Compromised HOXA5 function can limit p53 expression in human breast tumours

Nature

Volumn 405, Issue 6789, 2000, Pages 974-978

  Raman, Venu ^a   Martenser, Shelby A ^a   Reisman, David ^b   Evron, Ella ^a   Odenwald, Wart F ^c   Jaffee, Elizabeth ^a   Marks, Jeffrey ^d   Sukumar, Saraswati ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b UNIVERSITY OF SOUTH CAROLINA   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PROTEIN P53; TRANSCRIPTION FACTOR;

APOPTOSIS; ARTICLE; BREAST TUMOR; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALIGNANT TRANSFORMATION; METHYLATION; PRIORITY JOURNAL; PROMOTER REGION; TUMOR SUPPRESSOR GENE;

ANIMALS; APOPTOSIS; BINDING SITES; BREAST NEOPLASMS; DNA, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, HOMEOBOX; GENES, P53; HOMEODOMAIN PROTEINS; HUMANS; MICE; PHOSPHOPROTEINS; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034702232     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35016125     Document Type: Article

References (28)

1. Prives, C. & Hall, P. A. The p53 pathway. J. Pathol. 187, 112-126 (1999).
2. Reisman, D. & Loging, W. T. Transcriptional regulation of the p53 tumor suppressor gene. Semin. Cancer Biol. 8, 317-324 (1998).
3. Pellerin, I., Schnabel, C., Catron, K. M. & Abate, C. Hox proteins have different affinities for a consensus DNA site that correlate with the positions of their genes on the hox cluster. Mol. Cell Biol. 14, 4532-4545 (1994).
4. Zhao, J. J., Lazzarini, R. A. & Pick, L. Functional dissection of the mouse Hox-a5 gene. EMBO J. 15, 1313-1322 (1996).
5. Reisman, D., Greenberg, M. & Rotter, V. Human p53 oncogene contains one promoter upstream of exon 1 and a second, stronger promoter within intron 1. Proc. Natl Acad. Sci. USA 85, 5146-5150 (1988).
6. Bunz, F. et al. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282, 1497-1501 (1998).
7. Pharoah, P. D. P., Day, N. E. & Caldas, C. Somatic mutations in the p53 gene and prognosis in breast cancer: a meta-analysis. Brit. J. Cancer 80, 1968-1973 (1999).
8. Deschamps, J. & Meijlink, F. Mammalian homeobox genes in normal development and neoplasia. Crit. Rev. Oncog. 3, 117-173 (1992).
9. Scott, M. P. Hox genes, arms and the man. Nature Genet. 15, 117-118 (1997).
10. Cillo, C. et al. Hox gene expression in normal and neoplastic human kidney. Int. J. Cancer 51, 892-897 (1992).
11. De Vita, G. et al. Expression of homeobox-containing genes in primary and metastatic colorectal cancer. Eur. J. Cancer 6, 887-893 (1993).
12. Care, A. et al. HOXB7 constitutively activates fibroblast growth factor in melanomas. Mol. Cell. Biol. 16, 4842-4851 (1996).
13. Chariot, A., & Castronovo, V. Detection of HOXA1 expression in human breast cancer. Biochem. Biophys. Res. Commun. 222, 292-297 (1996).
14. Cillo, C., Faiella, A., Cantile, M. & Boncinelli, E. Homeobox genes and cancer. Exp. Cell. Res. 248, 1-9 (1999).
15. Snedecor G. W. & Cochran, W. G. Statistical Methods (Iowa State Univ. Press, Ames, 1982).
16. Li, F. et al. Cell-specific induction of apoptosis by microinjection of cytochrome c. Bcl-xL has activity independent of cytochrome c release. J. Biol. Chem. 272, 30299-30305 (1997).
17. Larochelle, C., Tremblay, M., Bernier, D., Aubin, J. & Jeanotte, L. Multiple cis-acting regions are required for restricted spatio-temporal Hoxa5 gene expression. Dev. Dyn. 214, 127-140 (1999).
18. Aubin, J., Lemieux, M., Tremblay, M., Behringer, R. R. & Jeanotte, L. Transcriptional interferences at the Hoxa4/Hoxa5 locus: importance of correct Hoxa5 expression for proper specification of the axial skeletal. Dev. Dyn. 212, 141-156 (1999).
19. Hanson, R. D. et al. Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development. Proc. Natl Acad. Sci. USA 96, 14372-14377 (1999).
20. Bird, A. P. & Wolffe, A. P. Methylation-induced repression-belts, braces, and chromatin. Cell 99, 451-454 (1999).
21. Herman J. G., Graff, J. R., Myohanen, S., Nelkin, B. D. & Baylin, S. B. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc. Natl Acad. Sci. 93, 9821-9826 (1996).
22. Runnebaum, I. B., Nagarajan, M., Bowman, M., Soto, D. & Sukumar, S. Mutations in p53 as potential molecular markers for human breast cancer. Proc. Natl Acad. Sci USA 88, 10657-10661 (1991).
23. Glebov, O. K., Mc Kenzie, K. E., White, C. A. & Sukumar, S. Frequent p53 gene mutations and novel alleles in familial breast cancer. Cancer Res. 54, 3703-3709 (1994).
24. Bates, S. A. V. & Vousden, K. H. Mechanisms of p53-mediated apoptosis. Cell. Mol Life Sci. 55, 28-37 (1999).
25. Venkatachalam, S. et al. Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation. EMBO J. 17, 4657-4667 (1998).
26. Gottleib, E. et al. Transgenic mouse model for studying the transcnptional activity of the p53 protein: age and tissue dependent changes in radiaton-induced activation during embryogenesis. EMBO J. 16, 1381-1390 (1997).
27. Seed B. & Sheen, J. Y. A simple phase extraction assay for chloramphenicol activity. Gene 67, 271 -277 (1988).
28. Raman, V., Andrews, M. E., Harkey, M. A. & Raff, R. A. Protein-DNA interactions at putative regulatory regions of two coordinately expressed genes, msp130 and PM27, during skeletogenesis in sea urchin embryos. Int. J. Dev. Biol 37, 499-507 (1993).