Angiogenesis-Inflammation Cross-Talk: Vascular Endothelial Growth Factor Is Secreted by Activated T Cells and Induces Th1 Polarization

Journal of Immunology

Volumn 172, Issue 7, 2004, Pages 4618-4623

  Mor, Felix ^a,b,c   Quintana, Francisco J ^a   Cohen, Irun R ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b RABIN MEDICAL CENTER   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; MITOGENIC AGENT; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

ANGIOGENESIS; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL POLARITY; CONTROLLED STUDY; CYTOKINE RELEASE; ENCEPHALOMYELITIS; ENDOTHELIUM CELL; FEMALE; HYPOXIA; INFLAMMATION; LYMPHOCYTE DIFFERENTIATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; T LYMPHOCYTE; TH1 CELL;

EID: 1642348866     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.7.4618     Document Type: Article

References (52)

1. Folkman, J. 1992. The role of angiogenesis in tumor growth. Semin. Cancer Biol. 3:65.
2. Pe'er, J., R. Folberg, A. Itin, H. Gnessin, I. Hemo, and E. Keshet. 1996. Upregulated expression of vascular endothelial growth factor in proliferative diabetic retinopathy. Br. J. Ophthalmol. 80:241.
3. Isner, J. M. 2002. Myocardial gene therapy. Nature 415:234.
4. Isner, J. M. 1999. Manipulating angiogenesis against vascular disease. Hosp. Pract. (Off. Ed.). 34:69.
5. Hau, M., C. Kneitz, H. P. Tony, M. Keberle, R. Jahns, and M. Jenett. 2002. High resolution ultrasound detects a decrease in pannus vascularisation of small finger joints in patients with rheumatoid arthritis receiving treatment with soluble tumour necrosis factor a receptor (etanercept). Ann. Rheum. Dis. 61:55.
6. Afuwape, A. O., S. Kiriakidis, and E. M. Paleolog. 2002. The role of the angiogenic molecule VEGF in the pathogenesis of rheumatoid arthritis. Histol. Histopathol. 17:961.
7. Kasama, T., F. Shiozawa, K. Kobayashi, N. Yajima, M. Hanyuda, H. T. Takeuchi, Y. Mori, M. Negishi, H. Ide, and M. Adachi. 2001. Vascular endothelial growth factor expression by activated synovial leukocytes in rheumatoid arthritis: critical involvement of the interaction with synovial fibroblasts. Arthritis Rheum. 44:2512.
8. Ferrara, N., and T. Davis-Smyth. 1997. The biology of vascular endothelial growth factor. Endocr. Rev. 18:4.
9. Connolly, D. T. 1991. Vascular permeability factor: a unique regulator of blood vessel function. J. Cell. Biochem. 47:219.
10. Wellmann, S., T. Taube, K. Paal, V. E. H. Graf, W. Geilen, G. Seifert, C. Eckert, G. Henze, and K. Seeger. 2001. Specific reverse transcription-PCR quantification of vascular endothelial growth factor (VEGF) splice variants by LightCycler technology. Clin. Chem. 47:654.
11. Freeman, M. R., F. X. Schneck, M. L. Gagnon, C. Corless, S. Soker, K. Niknejad, G. E. Peoples, and M. Klagsbrun. 1995. Peripheral blood T lymphocytes and lymphocytes infiltrating human cancers express vascular endothelial growth factor: a potential role for T cells in angiogenesis. Cancer Res. 55:4140.
12. Gunsilius, E., A. Petzer, G. Stockhammer, W. Nussbaumer, P. Schumacher, J. Clausen, and G. Gastl. 2000. Thrombocytes are the major source for soluble vascular endothelial growth factor in peripheral blood. Oncology 58:169.
13. Anderton, S. M., and D. C. Wraith. 2002. Selection and fine-tuning of the autoimmune T-cell repertoire. Nat. Rev. Immunol. 2:487.
14. Glimcher, L. H., and K. M. Murphy. 2000. Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes Dev. 14:1693.
15. Yellin, M. J., J. Brett, D. Baum, A. Matsushima, M. Szabolcs, D. Stem, and L. Chess. 1995. Functional interactions of T cells with endothelial cells: the role of CD40L-CD40-mediated signals. J. Exp. Med. 182:1857.
16. Luttun, A., M. Tjwa, L. Moons, Y. Wu, A. Angelillo-Scherrer, F. Liao, J. A. Nagy, A. Hooper, J. Priller, et al. 2002. Revascularization of ischemic tissues by P1GF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat. Med. 8:831.
17. Mor, F., and I. R. Cohen. 1993. Shifts in the epitopes of myelin basic protein recognized by Lewis rat T cells before, during, and after the induction of experimental autoimmune encephalomyelitis. J. Clin. Invest. 92:2199.
18. Mor, F., and I. R. Cohen. 1996. IL-2 rescues antigen-specific T cells from radiation or dexamethasone-induced apoptosis: correlation with induction of Bcl-2. J. Immunol. 156:515.
19. Mor, F., F. Quintana, A. Mimran, and I. R. Cohen. 2003. Autoimmune encephalomyelitis and uveitis induced by T cell immunity to self β-synuclein. J. Immunol. 170:628.
20. Holoshitz, J., A. Matitiau, and I. R. Cohen. 1984. Arthritis induced in rats by cloned T lymphocytes responsive to mycobacteria but not to collagen type II. J. Clin. Invest. 73:211.
21. Taams, L. S., W. van Eden, and M. H. Wauben. 1999. Antigen presentation by T cells versus professional antigen-presenting cells (APC): differential consequences for T cell activation and subsequent T cell-APC interactions. Eur. J. Immunol. 29:1543.
22. Mor, F., B. Reizis, I. R. Cohen, and L. Steinman. 1996. IL-2 and TNF receptors as targets of regulatory T-T interactions: isolation and characterization of cytokine receptor-reactive T cell lines in the Lewis rat. J. Immunol. 157:4855.
23. Mor, F., A. Weinberger, and I. R. Cohen. 2002. Identification of α-tropomyosin as a target self-antigen in Behçet's syndrome. Eur. J. Immunol. 32:356.
24. Ng, C. E., C. J. Koch, and W. R. Inch. 1980. Buoyant density of EMT6 fibrosarcoma cells: time course of the density changes after growth in hypoxia. Cell Biophys. 2:153.
25. Guedez, L., A. M. Rivera, R. Salloum, M. L. Miller, J. J. Diegmueller, P. M. Bungay, and W. G. Stelter-Stevenson. 2003. Quantitative assessment of angiogenic responses by the directed in vivo angiogenesis assay. Am. J. Pathol. 162:1431.
26. Cohen, A. W., J. M. Carbajal, and R. C. Schaeffer, Jr. 1999. VEGF stimulates tyrosine phosphorylation of β-catenin and small-pore endothelial barrier dysfunction. Am. J. Physiol. 277:H2038.
27. Deodato, B., N. Arsic, L. Zentilin, M. Galeano, D. Santoro, V. Torre, D. Altavilla, D. Valdembri, F. Bussolino, F. Squadrito, and M. Giacca. 2002. Recombinant AAV vector encoding human VEGF165 enhances wound healing. Gene Ther. 9:777.
28. Zhu, W. H., A. MacIntyre, and R. F. Nicosia. 2002. Regulation of angiogenesis by vascular endothelial growth factor and angiopoietin-1 in the rat aorta model: distinct temporal patterns of intracellular signaling correlate with induction of angiogenic sprouting. Am. J. Pathol. 161:823.
29. Burchardt, T., M. Burchardt, M. W. Chen, R. Buttyan, A. de la Taille, A. Shabsigh, and R. Shabsigh. 1999. Expression of VEGF splice variants 144/145 and 205/206 in adult male tissues. IUBMB Life 48:405.
30. Mor, F., and I. R. Cohen. 2002. Propagation of Lewis rat encephalitogenic T cell lines: T-cell-growth factor is superior to recombinant IL-2. J. Neuroimmunol. 123:76.
31. Shweiki, D., A. Itin, D. Soffer, and E. Keshet. 1992. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359:843.
32. Gerber, H. P., A. McMurtrey, J. Kowalski, M. Yan, B. A. Keyt, V. Dixit, and N. Ferrara. 1998. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway: requirement for Flk-1/KDR activation. J. Biol. Chem. 273:30336.
33. Quintana, F. J., P. Carmi, F. Mor, and I. R. Cohen. 2002. Inhibition of adjuvant arthritis by a DNA vaccine encoding human heat shock protein 60. J. Immunol. 169:3422.
34. LaSalle, J. M., F. Toneguzzo, M. Saadeh, D. E. Golan, R. Taber, and D. A. Hafler. 1993. T-cell presentation of antigen requires cell-to-cell contact for proliferation and anergy induction. Differential MHC requirements for superantigen and autoantigen. J. Immunol. 151:649.
35. Waisman, A., P. J. Ruiz, D. L. Hirschberg, A. Gelman, J. R. Oksenberg, S. Brocke, F. Mor, I. R. Cohen, and L. Steinman. 1996. Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity. Nat. Med. 2:899.
36. Iijima, K., N. Yoshikawa, and H. Nakamura. 1996. Activation-induced expression of vascular permeability factor by human peripheral T cells: a nonradioisotopic semiquantitative reverse transcription-polymerase chain reaction assay. J. Immunol. Methods 196:199.
37. Chen, H., A. T. Treweeke, D. C. West, K. J. Till, J. C. Cawley, M. Zuzel, and C. H. Toh. 2000. In vitro and in vivo production of vascular endothelial growth factor by chronic lymphocytic leukemia cells. Blood 96:3181.
38. Ascherl, G., C. Hohenadl, O. Schatz, E. Shumay, J. Bogner, L. Eckhart, E. Tschachler, P. Monini, B. Ensoli, and M. Sturzl. 1999. Infection with human immunodeficiency virus-1 increases expression of vascular endothelial cell growth factor in T cells: implications for acquired immunodeficiency syndrome-associated vasculopathy. Blood 93:4232.
39. El-Sabban, M. E., R. A. Merhi, H. A. Haidar, B. Amulf, H. Khoury, J. Basbous, J. Nijmeh, H. de The, O. Hermine, and A. Bazarbachi. 2002. Human T-cell lymphotropic virus type 1-transformed cells induce angiogenesis and establish functional gap junctions with endothelial cells. Blood 99:3383.
40. + T cells. Proc. Natl. Acad. Sci. USA 91:2890.
41. Vinores, S. A., C. C. Chan, M. A. Vinores, D. M. Matteson, Y. S. Chen, D. A. Klein, A. Shi, H. Ozaki, and P. A. Campochiaro. 1998. Increased vascular endothelial growth factor (VEGF) and transforming growth factor β (TGFβ) in experimental autoimmune uveorefinitis: upregulation of VEGF without neovascularization. J. Neuroimmunol. 89:43.
42. Steinman, L. 1996. A few autoreactive cells in an autoimmune infiltrate control a vast population of nonspecific cells: a tale of smart bombs and the infantry. Proc. Natl. Acad. Sci. USA 93:2253.
43. Flugel, A., T. Berkowicz, T. Ritter, M. Labeur, D. E. Jenne, Z. Li, J. W. Ellwart, M. Willem, H. Lassmann, and H. Wekerle. 2001. Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis. Immunity 14:547.
44. Campbell, I. K., K. O'Donnell, K. E. Lawlor, and I. P. Wicks. 2001. Severe inflammatory arthritis and lymphadenopathy in the absence of TNF. J. Clin. Invest. 107:1519.
45. Moalem, G., A. Gdalyahu, Y. Shani, U. Otten, P. Lazarovici, I. R. Cohen, and M. Schwartz. 2000. Production of neurotrophins by activated T cells: implications for neuroprotective autoimmunity. J. Autoimmun. 15:331.
46. Schwartz, M., and I. R. Cohen. 2000. Autoimmunity can benefit self-maintenance. Immunol. Today 21:265.
47. Florey, H. 1970. General Pathology. Lloyd-Luke Medical Books, London.
48. Cohen, I. R. 2000. Discrimination and dialogue in the immune system. Semin. Immunol. 12:215.
49. Cohen, I. R. 2000. Tending Adam's Garden: Evolving the Cognitive Immune Self Academic Press, London.
50. Blankesteijn, W. M., M. E. van Gijn, Y. P. Essers-Janssen, M. J. Daemen, and J. F. Smits. 2000. β-catenin, an inducer of uncontrolled cell proliferation and migration in malignancies, is localized in the cytoplasm of vascular endothelium during neovascularization after myocardial infarction. Am. J. Pathol. 157:877.
51. Wikstrom, P., I. F. Lissbrant, P. Stattin, L. Egevad, and A. Bergh. 2002. Endoglin (CD105) is expressed on immature blood vessels and is a marker for survival in prostate cancer. Prostate 51:268.
52. Sukbuntherng, J., G. Cropp, A. Hannah, G. S. Wagner, L. K. Shawver, and L. Antonian. 2001. Pharmacokinetics and interspecies scaling of a novel VEGF receptor inhibitor, SU5416. J. Pharm. Pharmacol. 53:1629.