Vascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophages

Molecular Oncology

Volumn 1, Issue 3, 2007, Pages 288-302

  Lin, Elaine Y ^b   Li, Jiu feng ^a   Bricard, Gabriel ^b   Wang, Weigang ^b   Deng, Yan ^b   Sellers, Rani ^b   Porcelli, Steven A ^b   Pollard, Jeffrey W ^a  

^a ALBERT EINSTEIN CANCER CENTER   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Angiogenesis; Macrophages; Malignancy; Mammary; Mouse; Progression; PyMT; Transgenic; Tumor; Vascular endothelial growth factor

Indexed keywords

VASCULOTROPIN A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER GROWTH; CANCER INFILTRATION; CANCER INVASION; CANCER STAGING; CARCINOGENESIS; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; GENETIC ANALYSIS; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION;

MUS;

EID: 36549025804     PISSN: 15747891     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molonc.2007.10.003     Document Type: Article

References (40)

1. Barleon B., Sozzani S., Zhou D., Weich H.A., Mantovani A., and Marme D. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood 87 (1996) 3336-3343
2. Cho C.H., Koh Y.J., Han J., Sung H.K., Jong Lee H., Morisada T., Schwendener R.A., Brekken R.A., Kang G., Oike Y., Choi T.S., Suda T., Yoo O.J., and Koh G.Y. Angiogenic role of LYVE-1-positive macrophages in adipose tissue. Circ. Res. 100 (2007) e47-e57
3. Dong J., Grunstein J., Tejada M., Peale F., Frantz G., Liang W.C., Bai W., Yu L., Kowalski J., Liang X., Fuh G., Gerber H.P., and Ferrara N. VEGF-null cells require PDGFR alpha signaling-mediated stromal fibroblast recruitment for tumorigenesis. EMBO J 23 (2004) 2800-2810
4. Donnelly M.L., Hughes L.E., Luke G., Mendoza H., ten Dam E., Gani D., and Ryan M.D. The 'cleavage' activities of foot-and-mouth disease virus 2A site-directed mutants and naturally occurring '2A-like' sequences. J. Gen. Virol. 82 (2001) 1027-1041
5. Dvorak H.F. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J. Clin. Oncol. 20 (2002) 4368-4380
6. Eubank T.D., Galloway M., Montague C.M., Waldman W.J., and Marsh C.B. M-CSF induces vascular endothelial growth factor production and angiogenic activity from human monocytes. J. Immunol. 171 (2003) 2637-2643
7. de Felipe P. Skipping the co-expression problem: the new 2A "CHYSEL" technology. Genet. Vaccines Ther. 2 (2004) 13
8. Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr. Rev. 25 (2004) 581-611
9. Ferrara N., Gerber H.P., and LeCouter J. The biology of VEGF and its receptors. Nat. Med. 9 (2003) 669-676
10. Folkman J. Role of angiogenesis in tumor growth and metastasis. Semin. Oncol. 29 (2002) 15-18
11. Giraudo E., Inoue M., and Hanahan D. An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis. J. Clin. Invest. 114 (2004) 623-633
12. Gouon-Evans V., Rothenberg M.E., and Pollard J.W. Postnatal mammary gland development requires macrophages and eosinophils. Development 127 (2000) 2269-2282
13. Grunewald M., Avraham I., Dor Y., Bachar-Lustig E., Itin A., Jung S., Chimenti S., Landsman L., Abramovitch R., and Keshet E. VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells. Cell. 124 (2006) 175-189
14. Gunther E.J., Belka G.K., Wertheim G.B.W., Wang J., Hartman J.L., Boxer R.B., and Chodosh L.A. A novel doxycycline-inducible system for the transgenic analysis of mammary gland biology. FASEB J. 16 (2002) 283-292
15. Guy C.T., Cardiff R.D., and Muller W.J. Induction of mammary tumors by expression of polyomovirus middle T oncogenes: a transgenic mouse mode of a metastatic disease. Mol. Cell. Biol. 12 (1992) 954-961
16. Hanahan D., and Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86 (1996) 353-364
17. Jain R.K., Duda D.G., Clark J.W., and Loeffler J.S. Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nat. Clin. Pract. Oncol. 3 (2006) 24-40
18. Keyt B.A., Berleau L.T., Nguyen H.V., Chen H., Heinsohn H., Vandlen R., and Ferrara N. The carboxyl-terminal domain (111-165) of vascular endothelial growth factor is critical for its mitogenic potency. J. Biol. Chem. 271 (1996) 7788-7795
19. Kumaraswamy E., Carlson B.A., Morgan F., Miyoshi K., Robinson G.W., Su D., Wang S., Southon E., Tessarollo L., Lee B.J., Gladyshev V.N., Hennighausen L., and Hatfield D.L. Selective removal of the selenocysteine tRNA[Ser}Sec gene (Trsp) in mouse mammary epithelium. Mol. Cell. Biol. 23 (2003) 1477-1488
20. Leek R.D., and Harris A.L. Tumor-associated macrophages in breast cancer. J. Mamm. Gland Biol. Neoplasia 7 (2002) 177-189
21. Leek R.D., Lewis C.E., Whitehouse R., Greenall M., Clarke J., and Harris A.L. Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Res. 56 (1996) 4625-4629
22. Leek R.D., Hunt N.C., Landers R.J., Lewis C.E., Royds J.A., and Harris A.L. Macrophage infiltration is associated with VEGF and EGFR expression in breast cancer. J. Pathol. 190 (2000) 430-436
23. Leung D.W., Cachianes G., Kuang W.J., Goeddel D.V., and Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246 (1989) 1306-1309
24. Lewis C.E., and Pollard J.W. Distinct role of macrophages in different tumor microenvironments. Cancer Res. 66 (2006) 605-612
25. Lin E.Y., and Pollard J.W. Tumor-associated macrophages press the angiogenic switch in breast cancer. Cancer Res. 67 (2007) 5064-5066
26. Lin E.Y., Nguyen A.V., Russell R.G., and Pollard J.W. Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J. Exp. Med. 193 (2001) 727-740
27. Lin E.Y., Gouon-Evans V., Nguyen A.V., and Pollard J.W. The macrophage growth factor, CSF-1, in mammary gland development and tumor progression. J. Mamm. Gland Biol. Neoplasia 7 (2002) 147-162
28. Lin E.Y., Li J.F., Gnatovskiy L., Deng Y., Zhu L., Grzesik D.A., Qian H., Xue X.N., and Pollard J.W. Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Cancer Res. 66 (2006) 11238-11246
29. Lobov I.B., Rao S., Carroll T.J., Vallance J.E., Ito M., Ondr J.K., Kurup S., Glass D.A., Patel M.S., Shu W., Morrisey E.E., McMahon A.P., Karsenty G., and Lang R.A. WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature 437 (2005) 417-421
30. Mok E., Golovkina T.V., and Ross S.R. A mouse mammary tumor virus mammary gland enhancer confers tissue-specific but not lactation-dependent expression in transgenic mice. J. Virol. 66 (1992) 7529-7532
31. Naumov G.N., Akslen L.A., and Folkman J. Role of angiogenesis in human tumor dormancy: animal models of the angiogenic switch. Cell Cycle 5 (2006) 1779-1787
32. Pollard J.W., and Stanley E.R. Pleiotropic roles for CSF-1 in development defined by the mouse mutation osteopetrotic (op). Adv. Dev. Biochem. 4 (1996) 153-193
33. Ross S.R., Hsu C.-L.L., Choi Y., Mok E., and Dudley J.P. Negative regulation in correct tissue-specific expression of mouse mammary tumor virus in transgenic mice. Mol. Cell. Biol. 10 (1990) 5822-5829
34. Sasmono R.T., Oceandy D., Pollard J.W., Tong W., Pavli P., Wainwright B.J., Ostrowski M.C., Himes S.R., and Hume D.A. A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood 101 (2003) 1155-1163
35. Schoeffner D.J., Matheny S.L., Akahane T., Factor V., Berry A., Merlino G., and Thorgeirsson U.P. VEGF contributes to mammary tumor growth in transgenic mice through paracrine and autocrine mechanisms. Lab. Invest. 85 (2005) 608-623
36. Scholl S.M., Pallud C., Beuvon F., Hacene K., Stanley E.R., Rohrschneider L.R., Tang R., Pouillart P., and Lidereau R. Anti-colony-stimulating factor-1 antibody staining in primary breast adenocarcinomas correlates with marked inflammatory cell infiltrates and prognosis. J. Natl. Cancer Inst. 86 (1994) 120-126
37. Shima D.T., Kuroki M., Deutsch U., Ng Y.S., Adamis A.P., and D'Amore P.A. The mouse gene for vascular endothelial growth factor. Genomic structure, definition of the transcriptional unit, and characterization of transcriptional and post-transcriptional regulatory sequences. J. Biol. Chem. 271 (1996) 3877-3883
38. Sunderkotter C., Steinbrink K., GoebelerBhardwaj R., and Sorg C. Macrophages and angiogenesis. J. Leukocyte Biol. 55 (1994) 410-422
39. Varney M.L., Olsen K.J., Mosley R.L., and Singh R.K. Paracrine regulation of vascular endothelial growth factor-a expression during macrophage-melanoma cell interaction: role of monocyte chemotactic protein-1 and macrophage colony-stimulating factor. J. Interferon Cytokine Res. 25 (2005) 674-683
40. Yoshida A., Anand-Apte B., and Zetter B.R. Differential endothelial migration and proliferation to basic fibroblast growth factor and vascular endothelial growth factor. Growth Factors 13 (1996) 57-64