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Zagursky RJ, Russell D: Bioinformatics: Use in Bacterial Vaccine Discovery. In BioComputing: Computer Tools for Biologists. Edited by Brown SM. Eaton Publishing; 2003:261-285.
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Adu-Bobie J., Capecchi B., Serruto D., Rappuoli R., Pizza M. Two years into reverse vaccinology. Vaccine. 21:2003;605-610
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Lei B., Liu M., Chesney G.L., Musser J.M. Identification of new candidate vaccine antigens made by Streptococcus pyogenes: Purification and characterization of 16 Putative extracellular lipoproteins. J Infect Dis. 189:2004;79-89
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Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J., DeBoy R., Dodson R., Gwinn M., Haft D., et al. Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains. J Bacteriol. 184:2002;5479-5490
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Cockle P.J., Gordon S.V., Lalvani A., Buddle B.M., Hewinson R.G., Vordermeier H.M. Identification of novel Mycobacterium tuberculosis antigens with potential as diagnostic reagents or subunit vaccine candidates by comparative genomics. Infect Immun. 70:2002;6996-7003
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Search for potential vaccine candidate open reading frames in the Bacillus anthracis virulence plasmid pXO1: In silico and in vitro screening
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Ariel N., Zvi A., Grosfeld H., Gat O., Inbar Y., Velan B., Cohen S., Shafferman A. Search for potential vaccine candidate open reading frames in the Bacillus anthracis virulence plasmid pXO1: in silico and in vitro screening. Infect Immun. 70:2002;6817-6827
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Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae
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An excellent example of how DNA array-based genome comparison supports vaccine development by depicting candidates that are conserved among different serotypes.
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Tettelin H., Masignani V., Cieslewicz M.J., Eisen J.A., Peterson S., Wessels M.R., Paulsen I.T., Nelson K.E., Margarit I., Read T.D., et al. Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae. Proc Natl Acad Sci USA. 99:2002;12391-12396 An excellent example of how DNA array-based genome comparison supports vaccine development by depicting candidates that are conserved among different serotypes.
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One of the first examples of transcriptional profiling of an important pathogen, directly isolated from diseased individuals.
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Merrell D.S., Butler S.M., Qadri F., Dolganov N.A., Alam A., Cohen M.B., Calderwood S.B., Schoolnik G.K., Camilli A. Host-induced epidemic spread of the cholera bacterium. Nature. 417:2002;642-645 One of the first examples of transcriptional profiling of an important pathogen, directly isolated from diseased individuals.
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Fisher M.A., Plikaytis B.B., Shinnick T.M. Microarray analysis of the Mycobacterium tuberculosis transcriptional response to the acidic conditions found in phagosomes. J Bacteriol. 184:2002;4025-4032
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The authors demonstrate the power of transcriptional profiling to identify vaccine candidates inducing protective immune responses from a selected pool of meningococcal genes that are differentially regulated upon host-cell contact.
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Grifantini R., Bartolini E., Muzzi A., Draghi M., Frigimelica E., Berger J., Ratti G., Petracca R., Galli G., Agnusdei M., et al. Previously unrecognized vaccine candidates against group B meningococcus identified by DNA microarrays. Nat Biotechnol. 20:2002;914-921 The authors demonstrate the power of transcriptional profiling to identify vaccine candidates inducing protective immune responses from a selected pool of meningococcal genes that are differentially regulated upon host-cell contact.
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Grifantini R., Bartolini E., Muzzi A., Draghi M., Frigimelica E., Berger J., Randazzo F., Grandi G. Gene expression profile in Neisseria meningitidis and Neisseria lactamica upon host-cell contact: from basic research to vaccine development. Ann N Y Acad Sci. 975:2002;202-216
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Genome sequence and comparative microarray analysis of serotype M18 group a Streptococcus strains associated with acute rheumatic fever outbreaks
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Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S., Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D., et al. Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks. Proc Natl Acad Sci USA. 99:2002;4668-4673
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This work represents the first systematic application of transposon mutagenesis to identify H. pylori genes that are essential for colonization in a relevant in vivo model.
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Ariel N., Zvi A., Makarova K.S., Chitlaru T., Elhanany E., Velan B., Cohen S., Friedlander A.M., Shafferman A. Genome-based bioinformatic selection of chromosomal Bacillus anthracis putative vaccine candidates coupled with proteomic identification of surface-associated antigens. Infect Immun. 71:2003;4563-4579
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Ariel, N.1
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41
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Identification of major outer surface proteins of Streptococcus agalactiae
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Hughes M.J., Moore J.C., Lane J.D., Wilson R., Pribul P.K., Younes Z.N., Dobson R.J., Everest P., Reason A.J., Redfern J.M., et al. Identification of major outer surface proteins of Streptococcus agalactiae. Infect Immun. 70:2002;1254-1259
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Hughes, M.J.1
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Multiparameter selection of Helicobacter pylori antigens identifies two novel antigens with high protective efficacy
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Sabarth N., Hurwitz R., Meyer T.F., Bumann D. Multiparameter selection of Helicobacter pylori antigens identifies two novel antigens with high protective efficacy. Infect Immun. 70:2002;6499-6503
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Sabarth, N.1
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Identification of in vivo expressed vaccine candidate antigens from Staphylococcus aureus
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The authors describe a novel platform technology for the genome-wide identification of antigens by using small-insert bacterial display peptide libraries in combination with human serum antibodies as selection reagents, and provide rapid validation strategy without the need for high-throughput recombinant protein expression.
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Etz H., Minh D.B., Henics T., Dryla A., Winkler B., Triska C., Boyd A.P., Sollner J., Schmidt W., von Ahsen U., et al. Identification of in vivo expressed vaccine candidate antigens from Staphylococcus aureus. Proc Natl Acad Sci USA. 99:2002;6573-6578 The authors describe a novel platform technology for the genome-wide identification of antigens by using small-insert bacterial display peptide libraries in combination with human serum antibodies as selection reagents, and provide rapid validation strategy without the need for high-throughput recombinant protein expression.
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Etz, H.1
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Boyd, A.P.7
Sollner, J.8
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44
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Small fragment genomic libraries for the display of putative epitopes of pathogens with high medical importance
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Henics T., Winkler B., Pfeifer U., Gill S.R., Buschle M., von Gabain A., Meinke A. Small fragment genomic libraries for the display of putative epitopes of pathogens with high medical importance. BioTechniques. 35:2003;196-202
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Henics, T.1
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Identification of the 'antigenome' - A novel tool for design and development of subunit vaccines against bacterial pathogens
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Edited by Grandi G. John Wiley & Sons, Inc.;
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Nagy E, Henics T, von Gabain, A, and Meinke A: Identification of the 'antigenome' - a novel tool for design and development of subunit vaccines against bacterial pathogens. In Genomics, Proteomics, and Vaccines, Edited by Grandi G. John Wiley & Sons, Inc.; 2004:223-243.
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46
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Functional selection of vaccine candidate peptides from Staphylococcus aureus whole-genome expression libraries in vitro
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Weichhart T., Horky M., Sollner J., Gangl S., Henics T., Nagy E., Meinke A., von Gabain A., Fraser C.M., Gill S.R., et al. Functional selection of vaccine candidate peptides from Staphylococcus aureus whole-genome expression libraries in vitro. Infect Immun. 71:2003;4633-4641
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Meinke, A.7
Von Gabain, A.8
Fraser, C.M.9
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47
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Use of in vivo-induced antigen technology (IVIAT) to identify genes uniquely expressed during human infection with Vibrio cholerae
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Hang L., John M., Asaduzzaman M., Bridges E.A., Vanderspurt C., Kirn T.J., Taylor R.K., Hillman J.D., Progulske-Fox A., Handfield M., et al. Use of in vivo-induced antigen technology (IVIAT) to identify genes uniquely expressed during human infection with Vibrio cholerae. Proc Natl Acad Sci USA. 100:2003;8508-8513
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Hang, L.1
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Taylor, R.K.7
Hillman, J.D.8
Progulske-Fox, A.9
Handfield, M.10
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48
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Characterization and pathogenic significance of Vibrio vulnificus antigens preferentially expressed in septicemic patients
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Kim Y.R., Lee S.E., Kim C.M., Kim S.Y., Shin E.K., Shin D.H., Chung S.S., Choy H.E., Progulske-Fox A., Hillman J.D., et al. Characterization and pathogenic significance of Vibrio vulnificus antigens preferentially expressed in septicemic patients. Infect Immun. 71:2003;5461-5471
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Kim, Y.R.1
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Choy, H.E.8
Progulske-Fox, A.9
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Identification of a protective antigen of Coccidioides immitis by expression library immunization
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Ivey F.D., Magee D.M., Woitaske M.D., Johnston S.A., Cox R.A. Identification of a protective antigen of Coccidioides immitis by expression library immunization. Vaccine. 21:2003;4359-4367
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Ivey, F.D.1
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50
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Long-term protective immune response elicited by vaccination with an expression genomic library of Toxoplasma gondii
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Fachado A., Rodriguez A., Molina J., Silverio J.C., Marino A.P., Pinto L.M., Angel S.O., Infante J.F., Traub-Cseko Y., Amendoeira R.R., et al. Long-term protective immune response elicited by vaccination with an expression genomic library of Toxoplasma gondii. Infect Immun. 71:2003;5407-5411
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Fachado, A.1
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Identification of protective antigens for the control of Ixodes scapularis infestations using cDNA expression library immunization
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Almazan C., Kocan K.M., Bergman D.K., Garcia-Garcia J.C., Blouin E.F., de la Fuente J. Identification of protective antigens for the control of Ixodes scapularis infestations using cDNA expression library immunization. Vaccine. 21:2003;1492-1501
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Almazan, C.1
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52
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A genome-based functional screening approach to vaccine development that combines in vitro assays and DNA immunization
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In this paper, a comprehensive approach is described, in which vaccine candidates from M. tuberculosis are identified by relying on in vivo protection in a relevant animal model as selection criteria. This approach involves immunization with plasmid pools that are pre-selected in in vitro functional assays.
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Delcayre A., Peake J.S., White D.J., Yuan S., McDonald M.K., Liang A., Tan P.L., Watson J.D. A genome-based functional screening approach to vaccine development that combines in vitro assays and DNA immunization. Vaccine. 21:2003;3259-3264 In this paper, a comprehensive approach is described, in which vaccine candidates from M. tuberculosis are identified by relying on in vivo protection in a relevant animal model as selection criteria. This approach involves immunization with plasmid pools that are pre-selected in in vitro functional assays.
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Vaccine
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Delcayre, A.1
Peake, J.S.2
White, D.J.3
Yuan, S.4
McDonald, M.K.5
Liang, A.6
Tan, P.L.7
Watson, J.D.8
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