VentX trans-activates p53 and p16ink4a to regulate cellular senescence

Journal of Biological Chemistry

Volumn 286, Issue 14, 2011, Pages 12693-12701

  Wu, Xiaoming ^a   Gao, Hong ^a   Ke, Weixiong ^a   Hager, Martin ^b   Xiao, Sheng ^a   Freeman, Michael R ^b   Zhu, Zhenglun ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER CELLS; CANCER PREVENTION; CELL-CYCLE ARREST; CELLULAR SENESCENCE; CHEMOTHERAPEUTIC AGENTS; ECTOPIC EXPRESSIONS; HOMEOBOX GENES; LYMPHOCYTIC LEUKEMIA; REVERSE GENETICS; RNA INTERFERENCE; TRANSCRIPTIONAL ACTIVATORS; TUMOR SUPPRESSION; TUMOR SUPPRESSORS; XENOPUS;

CELL PROLIFERATION; GENES; RNA; RUBIDIUM; TUMORS;

DISEASES;

CYCLIN DEPENDENT KINASE INHIBITOR 2A; HOMEODOMAIN PROTEIN; PROTEIN P21; PROTEIN P53; PROTEIN VENTX; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER INHIBITION; CELL AGING; CELL CYCLE ARREST; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEUKEMIA CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; REGULATORY MECHANISM; RNA INTERFERENCE; TRANSCRIPTION REGULATION;

BLOTTING, WESTERN; CELL AGING; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FLOW CYTOMETRY; HOMEODOMAIN PROTEINS; HUMANS; LYMPHOCYTES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

VERTEBRATA;

EID: 79953320011     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.206078     Document Type: Article

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