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Volumn 71, Issue 7, 2006, Pages 1096-1102

When will the genomics investment pay off for antibacterial discovery?

Author keywords

Antibacterial; Bioinformatic; Genomic; Resistance; Screening; Target

Indexed keywords

ANTIINFECTIVE AGENT; CIPROFLOXACIN; DAPTOMYCIN; GATIFLOXACIN; LEVOFLOXACIN; LINEZOLID; METICILLIN; MOXIFLOXACIN; NORFLOXACIN; PENICILLIN G; QUINOLINE DERIVED ANTIINFECTIVE AGENT; VANCOMYCIN;

EID: 33644557421     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.11.025     Document Type: Note
Times cited : (51)

References (67)
  • 1
    • 0242291985 scopus 로고    scopus 로고
    • Why is big pharma getting out of antibacterial drug discovery?
    • S.J. Projan Why is big pharma getting out of antibacterial drug discovery? Curr Opin Microbiol 6 2003 427 430
    • (2003) Curr Opin Microbiol , vol.6 , pp. 427-430
    • Projan, S.J.1
  • 3
    • 12844274375 scopus 로고    scopus 로고
    • Antibiotics: Where did we go wrong?
    • K.M. Overbye, and J.F. Barrett Antibiotics: where did we go wrong? Drug Discov Today 10 2005 45 52
    • (2005) Drug Discov Today , vol.10 , pp. 45-52
    • Overbye, K.M.1    Barrett, J.F.2
  • 4
    • 12944302098 scopus 로고    scopus 로고
    • Lack of development of new antimicrobial drugs: A potential serious threat to public health
    • S.R. Norrby, C.E. Nord, and R. Finch Lack of development of new antimicrobial drugs: a potential serious threat to public health Lancet Infect Dis 5 2005 115 119
    • (2005) Lancet Infect Dis , vol.5 , pp. 115-119
    • Norrby, S.R.1    Nord, C.E.2    Finch, R.3
  • 6
    • 0037458217 scopus 로고    scopus 로고
    • Linezolid: The first oxazolidinone antimicrobial
    • R.C. Moellering Linezolid: the first oxazolidinone antimicrobial Ann Intern Med 138 2003 135 142
    • (2003) Ann Intern Med , vol.138 , pp. 135-142
    • Moellering, R.C.1
  • 7
    • 8544232151 scopus 로고    scopus 로고
    • Daptomycin - A novel antibiotic against Gram-positive pathogens
    • K.L. LaPlante, and M.J. Rybak Daptomycin - a novel antibiotic against Gram-positive pathogens Expert Opin Pharmacother 5 2004 2321 2331
    • (2004) Expert Opin Pharmacother , vol.5 , pp. 2321-2331
    • Laplante, K.L.1    Rybak, M.J.2
  • 8
    • 0345839252 scopus 로고    scopus 로고
    • Where will new antibiotics come from?
    • C. Walsh Where will new antibiotics come from? Nat Rev Microbiol 1 2003 65 70
    • (2003) Nat Rev Microbiol , vol.1 , pp. 65-70
    • Walsh, C.1
  • 9
    • 2942558870 scopus 로고    scopus 로고
    • Relationship of MIC and bactericidal activity to efficacy of vancomycin for treatment of methicillin-resistant Staphylococcus aureus bacteremia
    • G. Sakoulas, P.A. Moise-Broder, J. Schentag, A. Forrest, R.C. Moellering, and G.M. Eliopoulos Relationship of MIC and bactericidal activity to efficacy of vancomycin for treatment of methicillin-resistant Staphylococcus aureus bacteremia J Clin Microbiol 42 2004 2398 2402
    • (2004) J Clin Microbiol , vol.42 , pp. 2398-2402
    • Sakoulas, G.1    Moise-Broder, P.A.2    Schentag, J.3    Forrest, A.4    Moellering, R.C.5    Eliopoulos, G.M.6
  • 10
    • 0037024849 scopus 로고    scopus 로고
    • Staphylococcus aureus resistant to vancomycin-United States, 2002
    • Centers for Disease Control and Prevention. Staphylococcus aureus resistant to vancomycin-United States, 2002. Morb Mortal Wkly Rep 2002;51:565-67.
    • (2002) Morb Mortal Wkly Rep , vol.51 , pp. 565-567
  • 13
    • 15744365907 scopus 로고    scopus 로고
    • Daptomycin-resistant, methicillin-resistant Staphylococcus aureus bacteremia
    • A. Mangili, I. Bica, D.R. Snydman, and D.H. Hamer Daptomycin-resistant, methicillin-resistant Staphylococcus aureus bacteremia Clin Infect Dis 40 2005 1058 1060
    • (2005) Clin Infect Dis , vol.40 , pp. 1058-1060
    • Mangili, A.1    Bica, I.2    Snydman, D.R.3    Hamer, D.H.4
  • 16
    • 0034571148 scopus 로고    scopus 로고
    • How many genes can make a cell: The minimal-gene-set concept
    • E.V. Koonin How many genes can make a cell: the minimal-gene-set concept Annu Rev Genomics Hum Genet 1 2000 99 116
    • (2000) Annu Rev Genomics Hum Genet , vol.1 , pp. 99-116
    • Koonin, E.V.1
  • 17
    • 4544371669 scopus 로고    scopus 로고
    • Determination of the core of a minimal bacterial gene set
    • R. Gil, F.J. Silva, J. Pereto, and A. Moya Determination of the core of a minimal bacterial gene set Microbiol Mol Biol Rev 68 2004 518 537
    • (2004) Microbiol Mol Biol Rev , vol.68 , pp. 518-537
    • Gil, R.1    Silva, F.J.2    Pereto, J.3    Moya, A.4
  • 18
    • 0033552961 scopus 로고    scopus 로고
    • Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori
    • R.A. Alm, L.S. Ling, D.T. Moir, B.L. King, E.D. Brown, and P.C. Doig Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori Nature 397 1999 176 180
    • (1999) Nature , vol.397 , pp. 176-180
    • Alm, R.A.1    Ling, L.S.2    Moir, D.T.3    King, B.L.4    Brown, E.D.5    Doig, P.C.6
  • 19
    • 33644524442 scopus 로고    scopus 로고
    • The National Center for Biotechnology Information's Entrez Genome Project web page, http://www.ncbi.nlm.nih.gov/genomes/lproks.cgi.
  • 21
    • 3342960836 scopus 로고    scopus 로고
    • Staphylococcus aureus: Superbug, supergenome?
    • J.A. Lindsay, and MT.G. Holden Staphylococcus aureus: superbug, supergenome? Trends Microbiol 12 2004 378 385
    • (2004) Trends Microbiol , vol.12 , pp. 378-385
    • Lindsay, J.A.1    Holden, M.G.2
  • 24
    • 26944443933 scopus 로고    scopus 로고
    • Bioinformatics in microbial biotechnology - A mini review
    • A.K. Bansal Bioinformatics in microbial biotechnology - a mini review Microb Cell Factories 4 2005 19
    • (2005) Microb Cell Factories , vol.4 , pp. 19
    • Bansal, A.K.1
  • 26
    • 33644528823 scopus 로고    scopus 로고
    • The Institute for Genomic Research's Comprehensive Microbial Resource web page, www.tigr.org.
  • 27
    • 0029084854 scopus 로고
    • Epidemiology and treatment of chronic bronchitis and its exacerbations
    • P. Ball Epidemiology and treatment of chronic bronchitis and its exacerbations Chest 108 1995 43 52
    • (1995) Chest , vol.108 , pp. 43-52
    • Ball, P.1
  • 28
    • 0034730128 scopus 로고    scopus 로고
    • Genetic footprinting with mariner-based transposition in Pseudomonas aeruginosa
    • S.M. Wong, and J.J. Mekalanos Genetic footprinting with mariner-based transposition in Pseudomonas aeruginosa Proc Natl Acad Sci USA 97 2000 10191 10196
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10191-10196
    • Wong, S.M.1    Mekalanos, J.J.2
  • 30
    • 0037154255 scopus 로고    scopus 로고
    • A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae
    • B.J. Akerley, E.J. Rubin, V.L. Novick, K. Amaya, N. Judson, and J.J. Mekalanos A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae Proc Natl Acad Sci USA 99 2002 966 971
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 966-971
    • Akerley, B.J.1    Rubin, E.J.2    Novick, V.L.3    Amaya, K.4    Judson, N.5    Mekalanos, J.J.6
  • 31
    • 0035929121 scopus 로고    scopus 로고
    • Identification of critical Staphylococcal genes using conditional phenotypes generated by antisense RNA
    • Y. Ji, B. Zhang, S.F. Van Horn, P. Warren, G. Woodnut, and MKR Burnham Identification of critical Staphylococcal genes using conditional phenotypes generated by antisense RNA Science 293 2001 2266 2269
    • (2001) Science , vol.293 , pp. 2266-2269
    • Ji, Y.1    Zhang, B.2    Van Horn, S.F.3    Warren, P.4    Woodnut, G.5    Burnham, M.K.R.6
  • 32
  • 33
    • 0037100683 scopus 로고    scopus 로고
    • Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae
    • J.A. Thanassi, S.L. Hartman-Neumann, T.J. Dougherty, B.A. Dougherty, and M.J. Pucci Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae Nucleic Acids Res 30 2002 3152 3162
    • (2002) Nucleic Acids Res , vol.30 , pp. 3152-3162
    • Thanassi, J.A.1    Hartman-Neumann, S.L.2    Dougherty, T.J.3    Dougherty, B.A.4    Pucci, M.J.5
  • 34
    • 27244451533 scopus 로고    scopus 로고
    • Identification of essential genes in Streptococcus pneumoniae by allelic replacement mutagenesis
    • J.H. Song, K.S. Ko, J.Y. Lee, J.Y. Baek, W.S. Oh, and H.S. Yoon Identification of essential genes in Streptococcus pneumoniae by allelic replacement mutagenesis Mol Cells 19 2005 365 374
    • (2005) Mol Cells , vol.19 , pp. 365-374
    • Song, J.H.1    Ko, K.S.2    Lee, J.Y.3    Baek, J.Y.4    Oh, W.S.5    Yoon, H.S.6
  • 37
    • 0030796260 scopus 로고    scopus 로고
    • Methods for generating precise deletions and insertions in the genome of wild-type Escherichia coli: Application to open reading frame characterization
    • A. Link, D. Phillips, and G. Church Methods for generating precise deletions and insertions in the genome of wild-type Escherichia coli: application to open reading frame characterization J Bacteriol 179 1997 6228 6237
    • (1997) J Bacteriol , vol.179 , pp. 6228-6237
    • Link, A.1    Phillips, D.2    Church, G.3
  • 38
    • 0032820632 scopus 로고    scopus 로고
    • Rapid method for the identification of essential genes in Staphylococcus aureus
    • M. Xia, R.D. Lunsford, D. McDevitt, and S. Lordanescu Rapid method for the identification of essential genes in Staphylococcus aureus Plasmid 42 1999 144 149
    • (1999) Plasmid , vol.42 , pp. 144-149
    • Xia, M.1    Lunsford, R.D.2    McDevitt, D.3    Lordanescu, S.4
  • 39
    • 3242748400 scopus 로고    scopus 로고
    • Development of an essential gene knockout and complementation system for Haemophilus influenzae using riboflavin synthase (ribC) as a model
    • A. Saeed-Koithe, W. Yang, and S.D. Mills Development of an essential gene knockout and complementation system for Haemophilus influenzae using riboflavin synthase (ribC) as a model Appl Environ Microbiol 70 2004 4136 4143
    • (2004) Appl Environ Microbiol , vol.70 , pp. 4136-4143
    • Saeed-Koithe, A.1    Yang, W.2    Mills, S.D.3
  • 41
    • 0037336363 scopus 로고    scopus 로고
    • Characterization of a novel fucose regulated promoter (PfcsK) suitable for gene essentiality and antibacterial mode-of-action studies in Streptococcus pneumoniae
    • P.F. Chan, K.M. O'Dwyer, L.M. Palmer, J.D. Ambrad, K.A. Ingraham, and C. So Characterization of a novel fucose regulated promoter (PfcsK) suitable for gene essentiality and antibacterial mode-of-action studies in Streptococcus pneumoniae J Bacteriol 185 2003 2051 2058
    • (2003) J Bacteriol , vol.185 , pp. 2051-2058
    • Chan, P.F.1    O'Dwyer, K.M.2    Palmer, L.M.3    Ambrad, J.D.4    Ingraham, K.A.5    So, C.6
  • 42
    • 0038779197 scopus 로고    scopus 로고
    • Genetic strategies for antibacterial drug discovery
    • L. Miesel, J. Greene, and T.A. Black Genetic strategies for antibacterial drug discovery Nat Rev Genet 4 2003 442 456
    • (2003) Nat Rev Genet , vol.4 , pp. 442-456
    • Miesel, L.1    Greene, J.2    Black, T.A.3
  • 46
    • 0347766000 scopus 로고    scopus 로고
    • Identification of antibiotic stress-inducible promoters: A systematic approach to novel pathway-specific reporter assays for antibacterial drug discovery
    • H.P. Fischer, N.A. Brunner, B. Wieland, J. Paquette, L. Macko, and K. Ziegelbauer Identification of antibiotic stress-inducible promoters: a systematic approach to novel pathway-specific reporter assays for antibacterial drug discovery Genome Res 14 2004 90 98
    • (2004) Genome Res , vol.14 , pp. 90-98
    • Fischer, H.P.1    Brunner, N.A.2    Wieland, B.3    Paquette, J.4    MacKo, L.5    Ziegelbauer, K.6
  • 47
    • 4644248905 scopus 로고    scopus 로고
    • Dual effects of MLS antibiotics: Transcriptional modulation and interactions on the ribosome
    • W.H. Tsui, G. Yim, H.H. Wang, J.E. McClure, M.G. Surette, and J. Davies Dual effects of MLS antibiotics: transcriptional modulation and interactions on the ribosome Chem Biol 11 2004 1307 1316
    • (2004) Chem Biol , vol.11 , pp. 1307-1316
    • Tsui, W.H.1    Yim, G.2    Wang, H.H.3    McClure, J.E.4    Surette, M.G.5    Davies, J.6
  • 48
    • 3042670809 scopus 로고    scopus 로고
    • Molecular characterization of benzimidazole resistance in Helicobacter pylori
    • S.D. Mils, W. Yang, and K. MacCormack Molecular characterization of benzimidazole resistance in Helicobacter pylori Antimicrob Agents Chemother 48 2004 2524 2530
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 2524-2530
    • Mils, S.D.1    Yang, W.2    MacCormack, K.3
  • 49
    • 21444455372 scopus 로고    scopus 로고
    • Novel approach to mapping of resistance mutations in whole genomes by using restriction enzyme modulation of transformation efficiency
    • C.G. Lerner, S.J. Kakavas, C. Wagner, R.T. Chang, and P.J. Merta Novel approach to mapping of resistance mutations in whole genomes by using restriction enzyme modulation of transformation efficiency Antimicrob Agents Chemother 49 2005 2767 2777
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 2767-2777
    • Lerner, C.G.1    Kakavas, S.J.2    Wagner, C.3    Chang, R.T.4    Merta, P.J.5
  • 50
    • 12944327876 scopus 로고    scopus 로고
    • Discovering the mechanism of action of novel antibacterial agents through transcriptional profiling of conditional mutants
    • C. Freiberg, H.P. Fischer, and N.A. Brunner Discovering the mechanism of action of novel antibacterial agents through transcriptional profiling of conditional mutants Antimicrob Agents Chemother 49 2005 749 759
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 749-759
    • Freiberg, C.1    Fischer, H.P.2    Brunner, N.A.3
  • 52
    • 4344698841 scopus 로고    scopus 로고
    • Technological advances in high-throughout screening
    • B. Liu, S. Li, and J. Hu Technological advances in high-throughout screening Am J Pharmacogenomics 4 2004 263 276
    • (2004) Am J Pharmacogenomics , vol.4 , pp. 263-276
    • Liu, B.1    Li, S.2    Hu, J.3
  • 53
    • 12844283957 scopus 로고    scopus 로고
    • High-throughput drug discovery: What can we expect from HTS?
    • P. Gribbon, and A. Sewing High-throughput drug discovery: what can we expect from HTS? Drug Discov Today 10 2005 18 22
    • (2005) Drug Discov Today , vol.10 , pp. 18-22
    • Gribbon, P.1    Sewing, A.2
  • 54
    • 2942746756 scopus 로고    scopus 로고
    • The potential of bacterial fatty acid biosynthetic enzymes as a source of novel antibacterial agents
    • D.J. Payne The potential of bacterial fatty acid biosynthetic enzymes as a source of novel antibacterial agents Drug News Perspect 17 2004 187 194
    • (2004) Drug News Perspect , vol.17 , pp. 187-194
    • Payne, D.J.1
  • 55
    • 20144370577 scopus 로고    scopus 로고
    • Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial agents
    • Z. Me, C. Perretta, J. Lu, Y. Su, S. Margosiak, and K.S. Gajiwala Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial agents J Med Chem 48 2005 1596 1609
    • (2005) J Med Chem , vol.48 , pp. 1596-1609
    • Me, Z.1    Perretta, C.2    Lu, J.3    Su, Y.4    Margosiak, S.5    Gajiwala, K.S.6
  • 56
  • 57
    • 9144268506 scopus 로고    scopus 로고
    • Peptide deformylase inhibitors as antibacterial agents: Identification of VRC3375, a proline-3-alkylsuccinyl hydroxamate derivative, by using an integrated combinatorial and medicinal chemistry approach
    • D. Chen, C. Hackbarth, Z.J. Ni, C. Wu, W. Wang, and R. Jain Peptide deformylase inhibitors as antibacterial agents: identification of VRC3375, a proline-3-alkylsuccinyl hydroxamate derivative, by using an integrated combinatorial and medicinal chemistry approach Antimicrob Agents Chemother 48 2004 250 261
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 250-261
    • Chen, D.1    Hackbarth, C.2    Ni, Z.J.3    Wu, C.4    Wang, W.5    Jain, R.6
  • 58
    • 0037046549 scopus 로고    scopus 로고
    • Nanamolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against Gram-positive pathogens
    • R.L. Jarvest, J.M. Berge, V. Berry, H.F. Boyd, M.J. Brown, and J.S. Elder Nanamolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against Gram-positive pathogens J Med Chem 45 2002 1959 1962
    • (2002) J Med Chem , vol.45 , pp. 1959-1962
    • Jarvest, R.L.1    Berge, J.M.2    Berry, V.3    Boyd, H.F.4    Brown, M.J.5    Elder, J.S.6
  • 59
    • 1242328740 scopus 로고    scopus 로고
    • Reconstruction of microbial transcriptional regulatory networks
    • M.J. Herrgard, M.W. Covert, and B.Ø. Palsson Reconstruction of microbial transcriptional regulatory networks Curr Opin Biotechnol 15 2004 70 77
    • (2004) Curr Opin Biotechnol , vol.15 , pp. 70-77
    • Herrgard, M.J.1    Covert, M.W.2    Palsson B.Ø3
  • 60
    • 2342648924 scopus 로고    scopus 로고
    • Integrating high-throughput and computational data elucidates bacterial networks
    • M.W. Covert, E.M. Knight, J.L. Reed, M.J. Herrgård, and B.Ø. Palsson Integrating high-throughput and computational data elucidates bacterial networks Nature 429 2004 92 96
    • (2004) Nature , vol.429 , pp. 92-96
    • Covert, M.W.1    Knight, E.M.2    Reed, J.L.3    Herrgård, M.J.4    Palsson B.Ø5
  • 62
    • 0035520472 scopus 로고    scopus 로고
    • Evolutionary genomics of pathogenic bacteria
    • J.R. Fitzgerald, and J.M. Musser Evolutionary genomics of pathogenic bacteria Trends Microbiol 9 2001 547 553
    • (2001) Trends Microbiol , vol.9 , pp. 547-553
    • Fitzgerald, J.R.1    Musser, J.M.2
  • 63
    • 0037040394 scopus 로고    scopus 로고
    • Microbial minimalism: Genome reduction in bacterial pathogens
    • N.A. Moran Microbial minimalism: genome reduction in bacterial pathogens Cell 108 2002 583 586
    • (2002) Cell , vol.108 , pp. 583-586
    • Moran, N.A.1
  • 64
    • 4444295503 scopus 로고    scopus 로고
    • Seeing is believing: The impact of structural genomics on antimicrobial drug discovery
    • M.B. Schmid Seeing is believing: the impact of structural genomics on antimicrobial drug discovery Nat Rev Microbiol 2 2004 739 746
    • (2004) Nat Rev Microbiol , vol.2 , pp. 739-746
    • Schmid, M.B.1
  • 65
    • 3142675039 scopus 로고    scopus 로고
    • Pharmacogenomic strategies against resistance development in microbial infections
    • W. Ziebuhr, K. Xiao, B. Coulibaly, R. Schwarz, and T. Dandekar Pharmacogenomic strategies against resistance development in microbial infections Pharmacogenomics 5 2004 361 379
    • (2004) Pharmacogenomics , vol.5 , pp. 361-379
    • Ziebuhr, W.1    Xiao, K.2    Coulibaly, B.3    Schwarz, R.4    Dandekar, T.5
  • 67
    • 19544387812 scopus 로고    scopus 로고
    • In pursuit of effective toxicogenomics
    • T.W. Gant, and S.D. Zhang In pursuit of effective toxicogenomics Mutat Res 575 2005 4 16
    • (2005) Mutat Res , vol.575 , pp. 4-16
    • Gant, T.W.1    Zhang, S.D.2


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