Carbonic anhydrase activators. Part 14. Syntheses of mono and bis pyridinium salt derivatives of 2-amino-5-(2-aminoethyl)- and 2-amino-5-(3-aminopropyl)-1,3,4-thiadiazole and their interaction with isozyme II

European Journal of Medicinal Chemistry

Volumn 31, Issue 7-8, 1996, Pages 597-606

  Supuran, C T ^a   Barboiu, M ^b   Luca, C ^b   Pop, E ^c   Brewster, M E ^c   Dinculescu, A ^c  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY POLITEHNICA OF BUCHAREST   (Romania)

^c Pharmos Corporation   (United States)

Author keywords

1,3,4 thiadiazole; Activator; Carbonic anhydrase; Isozyme II; Pyrylium salt

Indexed keywords

1,3,4 THIADIAZOLE DERIVATIVE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE II; ISOENZYME; PYRIDINIUM DERIVATIVE;

ANIMAL TISSUE; ARTICLE; CATTLE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME BINDING; IN VITRO STUDY; INFRARED SPECTROPHOTOMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTON TRANSPORT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

EID: 0029788683     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/0223-5234(96)89555-9     Document Type: Article

References (25)

1. 1 Part 13 of this series: Coltau M, Puscas I, Supuran CT (1994) Rev Roum Chim 34, 457-462
2. 2 Maren TH (1967) Physiol Rev 47, 595-781
3. 3 Supuran CT (1993) Roum Chem Quart Rev 1, 77-116
4. 4 Sugrue MF (1989) Pharm Ther 43, 91-133
5. 5 Woodbury DM (1980) Inhibitors of carbonic anhydrase. In: Antiepileptic Drugs. Mechanisms of Action (Glaser GH, Perry JK, Woodbury DM, eds) Raven, New York, 617-633
6. 6 Puscas I (1984) Ann NY Acad Sci 429, 587-591
7. 7 Puscas I, Supuran CT, Manole G (1990) Rev Roum Chim 35, 683-688
8. 8 Rowlett RS, Gargiulo NJ, III, Santoli FA, Jackson M, Corbett H (1991) J Biol Chem 266, 933-945
9. 9 Supuran CT (1992) Rev Roum Chim 37, 411-421
10. 10 Silverman DN, Lindskog S (1988) Acc Chem Res 21, 30-36
11. 11 Supuran CT, Baciu I, Balaban AT (1993) Rev Roum Chim 38, 725-731
12. 12 Otha M (1952) J Pharm Soc Jpn 72, 1636-1639
13. 13 Grechishkin LL, Gavrovskaya LK, Goldfarb VL (1978) US Patent 885,367
14. 14 Supuran CT, Puscas I (1994) Carbonic anhydrase activators. In: Carbonic Anhydrase and Modulation of Physiologic and Pathologic Processes in the Organism, Helicon Publishing House, Timisoara, Roumania, 107-139
15. 15 Gabriel S (1908) Ber Dtsch Chem Ges 41, 242-248
16. 16 Ainsworth C, Jones RG (1953) J Am Chem Soc 75, 4915-4918
17. 17 Balaban AT, Dinculescu A, Dorofeenko GN et al (1982) Pyrylium salts; syntheses, reactions and physical properties. In: Adv Heterocycl Chem (Katritzky AR, ed) Academic Press, New York, 14-280
18. 18 Balaban AT, Dinculescu A, Kontrakis HN, Chiraleu F (1979) Tetrahedron Lett 437-440
19. 19 Dinculescu A, Balaban AT (1980) Rev Roum Chim 25, 1505-1528
20. 20 Maren TH (1960) J Pharmacol Exp Ther 130, 26-30
21. 21 Supuran CT, Dinculescu A, Manole G et al (1992) J Pharm Sci 81, 716-719
22. 22 Supuran CT, Clare BW (1995) Eur J Med Chem 30, 687-696
23. 23 Supuran CT, Clare BW (1994) J Pharm Sci 83, 768-773
24. 24 Supuran CT, Puscas I (1994) Roum Chem Quart Rev 2, 313-341
25. 25 Balaban AT, Nenitzescu CD (1973) Org Synth Coll, Vol 5, 1106-1108