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Volumn 4, Issue 4, 2007, Pages 473-478

Alzhemed: A potential treatment for Alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

1,3 PROPANEDISULFONIC ACID; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; BETA SECRETASE INHIBITOR; FLURBIPROFEN; GAMMA SECRETASE INHIBITOR; HOMOTAURINE; NEUROTOXIN; NONSTEROID ANTIINFLAMMATORY AGENT; NOOTROPIC AGENT; PLACEBO; UNCLASSIFIED DRUG;

EID: 34548689646     PISSN: 15672050     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720507781788882     Document Type: Conference Paper
Times cited : (103)

References (32)
  • 4
    • 0345872128 scopus 로고    scopus 로고
    • Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: A randomized controlled trial
    • Tariot PN, Farlow MR, Grossberg GT, Graham SM, McDonald S, Gergel I. Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial. Jama 291:317-24 (2004).
    • (2004) Jama , vol.291 , pp. 317-324
    • Tariot, P.N.1    Farlow, M.R.2    Grossberg, G.T.3    Graham, S.M.4    McDonald, S.5    Gergel, I.6
  • 5
    • 3042857903 scopus 로고    scopus 로고
    • Cummings JL. Alzheimer's disease. N Engl J Med 351:56-67 (2004).
    • Cummings JL. Alzheimer's disease. N Engl J Med 351:56-67 (2004).
  • 6
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297:353-6 (2002).
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 8
    • 33144487701 scopus 로고    scopus 로고
    • Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology
    • Oddo S, Caccamo A, Tran L, Lambert MP, Glabe CG, Klein WL, et al. Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology. J Biol Chem 281:1599-604 (2006).
    • (2006) J Biol Chem , vol.281 , pp. 1599-1604
    • Oddo, S.1    Caccamo, A.2    Tran, L.3    Lambert, M.P.4    Glabe, C.G.5    Klein, W.L.6
  • 9
    • 28844456475 scopus 로고    scopus 로고
    • The development of anti-amyloid therapy for Alzheimer's disease : From secretase modulators to polymerisation inhibitors
    • Aisen PS. The development of anti-amyloid therapy for Alzheimer's disease : from secretase modulators to polymerisation inhibitors. CNS Drugs 19:989-96 (2005).
    • (2005) CNS Drugs , vol.19 , pp. 989-996
    • Aisen, P.S.1
  • 10
    • 17344388652 scopus 로고    scopus 로고
    • BACE knockout mice are healthy despite lacking the primary beta- secretase activity in brain: Implications for Alzheimer's disease therapeutics
    • Roberds SL, Anderson J, Basi G, Bienkowski MJ, Branstetter DG, Chen KS, et al. BACE knockout mice are healthy despite lacking the primary beta- secretase activity in brain: implications for Alzheimer's disease therapeutics. Hum Mol Genet 10:1317-24 (2001).
    • (2001) Hum Mol Genet , vol.10 , pp. 1317-1324
    • Roberds, S.L.1    Anderson, J.2    Basi, G.3    Bienkowski, M.J.4    Branstetter, D.G.5    Chen, K.S.6
  • 11
    • 0035116273 scopus 로고    scopus 로고
    • Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation
    • Luo Y, Bolon B, Kahn S, Bennett BD, Babu-Khan S, Denis P, et al. Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation. Nat Neurosci 4:231-2 (2001).
    • (2001) Nat Neurosci , vol.4 , pp. 231-232
    • Luo, Y.1    Bolon, B.2    Kahn, S.3    Bennett, B.D.4    Babu-Khan, S.5    Denis, P.6
  • 12
    • 0035829592 scopus 로고    scopus 로고
    • A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity
    • Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, et al. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature 414:212-6 (2001).
    • (2001) Nature , vol.414 , pp. 212-216
    • Weggen, S.1    Eriksen, J.L.2    Das, P.3    Sagi, S.A.4    Wang, R.5    Pietrzik, C.U.6
  • 13
    • 85047657213 scopus 로고    scopus 로고
    • Molecule of the month. MPC-7869 (Flurizan)
    • Molecule of the month. MPC-7869 (Flurizan). Drug News Perspect 18:141 (2005).
    • (2005) Drug News Perspect , vol.18 , pp. 141
  • 14
    • 20944448555 scopus 로고    scopus 로고
    • Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial
    • Gilman S, Koller M, Black RS, Jenkins L, Griffith SG, Fox NC, et al. Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial. Neurology 64:1553-62 (2005).
    • (2005) Neurology , vol.64 , pp. 1553-1562
    • Gilman, S.1    Koller, M.2    Black, R.S.3    Jenkins, L.4    Griffith, S.G.5    Fox, N.C.6
  • 15
    • 34548664313 scopus 로고    scopus 로고
    • Peripheral anti-Abeta antibody alters CNS and plasma Abeta clearance and decreases brain Abeta burden in a mouse model of Alzheimer's disease
    • DeMattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM. Peripheral anti-Abeta antibody alters CNS and plasma Abeta clearance and decreases brain Abeta burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 3:3(2001).
    • (2001) Proc Natl Acad Sci USA , vol.3 , pp. 3
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Dodart, J.C.4    Paul, S.M.5    Holtzman, D.M.6
  • 16
    • 0037223101 scopus 로고    scopus 로고
    • Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid
    • Matsuoka Y, Saito M, LaFrancois J, Gaynor K, Olm V, Wang L, et al. Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid. J Neurosci 23:29-33 (2003).
    • (2003) J Neurosci , vol.23 , pp. 29-33
    • Matsuoka, Y.1    Saito, M.2    LaFrancois, J.3    Gaynor, K.4    Olm, V.5    Wang, L.6
  • 17
    • 0037386086 scopus 로고    scopus 로고
    • The metallobiology of Alzheimer's disease
    • Bush AI. The metallobiology of Alzheimer's disease. Trends Neurosci 26:207-14 (2003).
    • (2003) Trends Neurosci , vol.26 , pp. 207-214
    • Bush, A.I.1
  • 18
    • 18144374793 scopus 로고    scopus 로고
    • Metal ion-dependent effects of clioquinol on the fibril growth of an amyloid {beta} peptide
    • Raman B, Ban T, Yamaguchi K, Sakai M, Kawai T, Naiki H, et al. Metal ion-dependent effects of clioquinol on the fibril growth of an amyloid {beta} peptide. J Biol Chem 280:16157-62 (2005).
    • (2005) J Biol Chem , vol.280 , pp. 16157-16162
    • Raman, B.1    Ban, T.2    Yamaguchi, K.3    Sakai, M.4    Kawai, T.5    Naiki, H.6
  • 19
    • 0032500717 scopus 로고    scopus 로고
    • Klunk WE, Debnath ML, Koros AC, Pettegrew JW. Chrysamine-G, a lipophilic analogue of Congo red, inhibits Abeta-induced toxicity in PC12 cells. Life Sci 63:1807-14 (1998).
    • Klunk WE, Debnath ML, Koros AC, Pettegrew JW. Chrysamine-G, a lipophilic analogue of Congo red, inhibits Abeta-induced toxicity in PC12 cells. Life Sci 63:1807-14 (1998).
  • 21
    • 0034820554 scopus 로고    scopus 로고
    • Glycosaminoglycan mimetics: A therapeutic approach to cerebral amyloid angiopathy
    • Gervais F, Chalifour R, Garceau D, Kong X, Laurin J, McLaughlin R, et al. Glycosaminoglycan mimetics: a therapeutic approach to cerebral amyloid angiopathy. Amyloid 8 Suppl 1:28-35 (2001).
    • (2001) Amyloid , vol.8 , Issue.SUPPL. 1 , pp. 28-35
    • Gervais, F.1    Chalifour, R.2    Garceau, D.3    Kong, X.4    Laurin, J.5    McLaughlin, R.6
  • 22
    • 33645220400 scopus 로고    scopus 로고
    • Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice
    • Lee EB, Leng LZ, Zhang B, Kwong L, Trojanowski JQ, Abel T, et al. Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice. J Biol Chem 281:4292-9 (2006).
    • (2006) J Biol Chem , vol.281 , pp. 4292-4299
    • Lee, E.B.1    Leng, L.Z.2    Zhang, B.3    Kwong, L.4    Trojanowski, J.Q.5    Abel, T.6
  • 23
    • 4644275963 scopus 로고    scopus 로고
    • Intravenous immunoglobulins containing antibodies against beta-amyloid for the treatment of Alzheimer's disease
    • Dodel RC, Du Y, Depboylu C, Hampel H, Frolich L, Haag A, et al. Intravenous immunoglobulins containing antibodies against beta-amyloid for the treatment of Alzheimer's disease. J Neurol Neurosurg Psychiatry 75:1472-4 (2004).
    • (2004) J Neurol Neurosurg Psychiatry , vol.75 , pp. 1472-1474
    • Dodel, R.C.1    Du, Y.2    Depboylu, C.3    Hampel, H.4    Frolich, L.5    Haag, A.6
  • 25
    • 0021520020 scopus 로고
    • A new rating scale for Alzheimer's disease
    • Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer's disease. Am J Psych 141:1356-64 (1984).
    • (1984) Am J Psych , vol.141 , pp. 1356-1364
    • Rosen, W.G.1    Mohs, R.C.2    Davis, K.L.3
  • 26
    • 0027425211 scopus 로고
    • The Clinical Dementia Rating (CDR): Current version and scoring rules
    • Morris JC. The Clinical Dementia Rating (CDR): Current version and scoring rules. Neurology 43:2412-4 (1993).
    • (1993) Neurology , vol.43 , pp. 2412-2414
    • Morris, J.C.1
  • 27
    • 19944430290 scopus 로고    scopus 로고
    • Dynamics of {beta}-Amyloid Reductions in Brain, Cerebrospinal Fluid and Plasma of {beta}-Amyloid Precursor Protein Transgenic Mice Treated with a {gamma}-Secretase Inhibitor
    • Barten DM, Guss VL, Corsa JA, Loo AT, Hansel SB, Zheng M, et al. Dynamics of {beta}-Amyloid Reductions in Brain, Cerebrospinal Fluid and Plasma of {beta}-Amyloid Precursor Protein Transgenic Mice Treated with a {gamma}-Secretase Inhibitor. J Pharmacol Exp Ther 312:635-43 (2004).
    • (2004) J Pharmacol Exp Ther , vol.312 , pp. 635-643
    • Barten, D.M.1    Guss, V.L.2    Corsa, J.A.3    Loo, A.T.4    Hansel, S.B.5    Zheng, M.6
  • 28
    • 33645871592 scopus 로고    scopus 로고
    • Best JD, Jay MT, Otu F, Churcher I, Reilly M, Morentin-Gutierrez P, et al. In vivo characterisation of A{beta}(40) changes in brain and CSF using the novel {gamma}-secretase inhibitor MRK-560 (N-[cis-4-[(4-chlorophenyl) sulfonyl]-4- (2,5-difluorophenyl)cyclohexyl]-1,1,1- trifluoromethanesulfonamide) in the rat. J Pharmacol Exp Ther 317:786-90 (2006).
    • Best JD, Jay MT, Otu F, Churcher I, Reilly M, Morentin-Gutierrez P, et al. In vivo characterisation of A{beta}(40) changes in brain and CSF using the novel {gamma}-secretase inhibitor MRK-560 (N-[cis-4-[(4-chlorophenyl) sulfonyl]-4- (2,5-difluorophenyl)cyclohexyl]-1,1,1- trifluoromethanesulfonamide) in the rat. J Pharmacol Exp Ther 317:786-90 (2006).
  • 29
    • 3042692322 scopus 로고    scopus 로고
    • Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet
    • Lemere CA, Beierschmitt A, Iglesias M, Spooner ET, Bloom JK, Leverone JF, et al. Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet. Am J Pathol 2004;165:283-97.
    • (2004) Am J Pathol , vol.165 , pp. 283-297
    • Lemere, C.A.1    Beierschmitt, A.2    Iglesias, M.3    Spooner, E.T.4    Bloom, J.K.5    Leverone, J.F.6
  • 31
    • 0030958347 scopus 로고    scopus 로고
    • The neuropsychiatric inventory: Assessing psychopathology in dementia patients
    • Cummings J. The neuropsychiatric inventory: Assessing psychopathology in dementia patients. Neurology 48 (Suppl 6):S10-S6 (1997).
    • (1997) Neurology , vol.48 , Issue.SUPPL. 6
    • Cummings, J.1
  • 32
    • 0033193134 scopus 로고    scopus 로고
    • Development of a functional measure for persons with Alzheimer's disease: The disability assessment for dementia
    • Gelinas I, Gauthier L, McIntyre M, Gauthier S. Development of a functional measure for persons with Alzheimer's disease: the disability assessment for dementia. Am J Occup Ther 53:471-81 (1999).
    • (1999) Am J Occup Ther , vol.53 , pp. 471-481
    • Gelinas, I.1    Gauthier, L.2    McIntyre, M.3    Gauthier, S.4


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