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Volumn 7, Issue 3, 2011, Pages 395-408

Influence of the tumor microenvironment on angiogenesis

Author keywords

angiogenesis; extracellular matrix; fibroblast; microenvironment; stroma

Indexed keywords

ACETYLSALICYLIC ACID; ANGIOPOIETIN 1; ANGIOPOIETIN RECEPTOR; ANGIOSTATIN; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CATHEPSIN; CHEMOKINE RECEPTOR CXCR4; CILENGITIDE; ENDOSTATIN; FIBROBLAST GROWTH FACTOR 2; GLYCOSAMINOGLYCAN; GRANULOCYTE CHEMOTACTIC PROTEIN 2; INTERLEUKIN 1; INTERLEUKIN 12; INTERLEUKIN 6; INTERLEUKIN 8; NONSTEROID ANTIINFLAMMATORY AGENT; PLASMIN; PLATELET DERIVED GROWTH FACTOR; PROSTAGLANDIN SYNTHASE INHIBITOR; STROMAL CELL DERIVED FACTOR 1ALPHA; THROMBIN; THROMBOPLASTIN; THROMBOSPONDIN 1; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG; UROKINASE; VASCULOTROPIN A;

EID: 79953154623     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.11.13     Document Type: Review
Times cited : (22)

References (167)
  • 1
    • 0036990109 scopus 로고    scopus 로고
    • The organizing principle: Microenvironmental influences in the normal and malignant breast
    • DOI 10.1046/j.1432-0436.2002.700907.x
    • Bissell MJ, Radisky DC, Rizki A, Weaver VM, Petersen OW: The organizing principle: microenvironmental influences in the normal and malignant breast. Differentiation 70(9-10), 537-546 (2002). (Pubitemid 36194318)
    • (2002) Differentiation , vol.70 , Issue.9-10 , pp. 537-546
    • Bissell, M.J.1    Radisky, D.C.2    Rizki, A.3    Weaver, V.M.4    Petersen, O.W.5
  • 2
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • DOI 10.1038/nature01322
    • Coussens LM, Werb Z: Inflammation and cancer. Nature 420(6917), 860-867 (2002). (Pubitemid 36019639)
    • (2002) Nature , vol.420 , Issue.6917 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 3
    • 0002960887 scopus 로고    scopus 로고
    • Tissue repair: Cellular growth, fibrosis, and wound healing
    • (7th Edition). Saunders, PA, USA
    • Kumar V: Tissue repair: cellular growth, fibrosis, and wound healing. In: Robbins and Cotran Pathologic Basis of Disease (7th Edition). Saunders, PA, USA (2004).
    • (2004) Robbins and Cotran Pathologic Basis of Disease
    • Kumar, V.1
  • 6
    • 0029143990 scopus 로고
    • Tumor angiogenesis in breast cancer: Its importance as a prognostic indicator and the association with vascular endothelial growth factor expression
    • Toi M, Inada K, Suzuki H, Tominaga T: Tumor angiogenesis in breast cancer: its importance as a prognostic indicator and the association with vascular endothelial growth factor expression. Breast Cancer Res. Treat. 36(2), 193-204 (1995).
    • (1995) Breast Cancer Res. Treat , vol.36 , Issue.2 , pp. 193-204
    • Toi, M.1    Inada, K.2    Suzuki, H.3    Tominaga, T.4
  • 8
    • 0026083903 scopus 로고
    • Tumor angiogenesis and metastasis - Correlation in invasive breast carcinoma
    • Weidner N, Semple JP, Welch WR, Folkman J: Tumor angiogenesis and metastasis - correlation in invasive breast carcinoma. N. Engl. J. Med. 324(1), 1-8 (1991).
    • (1991) N. Engl. J. Med , vol.324 , Issue.1 , pp. 1-8
    • Weidner, N.1    Semple, J.P.2    Welch, W.R.3    Folkman, J.4
  • 9
    • 0037213979 scopus 로고    scopus 로고
    • Angiogenesis and invasive recurrence in ductal carcinoma in situ of the breast
    • DOI 10.1016/S0959-8049(02)00248-4, PII S0959804902002484
    • Teo NB, Shoker BS, Jarvis C, Martin L, Sloane JP, Holcombe C: Angiogenesis and invasive recurrence in ductal carcinoma in situ of the breast. Eur. J. Cancer 39(1), 38-44 (2003). (Pubitemid 36005423)
    • (2003) European Journal of Cancer , vol.39 , Issue.1 , pp. 38-44
    • Teo, N.B.1    Shoker, B.S.2    Jarvis, C.3    Martin, L.4    Sloane, J.P.5    Holcombe, C.6
  • 10
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • DOI 10.1016/S0092-8674(00)80108-7
    • Hanahan D, Folkman J: Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86(3), 353-364 (1996). (Pubitemid 26272076)
    • (1996) Cell , vol.86 , Issue.3 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 11
    • 24044459285 scopus 로고    scopus 로고
    • Matrix metalloproteinases and angiogenesis
    • Rundhaug JE: Matrix metalloproteinases and angiogenesis. J. Cell Mol. Med. 9(2), 267-285 (2005).
    • (2005) J. Cell Mol. Med , vol.9 , Issue.2 , pp. 267-285
    • Rundhaug, J.E.1
  • 13
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau W: Mechanisms of angiogenesis. Nature 386(6626), 671-674 (1997). (Pubitemid 27193480)
    • (1997) Nature , vol.386 , Issue.6626 , pp. 671-674
    • Risau, W.1
  • 14
    • 0032768156 scopus 로고    scopus 로고
    • Role of PDGF-B and PDGFR-β in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
    • Hellstrom M, Kalen M, Lindahl P, Abramsson A, Betsholtz C: Role of PDGF-B and PDGFR-b in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development 126(14), 3047-3055 (1999). (Pubitemid 29378170)
    • (1999) Development , vol.126 , Issue.14 , pp. 3047-3055
    • Hellstrom, M.1    Kalen, M.2    Lindahl, P.3    Abramsson, A.4    Betsholtz, C.5
  • 15
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • DOI 10.1038/nm0603-653
    • Carmeliet P: Angiogenesis in health and disease. Nat. Med. 9(6), 653-660 (2003). (Pubitemid 36749213)
    • (2003) Nature Medicine , vol.9 , Issue.6 , pp. 653-660
    • Carmeliet, P.1
  • 16
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J: Tumor angiogenesis: therapeutic implications. N. Engl. J. Med. 285(21), 1182-1186 (1971).
    • (1971) N. Engl. J. Med , vol.285 , Issue.21 , pp. 1182-1186
    • Folkman, J.1
  • 17
    • 0036848878 scopus 로고    scopus 로고
    • Vasculogenesis plays a role in the growth of Ewing's sarcoma in vivo
    • Bolontrade MF, Zhou RR, Kleinerman ES: Vasculogenesis plays a role in the growth of Ewing's sarcoma in vivo. Clin. Cancer Res. 8(11), 3622-3627 (2002). (Pubitemid 35340741)
    • (2002) Clinical Cancer Research , vol.8 , Issue.11 , pp. 3622-3627
    • Bolontrade, M.F.1    Zhou, R.-R.2    Kleinerman, E.S.3
  • 18
    • 24944587964 scopus 로고    scopus 로고
    • Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors
    • DOI 10.1016/j.ccr.2005.08.002, PII S1535610805002606
    • De Palma M, Venneri MA, Galli R, et al. Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell 8(3), 211-226 (2005). (Pubitemid 41317592)
    • (2005) Cancer Cell , vol.8 , Issue.3 , pp. 211-226
    • De Palma, M.1    Venneri, M.A.2    Galli, R.3    Sergi, L.S.4    Politi, L.S.5    Sampaolesi, M.6    Naldini, L.7
  • 20
    • 0036342667 scopus 로고    scopus 로고
    • Angiogenesis, thrombospondin, and ductal carcinoma in situ of the breast
    • Rice A, Quinn CM: Angiogenesis, thrombospondin, and ductal carcinoma in situ of the breast. J. Clin. Pathol. 55(8), 569-574 (2002).
    • (2002) J. Clin. Pathol , vol.55 , Issue.8 , pp. 569-574
    • Rice, A.1    Quinn, C.M.2
  • 21
    • 0031858958 scopus 로고    scopus 로고
    • Establishing a link between oncogenes and tumor angiogenesis
    • Kerbel RS, Viloria-Petit A, Okada F, Rak J: Establishing a link between oncogenes and tumor angiogenesis. Mol. Med. 4(5), 286-295 (1998). (Pubitemid 28361654)
    • (1998) Molecular Medicine , vol.4 , Issue.5 , pp. 286-295
    • Kerbel, R.S.1    Viloria-Petit, A.2    Okada, F.3    Rak, J.4
  • 22
    • 0034650744 scopus 로고    scopus 로고
    • Oncogenes and tumor angiogenesis: Differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts
    • Rak J, Mitsuhashi Y, Sheehan C, et al. Oncogenes and tumor angiogenesis: differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts. Cancer Res. 60(2), 490-498 (2000). (Pubitemid 30070780)
    • (2000) Cancer Research , vol.60 , Issue.2 , pp. 490-498
    • Rak, J.1    Mitsuhashi, Y.2    Sheehan, C.3    Tamir, A.4    Viloria-Petit, A.5    Filmus, J.6    Mansour, S.J.7    Ahn, N.G.8    Kerbel, R.S.9
  • 23
    • 0030735367 scopus 로고    scopus 로고
    • The von Hippel-Lindau gene product inhibits vascular permeability factor/vascular endothelial growth factor expression in renal cell carcinoma by blocking protein kinase C pathways
    • DOI 10.1074/jbc.272.44.27509
    • Pal S, Claffey KP, Dvorak HF, Mukhopadhyay D: The von Hippel-Lindau gene product inhibits vascular permeability factor/vascular endothelial growth factor expression in renal cell carcinoma by blocking protein kinase C pathways. J. Biol. Chem. 272(44), 27509-27512 (1997). (Pubitemid 27473535)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.44 , pp. 27509-27512
    • Pal, S.1    Claffey, K.P.2    Dvorak, H.F.3    Mukhopadhyay, D.4
  • 24
    • 0032101647 scopus 로고    scopus 로고
    • Adenovirus-mediated wild-type p53 gene transfer down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human colon cancer
    • Bouvet M, Ellis LM, Nishizaki M, et al. Adenovirus-mediated wild-type p53 gene transfer down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human colon cancer. Cancer Res. 58(11), 2288-2292 (1998). (Pubitemid 28252680)
    • (1998) Cancer Research , vol.58 , Issue.11 , pp. 2288-2292
    • Bouvet, M.1    Ellis, L.M.2    Nishizaki, M.3    Fujiwara, T.4    Liu, W.5    Bucana, C.D.6    Fang, B.7    Lee, J.J.8    Roth, J.A.9
  • 25
    • 0026639806 scopus 로고
    • Angiogenesis
    • Folkman J, Shing Y: Angiogenesis. J. Biol. Chem. 267(16), 10931-10934 (1992).
    • (1992) J. Biol. Chem , vol.267 , Issue.16 , pp. 10931-10934
    • Folkman, J.1    Shing, Y.2
  • 26
    • 0042863949 scopus 로고    scopus 로고
    • A reinforced random walk model of tumour angiogenesis and anti-angiogenic strategies
    • Plank MJ, Sleeman BD: A reinforced random walk model of tumour angiogenesis and anti-angiogenic strategies. Math. Med. Biol. 20(2), 135-181 (2003). (Pubitemid 37526839)
    • (2003) Mathematical Medicine and Biology , vol.20 , Issue.2 , pp. 135-181
    • Plank, M.J.1    Sleeman, B.D.2
  • 27
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet P, Jain RK: Angiogenesis in cancer and other diseases. Nature 407(6801), 249-257 (2000).
    • (2000) Nature , vol.407 , Issue.6801 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 28
    • 0024384470 scopus 로고
    • Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
    • DOI 10.1016/0006-291X(89)92678-8
    • Ferrara N, Henzel WJ: Pituitary follicular cells secrete a novel heparin in binding growth factors specific for vascular endothelial cells. Biochem. Biophys. Res. Comm. 161(2), 851-858 (1989). (Pubitemid 19162712)
    • (1989) Biochemical and Biophysical Research Communications , vol.161 , Issue.2 , pp. 851-858
    • Ferrara, N.1    Henzel, W.J.2
  • 29
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS, Dvorak HF: Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219(4587), 983-985 (1983).
    • (1983) Science , vol.219 , Issue.4587 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3    Perruzzi, C.A.4    Harvey, V.S.5    Dvorak, H.F.6
  • 31
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N: Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246(4935), 1306-1309 (1989). (Pubitemid 20066716)
    • (1989) Science , vol.246 , Issue.4935 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.-J.3    Goeddel, D.V.4    Ferrara, N.5
  • 32
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Basic science and clinical progress
    • DOI 10.1210/er.2003-0027
    • Ferrara N: Vascular endothelial growth factor: basic science and clinical progress. Endocr. Rev. 25(4), 581-611 (2004). (Pubitemid 39099316)
    • (2004) Endocrine Reviews , vol.25 , Issue.4 , pp. 581-611
    • Ferrara, N.1
  • 33
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • DOI 10.1200/JCO.2005.06.081
    • Hicklin DJ, Ellis LM: Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J. Clin. Oncol. 23(5), 1011-1027 (2005). (Pubitemid 46202320)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.5 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 34
    • 0032707249 scopus 로고    scopus 로고
    • A requirement for neuropilin-1 in embryonic vessel formation
    • Kawasaki T, Kitsukawa T, Bekku Y, et al. A requirement for neuropilin-1 in embryonic vessel formation. Development 126(21), 4895-4902 (1999).
    • (1999) Development , vol.126 , Issue.21 , pp. 4895-4902
    • Kawasaki, T.1    Kitsukawa, T.2    Bekku, Y.3
  • 36
    • 0026746234 scopus 로고
    • Is the relationship between angiogenesis and metastasis in breast cancer real?
    • Hall NR, Fish DE, Hunt N, Goldin RD, Guillou PJ, Monson JR: Is the relationship between angiogenesis and metastasis in breast cancer real? Surg. Oncol. 1(3), 223-229 (1992).
    • (1992) Surg. Oncol , vol.1 , Issue.3 , pp. 223-229
    • Hall, N.R.1    Fish, D.E.2    Hunt, N.3    Goldin, R.D.4    Guillou, P.J.5    Monson, J.R.6
  • 38
    • 0009941731 scopus 로고    scopus 로고
    • Prognostic factors in breast cancer. College of American Pathologists Consensus Statement 1999
    • Fitzgibbons PL, Page DL, Weaver D, et al. Prognostic factors in breast cancer. College of American Pathologists Consensus Statement 1999. Arch. Pathol. Lab. Med. 124(7), 966-978 (2000).
    • (2000) Arch. Pathol. Lab. Med , vol.124 , Issue.7 , pp. 966-978
    • Fitzgibbons, P.L.1    Page, D.L.2    Weaver, D.3
  • 39
    • 0028861231 scopus 로고
    • Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer
    • Brown LF, Berse B, Jakman RW, et al. Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer. Hum. Pathol. 26(1), 86-91 (1995).
    • (1995) Hum. Pathol , vol.26 , Issue.1 , pp. 86-91
    • Brown, L.F.1    Berse, B.2    Jakman, R.W.3
  • 40
    • 0031038068 scopus 로고    scopus 로고
    • Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor β-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis
    • Relf M, LeJeune S, Scott PA, et al. Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor b-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis. Cancer Res. 57(5), 963-969 (1997). (Pubitemid 27098025)
    • (1997) Cancer Research , vol.57 , Issue.5 , pp. 963-969
    • Relf, M.1    Lejeune, S.2    Scott, P.A.E.3    Fox, S.4    Smith, K.5    Leek, R.6    Moghaddam, A.7    Whitehouse, R.8    Bicknell, R.9    Harris, A.L.10
  • 41
    • 0029985805 scopus 로고    scopus 로고
    • Quantitative analysis of vascular endothelial growth factor in primary breast cancer
    • DOI 10.1002/(SICI)1097-0142(19960315)77:6<1101::AID-CNCR15>3.0. CO;2-5
    • Toi M, Kondo S, Suzuki H, et al. Quantitative analysis of vascular endothelial growth factor in primary breast cancer. Cancer 77(6), 1101-1106 (1996). (Pubitemid 26080900)
    • (1996) Cancer , vol.77 , Issue.6 , pp. 1101-1106
    • Toi, M.1    Kondo, S.2    Suzuki, H.3    Yamamoto, Y.4    Inada, K.5    Imazawa, T.6    Taniguchi, T.7    Tominaga, T.8
  • 42
    • 0036330702 scopus 로고    scopus 로고
    • The correlation between immunohistochemically-detected markers of angiogenesis and serum vascular endothelial growth factor in patients with breast cancer
    • Lantzsch T, Hefler L, Krause U, et al. The correlation between immunohistochemically-detected markers of angiogenesis and serum vascular endothelial growth factor in patients with breast cancer. Anticancer Res. 22(3), 1925-1928 (2002). (Pubitemid 34839222)
    • (2002) Anticancer Research , vol.22 , Issue.3 , pp. 1925-1928
    • Lantzsch, T.1    Hefler, L.2    Krause, U.3    Kehl, A.4    Goepel, C.5    Koelbl, H.6    Dunst, J.7    Lampe, D.8
  • 43
    • 0036329210 scopus 로고    scopus 로고
    • Correlation between vascular endothelial growth factor, angiogenesis, and tumor-associated macrophages in invasive ductal breast carcinoma
    • DOI 10.1007/s004280100458
    • Valkovic T, Dobrila F, Melato M, Sasso F, Rizzardi C, Jonjic N: Correlation between vascular endothelial growth factor, angiogenesis, and tumor-associated macrophages in invasive ductal breast carcinoma. Virchows Arch. 440(6), 583-588 (2002). (Pubitemid 34809688)
    • (2002) Virchows Archiv , vol.440 , Issue.6 , pp. 583-588
    • Valkovic, T.1    Dobrila, F.2    Melato, M.3    Sasso, F.4    Rizzardi, C.5    Jonjic, N.6
  • 44
    • 0030698053 scopus 로고    scopus 로고
    • Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in patients with ductal carcinoma in situ of the breast
    • DOI 10.1002/(SICI)1097-0142(19971115)80:10<1945::AID-CNCR11>3.0. CO;2-Y
    • Guidi AJ, Schnitt SJ, Fischer L, et al. Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in patients with ductal carcinoma in situ of the breast. Cancer 80(10), 1945-1953 (1997). (Pubitemid 27479789)
    • (1997) Cancer , vol.80 , Issue.10 , pp. 1945-1953
    • Guidi, A.J.1    Schnitt, S.J.2    Fischer, L.3    Tognazzi, K.4    Harris, J.R.5    Dvorak, H.F.6    Brown, L.F.7
  • 48
    • 65549083899 scopus 로고    scopus 로고
    • A critical analysis of current in vitro and in vivo angiogenesis assays
    • Staton CA, Reed MW, Brown NJ: A critical analysis of current in vitro and in vivo angiogenesis assays. Int. J. Exp. Pathol. 90(3), 195-221 (2009).
    • (2009) Int. J. Exp. Pathol , vol.90 , Issue.3 , pp. 195-221
    • Staton, C.A.1    Reed, M.W.2    Brown, N.J.3
  • 49
    • 0030774116 scopus 로고    scopus 로고
    • Human microvascular endothelial cells differ from macrovascular endothelial cells in their expression of matrix metalloproteinases
    • DOI 10.1016/S1357-2725(97)00061-7, PII S1357272597000617
    • Jackson CJ, Nguyen M: Human microvascular endothelial cells differ from macrovascular endothelial cells in their expression of matrix metalloproteinases. Int. J. Biochem. Cell Biol. 29(10), 1167-1177 (1997). (Pubitemid 27522556)
    • (1997) International Journal of Biochemistry and Cell Biology , vol.29 , Issue.10 , pp. 1167-1177
    • Jackson, C.J.1    Nguyen, M.2
  • 50
    • 0037394660 scopus 로고    scopus 로고
    • Endothelial cell heterogeneity
    • Aird WC: Endothelial cell heterogeneity. Crit. Care Med. 31(Suppl. 4), S221-S230 (2003). (Pubitemid 36458171)
    • (2003) Critical Care Medicine , vol.31 , Issue.4 SUPPL.
    • Aird, W.C.1
  • 52
    • 0034688260 scopus 로고    scopus 로고
    • Regressions of established breast carcinoma xenografts by carboxypeptidase G2 suicide gene therapy and the prodrug CMDA are due to a bystander effect
    • DOI 10.1089/10430340050016021
    • Stribbling SM, Friedlos F, Martin J, et al. Regressions of established breast carcinoma xenografts by carboxypeptidase G2 suicide gene therapy and the prodrug CMDA are due to a bystander effect. Hum. Gene Ther. 11(2), 285-292 (2000). (Pubitemid 30080386)
    • (2000) Human Gene Therapy , vol.11 , Issue.2 , pp. 285-292
    • Stribbling, S.M.1    Friedlos, F.2    Martin, J.3    Davies, L.4    Spooner, R.A.5    Marais, R.6    Springer, C.J.7
  • 53
    • 0037024430 scopus 로고    scopus 로고
    • Fibrinogen E fragment selectively disrupts the vasculature and inhibits the growth of tumours in a syngeneic murine model
    • DOI 10.1038/sj.bjc.6600320
    • Brown NJ, Staton CA, Rodgers GR, Corke KP, Underwood JC, Lewis CE: Fibrinogen E fragment selectively disrupts the vasculature and inhibits the growth of tumours in a syngeneic murine model. Br. J. Cancer 86(11), 1813-1816 (2002). (Pubitemid 34712928)
    • (2002) British Journal of Cancer , vol.86 , Issue.11 , pp. 1813-1816
    • Brown, N.J.1    Staton, C.A.2    Rodgers, G.R.3    Corke, K.P.4    Underwood, J.C.E.5    Lewis, C.E.6
  • 55
    • 0035865450 scopus 로고    scopus 로고
    • Clinical implications of circulating angiogenic factors in cancer patients
    • Poon RT, Fan ST, Wong J: Clinical implications of circulating angiogenic factors in cancer patients. J. Clin. Oncol. 19(4), 1207-1225 (2001). (Pubitemid 32176299)
    • (2001) Journal of Clinical Oncology , vol.19 , Issue.4 , pp. 1207-1225
    • Poon, R.T.-P.1    Fan, S.-T.2    Wong, J.3
  • 56
    • 33750286135 scopus 로고    scopus 로고
    • The multifaceted circulating endothelial cell in cancer: Towards marker and target identification
    • DOI 10.1038/nrc1971, PII NRC1971
    • Bertolini F, Shaked Y, Mancuso P, Kerbel RS: The multifaceted circulating endothelial cell in cancer: towards marker and target identification. Nat. Rev. Cancer 6(11), 835-845 (2006). (Pubitemid 44629895)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.11 , pp. 835-845
    • Bertolini, F.1    Shaked, Y.2    Mancuso, P.3    Kerbel, R.S.4
  • 58
    • 20944436688 scopus 로고    scopus 로고
    • Differential effects of vascular endothelial growth factor receptor-2 inhibitor ZD6474 on circulating endothelial progenitors an- mature circulating endothelial cells: Implications for use as a surrogate marker of antiangiogenic activity
    • Beaudry P, Force J, Naumov GN, et al. Differential effects of vascular endothelial growth factor receptor-2 inhibitor ZD6474 on circulating endothelial progenitors an- mature circulating endothelial cells: implications for use as a surrogate marker of antiangiogenic activity. Clin. Cancer Res. 11(9), 3514-3522 (2005).
    • (2005) Clin. Cancer Res , vol.11 , Issue.9 , pp. 3514-3522
    • Beaudry, P.1    Force, J.2    Naumov, G.N.3
  • 59
    • 46949084994 scopus 로고    scopus 로고
    • Biomarkers of angiogenesis for the development of antiangiogenic therapies in oncology: Tools or decorations?
    • DOI 10.1038/ncponc1150, PII NCPONC1150
    • Sessa C, Guibal A, Del Conte G, Ruegg C: Biomarkers of angiogenesis for the development of antiangiogenic therapies in oncology: tools or decorations? Nat. Clin. Pract. Oncol. 5(7), 378-391 (2008). (Pubitemid 351958963)
    • (2008) Nature Clinical Practice Oncology , vol.5 , Issue.7 , pp. 378-391
    • Sessa, C.1    Guibal, A.2    Del Conte, G.3    Ruegg, C.4
  • 61
    • 0033215242 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium
    • Olumi AF, Grossfeld GD, Hayward SW, Carroll PR, Tlsty TD, Cunha GR: Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res. 59(19), 5002-5011 (1999). (Pubitemid 29472907)
    • (1999) Cancer Research , vol.59 , Issue.19 , pp. 5002-5011
    • Olumi, A.F.1    Grossfeld, G.D.2    Hayward, S.W.3    Carroll, P.R.4    Tlsty, T.D.5    Cunha, G.R.6
  • 62
    • 9244227134 scopus 로고    scopus 로고
    • Stromal fibroblasts in cancer initiation and progression
    • DOI 10.1038/nature03096
    • Bhowmick NA, Neilson EG, Moses HL: Stromal fibroblasts in cancer initiation and progression. Nature 432(7015), 332-337 (2004). (Pubitemid 39551661)
    • (2004) Nature , vol.432 , Issue.7015 , pp. 332-337
    • Bhowmick, N.A.1    Neilson, E.G.2    Moses, H.L.3
  • 63
    • 33747859659 scopus 로고    scopus 로고
    • Stromal fibroblasts in cancer: A novel tumor-promoting cell type
    • Orimo A, Weinberg RA: Stromal fibroblasts in cancer: a novel tumor-promoting cell type. Cell Cycle 5(15), 1597-1601 (2006). (Pubitemid 44285243)
    • (2006) Cell Cycle , vol.5 , Issue.15 , pp. 1597-1601
    • Orimo, A.1    Weinberg, R.A.2
  • 65
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    • DOI 10.1016/j.cell.2005.02.034, PII S0092867405002370
    • Orimo A, Gupta PB, Sgroi DC, et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121(3), 335-348 (2005). (Pubitemid 40692295)
    • (2005) Cell , vol.121 , Issue.3 , pp. 335-348
    • Orimo, A.1    Gupta, P.B.2    Sgroi, D.C.3    Arenzana-Seisdedos, F.4    Delaunay, T.5    Naeem, R.6    Carey, V.J.7    Richardson, A.L.8    Weinberg, R.A.9
  • 66
    • 0034618408 scopus 로고    scopus 로고
    • Human breast carcinoma desmoplasia is PDGF initiated
    • Shao ZM, Nguyen M, Barsky SH: Human breast carcinoma desmoplasia is PDGF initiated. Oncogene 19(38), 4337-4345 (2000).
    • (2000) Oncogene , vol.19 , Issue.38 , pp. 4337-4345
    • Shao, Z.M.1    Nguyen, M.2    Barsky, S.H.3
  • 68
    • 0034283023 scopus 로고    scopus 로고
    • Vascular endothelial growth factor, interleukin 8, platelet-derived endothelial cell growth factor, and basic fibroblast growth factor promote angiogenesis and metastasis in human melanoma xenografts
    • Rofstad EK, Halsor EF: Vascular endothelial growth factor, interleukin 8, platelet-derived endothelial cell growth factor, and basic fibroblast growth factor promote angiogenesis and metastasis in human melanoma xenografts. Cancer Res. 60(17), 4932-4938 (2000).
    • (2000) Cancer Res , vol.60 , Issue.17 , pp. 4932-4938
    • Rofstad, E.K.1    Halsor, E.F.2
  • 69
    • 31544465706 scopus 로고    scopus 로고
    • 2-stimulated intestinal epithelial proliferation and angiogenesis
    • DOI 10.1158/0008-5472.CAN-05-2606
    • Shao J, Sheng GG, Mifflin RC, Powell DW, Sheng H: Roles of myofibroblasts in prostaglandin E2-stimulated intestinal epithelial proliferation and angiogenesis. Cancer Res. 66(2), 846-855 (2006). (Pubitemid 43165950)
    • (2006) Cancer Research , vol.66 , Issue.2 , pp. 846-855
    • Shao, J.1    Sheng, G.G.2    Mifflin, R.C.3    Powell, D.W.4    Sheng, H.5
  • 72
    • 0026619795 scopus 로고
    • Human recombinant migration inhibitory factor activates human macrophages to kill tumor cells
    • DOI 10.1016/0008-8749(92)90339-Q
    • Pozzi LA, Weiser WY: Human recombinant migration inhibitory factor activates human macrophages to kill tumor cells. Cell Immunol. 145(2), 372-379 (1992). (Pubitemid 23004550)
    • (1992) Cellular Immunology , vol.145 , Issue.2 , pp. 372-379
    • Pozzi, L.-A.M.1    Weiser, W.Y.2
  • 73
    • 0036187615 scopus 로고    scopus 로고
    • The role of tumour-associated macrophages in tumour progression: Implications for new anticancer therapies
    • DOI 10.1002/path.1027
    • Bingle L, Brown NJ, Lewis CE: The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies. J. Pathol. 196(3), 254-265 (2002). (Pubitemid 34189413)
    • (2002) Journal of Pathology , vol.196 , Issue.3 , pp. 254-265
    • Bingle, L.1    Brown, N.J.2    Lewis, C.E.3
  • 74
    • 58149267580 scopus 로고    scopus 로고
    • Corrupt policemen: Inflammatory cells promote tumor angiogenesis
    • Zumsteg A, Christofori G: Corrupt policemen: inflammatory cells promote tumor angiogenesis. Curr. Opin. Oncol. 21(1), 60-70 (2009).
    • (2009) Curr. Opin. Oncol , vol.21 , Issue.1 , pp. 60-70
    • Zumsteg, A.1    Christofori, G.2
  • 75
    • 0035911221 scopus 로고    scopus 로고
    • Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy
    • Lin EY, Nguyen AV, Russell RG, Pollard JW: Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J. Exp. Med. 193(6), 727-740 (2001).
    • (2001) J. Exp. Med , vol.193 , Issue.6 , pp. 727-740
    • Lin, E.Y.1    Nguyen, A.V.2    Russell, R.G.3    Pollard, J.W.4
  • 76
    • 33750703246 scopus 로고    scopus 로고
    • Hypoxia induces PECAM-1 phosphorylation and transendothelial migration of monocytes
    • Kalra VK, Shen Y, Sultana C, Rattan V: Hypoxia induces PECAM-1 phosphorylation and transendothelial migration of monocytes. Am. J. Physiol. 271(5 Pt 2), H2025-H2034 (1996).
    • (1996) Am. J. Physiol , vol.271 , Issue.5 PART 2
    • Kalra, V.K.1    Shen, Y.2    Sultana, C.3    Rattan, V.4
  • 77
    • 68749109536 scopus 로고    scopus 로고
    • A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth
    • Qian B, Deng Y, Im JH, et al. A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. PLoS One 4(8), E6562 (2009).
    • (2009) PLoS One , vol.4 , Issue.8
    • Qian, B.1    Deng, Y.2    Im, J.H.3
  • 78
    • 76249106734 scopus 로고    scopus 로고
    • Gene expression analysis of macrophages that facilitate tumor invasion supports a role for Wnt-signaling in mediating their activity in primary mammary tumors
    • Ojalvo LS, Whittaker CA, Condeelis JS, Pollard JW: Gene expression analysis of macrophages that facilitate tumor invasion supports a role for Wnt-signaling in mediating their activity in primary mammary tumors. J. Immunol. 184(2), 702-712 (2010).
    • (2010) J. Immunol , vol.184 , Issue.2 , pp. 702-712
    • Ojalvo, L.S.1    Whittaker, C.A.2    Condeelis, J.S.3    Pollard, J.W.4
  • 79
    • 40049088602 scopus 로고    scopus 로고
    • The inflammatory micro-environment in tumor progression: The role of tumor-associated macrophages
    • DOI 10.1016/j.critrevonc.2007.07.004, PII S104084280700162X
    • Allavena P, Sica A, Solinas G, Porta C, Mantovani A: The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages. Crit. Rev. Oncol. Hematol. 66(1), 1-9 (2008). (Pubitemid 351324128)
    • (2008) Critical Reviews in Oncology/Hematology , vol.66 , Issue.1 , pp. 1-9
    • Allavena, P.1    Sica, A.2    Solinas, G.3    Porta, C.4    Mantovani, A.5
  • 80
    • 2142644409 scopus 로고    scopus 로고
    • Macrophage infiltration and angiogenesis in hu-an malignancy
    • discussion 200-184, 259-169
    • Knowles H, Leek R, Harris AL: Macrophage infiltration and angiogenesis in hu-an malignancy. Novartis Found. Symp. 256, 189-200; discussion 200-184, 259-169 (2004).
    • (2004) Novartis Found. Symp , vol.256 , pp. 189-200
    • Knowles, H.1    Leek, R.2    Harris, A.L.3
  • 81
    • 36549025804 scopus 로고    scopus 로고
    • Vascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophages
    • DOI 10.1016/j.molonc.2007.10.003, PII S1574789107000762
    • Lin EY, Li JF, Bricard G, et al. Vascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophages. Mol. Oncol. 1(3), 288-302 (2007). (Pubitemid 350181649)
    • (2007) Molecular Oncology , vol.1 , Issue.3 , pp. 288-302
    • Lin, E.Y.1    Li, J.-f.2    Bricard, G.3    Wang, W.4    Deng, Y.5    Sellers, R.6    Porcelli, S.A.7    Pollard, J.W.8
  • 83
    • 33746926292 scopus 로고    scopus 로고
    • Clodronate-liposome-mediated depletion of tumour-associated macrophages: A new and highly effective antiangiogenic therapy approach
    • DOI 10.1038/sj.bjc.6603240, PII 6603240
    • Zeisberger SM, Odermatt B, Marty C, Zehnder-Fjallman AH, Ballmer-Hofer K, Schwendener RA: Clodronate-liposome-mediated depletion of tumour-associated macrophages: a new and highly effective antiangiogenic therapy approach. Br. J. Cancer 95(3), 272-281 (2006). (Pubitemid 44187587)
    • (2006) British Journal of Cancer , vol.95 , Issue.3 , pp. 272-281
    • Zeisberger, S.M.1    Odermatt, B.2    Marty, C.3    Zehnder-Fjallman, A.H.M.4    Ballmer-Hofer, K.5    Schwendener, R.A.6
  • 84
    • 33644555196 scopus 로고    scopus 로고
    • Integrin a4b1 promotes monocyte trafficking and angiogenesis in tumors
    • Jin H, Su J, Garmy-Susini B, Kleeman J, Varner J: Integrin a4b1 promotes monocyte trafficking and angiogenesis in tumors. Cancer Res. 66(4), 2146-2152 (2006).
    • (2006) Cancer Res , vol.66 , Issue.4 , pp. 2146-2152
    • Jin, H.1    Su, J.2    Garmy-Susini, B.3    Kleeman, J.4    Varner, J.5
  • 85
    • 0030498694 scopus 로고    scopus 로고
    • How the extracellular matrix and macrophages contribute to angiogenesis-dependent diseases
    • Polverini PJ: How the extracellular matrix and macrophages contribute to angiogenesis-dependent diseases. Eur. J. Cancer 32A(14), 2430-2437 (1996).
    • (1996) Eur. J. Cancer , vol.32 , Issue.14 , pp. 2430-2437
    • Polverini, P.J.1
  • 88
    • 4944239035 scopus 로고    scopus 로고
    • An amino-bisphosphonate targets MMP-9 - Expressing macrophages and angiogenesis to impair cervical carcinogenesis
    • DOI 10.1172/JCI200422087
    • Giraudo E, Inoue M, Hanahan D: An amino-bisphosphonate targets MMP-9- expressing macrophages and angiogenesis to impair cervical carcinogenesis. J. Clin. Invest. 114(5), 623-633 (2004). (Pubitemid 39578752)
    • (2004) Journal of Clinical Investigation , vol.114 , Issue.5 , pp. 623-633
    • Giraudo, E.1    Inoue, M.2    Hanahan, D.3
  • 89
    • 2342430205 scopus 로고    scopus 로고
    • Secreted MMP9 promotes angiogenesis more efficiently than constitutive active MMP9 bound to the tumor cell surface
    • Mira E, Lacalle RA, Buesa JM, et al. Secreted MMP9 promotes angiogenesis more efficiently than constitutive active MMP9 bound to the tumor cell surface. J. Cell Sci. 117(Pt 9), 1847-1857 (2004).
    • (2004) J. Cell Sci , vol.117 , Issue.PART 9 , pp. 1847-1857
    • Mira, E.1    Lacalle, R.A.2    Buesa, J.M.3
  • 90
    • 0033780453 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomas
    • Lewis JS, Landers RJ, Underwood JC, Harris AL, Lewis CE: Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomas. J. Pathol. 192(2), 150-158 (2000).
    • (2000) J. Pathol , vol.192 , Issue.2 , pp. 150-158
    • Lewis, J.S.1    Landers, R.J.2    Underwood, J.C.3    Harris, A.L.4    Lewis, C.E.5
  • 91
    • 0033067163 scopus 로고    scopus 로고
    • Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast
    • DOI 10.1038/sj.bjc.6690158
    • Leek RD, Landers RJ, Harris AL, Lewis CE: Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast. Br. J. Cancer 79(5-6), 991-995 (1999). (Pubitemid 29082138)
    • (1999) British Journal of Cancer , vol.79 , Issue.5-6 , pp. 991-995
    • Leek, R.D.1    Landers, R.J.2    Harris, A.L.3    Lewis, C.E.4
  • 92
    • 0029816609 scopus 로고    scopus 로고
    • Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma
    • Leek RD, Lewis CE, Whitehouse R, Greenall M, Clarke J, Harris AL: Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Res. 56(20), 4625-4629 (1996). (Pubitemid 26338061)
    • (1996) Cancer Research , vol.56 , Issue.20 , pp. 4625-4629
    • Leek, R.D.1    Lewis, C.E.2    Whitehouse, R.3    Greenall, M.4    Clarke, J.5    Harris, A.L.6
  • 93
    • 84861186736 scopus 로고    scopus 로고
    • Jekyll and Hyde: The role of the microenvironment on the progression of cancer
    • Allen M, Louise Jones J: Jekyll and Hyde: the role of the microenvironment on the progression of cancer. J. Pathol. 223(2), 162-176 (2011).
    • (2011) J. Pathol , vol.223 , Issue.2 , pp. 162-176
    • Allen, M.1    Louise Jones, J.2
  • 95
    • 2542453735 scopus 로고    scopus 로고
    • The Tie-2 ligand Angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies
    • DOI 10.1182/blood-2003-10-3685
    • Fiedler U, Scharpfenecker M, Koidl S, et al. The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood 103(11), 4150-4156 (2004). (Pubitemid 38685356)
    • (2004) Blood , vol.103 , Issue.11 , pp. 4150-4156
    • Fiedler, U.1    Scharpfenecker, M.2    Koidl, S.3    Hegen, A.4    Grunow, V.5    Schmidt, J.M.6    Kriz, W.7    Thurston, G.8    Augustin, H.G.9
  • 96
    • 0038644403 scopus 로고    scopus 로고
    • Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells
    • DOI 10.1038/nm871
    • De Palma M, Venneri MA, Roca C, Naldini L: Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells. Nat. Med. 9(6), 789-795 (2003). (Pubitemid 36749231)
    • (2003) Nature Medicine , vol.9 , Issue.6 , pp. 789-795
    • De Palma, M.1    Venneri, M.A.2    Roca, C.3    Naldini, L.4
  • 98
    • 38049181485 scopus 로고    scopus 로고
    • Reversion of immune tolerance in advanced malignancy: Modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function
    • Pan PY, Wang GX, Yin B, et al. Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function. Blood 111(1), 219-228 (2008).
    • (2008) Blood , vol.111 , Issue.1 , pp. 219-228
    • Pan, P.Y.1    Wang, G.X.2    Yin, B.3
  • 99
    • 25144466458 scopus 로고    scopus 로고
    • + myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity
    • DOI 10.1158/1078-0432.CCR-05-0883
    • Suzuki E, Kapoor V, Jassar AS, Kaiser LR, Albelda SM: Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity. Clin. Cancer Res. 11(18), 6713-6721 (2005). (Pubitemid 41339014)
    • (2005) Clinical Cancer Research , vol.11 , Issue.18 , pp. 6713-6721
    • Suzuki, E.1    Kapoor, V.2    Jassar, A.S.3    Kaiser, L.R.4    Albelda, S.M.5
  • 100
  • 101
    • 0037071397 scopus 로고    scopus 로고
    • Transcriptional regulation of granulocyte and monocyte development
    • DOI 10.1038/sj.onc.1205324
    • Friedman AD: Transcriptional regulation of granulocyte and monocyte development. ncogene 21(21), 3377-3390 (2002). (Pubitemid 34587710)
    • (2002) Oncogene , vol.21 , Issue.21 REV. ISSUE 2 , pp. 3377-3390
    • Friedman, A.D.1
  • 102
    • 0033896471 scopus 로고    scopus 로고
    • Neutrophils, nitric oxide synthase, and mutations in the mutatect murine tumor model
    • Sandhu JK, Privora HF, Wenckebach G, Birnboim HC: Neutrophils, nitric oxide synthase, and mutations in the mutatect murine tumor model. Am. J. Pathol. 156(2), 509-518 (2000). (Pubitemid 30643806)
    • (2000) American Journal of Pathology , vol.156 , Issue.2 , pp. 509-518
    • Sandhu, J.K.1    Privora, H.F.2    Wenckebach, G.3    Birnboim, H.C.4
  • 103
    • 0016736754 scopus 로고
    • Neutrophil-mediated tumor cell cytotoxicity: Role of the peroxidase system
    • Clark RA, Klebanoff SJ: Neutrophil-mediated tumor cell cytotoxicity: role of the peroxidase system. J. Exp. Med. 141(6), 1442-1447 (1975).
    • (1975) J. Exp. Med , vol.141 , Issue.6 , pp. 1442-1447
    • Clark, R.A.1    Klebanoff, S.J.2
  • 104
    • 0033946338 scopus 로고    scopus 로고
    • Neutrophils infiltrating the endometrium express vascular endothelial growth factor: Potential role in endometrial angiogenesis
    • DOI 10.1016/S0015-0282(00)00555-0, PII S0015028200005550
    • Mueller MD, Lebovic DI, Garrett E, Taylor RN: Neutrophils infiltrating the endometrium express vascular endothelial growth factor: potential role in endometrial angiogenesis. Fertil. Steril. 74(1), 107-112 (2000). (Pubitemid 30427282)
    • (2000) Fertility and Sterility , vol.74 , Issue.1 , pp. 107-112
    • Mueller, M.D.1    Lebovic, D.I.2    Garrett, E.3    Taylor, R.N.4
  • 107
    • 0030293598 scopus 로고    scopus 로고
    • Matrix metalloproteinases and the development of cancer
    • Coussens LM, Werb Z: Matrix metalloproteinases and the development of cancer. Chem. Biol. 3(11), 895-904 (1996). (Pubitemid 27017088)
    • (1996) Chemistry and Biology , vol.3 , Issue.11 , pp. 895-904
    • Coussens, L.M.1    Werb, Z.2
  • 108
    • 38049177345 scopus 로고    scopus 로고
    • Human neutrophils uniquely release TIMP-free MMP-9 to provide a potent catalytic stimulator of angiogenesis
    • Ardi VC, Kupriyanova TA, Deryugina EI, Quigley JP: Human neutrophils uniquely release TIMP-free MMP-9 to provide a potent catalytic stimulator of angiogenesis. Proc. Natl Acad. Sci. USA 104(51), 20262-20267 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , Issue.51 , pp. 20262-20267
    • Ardi, V.C.1    Kupriyanova, T.A.2    Deryugina, E.I.3    Quigley, J.P.4
  • 109
    • 0344146580 scopus 로고    scopus 로고
    • Proinflammatory mediators stimulate neutrophil-directed angiogenesis
    • discussion 1331-1322
    • McCourt M, Wang JH, Sookhai S, Redmond HP: Proinflammatory mediators stimulate neutrophil-directed angiogenesis. Arch. Surg. 134(12), 1325-1331; discussion 1331-1322 (1999).
    • (1999) Arch. Surg , vol.134 , Issue.12 , pp. 1325-1331
    • McCourt, M.1    Wang, J.H.2    Sookhai, S.3    Redmond, H.P.4
  • 110
    • 0033067441 scopus 로고    scopus 로고
    • Neutrophil-derived proteins: Selling cytokines by the pound
    • Cassatella MA: Neutrophil-derived proteins: selling cytokines by the pound. Adv. Immunol. 73, 369-509 (1999). (Pubitemid 29300434)
    • (1999) Advances in Immunology , vol.73 , pp. 369-509
    • Cassatella, M.A.1
  • 112
    • 0027453990 scopus 로고
    • Neutrophils roll on E-selectin
    • Lawrence MB, Springer TA: Neutrophils roll on E-selectin. J. Immunol. 151(11), 6338-6346 (1993). (Pubitemid 23340380)
    • (1993) Journal of Immunology , vol.151 , Issue.11 , pp. 6338-6346
    • Lawrence, M.B.1    Springer, T.A.2
  • 113
    • 41649116240 scopus 로고    scopus 로고
    • Plasticity in tumor-promoting inflammation: Impairment of macrophage recruitment evokes a compensatory neutrophil response
    • Pahler JC, Tazzyman S, Erez N, et al. Plasticity in tumor-promoting inflammation: impairment of macrophage recruitment evokes a compensatory neutrophil response. Neoplasia 10(4), 329-340 (2008).
    • (2008) Neoplasia , vol.10 , Issue.4 , pp. 329-340
    • Pahler, J.C.1    Tazzyman, S.2    Erez, N.3
  • 114
    • 0027398032 scopus 로고
    • Evidence that granulocyte macrophage-colony-stimulating factor regulates the distribution and differentiated state of dendritic cells/Langerhans cells in human lung and lung cancers
    • Tazi A, Bouchonnet F, Grandsaigne M, Boumsell L, Hance AJ, Soler P: Evidence that granulocyte macrophage-colony-stimulating factor regulates the distribution and differentiated state of dendritic cells/Langerhans cells in human lung and lung cancers. J. Clin. Invest. 91(2), 566-576 (1993). (Pubitemid 23064142)
    • (1993) Journal of Clinical Investigation , vol.91 , Issue.2 , pp. 566-576
    • Tazi, A.1    Bouchonnet, F.2    Grandsaigne, M.3    Boumsell, L.4    Hance, A.J.5    Soler, P.6
  • 115
    • 0036846118 scopus 로고    scopus 로고
    • Tumor infiltrating lymphocytes and macrophages have a potential dual role in lung cancer by supporting both host-defense and tumor progression
    • DOI 10.1067/mlc.2002.128317
    • Kataki A, Scheid P, Piet M, et al. Tumor infiltrating lymphocytes and macrophages have a potential dual role in lung cancer by supporting both host-defense and tumor progression. J. Lab. Clin. Med. 140(5), 320-328 (2002). (Pubitemid 35302024)
    • (2002) Journal of Laboratory and Clinical Medicine , vol.140 , Issue.5 , pp. 320-328
    • Kataki, A.1    Scheid, P.2    Piet, M.3    Marie, B.4    Martinet, N.5    Martinet, Y.6    Vignaud, J.-M.7
  • 116
    • 1642348866 scopus 로고    scopus 로고
    • Angiogenesis-inflammation cross-talk: Vascular endothelial growth factor is secreted by activated T cells and induces Th1 polarization
    • Mor F, Quintana FJ, Cohen IR: Angiogenesis-inflammation cross-talk: vascular endothelial growth factor is secreted by activated T cells and induces Th1 polarization. J. Immunol. 172(7), 4618-4623 (2004). (Pubitemid 38375280)
    • (2004) Journal of Immunology , vol.172 , Issue.7 , pp. 4618-4623
    • Mor, F.1    Quintana, F.J.2    Cohen, I.R.3
  • 118
    • 33344468704 scopus 로고    scopus 로고
    • Pericytes and vascular stability
    • DOI 10.1016/j.yexcr.2005.10.019, PII S0014482705004866
    • von Tell D, Armulik A, Betsholtz C: Pericytes and vascular stability. Exp. Cell Res. 312(5), 623-629 (2006). (Pubitemid 43290338)
    • (2006) Experimental Cell Research , vol.312 , Issue.5 , pp. 623-629
    • Von Tell, D.1    Armulik, A.2    Betsholtz, C.3
  • 120
    • 0032952010 scopus 로고    scopus 로고
    • Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
    • Benjamin LE, Golijanin D, Itin A, Pode D, Keshet E: Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J. Clin. Invest. 103(2), 159-165 (1999). (Pubitemid 29053133)
    • (1999) Journal of Clinical Investigation , vol.103 , Issue.2 , pp. 159-165
    • Benjamin, L.E.1    Golijanin, D.2    Itin, A.3    Pode, D.4    Keshet, E.5
  • 122
    • 1442290142 scopus 로고    scopus 로고
    • Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms
    • Erber R, Thurnher A, Katsen AD, et al. Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms. FASEB J. 18(2), 338-340 (2004).
    • (2004) FASEB J , vol.18 , Issue.2 , pp. 338-340
    • Erber, R.1    Thurnher, A.2    Katsen, A.D.3
  • 123
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • DOI 10.1172/JCI200317929
    • Bergers G, Song S, Meyer-Morse N, Bergsland E, Hanahan D: Benefits of targeting both pericytes and endothelial cells in the tu-or vasculature with kinase inhibitors. J. Clin. Invest. 111(9), 1287-1295 (2003). (Pubitemid 36554699)
    • (2003) Journal of Clinical Investigation , vol.111 , Issue.9 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3    Bergsland, E.4    Hanahan, D.5
  • 124
    • 2542628099 scopus 로고    scopus 로고
    • Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
    • DOI 10.1158/0008-5472.CAN-04-0074
    • Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK: Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res. 64(11), 3731-3736 (2004). (Pubitemid 38697278)
    • (2004) Cancer Research , vol.64 , Issue.11 , pp. 3731-3736
    • Tong, R.T.1    Boucher, Y.2    Kozin, S.V.3    Winkler, F.4    Hicklin, D.J.5    Jain, R.K.6
  • 125
    • 12444253931 scopus 로고    scopus 로고
    • Pathological angiogenesis is reduced by targeting pericytes via the NG2 proteoglycan
    • Ozerdem U, Stallcup WB: Pathological angiogenesis is reduced by targeting pericytes via the NG2 proteoglycan. Angiogenesis 7(3), 269-276 (2004).
    • (2004) Angiogenesis , vol.7 , Issue.3 , pp. 269-276
    • Ozerdem, U.1    Stallcup, W.B.2
  • 127
    • 0036329807 scopus 로고    scopus 로고
    • New insights into the role of extracellular matrix during tumor onset and progression
    • DOI 10.1002/jcp.10142
    • Pupa SM, Menard S, Forti S, Tagliabue E: New insights into the role of extracellular matrix during tumor onset and progression. J. Cell Physiol. 192(3), 259-267 (2002). (Pubitemid 34827603)
    • (2002) Journal of Cellular Physiology , vol.192 , Issue.3 , pp. 259-267
    • Pupa, S.M.1    Menard, S.2    Forti, S.3    Tagliabue, E.4
  • 128
    • 0030715322 scopus 로고    scopus 로고
    • ECM and cell surface proteolysis: Regulating cellular ecology
    • Werb Z: ECM and cell surface proteolysis: regulating cellular ecology. Cell 91(4), 439-442 (1997). (Pubitemid 27508232)
    • (1997) Cell , vol.91 , Issue.4 , pp. 439-442
    • Werb, Z.1
  • 129
    • 0035902141 scopus 로고    scopus 로고
    • The microenvironment of the tumour-host interface
    • Liotta LA, Kohn EC: The microenvironment of the tumour-host interface. Nature 411(6835), 375-379 (2001).
    • (2001) Nature , vol.411 , Issue.6835 , pp. 375-379
    • Liotta, L.A.1    Kohn, E.C.2
  • 130
    • 20444453976 scopus 로고    scopus 로고
    • Epidemiological modelling of routine use of low dose aspirin for the primary prevention of coronary heart disease and stroke in those aged > or =70
    • Nelson MR, Liew D, Bertram M, Vos T: Epidemiological modelling of routine use of low dose aspirin for the primary prevention of coronary heart disease and stroke in those aged > or =70. BMJ 330(7503), 1306 (2005).
    • (2005) BMJ , vol.330 , Issue.7503 , pp. 1306
    • Nelson, M.R.1    Liew, D.2    Bertram, M.3    Vos, T.4
  • 132
    • 0028131531 scopus 로고
    • Distribution of oncofetal fibronectin isoforms in normal, hyperplastic and neoplastic human breast tissues
    • DOI 10.1002/ijc.2910590104
    • Kaczmarek J, Castellani P, Nicolo G, Spina B, Allemanni G, Zardi L: Distribution of oncofetal fibronectin isoforms in normal, hyperplastic and neoplastic human breast tissues. Int. J. Cancer 59(1), 11-16 (1994). (Pubitemid 24310940)
    • (1994) International Journal of Cancer , vol.59 , Issue.1 , pp. 11-16
    • Kaczmarek, J.1    Castellani, P.2    Nicolo, G.3    Spina, B.4    Allemanni, G.5    Zardi, L.6
  • 134
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - A key regulatory factor in tumour growth
    • Harris AL: Hypoxia - a key regulatory factor in tumour growth. Nat. Rev. Cancer 2(1), 38-47 (2002). (Pubitemid 37328806)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.1 , pp. 38-47
    • Harris, A.L.1
  • 135
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1a in common human cancers and their metastases
    • Zhong H, De Marzo AM, Laughner E, et al. Overexpression of hypoxia-inducible factor 1a in common human cancers and their metastases. Cancer Res. 59(22), 5830-5835 (1999).
    • (1999) Cancer Res , vol.59 , Issue.22 , pp. 5830-5835
    • Zhong, H.1    De Marzo, A.M.2    Laughner, E.3
  • 136
    • 33646153307 scopus 로고    scopus 로고
    • Hypoxia stimulates breast carcinoma cell invasion through MT1-MMP and MMP-2 activation
    • Munoz-Najar UM, Neurath KM, Vumbaca F, Claffey KP: Hypoxia stimulates breast carcinoma cell invasion through MT1-MMP and MMP-2 activation. Oncogene 25(16), 2379-2392 (2006).
    • (2006) Oncogene , vol.25 , Issue.16 , pp. 2379-2392
    • Munoz-Najar, U.M.1    Neurath, K.M.2    Vumbaca, F.3    Claffey, K.P.4
  • 137
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL: Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 3(10), 721-732 (2003). (Pubitemid 37328811)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.10 , pp. 721-732
    • Semenza, G.L.1
  • 139
    • 0035071662 scopus 로고    scopus 로고
    • The effects of extracellular pH on immune function
    • Lardner A: The effects of extracellular pH on immune function. J. Leukoc. Biol. 69(4), 522-530 (2001). (Pubitemid 32294836)
    • (2001) Journal of Leukocyte Biology , vol.69 , Issue.4 , pp. 522-530
    • Lardner, A.1
  • 141
    • 34249791475 scopus 로고    scopus 로고
    • Expression of Tie-2 by human monocytes and their responses to angiopoietin-2
    • Murdoch C, Tazzyman S, Webster S, Lewis CE: Expression of Tie-2 by human monocytes and their responses to angiopoietin-2. J. Immunol. 178(11), 7405-7411 (2007). (Pubitemid 46847468)
    • (2007) Journal of Immunology , vol.178 , Issue.11 , pp. 7405-7411
    • Murdoch, C.1    Tazzyman, S.2    Webster, S.3    Lewis, C.E.4
  • 142
    • 0027026622 scopus 로고
    • Tumour necrosis factor and cancer
    • Balkwill FR: Tumour necrosis factor and cancer. Prog. Growth Factor Res. 4(2), 121-137 (1992).
    • (1992) Prog. Growth Factor Res , vol.4 , Issue.2 , pp. 121-137
    • Balkwill, F.R.1
  • 143
    • 68349133231 scopus 로고    scopus 로고
    • Hypoxic tumor microenvironment and cancer cell differentiation
    • Kim Y, Lin Q, Glazer PM, Yun Z: Hypoxic tumor microenvironment and cancer cell differentiation. Curr. Mol. Med. 9(4), 425-434 (2009).
    • (2009) Curr. Mol. Med , vol.9 , Issue.4 , pp. 425-434
    • Kim, Y.1    Lin, Q.2    Glazer, P.M.3    Yun, Z.4
  • 144
    • 58149334773 scopus 로고    scopus 로고
    • A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer
    • Farmer P, Bonnefoi H, Anderle P, et al. A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer. Nat. Med. 15(1), 68-74 (2009).
    • (2009) Nat. Med , vol.15 , Issue.1 , pp. 68-74
    • Farmer, P.1    Bonnefoi, H.2    Anderle, P.3
  • 145
    • 8444250723 scopus 로고    scopus 로고
    • Tumour-stroma interaction: Cancer-associated fibroblasts as novel targets in anti-cancer therapy?
    • DOI 10.1016/j.lungcan.2004.07.977, PII S0169500204800230, Trends in Diagnostic and Therapy of Lung Cancer
    • Micke P, Ostman A: Tumour-stroma interaction: cancer-associated fibroblasts as novel targets in anti-cancer therapy? Lung Cancer 45(Suppl. 2), S163-S175 (2004). (Pubitemid 39488186)
    • (2004) Lung Cancer , vol.45 , Issue.SUPPL. 2
    • Micke, P.1    Ostman, A.2
  • 146
    • 20444412646 scopus 로고    scopus 로고
    • Therapeutic targeting of the tumor microenvironment
    • DOI 10.1016/j.ccr.2005.05.024, PII S1535610805001650
    • Joyce JA: Therapeutic targeting of the tumor microenvironment. Cancer Cell 7(6), 513-520 (2005). (Pubitemid 40799245)
    • (2005) Cancer Cell , vol.7 , Issue.6 , pp. 513-520
    • Joyce, J.A.1
  • 147
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • DOI 10.1126/science.1104819
    • Jain RK: Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307(5706), 58-62 (2005). (Pubitemid 40093472)
    • (2005) Science , vol.307 , Issue.5706 , pp. 58-62
    • Jain, R.K.1
  • 148
    • 3042548695 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of en-othelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts
    • Inai T, Mancuso M, Hashizume H, et al. Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of en-othelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. Am. J. Pathol. 165(1), 35-52 (2004).
    • (2004) Am. J. Pathol , vol.165 , Issue.1 , pp. 35-52
    • Inai, T.1    Mancuso, M.2    Hashizume, H.3
  • 149
    • 12344312042 scopus 로고    scopus 로고
    • Cellular abnormalities of blood vessels as targets in cancer
    • DOI 10.1016/j.gde.2004.12.005, PII S0959437X04001911, Oncogenes and Cell Proliferation
    • Baluk P, Hashizume H, McDonald DM: Cellular abnormalities of blood vessels as targets in cancer. Curr. Opin. Genet. Dev. 15(1), 102-111 (2005). (Pubitemid 40127638)
    • (2005) Current Opinion in Genetics and Development , vol.15 , Issue.1 , pp. 102-111
    • Baluk, P.1    Hashizume, H.2    McDonald, D.M.3
  • 150
    • 0038443099 scopus 로고    scopus 로고
    • Anti-angiogenic therapy: Rationale, challenges and clinical studies
    • DOI 10.1023/A:1024532022166
    • Longo R, Sarmiento R, Fanelli M, Capaccetti B, Gattuso D, Gasparini G: Anti-angiogenic therapy: rationale, challenges and clinical studies. Angiogenesis 5(4), 237-256 (2002). (Pubitemid 36875123)
    • (2002) Angiogenesis , vol.5 , Issue.4 , pp. 237-256
    • Longo, R.1    Sarmiento, R.2    Fanelli, M.3    Capaccetti, B.4    Gattuso, D.5    Gasparini, G.6
  • 151
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • DOI 10.1056/NEJMra0706596
    • Kerbel RS: Tumor angiogenesis. N. Engl. J. Med. 358(19), 2039-2049 (2008). (Pubitemid 351656458)
    • (2008) New England Journal of Medicine , vol.358 , Issue.19 , pp. 2039-2049
    • Kerbel, R.S.1
  • 152
    • 58149190795 scopus 로고    scopus 로고
    • Pathways mediating resistance to vascular endothelial growth factor-targeted therapy
    • Ellis LM, Hicklin DJ: Pathways mediating resistance to vascular endothelial growth factor-targeted therapy. Clin. Cancer Res. 14(20), 6371-6375 (2008).
    • (2008) Clin. Cancer Res , vol.14 , Issue.20 , pp. 6371-6375
    • Ellis, L.M.1    Hicklin, D.J.2
  • 154
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K, Wang M, Gralow J, et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N. Engl. J. Med. 357(26), 2666-2676 (2007).
    • (2007) N. Engl. J. Med , vol.357 , Issue.26 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3
  • 156
    • 33846188062 scopus 로고    scopus 로고
    • Direct targeting of avb3 integrin on tumor cells with a monoclonal antibody
    • Mulgrew K, Kinneer K, Yao XT, et al. Direct targeting of avb3 integrin on tumor cells with a monoclonal antibody, Abegrin. Mol. Cancer Ther. 5(12), 3122-3129 (2006).
    • (2006) Abegrin. Mol. Cancer Ther , vol.5 , Issue.12 , pp. 3122-3129
    • Mulgrew, K.1    Kinneer, K.2    Yao, X.T.3
  • 162
    • 61549118154 scopus 로고    scopus 로고
    • Aspirin and NSAIDs for the prevention of colorectal cancer
    • Baron JA: Aspirin and NSAIDs for the prevention of colorectal cancer. Recent Results Cancer Res. 181, 223-229 (2009).
    • (2009) Recent Results Cancer Res , vol.181 , pp. 223-229
    • Baron, J.A.1
  • 163
    • 77950243302 scopus 로고    scopus 로고
    • A Phase II pilot trial of low-dose, continuous infusion, or metronomic paclitaxel and oral celecoxib in patients with metastatic melanoma
    • Bhatt RS, Merchan J, Parker R, et al. A Phase II pilot trial of low-dose, continuous infusion, or ?metronomic? paclitaxel and oral celecoxib in patients with metastatic melanoma. Cancer 116(7), 1751-1756 (2010).
    • (2010) Cancer , vol.116 , Issue.7 , pp. 1751-1756
    • Bhatt, R.S.1    Merchan, J.2    Parker, R.3
  • 164
    • 77950006166 scopus 로고    scopus 로고
    • Phase II trial of gemcitabine, irinotecan, and celecoxib in patients with advanced pancreatic cancer
    • Lipton A, Campbell-Baird C, Witters L, Harvey H, Ali S: Phase II trial of gemcitabine, irinotecan, and celecoxib in patients with advanced pancreatic cancer. J. Clin. Gastroenterol. 44(4), 286-288 (2010).
    • (2010) J. Clin. Gastroenterol , vol.44 , Issue.4 , pp. 286-288
    • Lipton, A.1    Campbell-Baird, C.2    Witters, L.3    Harvey, H.4    Ali, S.5
  • 165
    • 33847666928 scopus 로고    scopus 로고
    • Antiangiogenesis to treat cancer and intraocular neovascular disorders
    • DOI 10.1038/labinvest.3700526, PII 3700526
    • Shojaei F, Ferrara N: Antiangiogenesis to treat cancer and intraocular neovascular disorders. Lab. Invest. 87(3), 227-230 (2007). (Pubitemid 46353946)
    • (2007) Laboratory Investigation , vol.87 , Issue.3 , pp. 227-230
    • Shojaei, F.1    Ferrara, N.2
  • 167
    • 56749107194 scopus 로고    scopus 로고
    • The tumor microenvironment and its contribution to tumor evolution toward metastasis
    • Lorusso G, Ruegg C: The tumor microenvironment and its contribution to tumor evolution toward metastasis. Histochem. Cell Biol. 130(6), 1091-1103 (2008).
    • (2008) Histochem. Cell Biol , vol.130 , Issue.6 , pp. 1091-1103
    • Lorusso, G.1    Ruegg, C.2


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