    • HOBACGEN: Database system for comparative genomics in bacteria
    • DOI 10.1101/gr.10.3.379
    • Perrière G, Duret L, Gouy M., 2000. HOBACGEN: database system for comparative genomics in bacteria. Genome Res 10: 379-385. (Pubitemid 30168670)
    • (2000) Genome Research , vol.10 , Issue.3 , pp. 379-385
    • Perriere, G.1    Duret, L.2    Gouy, M.3
  • 55
    • 38949196018 scopus 로고    scopus 로고
    • Differential genome analyses of metabolic enzymes in pseudomonas aeruginosa for drug target identification
    • Perumal D, Lim CS, Sakharkar KR, Sakharkar MK., 2007. Differential genome analyses of metabolic enzymes in Pseudomonas aeruginosa for drug target identification. In Silico Biol 7: 453-465. (Pubitemid 351217190)
    • (2007) Silico Biology , vol.7 , Issue.4-5 , pp. 453-465
    • Perumal, D.1    Lim, C.S.2    Sakharkar, K.R.3    Sakharkar, M.K.4
  • 57
    • 20044365108 scopus 로고    scopus 로고
    • Why certain vaccines have been delayed or not developed at all
    • Plotkin SA., 2005. Why certain vaccines have been delayed or not developed at all. Health Aff (Millwood) 24: 631-634.
    • (2005) Health Aff (Millwood) , vol.24 , pp. 631-634
    • Plotkin, S.A.1
  • 58
    • 33644514658 scopus 로고    scopus 로고
    • Use of genomics to select antibacterial targets
    • Pucci MJ., 2006. Use of genomics to select antibacterial targets. Biochem Pharmacol 71: 1066-1072.
    • (2006) Biochem Pharmacol , vol.71 , pp. 1066-1072
    • Pucci, M.J.1
  • 59
    • 0033787577 scopus 로고    scopus 로고
    • Reverse vaccinology
    • Rappuoli R., 2000. Reverse vaccinology. Curr Opin Microbiol 3: 445-450.
    • (2000) Curr Opin Microbiol , vol.3 , pp. 445-450
    • Rappuoli, R.1
  • 60
    • 79953861876 scopus 로고    scopus 로고
    • Genome subtraction for novel target definition in Salmonella typhi
    • Rathi B, Aditya N, Sarangi AN, Trivedi N., 2009. Genome subtraction for novel target definition in Salmonella typhi. Bioinformation 4: 143-150.
    • (2009) Bioinformation , vol.4 , pp. 143-150
    • Rathi, B.1    Aditya, N.2    Sarangi, A.N.3    Trivedi, N.4
  • 61
    • 10044239624 scopus 로고    scopus 로고
    • A novel genomics approach for the identification of drug targets in pathogens, with special reference to Pseudomonas aeruginosa
    • Sakharkar KR, Sakharkar MK, Chow VT., 2004. A novel genomics approach for the identification of drug targets in pathogens, with special reference to Pseudomonas aeruginosa. In Silico Biol 4: 355-360. (Pubitemid 39600481)
    • (2004) Silico Biology , vol.4 , Issue.3 , pp. 355-360
    • Sakharkar, K.R.1    Sakharkar, M.K.2    Chow, V.T.K.3
  • 62
    • 79953848872 scopus 로고    scopus 로고
    • Subtractive genomics approach for in silico identification and characterization of novel drug targets in Neisseria meningitidis serogroup B
    • Sarangi AN, Aggarwal R, Rahman Q, Trivedi N., 2009. Subtractive genomics approach for in silico identification and characterization of novel drug targets in Neisseria meningitidis serogroup B. J Comput Sci Syst Biol 2: 255-258.
    • (2009) J Comput Sci Syst Biol , vol.2 , pp. 255-258
    • Sarangi, A.N.1    Aggarwal, R.2    Rahman, Q.3    Trivedi, N.4
  • 63
    • 33646569665 scopus 로고    scopus 로고
    • Post-genomic vaccine development
    • DOI 10.1016/j.febslet.2006.04.084, PII S0014579306005412
    • Serruto D, Rappuoli R., 2006. Post-genomic vaccine development. FEBS Lett 580: 2985-2992. (Pubitemid 43729171)
    • (2006) FEBS Letters , vol.580 , Issue.12 , pp. 2985-2992
    • Serruto, D.1    Rappuoli, R.2
  • 64
    • 79953851912 scopus 로고    scopus 로고
    • Computational genome analyses of metabolic enzymes in Mycobacterium leprae for drug target identification
    • Shanmugam A, Natarajan J., 2010. Computational genome analyses of metabolic enzymes in Mycobacterium leprae for drug target identification. Bioinformation 4: 392-395.
    • (2010) Bioinformation , vol.4 , pp. 392-395
    • Shanmugam, A.1    Natarajan, J.2
  • 65
    • 77954265673 scopus 로고    scopus 로고
    • MGenomeSubtractor: A web-based tool for parallel in silico subtractive hybridization analysis of multiple bacterial genomes
    • Shao Y, He X, Harrison EM, Tai C, Ou HY, Rajakumar K, Deng Z., 2010. mGenomeSubtractor: a web-based tool for parallel in silico subtractive hybridization analysis of multiple bacterial genomes. Nucleic Acids Res 38: 194-200.
    • (2010) Nucleic Acids Res , vol.38 , pp. 194-200
    • Shao, Y.1    He, X.2    Harrison, E.M.3    Tai, C.4    Ou, H.Y.5    Rajakumar, K.6    Deng, Z.7
  • 66
    • 53249117471 scopus 로고    scopus 로고
    • In silico identification of putative drug targets from different metabolic pathways of Aeromonas hydrophila
    • Sharma V, Gupta P, Dixit A., 2008. In silico identification of putative drug targets from different metabolic pathways of Aeromonas hydrophila. In Silico Biol 8: 331-338.
    • (2008) Silico Biol , vol.8 , pp. 331-338
    • Sharma, V.1    Gupta, P.2    Dixit, A.3
  • 68
    • 60049091769 scopus 로고    scopus 로고
    • ESX/type VII secretion systems and their role in host-pathogen interaction
    • Simeone R, Bottai D, Brosch R., 2009. ESX/type VII secretion systems and their role in host-pathogen interaction. Curr Opin Microbiol 12: 4-10.
    • (2009) Curr Opin Microbiol , vol.12 , pp. 4-10
    • Simeone, R.1    Bottai, D.2    Brosch, R.3
  • 69
    • 34250647863 scopus 로고    scopus 로고
    • T-iDT: Tool for Identification of drug target in bacteria and validation by mycobacterium tuberculosis
    • Singh NK, Selvam SM, Chakravarthy P., 2006. T-iDT: tool for identification of drug target in bacteria and validation by Mycobacterium tuberculosis. In Silico Biol 6: 485-493. (Pubitemid 47028641)
    • (2006) Silico Biology , vol.6 , Issue.6 , pp. 485-493
    • Singh, N.K.1    Selvam, S.M.2    Chakravarthy, P.3
  • 70
    • 34248180074 scopus 로고    scopus 로고
    • Metabolic pathway analysis of S. Pneumoniae: An in silico approach towards drug-design
    • DOI 10.1142/S0219720007002564, PII S0219720007002564
    • Singh S, Malik BK, Sharma DK., 2007. Metabolic pathway analysis of S. pneumoniae: an in silico approach towards drug-design. J Bioinform Comput Biol 5: 135-153. (Pubitemid 46705938)
    • (2007) Journal of Bioinformatics and Computational Biology , vol.5 , Issue.1 , pp. 135-153
    • Singh, S.1    Malik, B.K.2    Sharma, D.K.3
  • 71
    • 38049184489 scopus 로고    scopus 로고
    • Host-pathogen interplay and the evolution of bacterial effectors
    • Stavrinides J, McCann HC, Guttman DS., 2008. Host-pathogen interplay and the evolution of bacterial effectors. Cell Microbiol 10: 285-292.
    • (2008) Cell Microbiol , vol.10 , pp. 285-292
    • Stavrinides, J.1    McCann, H.C.2    Guttman, D.S.3
  • 72
    • 0036443984 scopus 로고    scopus 로고
    • Deductive genomics: A functional approach to identify innovative drug targets in the post-genome era
    • Stumm G, Russ A, Nehls M., 2002. Deductive genomics: a functional approach to identify innovative drug targets in the post-genome era. Am J Pharmacogenom 2: 263-271. (Pubitemid 35429316)
    • (2002) American Journal of PharmacoGenomics , vol.2 , Issue.4 , pp. 263-271
    • Stumm, G.1    Russ, A.2    Nehls, M.3
  • 73
    • 0030660581 scopus 로고    scopus 로고
    • A genomic perspective on protein families
    • DOI 10.1126/science.278.5338.631
    • Tatusov RL, Koonin EV, Lipman DJ., 1997. A genomic perspective on protein families. Science 278: 631-637. (Pubitemid 27464953)
    • (1997) Science , vol.278 , Issue.5338 , pp. 631-637
    • Tatusov, R.L.1    Koonin, E.V.2    Lipman, D.J.3
  • 75
    • 67651115984 scopus 로고    scopus 로고
    • Essential pathway identification: From in silico analysis to potential antifungal targets in Aspergillus fumigatus
    • Thykaer J, Andersen MR, Baker SE., 2009. Essential pathway identification: from in silico analysis to potential antifungal targets in Aspergillus fumigatus. Med Mycol 47: S80-S87.
    • (2009) Med Mycol , vol.47
    • Thykaer, J.1    Andersen, M.R.2    Baker, S.E.3
  • 77
    • 0032726692 scopus 로고    scopus 로고
    • ProtoMap: Automatic classification of protein sequences, a hierarchy of protein families, and local maps of the protein space
    • DOI 10.1002/(SICI)1097-0134(19991115)37:3<360::AID-PROT5>3.0.CO;2-Z
    • Yona G, Linial N, Linial M., 1999. ProtoMap: automatic classification of protein sequences, a hierarchy of protein families, and local maps of the protein space. Proteins 37: 360-378. (Pubitemid 29519727)
    • (1999) Proteins: Structure, Function and Genetics , vol.37 , Issue.3 , pp. 360-378
    • Yona, G.1    Linial, N.2    Linial, M.3
  • 78
    • 1942505330 scopus 로고    scopus 로고
    • Predicting subcellular localization of proteins for Gram-negative bacteria by support vector machines based on n-peptide compositions
    • Yu CS, Lin CJ, Hwang JK., 2004. Predicting subcellular localization of proteins for Gram-negative bacteria by support vector machines based on n-peptide compositions. Protein Sci 13: 1402-1406.
    • (2004) Protein Sci , vol.13 , pp. 1402-1406
    • Yu, C.S.1    Lin, C.J.2    Hwang, J.K.3
  • 79


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.