-
1
-
-
84889385876
-
Carbonic Anhydrases as Drug Targets: General Presentation
-
C. T. Supuran, J.-Y. Winum, Wiley, Hoboken, Ed.
-
C. T. Supuran, Carbonic Anhydrases as Drug Targets: General Presentation, in Drug Design of Zinc-Enzyme Inhibitors. Functional, Structural, and Disease Applications, ed., C. T. Supuran, J.-Y. Winum, Wiley, Hoboken, 2009; pp 13-38
-
(2009)
Drug Design of Zinc-Enzyme Inhibitors. Functional, Structural, and Disease Applications
, pp. 13-38
-
-
Supuran, C.T.1
-
2
-
-
38849143765
-
Carbonic anhydrases: Novel therapeutic applications for inhibitors and activators
-
DOI 10.1038/nrd2467, PII NRD2467
-
C. T. Supuran Carbonic anhydrases: novel therapeutic applications for inhibitors and activators Nat. Rev. Drug Discovery 2008 7 168 181 (Pubitemid 351194064)
-
(2008)
Nature Reviews Drug Discovery
, vol.7
, Issue.2
, pp. 168-181
-
-
Supuran, C.T.1
-
3
-
-
77954218410
-
Carbonic anhydrase inhibitors
-
C. T. Supuran Carbonic anhydrase inhibitors Bioorg. Med. Chem. Lett. 2010 20 3467 3474
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, pp. 3467-3474
-
-
Supuran, C.T.1
-
4
-
-
42149143745
-
Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein-ligand binding
-
DOI 10.1021/cr050262p
-
V. M. Krishnamurthy G. K. Kaufman A. R. Urbach I. Gitlin K. L. Gudiksen D. B. Weibel G. M. Whitesides Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein-ligand binding Chem. Rev. 2008 108 3 946 1051 (Pubitemid 351577855)
-
(2008)
Chemical Reviews
, vol.108
, Issue.3
, pp. 946-1051
-
-
Krishnamurthy, V.M.1
Kaufman, G.K.2
Urbach, A.R.3
Gitlin, I.4
Gudiksen, K.L.5
Weibel, D.B.6
Whitesides, G.M.7
-
5
-
-
84889476926
-
X-Ray crystallography of CA inhibitors and its importance in drug design
-
C. T. Supuran, J. Y. Winum, Wiley, Hoboken, Ed.
-
V. Alterio, A. Di Fiore, K. D'Ambrosio, C. T. Supuran, G. De Simone, X-Ray crystallography of CA inhibitors and its importance in drug design, in Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications, ed., C. T. Supuran, J. Y. Winum, Wiley, Hoboken, 2009, pp 73-138
-
(2009)
Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications
, pp. 73-138
-
-
Alterio, V.1
Di Fiore, A.2
D'Ambrosio, K.3
Supuran, C.T.4
De Simone, G.5
-
6
-
-
0034573012
-
X-ray crystallographic studies of mammalian carbonic anhydrase isozymes
-
W. R. Chegwidden, N. Carter, Y. Edwards, Birkhauser Verlag, Basel, Switzerland, Ed.
-
T. Stams, D. W. Christianson, X-ray crystallographic studies of mammalian carbonic anhydrase isozymes, in The Carbonic Anhydrases - New Horizons, ed., W. R. Chegwidden, N. Carter, Y. Edwards, Birkhauser Verlag, Basel, Switzerland, 2000, pp 159-74
-
(2000)
The Carbonic Anhydrases - New Horizons
, pp. 159-174
-
-
Stams, T.1
Christianson, D.W.2
-
7
-
-
2442579987
-
Carbonic anhydrases: Catalytic and inhibition mechanisms, distribution and physiological roles, in
-
C. T. Supuran, A. Scozzafava, J. Conway, Eds., CRC Press, Boca Raton
-
C. T. Supuran, Carbonic anhydrases: Catalytic and inhibition mechanisms, distribution and physiological roles, in Carbonic Anhydrase - Its Inhibitors and Activators, C. T. Supuran, A. Scozzafava, J. Conway, Eds., CRC Press, Boca Raton, 2004, pp 1-23
-
(2004)
Carbonic Anhydrase - Its Inhibitors and Activators
, pp. 1-23
-
-
Supuran, C.T.1
-
8
-
-
0000726701
-
Carbonic Anhydrase: Evolution of the Zinc Binding Site by Nature and by Design
-
D. W. Christianson C. A. Fierke Carbonic anhydrase: Evolution of the zinc binding site by nature and by design Acc. Chem. Res. 1996 29 7 331 339 (Pubitemid 126453208)
-
(1996)
Accounts of Chemical Research
, vol.29
, Issue.7
, pp. 331-339
-
-
Christianson, D.W.1
Fierke, C.A.2
-
9
-
-
0034568949
-
The catalytic mechanism of mammalian carbonic anhydrases
-
S. Lindskog D. N. Silverman The catalytic mechanism of mammalian carbonic anhydrases Exs 2000 90 175 95
-
(2000)
Exs
, Issue.90
, pp. 175-195
-
-
Lindskog, S.1
Silverman, D.N.2
-
10
-
-
0009593678
-
Unexpected Ph-Dependent Conformation of His-64, the Proton Shuttle of Carbonic Anhydrase II
-
S. K. Nair D. W. Christianson Unexpected Ph-Dependent Conformation of His-64, the Proton Shuttle of Carbonic Anhydrase II J. Am. Chem. Soc. 1991 113 25 9455 9458
-
(1991)
J. Am. Chem. Soc.
, vol.113
, Issue.25
, pp. 9455-9458
-
-
Nair, S.K.1
Christianson, D.W.2
-
11
-
-
34548724094
-
Solvent-mediated proton transfer in catalysis by carbonic anhydrase
-
D. N. Silverman R. McKenna Solvent-mediated proton transfer in catalysis by carbonic anhydrase Acc. Chem. Res. 2007 40 8 669 675
-
(2007)
Acc. Chem. Res.
, vol.40
, Issue.8
, pp. 669-675
-
-
Silverman, D.N.1
McKenna, R.2
-
12
-
-
77949344262
-
Zinc Binding Functions in the Design of Carbonic Anhydrase Inhibitors
-
C. T. Supuran, J.-Y. Winum, Wiley: Hoboken, Ed.
-
J. Y. Winum, J.-L. Montero, A. Scozzafava, C. T. Supuran, Zinc Binding Functions in the Design of Carbonic Anhydrase Inhibitors, in Drug Design of Zinc-Enzyme Inhibitors. Functional, Structural, and Disease Applications, ed., C. T. Supuran, J.-Y. Winum, Wiley: Hoboken, 2009, pp 39-72
-
(2009)
Drug Design of Zinc-Enzyme Inhibitors. Functional, Structural, and Disease Applications
, pp. 39-72
-
-
Winum, J.Y.1
Montero, J.-L.2
Scozzafava, A.3
Supuran, C.T.4
-
13
-
-
5144224910
-
Development of sulfonamide carbonic anhydrase inhibitors
-
C. T. Supuran, A. Scozzafava, J. Conway, CRC Press, Boca Raton, Ed.
-
C. T. Supuran, A. Casini, A. Scozzafava, Development of sulfonamide carbonic anhydrase inhibitors, in Carbonic Anhydrase: Its Inhibitors and Activators, ed., C. T. Supuran, A. Scozzafava, J. Conway, CRC Press, Boca Raton, 2004, pp 67-147
-
(2004)
Carbonic Anhydrase: Its Inhibitors and Activators
, pp. 67-147
-
-
Supuran, C.T.1
Casini, A.2
Scozzafava, A.3
-
14
-
-
5344251966
-
Nonsulfonamide carbonic anhydrase inhibitors
-
CRC Press, Boca Raton, Ed.
-
M. A. Ilies, M. D. Banciu, Nonsulfonamide carbonic anhydrase inhibitors, in Carbonic Anhydrase - Its Inhibitors and Activators, ed. C. T. Supuran, A. Scozzafava, J. Conway, CRC Press, Boca Raton, 2004, pp 209-241
-
(2004)
Carbonic Anhydrase - Its Inhibitors and Activators
, pp. 209-241
-
-
Ilies, M.A.1
Banciu, M.D.2
Supuran, C.T.3
Scozzafava, A.4
Conway, J.5
-
15
-
-
7044228995
-
Carbonic anhydrase activators
-
C. T. Supuran, A. Scozzafava, J. Conway, CRC Press, Boca Raton, Ed.
-
M. Ilies, A. Scozzafava, C. T. Supuran, Carbonic anhydrase activators, in Carbonic Anhydrase - Its inhibitors and activators, ed., C. T. Supuran, A. Scozzafava, J. Conway, CRC Press, Boca Raton, 2004, pp 317-352
-
(2004)
Carbonic Anhydrase - Its Inhibitors and Activators
, pp. 317-352
-
-
Ilies, M.1
Scozzafava, A.2
Supuran, C.T.3
-
16
-
-
84889439904
-
Drug Design Studies of Carbonic Anhydrase Activators
-
C. T. Supuran, J.-Y. Winum, Wiley, Hoboken, Ed.
-
C. Temperini, A. Scozzafava, C. T. Supuran, Drug Design Studies of Carbonic Anhydrase Activators, in Drug Design of Zinc-Enzyme Inhibitors - Functional, Structural, and Disease Applications, ed., C. T. Supuran, J.-Y. Winum, Wiley, Hoboken, 2009, pp 473-486
-
(2009)
Drug Design of Zinc-Enzyme Inhibitors - Functional, Structural, and Disease Applications
, pp. 473-486
-
-
Temperini, C.1
Scozzafava, A.2
Supuran, C.T.3
-
17
-
-
0001090891
-
The activators of carbonic acid anhydratase
-
M. Leiner G. Leiner The activators of carbonic acid anhydratase Naturwissenschaften 1941 29 195 197
-
(1941)
Naturwissenschaften
, vol.29
, pp. 195-197
-
-
Leiner, M.1
Leiner, G.2
-
18
-
-
3042811767
-
Activation of Bovine Carbonic Anhydrase by Ethylenediamine Tetraacetic Acid
-
C. Ho J. M. Sturtevant Activation of Bovine Carbonic Anhydrase by Ethylenediamine Tetraacetic Acid Biochem. Biophys. Res. Commun. 1960 3 1 20 23
-
(1960)
Biochem. Biophys. Res. Commun.
, vol.3
, Issue.1
, pp. 20-23
-
-
Ho, C.1
Sturtevant, J.M.2
-
19
-
-
0018626543
-
Direct activation by histamine of the carbonic anhydrase in the human gastric mucosa
-
I. Puscas G. Buzas P. Contrasiu P. Suranyi Direct Activation by Histamine of the Carbonic-Anhydrase in the Human Gastric-Mucosa Rev. Roum. Biochim. 1979 16 4 317 320 (Pubitemid 10098829)
-
(1979)
Revue Roumaine de Biochimie
, vol.16
, Issue.4
, pp. 317-320
-
-
Puscas, I.1
Buzas, G.2
Contrasiu, P.3
Suranyi, P.4
-
20
-
-
0017853497
-
Proton transfer between hemoglobin and the carbonic anhydrase active site
-
D. N. Silverman C. Tu G. C. Wynns Proton transfer between hemoglobin and the carbonic anhydrase active site J. Biol. Chem. 1978 253 8 2563 7 (Pubitemid 8328411)
-
(1978)
Journal of Biological Chemistry
, vol.253
, Issue.8
, pp. 2563-2567
-
-
Silverman, D.N.1
Tu, C.2
Wynns, G.C.3
-
21
-
-
0018407204
-
Role of hemoglobin in proton transfer to the active site of carbonic anhydrase
-
D. N. Silverman L. Backman C. Tu Role of hemoglobin in proton transfer to the active site of carbonic anhydrase J. Biol. Chem. 1979 254 8 2588 91 (Pubitemid 9196090)
-
(1979)
Journal of Biological Chemistry
, vol.254
, Issue.8
, pp. 2588-2591
-
-
Silverman, D.N.1
Backman, L.2
Tu, C.3
-
23
-
-
0023796768
-
Activation of Carbonic Anhydrase-III by Phosphate
-
J. B. Shelton W. R. Chegwidden Activation of Carbonic Anhydrase-III by Phosphate Biochem. Soc. Trans. 1988 16 5 853 854
-
(1988)
Biochem. Soc. Trans.
, vol.16
, Issue.5
, pp. 853-854
-
-
Shelton, J.B.1
Chegwidden, W.R.2
-
24
-
-
0024850617
-
Enhancement of carbonic anhydrase activity by erythrocyte membranes
-
DOI 10.1016/0003-9861(89)90392-5
-
J. L. Parkes P. S. Coleman Enhancement of carbonic anhydrase activity by erythrocyte membranes Arch. Biochem. Biophys. 1989 275 2 459 68 (Pubitemid 20022173)
-
(1989)
Archives of Biochemistry and Biophysics
, vol.275
, Issue.2
, pp. 459-468
-
-
Parkes, J.L.1
Coleman, P.S.2
-
26
-
-
0034569335
-
Activation of carbonic anhydrase isozymes
-
W. R. Chegwidden, N. Carter, Y. Edwards, Eds.; Birkhauser Verlag: Basel, Switzerland, Ed.
-
C. T. Supuran, A. Scozzafava, Activation of carbonic anhydrase isozymes, in The Carbonic Anhydrases - New Horizons, ed., W. R. Chegwidden, N. Carter, Y. Edwards, Eds.; Birkhauser Verlag: Basel, Switzerland, 2000, pp. 197-219
-
(2000)
The Carbonic Anhydrases - New Horizons
, pp. 197-219
-
-
Supuran, C.T.1
Scozzafava, A.2
-
27
-
-
0342680993
-
Carbonic-Anhydrase Activators 5. CA II Activation by 2,4,6-Trisubstituted Pyridinium Cations with 1-(Omega-Aminoalkyl) Side-Chains
-
C. T. Supuran A. Dinculescu A. T. Balaban Carbonic-Anhydrase Activators 5. CA II Activation by 2,4,6-Trisubstituted Pyridinium Cations with 1-(Omega-Aminoalkyl) Side-Chains Rev. Roum. Chim. 1993 38 3 343 349
-
(1993)
Rev. Roum. Chim.
, vol.38
, Issue.3
, pp. 343-349
-
-
Supuran, C.T.1
Dinculescu, A.2
Balaban, A.T.3
-
28
-
-
0029788683
-
Carbonic anhydrase activators. Part 14. Syntheses of mono and bis pyridinium salt derivatives of 2-amino-5-(2-aminoethyl)- and 2-amino-5-(3-aminopropyl)-1,3,4-thiadiazole and their interaction with isozyme II
-
DOI 10.1016/0223-5234(96)89555-9
-
C. T. Supuran M. Barboiu C. Luca E. Pop M. E. Brewster A. Dinculescu Carbonic anhydrase activators.14. Syntheses of mono and bis pyridinium salt derivatives of 2-amino-5-(2-aminoethyl)- and 2-amino-5-(3-aminopropyl)-1,3,4- thiadiazole and their interaction with isozyme II Eur. J. Med. Chem. 1996 31 7-8 597 606 (Pubitemid 26283970)
-
(1996)
European Journal of Medicinal Chemistry
, vol.31
, Issue.7-8
, pp. 597-606
-
-
Supuran, C.T.1
Barboiu, M.2
Luca, C.3
Pop, E.4
Brewster, M.E.5
Dinculescu, A.6
-
29
-
-
0027745222
-
Carbonic anhydrase activators. VII. Isozyme II activation by bisazolyl-methanes, -ethanes and related azoles
-
C. T. Supuran A. T. Balaban P. Cabildo R. M. Claramunt J. L. Lavandera J. Elguero Carbonic anhydrase activators. VII. Isozyme, II activation by bisazolyl-methanes, -ethanes and related azoles Biol. Pharm. Bull. 1993 16 12 1236 9 (Pubitemid 24049987)
-
(1993)
Biological and Pharmaceutical Bulletin
, vol.16
, Issue.12
, pp. 1236-1239
-
-
Supuran, C.T.1
Balaban, A.T.2
Cabildo, P.3
Claramunt, R.M.4
Lavandera, J.L.5
Elguero, J.6
-
30
-
-
0029824776
-
Carbonic anhydrase activators. XV. A kinetic study of the interaction of bovine isozyme II with pyrazoles, bis- and tris-azolyl-methanes
-
C. T. Supuran R. M. Claramunt J. L. Lavandera J. Elguero Carbonic anhydrase activators. XV. A kinetic study of the interaction of bovine isozyme II with pyrazoles, bis- and tris-azolyl-methanes Biol. Pharm. Bull. 1996 19 11 1417 22 (Pubitemid 26403244)
-
(1996)
Biological and Pharmaceutical Bulletin
, vol.19
, Issue.11
, pp. 1417-1422
-
-
Supuran, C.T.1
Claramunt, R.M.2
Lavandera, J.L.3
Elguero, J.4
-
31
-
-
0030772018
-
Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine
-
DOI 10.1021/bi970760v
-
F. Briganti S. Mangani P. Orioli A. Scozzafava G. Vernaglione C. T. Supuran Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine Biochemistry 1997 36 10384 92 (Pubitemid 27374130)
-
(1997)
Biochemistry
, vol.36
, Issue.34
, pp. 10384-10392
-
-
Briganti, F.1
Mangani, S.2
Orioli, P.3
Scozzafava, A.4
Vernaglione, G.5
Supuran, C.T.6
-
32
-
-
0030664701
-
Carbonic anhydrase activators. Part 17. Synthesis and activation study of a series of 1-1,2,4-triazole-(1H)-3-yl)-2,4,6-trisubstituted-pyridinium salts against isozymes I, II and IV
-
DOI 10.1016/S0223-5234(97)82777-8
-
M. A. Ilies M. D. Banciu M. Ilies F. Chiraleu F. Briganti A. Scozzafava C. T. Supuran Carbonic anhydrase activators. Part 17. Synthesis and activation study of a series of 1-(1,2,4-triazole-(1H)-3-yl)-2,4,6-trisubstituted- pyridinium salts against isozymes I, II and IV Eur. J. Med. Chem. 1997 32 911 918 (Pubitemid 27521035)
-
(1997)
European Journal of Medicinal Chemistry
, vol.32
, Issue.11
, pp. 911-918
-
-
Ilies, M.A.1
Banciu, M.D.2
Ilies, M.3
Chiraleu, F.4
Briganti, F.5
Scozzafava, A.6
Supuran, C.T.7
-
33
-
-
0037122755
-
Carbonic anhydrase activators: Design of high affinity isozymes I, II, and IV activators, incorporating tri-/tetrasubstituted-pyridinium-azole moieties
-
DOI 10.1021/jm011031n
-
M. Ilies M. D. Banciu M. A. Ilies A. Scozzafava M. T. Caproiu C. T. Supuran Carbonic anhydrase activators: design of high affinity isozymes I, II, and IV activators, incorporating tri-/tetrasubstituted-pyridinium-azole moieties J. Med. Chem. 2002 45 2 504 10 (Pubitemid 34073467)
-
(2002)
Journal of Medicinal Chemistry
, vol.45
, Issue.2
, pp. 504-510
-
-
Ilies, M.1
Banciu, M.D.2
Ilies, M.A.3
Scozzafava, A.4
Caproiu, M.T.5
Supuran, C.T.6
-
34
-
-
0033384171
-
Carbonic anhydrase activators: Amino acyl/dipeptidyl histamine derivatives bind with high affinity to isozymes I, II and IV and act as efficient activators
-
DOI 10.1016/S0968-0896(99)00227-8, PII S0968089699002278
-
C. T. Supuran A. Scozzafava Carbonic anhydrase activators: amino acyl/dipeptidyl histamine derivatives bind with high affinity to isozymes I, II and IV and act as efficient activators Bioorg. Med. Chem. 1999 7 12 2915 23 (Pubitemid 30105864)
-
(1999)
Bioorganic and Medicinal Chemistry
, vol.7
, Issue.12
, pp. 2915-2923
-
-
Supuran, C.T.1
Scozzafava, A.2
-
35
-
-
0037122754
-
Carbonic anhydrase activators: High affinity isozymes I, II, and IV activators, incorporating a β-alanyl-histidine scaffold
-
DOI 10.1021/jm010958k
-
A. Scozzafava C. T. Supuran Carbonic anhydrase activators: high affinity isozymes I, II, and IV activators, incorporating a beta-alanyl-histidine scaffold J. Med. Chem. 2002 45 2 284 91 (Pubitemid 34073447)
-
(2002)
Journal of Medicinal Chemistry
, vol.45
, Issue.2
, pp. 284-291
-
-
Scozzafava, A.1
Supuran, C.T.2
-
36
-
-
0033584160
-
Novel carbonic anhydrase isozymes I, II and IV activators incorporating sulfonyl-histamino moieties
-
DOI 10.1016/S0960-894X(99)00310-8, PII S0960894X99003108
-
F. Briganti A. Scozzafava C. T. Supuran Novel carbonic anhydrase isozymes I, II and IV activators incorporating sulfonyl-histamino moieties Bioorg. Med. Chem. Lett. 1999 9 14 2043 8 (Pubitemid 29336398)
-
(1999)
Bioorganic and Medicinal Chemistry Letters
, vol.9
, Issue.14
, pp. 2043-2048
-
-
Briganti, F.1
Scozzafava, A.2
Supuran, C.T.3
-
37
-
-
0033872086
-
Carbonic anhydrase activators: Synthesis of high affinity isozymes I, II and IV activators, derivatives of 4-(arysulfonylureido-amino acyl)ethyl-1H-imidazole
-
C. T. Supuran A. Scozzafava Carbonic anhydrase activators: synthesis of high affinity isozymes I, II and IV activators, derivatives of 4-(arylsulfonylureido-amino acyl)ethyl-1H-imidazole J. Enzyme Inhib. Med. Chem. 2000 15 5 471 86 (Pubitemid 30639433)
-
(2000)
Journal of Enzyme Inhibition
, vol.15
, Issue.5
, pp. 471-486
-
-
Supuran, C.T.1
Scozzafava, A.2
-
38
-
-
0035852857
-
Structural and kinetic analysis of the chemical rescue of the proton transfer function of carbonic anhydrase II
-
DOI 10.1021/bi002295z
-
D. Duda C. Tu M. Qian P. Laipis M. Agbandje-McKenna D. N. Silverman R. McKenna Structural and kinetic analysis of the chemical rescue of the proton transfer function of carbonic anhydrase II Biochemistry 2001 40 1741 8 (Pubitemid 32144045)
-
(2001)
Biochemistry
, vol.40
, Issue.6
, pp. 1741-1748
-
-
Duda, D.1
Tu, C.2
Qian, M.3
Laipis, P.4
Agbandje-McKenna, M.5
Silverman, D.N.6
McKenna, R.7
-
39
-
-
0346671207
-
Activation of carbonic anhydrase II by active-site incorporation of histidine analogs
-
DOI 10.1016/j.abb.2003.11.006
-
I. Elder S. Han C. Tu H. Steele P. J. Laipis R. E. Viola D. N. Silverman Activation of carbonic anhydrase II by active-site incorporation of histidine analogs Arch. Biochem. Biophys. 2004 421 283 9 (Pubitemid 38096263)
-
(2004)
Archives of Biochemistry and Biophysics
, vol.421
, Issue.2
, pp. 283-289
-
-
Elder, I.1
Han, S.2
Tu, C.3
Steele, H.4
Laipis, P.J.5
Viola, R.E.6
Silverman, D.N.7
-
41
-
-
26844500569
-
Carbonic anhydrase activators: X-ray crystal structure of the adduct of human isozyme II with l-histidine as a platform for the design of stronger activators
-
DOI 10.1016/j.bmcl.2005.08.069, PII S0960894X05011030
-
C. Temperini A. Scozzafava L. Puccetti C. T. Supuran Carbonic anhydrase activators: X-ray crystal structure of the adduct of human isozyme II with L-histidine as a platform for the design of stronger activators Bioorg. Med. Chem. Lett. 2005 15 5136 5141 (Pubitemid 41463634)
-
(2005)
Bioorganic and Medicinal Chemistry Letters
, vol.15
, Issue.23
, pp. 5136-5141
-
-
Temperini, C.1
Scozzafava, A.2
Puccetti, L.3
Supuran, C.T.4
-
42
-
-
33747520016
-
Carbonic anhydrase activators: The first X-ray crystallographic study of an adduct of isoform I
-
DOI 10.1016/j.bmcl.2006.07.021, PII S0960894X06007980
-
C. Temperini A. Scozzafava C. T. Supuran Carbonic anhydrase activators: The first X-ray crystallographic study of an adduct of isoform I Bioorg. Med. Chem. Lett. 2006 16 5152 5156 (Pubitemid 44255887)
-
(2006)
Bioorganic and Medicinal Chemistry Letters
, vol.16
, Issue.19
, pp. 5152-5156
-
-
Temperini, C.1
Scozzafava, A.2
Supuran, C.T.3
-
43
-
-
33749039202
-
Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with L- and D-histidine and crystallographic analysis of their adducts with isoform II: Engineering proton-transfer processes within the active site of an enzyme
-
DOI 10.1002/chem.200600159
-
C. Temperini A. Scozzafava D. Vullo C. T. Supuran Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme Chem.-Eur. J. 2006 12 7057 7066 (Pubitemid 44450132)
-
(2006)
Chemistry - A European Journal
, vol.12
, Issue.27
, pp. 7057-7066
-
-
Temperini, C.1
Scozzafava, A.2
Vullo, D.3
Supuran, C.T.4
-
44
-
-
33646751543
-
Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII and XIV with L- and D- phenylalanine and crystallographic analysis of their adducts with isozyme II: Sterospecific recognition within the active site of an enzyme and its consequences for the drug design
-
C. Temperini D. Vullo A. Scozzafava C. T. Supuran Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII and XIV with L- and D- phenylalanine and crystallographic analysis of their adducts with isozyme II: sterospecific recognition within the active site of an enzyme and its consequences for the drug design J. Med. Chem. 2006 49 3019 3027
-
(2006)
J. Med. Chem.
, vol.49
, pp. 3019-3027
-
-
Temperini, C.1
Vullo, D.2
Scozzafava, A.3
Supuran, C.T.4
-
45
-
-
0034047082
-
Carbonic anhydrase activators: Part 24. High affinity isozymes I, II and IV activators, derivatives of 4-(4-chlorophenylsulfonylureido-amino acyl)ethyl-1H-imidazole
-
DOI 10.1016/S0928-0987(99)00086-X, PII S092809879900086X
-
A. Scozzafava C. T. Supuran Carbonic anhydrase activators. Part 24. High affinity isozymes I, II and IV activators, derivatives of 4-(4- chlorophenylsulfonylureido-amino acyl)ethyl-1H-imidazole Eur. J. Pharm. Sci. 2000 10 29 41 (Pubitemid 30123142)
-
(2000)
European Journal of Pharmaceutical Sciences
, vol.10
, Issue.1
, pp. 29-41
-
-
Scozzafava, A.1
Supuran, C.T.2
-
46
-
-
0034008535
-
Carbonic anhydrase activators - Part 21. Novel activators of isozymes I, II and IV incorporating carboxamido and ureido histamine moieties
-
DOI 10.1016/S0223-5234(00)00102-1
-
A. Scozzafava C. T. Supuran Carbonic anhydrase activators - Part 21. Novel activators of isozymes I, II and IV incorporating carboxamido and ureido histamine moieties Eur. J. Med. Chem. 2000 35 31 9 (Pubitemid 30136686)
-
(2000)
European Journal of Medicinal Chemistry
, vol.35
, Issue.1
, pp. 31-39
-
-
Scozzafava, A.1
Supuran, C.T.2
-
47
-
-
0034009801
-
Carbonic anhydrase activators: Synthesis of high affinity isozymes I, II and IV activators, derivatives of 4-(4-tosylureido-amino acyl)ethyl-1H-imidazole (histamine derivatives)
-
A. Scozzafava B. Iorga C. T. Supuran Carbonic anhydrase activators: synthesis of high affinity isozymes I, II and IV activators, derivatives of 4-(4-tosylureido-amino acyl)ethyl-1H-imidazole (histamine derivatives) J. Enzyme Inhib. Med. Chem. 2000 15 139 61 (Pubitemid 30128985)
-
(2000)
Journal of Enzyme Inhibition
, vol.15
, Issue.2
, pp. 139-161
-
-
Scozzafava, A.1
Iorga, B.2
Supuran, C.T.3
-
48
-
-
0042285586
-
Rotation barriers in N-substituted 2,4,6-trimethylpyridinium cations
-
A. T. Balaban C. Uncuta A. Dinculescu M. Elian F. Chiraleu Rotation barriers in N-substituted 2,4,6-trimethylpyridinium cations Tetrahedron Lett. 1980 21 1553 1556
-
(1980)
Tetrahedron Lett.
, vol.21
, pp. 1553-1556
-
-
Balaban, A.T.1
Uncuta, C.2
Dinculescu, A.3
Elian, M.4
Chiraleu, F.5
-
49
-
-
34547807561
-
Dynamic 1H-NMR Conformational Study in a Series of Pyridinium Pyrazoles
-
M. Ilies M. T. Caproiu Dynamic 1H-NMR Conformational Study in a Series of Pyridinium Pyrazoles Revista de Chimie 2007 58 442 446
-
(2007)
Revista de Chimie
, vol.58
, pp. 442-446
-
-
Ilies, M.1
Caproiu, M.T.2
-
50
-
-
37049052033
-
Pyrylium salts obtained by diacylation of olefins. II. The, two pyrylium salts formed in the diacylation of 2-methyl-2-butene
-
A. T. Balaban C. D. Nenitzescu Pyrylium salts obtained by diacylation of olefins. II. The, two pyrylium salts formed in the diacylation of 2-methyl-2-butene J. Chem. Soc. 1961 3553 3560
-
(1961)
J. Chem. Soc.
, pp. 3553-3560
-
-
Balaban, A.T.1
Nenitzescu, C.D.2
-
51
-
-
37049045651
-
Pyrylium salts and related compounds. Part I. The, reaction between olefins and acylium perchlorates
-
P. F. G. Praill A. R. Whitear Pyrylium salts and related compounds. Part I. The, reaction between olefins and acylium perchlorates J. Chem. Soc. 1961 3573 3579
-
(1961)
J. Chem. Soc.
, pp. 3573-3579
-
-
Praill, P.F.G.1
Whitear, A.R.2
-
56
-
-
0029047482
-
Carbonic anhydrase inhibitors. Part 24. A quantitative structure-activity study of positively-charged sulfonamide inhibitors
-
C. T. Supuran B. W. Clare Carbonic anhydrase inhibitors. Part 24. A quantitative structure-activity study of positively-charged sulfonamide inhibitors Eur. J. Med. Chem. 1995 30 687 696
-
(1995)
Eur. J. Med. Chem.
, vol.30
, pp. 687-696
-
-
Supuran, C.T.1
Clare, B.W.2
-
57
-
-
0032122565
-
Carbonic anhydrase inhibitors - Part 53. Synthesis of substituted-pyridinium derivatives of aromatic sulfonamides: The first non-polymeric membrane-impermeable inhibitors with selectivity for isozyme IV
-
DOI 10.1016/S0223-5234(98)80017-2
-
C. T. Supuran A. Scozzafava M. A. Ilies B. Iorga T. Cristea F. Chiraleu M. D. Banciu Carbonic anhydrase inhibitors. Part 53. Synthesis of substituted-pyridinium derivatives of aromatic sulfonamides: the first non-polymeric membrane-impermeable inhibitors with selectivity for isozyme IV Eur. J. Med. Chem. 1998 33 577 594 (Pubitemid 28404767)
-
(1998)
European Journal of Medicinal Chemistry
, vol.33
, Issue.7-8
, pp. 577-594
-
-
Supuran, C.T.1
Scozzafava, A.2
Ilies, M.A.3
Iorga, B.4
Cristea, T.5
Briganti, F.6
Chiraleu, F.7
Banciu, M.D.8
-
58
-
-
0033919901
-
Carbonic anhydrase inhibitors: Synthesis of sulfonamides incorporating 2,4,6-trisubstituted-pyridinium-ethylcarboxamido moieties possessing membrane-impermeability and in vivo selectivity for the membrane-bound (CA IV) versus the cytosolic (CA I and CA II) isozymes
-
C. T. Supuran A. Scozzafava M. A. Ilies F. Briganti Carbonic anhydrase inhibitors. Synthesis of sulfonamides incorporating 2,4,6-trisubstituted- pyridinium-ethylcarboxamido moieties possessing membrane-impermeability and in vivo selectivity for the membrane-bound (CA IV) versus the cytosolic (CA I and CA II) isozymes J. Enzyme Inhib. Med. Chem. 2000 15 381 401 (Pubitemid 30433730)
-
(2000)
Journal of Enzyme Inhibition
, vol.15
, Issue.4
, pp. 381-401
-
-
Supuran, C.T.1
Scozzafava, A.2
Ilies, M.A.3
Briganti, F.4
-
59
-
-
0034719437
-
Carbonic anhydrase inhibitors: Synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes
-
DOI 10.1021/jm990479+
-
A. Scozzafava F. Briganti M. A. Ilies C. T. Supuran Carbonic anhydrase inhibitors: Synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus the cytosolic isozymes J. Med. Chem. 2000 43 292 300 (Pubitemid 30078161)
-
(2000)
Journal of Medicinal Chemistry
, vol.43
, Issue.2
, pp. 292-300
-
-
Scozzafava, A.1
Briganti, F.2
Ilies, M.A.3
Supuran, C.T.4
-
60
-
-
65549152739
-
Carbonic anhydrase inhibitors. Synthesis of 2,4,6-trimethylpyridinium derivatives of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides acting as potent inhibitors of the tumor-associated isoform IX and XII
-
Ö. Güzel A. Maresca A. Scozzafava A. Salman A. T. Balaban C. T. Supuran Carbonic anhydrase inhibitors. Synthesis of 2,4,6-trimethylpyridinium derivatives of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides acting as potent inhibitors of the tumor-associated isoform IX and XII Bioorg. Med. Chem. Lett. 2009 19 2931 2934
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 2931-2934
-
-
Güzel, Ö.1
Maresca, A.2
Scozzafava, A.3
Salman, A.4
Balaban, A.T.5
Supuran, C.T.6
-
61
-
-
1842628633
-
Carbonic Anhydrase Inhibitors. Design of Selective, Membrane-Impermeant Inhibitors Targeting the Human Tumor-Associated Isozyme IX
-
DOI 10.1021/jm031079w
-
J. R. Casey P. E. Morgan D. Vullo A. Scozzafava A. Mastrolorenzo C. T. Supuran Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX J. Med. Chem. 2004 47 2337 2347 (Pubitemid 38478857)
-
(2004)
Journal of Medicinal Chemistry
, vol.47
, Issue.9
, pp. 2337-2347
-
-
Casey, J.R.1
Morgan, P.E.2
Vullo, D.3
Scozzafava, A.4
Mastrolorenzo, A.5
Supuran, C.T.6
-
62
-
-
24744467784
-
Carbonic anhydrase inhibitors: Stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II
-
DOI 10.1021/jm050333c
-
V. Menchise G. De Simone V. Alterio A. Di Fiore C. Pedone A. Scozzafava C. T. Supuran Carbonic anhydrase inhibitors: Stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II J. Med. Chem. 2005 48 5721 5727 (Pubitemid 41298346)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.18
, pp. 5721-5727
-
-
Menchise, V.1
De Simone, G.2
Alterio, V.3
Di Fiore, A.4
Pedone, C.5
Scozzafava, A.6
Supuran, C.T.7
-
63
-
-
0033405657
-
Carbonic anhydrase inhibitors. Synthesis of topically effective intraocular pressure lowering agents derived from 5-(ω- aminoalkylcarboxamido)-1,3,4-thiadiazole-2-sulfonamide
-
M. Barboiu C. T. Supuran L. Menabuoni A. Scozzafava F. Mincione F. Briganti G. Mincione Carbonic anhydrase inhibitors. Part 75. Synthesis of topically effective intraocular pressure lowering agents derived from 5-(ω-aminoalkylcarboxamido)-1,3,4-thiadiazole-2-sulfonamide J. Enz. Inhib. 1999 15 23 46 (Pubitemid 30000283)
-
(1999)
Journal of Enzyme Inhibition
, vol.15
, Issue.1
, pp. 23-46
-
-
Barboiu, M.1
Supuran, C.T.2
Menabuoni, L.3
Scozzafava, A.4
Mincione, F.5
Briganti, F.6
Mincione, G.7
-
64
-
-
0015239422
-
The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow, kinetic studies on the native human isoenzymes B and C
-
R. G. Khalifah The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow, kinetic studies on the native human isoenzymes B and C J. Biol. Chem. 1971 246 2561 2573
-
(1971)
J. Biol. Chem.
, vol.246
, pp. 2561-2573
-
-
Khalifah, R.G.1
-
65
-
-
34347402594
-
Carbonic anhydrase activators: Activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines
-
DOI 10.1016/j.bmcl.2007.05.052, PII S0960894X07006166
-
D. Vullo A. Innocenti I. Nishimori A. Scozzafava K. Kaila C. T. Supuran Carbonic anhydrase activators. Activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines Bioorg. Med. Chem. Lett. 2007 17 4107 4112 (Pubitemid 47023151)
-
(2007)
Bioorganic and Medicinal Chemistry Letters
, vol.17
, Issue.15
, pp. 4107-4112
-
-
Vullo, D.1
Innocenti, A.2
Nishimori, I.3
Scozzafava, A.4
Kaila, K.5
Supuran, C.T.6
-
66
-
-
74449087013
-
Acetazolamide and midazolam act synergistically to inhibit neuropathic pain
-
M. Asiedu M. H. Ossipov K. Kaila T. J. Price Acetazolamide and midazolam act synergistically to inhibit neuropathic pain Pain 2010 148 302 308
-
(2010)
Pain
, vol.148
, pp. 302-308
-
-
Asiedu, M.1
Ossipov, M.H.2
Kaila, K.3
Price, T.J.4
-
68
-
-
0000661867
-
Reactions of pyrylium salts with nucleophiles. XIV. New, pyridinium salts with potential biological activity
-
A. Dinculescu A. T. Balaban Reactions of pyrylium salts with nucleophiles. XIV. New, pyridinium salts with potential biological activity Rev. Roum. Chim. 1980 25 1505 1528
-
(1980)
Rev. Roum. Chim.
, vol.25
, pp. 1505-1528
-
-
Dinculescu, A.1
Balaban, A.T.2
-
69
-
-
0002426893
-
Pyrylium Salts. Syntheses, reactions and Physical Properties
-
A. R. Katritzky, Academic Press, New York , ed.
-
A. T. Balaban, A. Dinculescu, G. N. Dorofeenko, G. W. Fischer, A. V. Koblik, V. V. Mezheritskii, W. Schroth, Pyrylium Salts. Syntheses, reactions and Physical Properties, in Advances in Heterocyclic Chemistry, ed., A. R. Katritzky, Academic Press, New York, 1982, Vol. 2, p. 298
-
(1982)
Advances in Heterocyclic Chemistry
, pp. 298
-
-
Balaban, A.T.1
Dinculescu, A.2
Dorofeenko, G.N.3
Fischer, G.W.4
Koblik, A.V.5
Mezheritskii, V.V.6
Schroth, W.7
|