메뉴 건너뛰기




Volumn 5, Issue 1, 2007, Pages 135-153

Metabolic pathway analysis of S. Pneumoniae: An in silico approach towards drug-design

Author keywords

KEGG; Metabolic pathways; Streptococcus pneumoniae

Indexed keywords

AMINO ACID; AMOXICILLIN PLUS CLAVULANIC ACID; CARBOHYDRATE; GEMIFLOXACIN; LIPID; NUCLEOTIDE; PROTEIN; PROTEOME; VITAMIN;

EID: 34248180074     PISSN: 02197200     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0219720007002564     Document Type: Article
Times cited : (17)

References (40)
  • 2
    • 0031610907 scopus 로고    scopus 로고
    • Bacterial iron transport: Mechanisms genetics, and regulation
    • Braun V, Hantke K, Koster W, Bacterial iron transport: Mechanisms genetics, and regulation, Met Ions Biol Syst 35:67, 1998.
    • (1998) Met Ions Biol Syst , vol.35 , pp. 67
    • Braun, V.1    Hantke, K.2    Koster, W.3
  • 3
    • 0035006337 scopus 로고    scopus 로고
    • A Streptococcus pneumoniae pathogenicity island encoding an ABC transporter involved in iron uptake and virulence
    • Brown JS, Gilliland SM, Holden DW, A Streptococcus pneumoniae pathogenicity island encoding an ABC transporter involved in iron uptake and virulence, Mol Microbiol 40:572, 2001.
    • (2001) Mol Microbiol , vol.40 , pp. 572
    • Brown, J.S.1    Gilliland, S.M.2    Holden, D.W.3
  • 4
    • 0034778154 scopus 로고    scopus 로고
    • Immunization with components of two iron-uptake ABC transporters protects mice against systemic infection with Streptococcus pneumoniae
    • Brown JS, Ogunniyi AD, Woodrow MC, Holden DW, Paton JC, Immunization with components of two iron-uptake ABC transporters protects mice against systemic infection with Streptococcus pneumoniae, Infect Immun 69:6702, 2001.
    • (2001) Infect Immun , vol.69 , pp. 6702
    • Brown, J.S.1    Ogunniyi, A.D.2    Woodrow, M.C.3    Holden, D.W.4    Paton, J.C.5
  • 5
    • 0031599682 scopus 로고    scopus 로고
    • Microbial iron transport: Iron acquisition by pathogenic microorganisms
    • Byers BR, Arceneaux JE, Microbial iron transport: Iron acquisition by pathogenic microorganisms, Met Ions Biol Syst 35:37, 1998.
    • (1998) Met Ions Biol Syst , vol.35 , pp. 37
    • Byers, B.R.1    Arceneaux, J.E.2
  • 6
    • 0033986977 scopus 로고    scopus 로고
    • Use of genomics and combinatorial chemistry in the development of new antimycobacterial drugs
    • Clifton EB III, Richard AS, Andrea ES, Richard EL, Use of genomics and combinatorial chemistry in the development of new antimycobacterial drugs, Biochem Pharmacol 59:221, 2000.
    • (2000) Biochem Pharmacol , vol.59 , pp. 221
    • Clifton III, E.B.1    Richard, A.S.2    Andrea, E.S.3    Richard, E.L.4
  • 7
    • 0141737064 scopus 로고    scopus 로고
    • A novel sensor of NADH/NAD+ redox poise in Streptomyces coelicolor A3
    • Dimitris B, Paget MSB, A novel sensor of NADH/NAD+ redox poise in Streptomyces coelicolor A3 (2), EMBO J 15:4856, 2003.
    • (2003) EMBO J , vol.15 , pp. 4856
    • Dimitris, B.1    Paget, M.S.B.2
  • 9
    • 0036276191 scopus 로고    scopus 로고
    • Streptococcus pneumoniae as a genomics platform for broadspectrum antibiotic discovery
    • Glass JI, Belanger AE, Robertson GT, Streptococcus pneumoniae as a genomics platform for broadspectrum antibiotic discovery, Curr Opin Microbiol 5:338, 2002.
    • (2002) Curr Opin Microbiol , vol.5 , pp. 338
    • Glass, J.I.1    Belanger, A.E.2    Robertson, G.T.3
  • 10
    • 0030927105 scopus 로고    scopus 로고
    • Crystal structure of UDP-N-acetylmuramoyl-L-alanine: D-glutamate ligase from Escherichia coli
    • Jay AB, Genevieve A, Eric F, Lydie M, Didier B, Jean Van H, Otto D, Crystal structure of UDP-N-acetylmuramoyl-L-alanine: D-glutamate ligase from Escherichia coli, EMBO J 16:3416, 1997.
    • (1997) EMBO J , vol.16 , pp. 3416
    • Jay, A.B.1    Genevieve, A.2    Eric, F.3    Lydie, M.4    Didier, B.5    Jean Van, H.6    Otto, D.7
  • 13
    • 0028963594 scopus 로고
    • Iron: Mammalian defense systems, mechanisms of disease, and chelation therapy approaches
    • Kontoghiorghes GJ, Weinberg ED, Iron: Mammalian defense systems, mechanisms of disease, and chelation therapy approaches, Blood Rev 9:33, 1995.
    • (1995) Blood Rev , vol.9 , pp. 33
    • Kontoghiorghes, G.J.1    Weinberg, E.D.2
  • 14
    • 0000243829 scopus 로고
    • PROCHECK: A program to check the stereochemical quality of protein structures
    • Laskowski RA, MacArthur MW, Moss DS, Thornton JM, PROCHECK: A program to check the stereochemical quality of protein structures, J Appl Cryst 26:283, 1993.
    • (1993) J Appl Cryst , vol.26 , pp. 283
    • Laskowski, R.A.1    MacArthur, M.W.2    Moss, D.S.3    Thornton, J.M.4
  • 15
    • 3042589219 scopus 로고    scopus 로고
    • Gemifloxacin once daily for 7 days compared to amoxicillin/clavulanic acid thrice daily for 10 days for the treatment of community-acquired pneumonia of suspected pneumococcal origin
    • Leophonte P, File T, Feldman C, Gemifloxacin once daily for 7 days compared to amoxicillin/clavulanic acid thrice daily for 10 days for the treatment of community-acquired pneumonia of suspected pneumococcal origin, Respir Med 98:708, 2004.
    • (2004) Respir Med , vol.98 , pp. 708
    • Leophonte, P.1    File, T.2    Feldman, C.3
  • 16
    • 0035789518 scopus 로고    scopus 로고
    • GROMACS 3.0: A package for molecular simulation and trajectory analysis
    • Lindahl E, Hess B, Van der Spoel D, GROMACS 3.0: A package for molecular simulation and trajectory analysis, J Mol Model 7:306, 2001.
    • (2001) J Mol Model , vol.7 , pp. 306
    • Lindahl, E.1    Hess, B.2    Van der Spoel, D.3
  • 17
    • 0028336881 scopus 로고
    • Characterization of the mutX gene of Streptococcus pneumoniae as a homologue of Escherichia coli mutT, and tentative definition of a catalytic domain of the dGTP pyrophosphohydrolases
    • Mejean V, Salles C, Bullions LC, Bessman MJ, Claverys JP, Characterization of the mutX gene of Streptococcus pneumoniae as a homologue of Escherichia coli mutT, and tentative definition of a catalytic domain of the dGTP pyrophosphohydrolases, Mol Microbiol 2:323, 1994.
    • (1994) Mol Microbiol , vol.2 , pp. 323
    • Mejean, V.1    Salles, C.2    Bullions, L.C.3    Bessman, M.J.4    Claverys, J.P.5
  • 18
    • 0032728399 scopus 로고    scopus 로고
    • Searching for drug targets in microbial genomes
    • Michael YG, Eugene VK, Searching for drug targets in microbial genomes, Curr Opin Biotechnol 10:571, 1999.
    • (1999) Curr Opin Biotechnol , vol.10 , pp. 571
    • Michael, Y.G.1    Eugene, V.K.2
  • 19
    • 0037251964 scopus 로고    scopus 로고
    • Mulder NJ, Apweiler R, Attwood TK, Bairoch A, Bateman A, Binns D, Biswas M, Bradley P, Bork P, Bucher P, Copley RR, Courcelle E, Das U, Durbin R, Falquet L, Fleischmann W, Griffiths-Jones S, Haft D, Harte N, Hulo N, Kahn D, Kanapin A, Krestyaninova M, Lopez R, Letunic I, Lonsdale D, Silventoinen V, Orchard SE, Pagni M, Peyruc D, Ponting CP, Selengut JD, Servant F, Sigrist CJ, Vaughan R, Zdobnov EM, The InterPro Database, 2003 brings increased coverage and new functions, Nucl Acids Res 31:315, 2003.
    • Mulder NJ, Apweiler R, Attwood TK, Bairoch A, Bateman A, Binns D, Biswas M, Bradley P, Bork P, Bucher P, Copley RR, Courcelle E, Das U, Durbin R, Falquet L, Fleischmann W, Griffiths-Jones S, Haft D, Harte N, Hulo N, Kahn D, Kanapin A, Krestyaninova M, Lopez R, Letunic I, Lonsdale D, Silventoinen V, Orchard SE, Pagni M, Peyruc D, Ponting CP, Selengut JD, Servant F, Sigrist CJ, Vaughan R, Zdobnov EM, The InterPro Database, 2003 brings increased coverage and new functions, Nucl Acids Res 31:315, 2003.
  • 20
    • 0034011950 scopus 로고    scopus 로고
    • Extracellular targeting of choline-binding proteins in Streptococcus pneumoniae by a zinc metalloprotease
    • Novak R, Charpentier E, Braun JS, Park E, Murti S, Tuomanen E, Masure R, Extracellular targeting of choline-binding proteins in Streptococcus pneumoniae by a zinc metalloprotease, Mol Microbiol 36 366, 2000.
    • (2000) Mol Microbiol , vol.36 , pp. 366
    • Novak, R.1    Charpentier, E.2    Braun, J.S.3    Park, E.4    Murti, S.5    Tuomanen, E.6    Masure, R.7
  • 22
    • 0027136282 scopus 로고
    • Comparative protein modeling by satisfaction of spatial restraints
    • Sali A, Blundell TL, Comparative protein modeling by satisfaction of spatial restraints, J Mol Biol 234:779, 1993.
    • (1993) J Mol Biol , vol.234 , pp. 779
    • Sali, A.1    Blundell, T.L.2
  • 24
    • 0015462556 scopus 로고
    • Peptidoglycan types of the bacterial cell walls and their taxonomic implications
    • Schleifer KH, Kandler O, Peptidoglycan types of the bacterial cell walls and their taxonomic implications, Bacteriol Rev 36:407, 1972.
    • (1972) Bacteriol Rev , vol.36 , pp. 407
    • Schleifer, K.H.1    Kandler, O.2
  • 25
    • 0346994789 scopus 로고    scopus 로고
    • Dual infection with Streptococcus pneumoniae and Mycobacterium tuberculosis in HIV-seropositive patients with community acquired pneumonia
    • Schleicher GK, Feldman C, Dual infection with Streptococcus pneumoniae and Mycobacterium tuberculosis in HIV-seropositive patients with community acquired pneumonia, Int J Tubercul Lung Dis 7:1207, 2003.
    • (2003) Int J Tubercul Lung Dis , vol.7 , pp. 1207
    • Schleicher, G.K.1    Feldman, C.2
  • 27
    • 0036791627 scopus 로고    scopus 로고
    • New (and not so new) antibacterial targets - from where and when will the novel drugs come
    • Steven JP, New (and not so new) antibacterial targets - from where and when will the novel drugs come, Curr Opin Pharmacol 2:513, 2002.
    • (2002) Curr Opin Pharmacol , vol.2 , pp. 513
    • Steven, J.P.1
  • 29
    • 0027363322 scopus 로고
    • Hemin utilization is related to virulence of Streptococcus pneumoniae
    • Tai SS, Lee CJ, Winter RE, Hemin utilization is related to virulence of Streptococcus pneumoniae, Infect Immun 61:5401, 1993.
    • (1993) Infect Immun , vol.61 , pp. 5401
    • Tai, S.S.1    Lee, C.J.2    Winter, R.E.3
  • 31
    • 0035919670 scopus 로고    scopus 로고
    • Tettelin H, Nelson KE, Paulsen IT, Eisen JA, Read TD, Peterson S, Heidelberg J, DeBoy RT, Haft DH, Dodson RJ, Durkin AS, Gwinn M, Kolonay JF, Nelson WC, Peterson JD, Umayam LA, White O, Salzberg SL, Lewis MR, Radune D, Holtzapple E, Khouri H, Wolf AM, Utterback TR, Hansen CL, McDonald LA, Feldblyum TV, Angiuoli S, Dickinson T, Hickey EK, Holt IE, Loftus BJ, Yang F, Smith HO, Venter JC, Dougherty BA, Morrison DA, Hollingshead SK, Fraser CM, Complete genome sequence of a virulent isolate of Streptococcus pneumoniae, Science 293:498, 2001.
    • Tettelin H, Nelson KE, Paulsen IT, Eisen JA, Read TD, Peterson S, Heidelberg J, DeBoy RT, Haft DH, Dodson RJ, Durkin AS, Gwinn M, Kolonay JF, Nelson WC, Peterson JD, Umayam LA, White O, Salzberg SL, Lewis MR, Radune D, Holtzapple E, Khouri H, Wolf AM, Utterback TR, Hansen CL, McDonald LA, Feldblyum TV, Angiuoli S, Dickinson T, Hickey EK, Holt IE, Loftus BJ, Yang F, Smith HO, Venter JC, Dougherty BA, Morrison DA, Hollingshead SK, Fraser CM, Complete genome sequence of a virulent isolate of Streptococcus pneumoniae, Science 293:498, 2001.
  • 32
    • 2042437650 scopus 로고    scopus 로고
    • Initial sequencing and analysis of the human genome
    • The Genome International Consortium
    • The Genome International Consortium, Initial sequencing and analysis of the human genome, Nature 409:860, 2001.
    • (2001) Nature , vol.409 , pp. 860
  • 33
    • 0027968068 scopus 로고
    • Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
    • Thompson JD, Higgins DG, Gibson TJ, CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice, Nucl Acids Res 22:4673, 1994.
    • (1994) Nucl Acids Res , vol.22 , pp. 4673
    • Thompson, J.D.1    Higgins, D.G.2    Gibson, T.J.3    CLUSTAL, W.4
  • 34
    • 0001786686 scopus 로고
    • Biosynthesis of the peptidoglycan unit
    • Ghuysen JM, Hakenbeck R eds, Elsevier Science B.V, Amsterdam, pp
    • Van Heijenoort J, Biosynthesis of the peptidoglycan unit, in Ghuysen JM, Hakenbeck R (eds.), Bacterial Cell Wall, Elsevier Science B.V., Amsterdam, pp. 39-54, 1994.
    • (1994) Bacterial Cell Wall , pp. 39-54
    • Van Heijenoort, J.1
  • 35
    • 0001607723 scopus 로고
    • Distantly related sequences in the α and α domain subunits of ATP synthetase, myosin, kinases and other ATP requiring enzymes and a common nucleotide binding fold
    • Walker JE, Saraste M, Runswick MJ, Gay NJ, Distantly related sequences in the α and α domain subunits of ATP synthetase, myosin, kinases and other ATP requiring enzymes and a common nucleotide binding fold, EMBO J 8:945, 1982.
    • (1982) EMBO J , vol.8 , pp. 945
    • Walker, J.E.1    Saraste, M.2    Runswick, M.J.3    Gay, N.J.4
  • 36
    • 0019973896 scopus 로고
    • Glyoxylate metabolism and adaptation of Mycobacterium tuberculosis to survival under anaerobic conditions
    • Wayne LG, Lin KY, Glyoxylate metabolism and adaptation of Mycobacterium tuberculosis to survival under anaerobic conditions, Infect Immun 37:1042, 1982.
    • (1982) Infect Immun , vol.37 , pp. 1042
    • Wayne, L.G.1    Lin, K.Y.2
  • 37
    • 0029976980 scopus 로고    scopus 로고
    • in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of non replicating persistence
    • Waynes LG, Haynes LG, An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of non replicating persistence, Infect Immunol 64:2062, 1996.
    • (1996) Infect Immunol , vol.64 , pp. 2062
    • Waynes, L.G.1    Haynes, L.G.2    An3
  • 38
    • 0032453525 scopus 로고    scopus 로고
    • Nitrate reduction as a marker for hypoxic shiftdown of Mycobacterium tuberculosis
    • Waynes LG, Haynes LG, Nitrate reduction as a marker for hypoxic shiftdown of Mycobacterium tuberculosis, Tubercul Lung Dis 79 127, 1998.
    • (1998) Tubercul Lung Dis , vol.79 , pp. 127
    • Waynes, L.G.1    Haynes, L.G.2
  • 39
    • 0016227934 scopus 로고
    • Iron and susceptibility to infectious disease
    • Weinberg ED, Iron and susceptibility to infectious disease, Science 184:952, 1974.
    • (1974) Science , vol.184 , pp. 952
    • Weinberg, E.D.1
  • 40
    • 34248170603 scopus 로고    scopus 로고
    • TIGR Comprehensive Microbial Resource on World Wide Web URL: http://www.tigr.org/tigr-scripts/CMR2/CMRHomePage.spl The suite of tools and microbial genome sequences provided on this webpage can be easily and effectively used for computational comparative genomics.
    • TIGR Comprehensive Microbial Resource on World Wide Web URL: http://www.tigr.org/tigr-scripts/CMR2/CMRHomePage.spl The suite of tools and microbial genome sequences provided on this webpage can be easily and effectively used for computational comparative genomics.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.