The vent-like homeobox gene VENTX promotes human myeloid differentiation and is highly expressed in acute myeloid leukemia

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 39, 2010, Pages 16946-16951

  Rawat, Vijay P S ^a   Arseni, Natalia ^b,c   Ahmed, Farid ^b,c   Mulaw, Medhanie A ^b,c   Thoene, Silvia ^a   Heilmeier, Bernhard ^b,c   Sadlon, Tim ^d   D'Andrea, Richard J ^d,e,f   Hiddemann, Wolfgang ^b,c   Bohlander, Stefan K ^b,c   Buske, Christian ^a   Feuring Buske, Michaela ^a  

^a UNIVERSITY HOSPITAL ULM   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

^d CHILD HEALTH RESEARCH INSTITUTE   (Australia)

^e UNIVERSITY OF ADELAIDE   (Australia)

^f QUEEN ELIZABETH HOSPITAL   (Australia)

Author keywords

Human; Myelopoiesis; VENTX2; Xvent

Indexed keywords

CD33 ANTIGEN; CD34 ANTIGEN; SHORT HAIRPIN RNA; HOMEODOMAIN PROTEIN; VENTX PROTEIN, HUMAN;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CELL SUBPOPULATION; CHROMOSOME TRANSLOCATION 21; CHROMOSOME TRANSLOCATION 8; COCULTURE; DIABETES MELLITUS; DOWN REGULATION; ERYTHROID CELL; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; GENETIC TRANSDUCTION; HEMATOPOIESIS; HEMATOPOIETIC CELL; HOMEOBOX; HUMAN; HUMAN CELL; KARYOTYPE; LEUKEMIA CELL; LYMPHOID CELL; MICROARRAY ANALYSIS; MOUSE; MYELOPOIESIS; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEVERE COMBINED IMMUNODEFICIENCY; STEM CELL; UPREGULATION; VENTX HOMEOBOX GENE; BIOSYNTHESIS; CYTOLOGY; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; METABOLISM;

COCULTURE TECHNIQUES; ERYTHROID CELLS; GENE EXPRESSION REGULATION, LEUKEMIC; GENE KNOCKDOWN TECHNIQUES; HOMEODOMAIN PROTEINS; HUMANS; LEUKEMIA, MYELOID, ACUTE; MYELOID CELLS; MYELOPOIESIS;

EID: 78049289467     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1001878107     Document Type: Article

References (27)

1. Antonchuk J, Sauvageau G, Humphries RK (2002) HOXB4-induced expansion of adult hematopoietic stem cells ex vivo. Cell 109:39-45. (Pubitemid 34327515)
2. Buske C, et al. (2002) Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells. Blood 100:862-868. (Pubitemid 34832611)
3. Buske C, Humphries RK (2000) Homeobox genes in leukemogenesis. Int J Hematol 71:301-308.
4. Thorsteinsdottir U, Kroon E, Jerome L, Blasi F, Sauvageau G (2001) Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia. Mol Cell Biol 21:224-234.
5. Thorsteinsdottir U, et al. (1997) Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia. Mol Cell Biol 17:495-505. (Pubitemid 26425639)
6. Buske C, et al. (2001) Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo. Blood 97:2286-2292. (Pubitemid 32291473)
7. Golub TR, et al. (1999) Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring. Science 286:531-537.
8. Rawat VP, et al. (2004) Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemia. Proc Natl Acad Sci USA 101:817-822.
9. Rawat VP, et al. (2008) Overexpression of CDX2 perturbs HOX gene expression in murine progenitors depending on its N-terminal domain and is closely correlated with deregulated HOX gene expression in human acute myeloid leukemia. Blood 111:309-319.
10. Scholl C, et al. (2007) The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis. J Clin Invest 117:1037-1048. (Pubitemid 46556760)
11. Davidson AJ, Zon LI (2000) Turning mesoderm into blood: The formation of hematopoietic stem cells during embryogenesis. Curr Top Dev Biol 50:45-60.
12. Rastegar S, Friedle H, Frommer G, Knöchel W (1999) Transcriptional regulation of Xvent homeobox genes. Mech Dev 81:139-149. (Pubitemid 29183052)
13. Ault KT, Dirksen ML, Jamrich M (1996) A novel homeobox gene PV.1 mediates induction of ventral mesoderm in Xenopus embryos. Proc Natl Acad Sci USA 93:6415-6420.
14. Huber TL, Zon LI (1998) Transcriptional regulation of blood formation during Xenopus development. Semin Immunol 10:103-109. (Pubitemid 28339780)
15. Friedle H, Knöchel W (2002) Cooperative interaction of Xvent-2 and GATA-2 in the activation of the ventral homeobox gene Xvent-1B. J Biol Chem 277:23872-23881. (Pubitemid 34952231)
16. Henningfeld KA, Friedle H, Rastegar S, Knöchel W (2002) Autoregulation of Xvent-2B: Direct interaction and functional cooperation of Xvent-2 and Smad1. J Biol Chem 277:2097-2103. (Pubitemid 34968793)
17. Deramaudt TB, Remy P, Stiegler P (2001) Identification of interaction partners for two closely-related members of the ETS protein family, FLI and ERG. Gene 274:169-177. (Pubitemid 32817134)
18. Schuler-Metz A, Knöchel S, Kaufmann E, Knöchel W (2000) The homeodomain transcription factor Xvent-2 mediates autocatalytic regulation of BMP-4 expression in Xenopus embryos. J Biol Chem 275:34365-34374.
19. Moretti PA, et al. (2001) Molecular cloning of a human Vent-like homeobox gene. Genomics 76:21-29. (Pubitemid 32744620)
20. Holland PW, Booth HA, Bruford EA (2007) Classification and nomenclature of all human homeobox genes. BMC Biol 5:47.
21. Kilpinen S, et al. (2008) Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues. Genome Biol 9:R139.
22. Sauvageau G, et al. (1994) Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells. Proc Natl Acad Sci USA 91:12223-12227. (Pubitemid 24368637)
23. Reya T, et al. (2000) Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism. Immunity 13:15-24.
24. Gao H, et al. (2010) Vent X, a novel lymphoid-enhancing factor/T-cell factor-associated transcription repressor, is a putative tumor suppressor. Cancer Res 70:202-211.
25. Dick JE (2008) Stem cell concepts renew cancer research. Blood 112:4793-4807.
26. Taussig DC, et al. (2008) Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells. Blood 112:568-575.
27. Howe D, Bromidge T (2006) Variation of LEF-1 mRNA expression in low-grade B-cell non-Hodgkin's lymphoma. Leuk Res 30:29-32. (Pubitemid 41654701)