-
1
-
-
45049084732
-
The chemical biology of nitric oxide: Implications in cellular signaling
-
• This review discusses the relationship between the fundamental chemistry of NO and the important influences on cellular microenvironment
-
Thomas DD, Ridnour LA, Isenberg JS, et al. The chemical biology of nitric oxide: Implications in cellular signaling. Free Radical Biol Med 2008;45(1):18-31 • This review discusses the relationship between the fundamental chemistry of NO and the important influences on cellular microenvironment
-
(2008)
Free Radical Biol Med
, vol.45
, Issue.1
, pp. 18-31
-
-
Thomas, D.D.1
Ridnour, L.A.2
Isenberg, J.S.3
-
2
-
-
0025883342
-
Nitric oxide: Physiology, pathophysiology, and pharmacology
-
Moncada S, Palmer RM, Higgs EA. Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991;21(2):109-42
-
(1991)
Pharmacol Rev
, vol.21
, Issue.2
, pp. 109-142
-
-
Moncada, S.1
Palmer, R.M.2
Higgs, E.A.3
-
3
-
-
35348978658
-
Design and synthesis of C5 methylated L-arginine analogues as active site probes for nitric oxide synthase
-
DOI 10.1021/ja0746159
-
Martin IN, Woodward JJ, Winter MB, et al. Design and synthesis of C5 Methylated L-arginine analogues as active site probes for nitric oxide synthase. J Am Chem Soc 2007;129:12563-70 (Pubitemid 47598257)
-
(2007)
Journal of the American Chemical Society
, vol.129
, Issue.41
, pp. 12563-12570
-
-
Martin, N.I.1
Woodward, J.J.2
Winter, M.B.3
Beeson, W.T.4
Marletta, M.A.5
-
4
-
-
0025773785
-
Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures
-
Dawson VL, Dawson TM, Lomdon ED, et al. Nitric oxide mediates glutamate neurotoxicicty in primary cortical cultures. Proc Natl Acad Sci 1991;88:6368-71 (Pubitemid 21914947)
-
(1991)
Proceedings of the National Academy of Sciences of the United States of America
, vol.88
, Issue.14
, pp. 6368-6371
-
-
Dawson, V.L.1
Dawson, T.M.2
London, E.D.3
Bredt, D.S.4
Snyder, S.H.5
-
5
-
-
0028815563
-
Nitric oxide: A new paradigm for second messengers
-
•• This review gives an in-depth overview of the molecular mechanism of NOS-mediated NO biosynthesis
-
Kerwin JF, Lancaster JR, Feldamn PL. Nitric oxide: A new paradigm for second messengers. J Med Chem 1995;38:4343-62 •• This review gives an in-depth overview of the molecular mechanism of NOS-mediated NO biosynthesis
-
(1995)
J Med Chem
, vol.38
, pp. 4343-4362
-
-
Kerwin, J.F.1
Lancaster, J.R.2
Feldamn, P.L.3
-
6
-
-
0028349156
-
Nitric oxide synthases in mammals
-
Knowles RG, Moncada S. Nitric oxide synthases in mammals. Biochem J 1994;298(2):249-58 (Pubitemid 24072462)
-
(1994)
Biochemical Journal
, vol.298
, Issue.2
, pp. 249-258
-
-
Knowles, R.G.1
Moncada, S.2
-
9
-
-
0036548323
-
Intrinsic and extrinsic modulation of nitric oxide synthase activity
-
DOI 10.1021/cr000661e
-
Roman LJ, Mattasek P, Masters BSS. Intrinsic and extrinsic modulation of nitric oxide synthase activity. Chem Rev 2002;102:1179-89 • This review is focused on the modes of regulation of the isoforms of NOS. The biochemistry and physiology of the NOS isoforms have revealed various interesting differences among the isoforms indicating that several regulatory mechanisms must be operating (Pubitemid 35377608)
-
(2002)
Chemical Reviews
, vol.102
, Issue.4
, pp. 1179-1189
-
-
Roman, L.J.1
Martasek, P.2
Masters, B.S.S.3
-
10
-
-
0027325255
-
Nitric oxide synthase structure and mechanism
-
Marletta MA. Nitric oxide synthase structure and mechanism. J Biol Chem 1993;268:12231-4 (Pubitemid 23182366)
-
(1993)
Journal of Biological Chemistry
, vol.268
, Issue.17
, pp. 12231-12234
-
-
Marletta, M.A.1
-
12
-
-
0035425503
-
Nitric oxide synthases: Structure, function and inhibition
-
DOI 10.1042/0264-6021:3570593
-
Alderton WK, Cooper CE, Knowles RG. Nitric oxide synthases: Structure function and inhibition. Biochem J 2001;357:593-615 •• A comprehensive and up-to-date review on the advances in NOS structure, function and inhibition (Pubitemid 32735142)
-
(2001)
Biochemical Journal
, vol.357
, Issue.3
, pp. 593-615
-
-
Alderton, W.K.1
Cooper, C.E.2
Knowles, R.G.3
-
13
-
-
0343046540
-
Formation of nitric oxide from L-arginine in the central nervous system: A transduction mechanism for stimulation of the soluble guanylate cyclase
-
Knowles RG, Palacios M, Palmer MRJ, et al. Formation of nitric oxide from L-Arginine in the central nervous system: A transduction mechanism for stimulation of the soluble guanylate cyclase. Proc Natl Acad Sci 1989;86:5159-62 (Pubitemid 19182253)
-
(1989)
Proceedings of the National Academy of Sciences of the United States of America
, vol.86
, Issue.13
, pp. 5159-5162
-
-
Knowles, R.G.1
Palacios, M.2
Palmer, R.M.J.3
Moncada, S.4
-
14
-
-
33745315287
-
S-Nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration
-
DOI 10.1038/nature04782, PII NATURE04782
-
Uehara T, Nakamura T, Yao D, et al. S-Nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration. Nature 2006;441(7092):513-17 (Pubitemid 44050153)
-
(2006)
Nature
, vol.441
, Issue.7092
, pp. 513-517
-
-
Uehara, T.1
Nakamura, T.2
Yao, D.3
Shi, Z.-Q.4
Gu, Z.5
Ma, Y.6
Masliah, E.7
Nomura, Y.8
Lipton, S.A.9
-
15
-
-
29344465714
-
Medicine: Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2
-
DOI 10.1126/science.1119407
-
Kim SF, Huri DA, Snyder SH. Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science 2005;310(5756):1966-70 (Pubitemid 43005992)
-
(2005)
Science
, vol.310
, Issue.5756
, pp. 1966-1970
-
-
Kim, S.F.1
Huri, D.A.2
Snyder, S.H.3
-
16
-
-
0036550216
-
Mechanism of free-radical generation by nitric oxide synthase
-
• This is a comprehensive review that discusses NOS as an enzyme which participates in secondary metabolism and free-radical generation
-
Rosen GM, Tsai P, Pou S. Mechanism of free-radical generation by nitric oxide synthase. Chem Rev 2002;102(1):191-200 • This is a comprehensive review that discusses NOS as an enzyme which participates in secondary metabolism and free-radical generation
-
(2002)
Chem Rev
, vol.102
, Issue.1
, pp. 191-200
-
-
Rosen, G.M.1
Tsai, P.2
Pou, S.3
-
17
-
-
13044260957
-
RNA diversity has profound effects on the translation of neuronal nitric oxide synthase
-
DOI 10.1073/pnas.96.21.12150
-
Wang Y, Newton DC, Robb GB, et al. RNA diversity has profound effects on the translation of neuronal nitric oxide synthase. Proc Natl Acad Sci USA 1999;96:12150-5 (Pubitemid 29502873)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.21
, pp. 12150-12155
-
-
Wang, Y.1
Newton, D.C.2
Robb, G.B.3
Kau, C.-L.4
Miller, T.L.5
Cheung, A.H.6
Hall, A.V.7
VanDamme, S.8
Wilcox, J.N.9
Marsden, P.A.10
-
18
-
-
13344277364
-
Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and α1-syntrophin mediated by PDZ domains
-
DOI 10.1016/S0092-8674(00)81053-3
-
Brenman JE, Chao DS, Gee SH, et al. Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains. Cell 1996;84:757-67 (Pubitemid 26094205)
-
(1996)
Cell
, vol.84
, Issue.5
, pp. 757-767
-
-
Brenman, J.E.1
Chao, D.S.2
Gee, S.H.3
McGee, A.W.4
Craven, S.E.5
Santillano, D.R.6
Wu, Z.7
Huang, F.8
Xia, H.9
Peters, M.F.10
Froehner, S.C.11
Bredt, D.S.12
-
19
-
-
0029933799
-
Neuronal nitric-oxide synthase-mu, an alternatively spliced isoform expressed in differentiated skeletal muscle
-
Silvagno F, Xia H, Bredt DS. Neuronal nitric-oxide synthase-mu, an alternatively spliced isoform expressed in differentiated skeletal muscle. J Biol Chem 1996;271:11204-8
-
(1996)
J Biol Chem
, vol.271
, pp. 11204-11208
-
-
Silvagno, F.1
Xia, H.2
Bredt, D.S.3
-
20
-
-
0001311181
-
Cloning of a novel neuronal nitric oxide synthase expressed in penis and lower urinary tract
-
DOI 10.1006/bbrc.1996.1324
-
Magee T, Fuentes AM, Garban H, et al. Cloning of a novel neuronal nitric oxide synthase expressed in penis and lower urinary tract. Biochem Biophys Res Commun 1996;226:145-51 (Pubitemid 26332177)
-
(1996)
Biochemical and Biophysical Research Communications
, vol.226
, Issue.1
, pp. 145-151
-
-
Magee, T.1
Fuentes, A.M.2
Garban, H.3
Rajavashisth, T.4
Marquez, D.5
Rodriguez, J.A.6
Rajfer, J.7
Gonzalez-Cadavid, N.F.8
-
21
-
-
0027237364
-
Structural diversity of neuronal nitric oxide synthase mRNA in the nervous system
-
Ogura T, Yokoyama T, Fujisawa, et al. Structural diversity of neuronal nitric oxide synthase mRNA in the nervous system. Biochem Biophys Res Commun 1993;193:1017-22
-
(1993)
Biochem Biophys Res Commun
, vol.193
, pp. 1017-1022
-
-
Ogura, T.1
Yokoyama T, Fujisawa.2
-
22
-
-
0028200313
-
Expression of two types of nitric oxide synthase mRNA in human neuroblastoma cell lines
-
Fujisawa H, Ogura T, Kurashima Y, et al. Expression of two types of nitric oxide synthase mRNA in human neuroblastoma cell lines. J Neurochem 1994;63:140-5 (Pubitemid 24184911)
-
(1994)
Journal of Neurochemistry
, vol.63
, Issue.1
, pp. 140-145
-
-
Fujisawa, H.1
Ogura, T.2
Kurashima, Y.3
Yokoyama, T.4
Yamashita, J.5
Esumi, H.6
-
23
-
-
0030983197
-
Regulation of neuronal nitric oxide synthase through alternative transcripts
-
Brenman JE, Xia H, Chao DS, et al. Regulation of neuronal nitric oxide synthase through alternative transcripts. Dev Neurosci 1997;19:224-31 (Pubitemid 27230840)
-
(1997)
Developmental Neuroscience
, vol.19
, Issue.3
, pp. 224-231
-
-
Brenman, J.E.1
Xia, H.2
Chao, D.S.3
Black, S.M.4
David, S.5
-
24
-
-
0030743849
-
Functionally differentiating two neuronal nitric oxide synthase isoforms through antisense mapping: Evidence for opposing NO actions on morphine analgesia and tolerance
-
DOI 10.1073/pnas.94.15.8220
-
Kolesnikov YA, Pan YX, Babey AM, et al. Functionally differentiating two neuronal nitric oxide synthase isoforms through antisense mapping: Evidence for opposing NO actions on morphine analgesia and tolerance. Proc Natl Acad Sci USA 1997;94:8220-5 (Pubitemid 27343804)
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.15
, pp. 8220-8225
-
-
Kolesnikov, Y.A.1
Pan, Y.-X.2
Babey, A.-M.3
Jain, S.4
Wilson, R.5
Pasternak, G.W.6
-
25
-
-
0030914284
-
Neuronal nitric oxide synthase alternatively spliced forms: Prominent functional localizations in the brain
-
DOI 10.1073/pnas.94.7.3396
-
Eliasson MJ, Blackshaw S, Schell MJ, et al. Neuronal nitric oxide synthase alternatively spliced forms: Prominent functional localizations in the brain. Proc Natl Acad Sci USA 1997;97:3396-401 (Pubitemid 27157323)
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.7
, pp. 3396-3401
-
-
Eliasson, M.J.L.1
Blackshaw, S.2
Schell, M.J.3
Snyder, S.H.4
-
26
-
-
0032479467
-
The protein inhibitor of neuronal nitric oxide synthase (PIN): Characterization of its action on pure nitric oxide synthases
-
DOI 10.1016/S0014-5793(98)00704-2, PII S0014579398007042
-
Hemmens B, Woschitz S, Pitters E, et al. The protein inhibitor of neuronal nitric oxide synthase: Characterization of its action on pure nitric oxide synthases. FEBS Lett 1998;430:397-400 (Pubitemid 28337952)
-
(1998)
FEBS Letters
, vol.430
, Issue.3
, pp. 397-400
-
-
Hemmens, B.1
Woschitz, S.2
Pitters, E.3
Klosch, B.4
Volker, C.5
Schmidt, K.6
Mayer, B.7
-
27
-
-
0033600913
-
PSD-95 assembles a ternary complex with the N-methyl-d-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain
-
Christopherson KS, Hillier BJ, Lim WA, et al. PSD-95 assembles a ternary complex with the N-methyl-d-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain. J Biol Chem 1999;274:27467-73
-
(1999)
J Biol Chem
, vol.274
, pp. 27467-27473
-
-
Christopherson, K.S.1
Hillier, B.J.2
Lim, W.A.3
-
28
-
-
0000255875
-
Inhibitors of nitric oxide synthase in inflammatory arthritis
-
Boughton SNK, Tinker AC. Inhibitors of nitric oxide synthase in inflammatory arthritis. IDrugs 1998;1:321-33 •• An excellent review on selective iNOS inhibitors and the activity of these compounds in animal models of arthritis (Pubitemid 128751608)
-
(1998)
IDrugs
, vol.1
, Issue.3
, pp. 321-333
-
-
Boughton-Smith, N.K.1
Tinker, A.C.2
-
29
-
-
1942500993
-
Targeting eNOS for stroke protection
-
DOI 10.1016/j.tins.2004.03.009, PII S016622360400102X
-
Endres M, Laufs U, Liao JK, et al. Targeting eNOS for stroke protection. Trends Neurosci 2004;27(5):283-9 (Pubitemid 38529957)
-
(2004)
Trends in Neurosciences
, vol.27
, Issue.5
, pp. 283-289
-
-
Endres, M.1
Laufs, U.2
Liao, J.K.3
Moskowitz, M.A.4
-
30
-
-
34250827108
-
Understanding eNOS for pharmacological modulation of endothelial function: A translational view
-
DOI 10.2174/138161207780831275
-
Braam B, Verhaar MC. Understanding eNOS for pharmacological modulation of endothelial function: A translational view. Curr Pharm 2007;13(17):1727-40 (Pubitemid 46979711)
-
(2007)
Current Pharmaceutical Design
, vol.13
, Issue.17
, pp. 1727-1740
-
-
Braam, B.1
Verhaar, M.C.2
-
31
-
-
0034193705
-
Transient changes in the synthesis of nitric oxide result in long-term as well as short-term changes in acetic acid-induced writhing in mice
-
DOI 10.1016/S0304-3959(00)00236-0, PII S0304395900002360
-
Larson AA, Kovacs KJ, Cooper JC, et al. Transient changes in the synthesis of nitric oxide result in long-term as well as short-term changes in acetic acid-induced writhing in mice. Pain 2000;86:103-11 • This review shows that commercially available inhibitors of nNOS induce both long- as well as short-term changes in nociception. This is consistent with the notion that NO is important in plasticity of nociceptive pathways (Pubitemid 30211709)
-
(2000)
Pain
, vol.86
, Issue.1-2
, pp. 103-111
-
-
Larson, A.A.1
Kovacs, K.J.2
Cooper, J.C.3
Kitto, K.F.4
-
32
-
-
33745740989
-
Computational studies of competitive inhibitors of nitric oxide synthase (NOS) enzymes: Towards the development of powerful and isoform-selective inhibitors
-
Tafi A, Angeli L, Venturini G, et al. Computational studies of competitive inhibitors of nitric oxide synthase (NOS) enzymes: Towards the development of powerful and isoform-selective inhibitors. Curr Med Chem 2006;13(16):1929-46
-
(2006)
Curr Med Chem
, vol.13
, Issue.16
, pp. 1929-1946
-
-
Tafi, A.1
Angeli, L.2
Venturini, G.3
-
33
-
-
0036242431
-
Progress in the development of selective nitric oxide synthase (NOS) inhibitors
-
DOI 10.2174/1381612023396375
-
Salerno L, Sorrenti V, Di Giacomo C, et al. Progress in the development of selective nitric oxide synthase (NOS) inhibitors. Curr Pharm Des 2002;8(3):177-200 (Pubitemid 34449889)
-
(2002)
Current Pharmaceutical Design
, vol.8
, Issue.3
, pp. 177-200
-
-
Salerno, L.1
Sorrenti, V.2
Di Giacomo, C.3
Romeo, G.4
Siracusa, M.A.5
-
34
-
-
0036883907
-
Blocking no synthesis: How, where and why?
-
DOI 10.1038/nrd960
-
Vallance P, Leiper J. Blocking nO synthesis: How, where and why? Nat Rev Drug Discov 2002;1(12):939-50 • This review focuses on the rationale and potential for approaches that reduce NO synthesis, which have led to the development of several compounds entering clinical trials (Pubitemid 37361600)
-
(2002)
Nature Reviews Drug Discovery
, vol.1
, Issue.12
, pp. 939-950
-
-
Vallance, P.1
Leiper, J.2
-
35
-
-
0033063534
-
Nitric oxide V. Therapeutic potential of nitric oxide donors and inhibitors
-
Muscara MN, Wallace JL. Nitric oxide V. Therapeutic potential of nitric oxide donors and inhibitors. Am J Physiol 1999;276:1313-16
-
(1999)
Am J Physiol
, vol.276
, pp. 1313-1316
-
-
Muscara, M.N.1
Wallace, J.L.2
-
36
-
-
0028836280
-
Inhibition of nitric oxide synthase-potential for a novel class of therapeutic agent
-
• Provides an overview of the different assay methods used to determine NOS activity
-
Ogden JE, Moore PK. Inhibition of nitric oxide synthase-potential for a novel class of therapeutic agent. Trends Biotech 1995;13:70-8 • Provides an overview of the different assay methods used to determine NOS activity
-
(1995)
Trends Biotech
, vol.13
, pp. 70-78
-
-
Ogden, J.E.1
Moore, P.K.2
-
37
-
-
0029795296
-
Nitric oxide synthase inhibitors: Amino acids
-
Griffith OW, Kilbourn RG. Nitric oxide synthase inhibitors: Amino acids. Methods Enzymol 1996;268:375-92 (Pubitemid 26286380)
-
(1996)
Methods in Enzymology
, vol.268
, pp. 375-392
-
-
Griffith, O.W.1
Kilbourn, R.G.2
-
38
-
-
0030040255
-
Selective pharmacological inhibition of distinct nitric oxide synthase isoforms
-
DOI 10.1016/0006-2952(95)02099-3
-
Southan GJ, Szabo C. Selective pharmacological inhibition of distinct nitric oxide synthase isoforms. Biochem Pharmacol 1996;51(4):383-94 (Pubitemid 26071171)
-
(1996)
Biochemical Pharmacology
, vol.51
, Issue.4
, pp. 383-394
-
-
Southan, G.J.1
Szabo, C.2
-
39
-
-
39549115445
-
Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2
-
DOI 10.1523/JNEUROSCI.5066-07.2008
-
Wilcock DM, Lewis MR, Van Nostrand WE, et al. Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2. J Neurosci 2008;28(7):1537-45 • This study shows that removal of NOS2 from an APP transgenic mouse results in development of a much greater spectrum of Alzheimer's disease-like pathology and behavioral impairments (Pubitemid 351287042)
-
(2008)
Journal of Neuroscience
, vol.28
, Issue.7
, pp. 1537-1545
-
-
Wilcock, D.M.1
Lewis, M.R.2
Van Nostrand, W.E.3
Davis, J.4
Previti, M.L.5
Gharkholonarehe, N.6
Vitek, M.P.7
Colton, C.A.8
-
40
-
-
0027323351
-
Inhibition of rat cerebellar nitric oxide synthase by 7-nitro indazole and related substituted indazoles
-
Babbedge RC, Bland-Ward PA, Hart SL, et al. Inhibition of rat cerebellar nitric oxide synthase by 7-nitro indazole and related substituted indazoles. Br J Pharmacol 1993;1(10):225-8 (Pubitemid 23257783)
-
(1993)
British Journal of Pharmacology
, vol.110
, Issue.1
, pp. 225-228
-
-
Babbedge, R.C.1
Bland-Ward, P.A.2
Hart, S.L.3
Moore, P.K.4
-
41
-
-
0032133353
-
Design of isoform-selective inhibitors of nitric oxide synthase
-
Babu BR, Griffith OW. Design of the isoform-selective inhibitors of nitric oxide synthase. Curr Opin Chem Biol 1998;2:491-500 (Pubitemid 128645702)
-
(1998)
Current Opinion in Chemical Biology
, vol.2
, Issue.4
, pp. 491-500
-
-
Babu, B.R.1
Griffith, O.W.2
-
42
-
-
0036418649
-
Two new nitric oxide synthase inhibitors: Pyridoxal aminoguanidine and 8-quinolinecarboxylic hydrazide selectively inhibit basal but not agonist-stimulated release of nitric oxide in rat aorta
-
DOI 10.1016/S1043661802001275
-
Pekiner C, Kelicen P, Uma S, et al. Two nitric oxide synthase inhibitors: Pyridoxal aminoguanidine and 8-quinolinecarboxylic hydrazide selectively inhibit basal but not agonist stimulated release of nitric oxide in rat aorta. Pharmacol Res 2002;46:317-20 (Pubitemid 35304480)
-
(2002)
Pharmacological Research
, vol.46
, Issue.4
, pp. 317-320
-
-
Pekiner, C.1
Kelicen, P.2
Serdar, U.3
Miwa, I.4
-
43
-
-
0028823098
-
The antinociceptive effect of 1-(2-trifluoromethylphenyl) imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse
-
Handy RLC, Wallace P, Gaffen ZA, et al. The antinociceptive effect of 1-(2-trifluoromethylphenyl) imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse. Br J Pharmacol 1995;116:2349-50
-
(1995)
Br J Pharmacol
, vol.116
, pp. 2349-2350
-
-
Handy, R.L.C.1
Wallace, P.2
Gaffen, Z.A.3
-
44
-
-
0029934405
-
ARL 17477, a potent and selective neuronal NOS inhibitor decreases infarct volume after transient middle cerebral artery occlusion in rats
-
Zhang ZG, Reif D, MacDonald WX, et al. ARL 17477, a potent and selective neuronal NOS inhibitor decreases infarct volume after transient middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab 1996;16:599-604 (Pubitemid 26227068)
-
(1996)
Journal of Cerebral Blood Flow and Metabolism
, vol.16
, Issue.4
, pp. 599-604
-
-
Zhang, Z.G.1
Reif, D.2
Macdonald, J.3
Tang, W.X.4
Kamp, D.K.5
Gentile, R.J.6
Shakespeare, W.C.7
Murray, R.J.8
Chopp, M.9
-
45
-
-
79952951727
-
-
Neuraxon Inc. Substituted indole compounds having NOS inhibitory activity. US20060258721
-
Neuraxon, Inc. Substituted indole compounds having NOS inhibitory activity. US20060258721; 2006
-
(2006)
-
-
-
46
-
-
79952965872
-
-
Neuraxon Inc. Substituted indole compounds having NOS inhibitory activity. WO2007063418
-
Neuraxon, Inc. Substituted indole compounds having NOS inhibitory activity. WO2007063418; 2007
-
(2007)
-
-
-
47
-
-
79952908648
-
-
Neuraxon Inc. 1,5 and 3,6-substituted indole compounds having NOS inhibitory activity. WO2007118314
-
Neuraxon, Inc. 1,5 and 3,6-substituted indole compounds having NOS inhibitory activity. WO2007118314; 2007
-
(2007)
-
-
-
48
-
-
79952920869
-
-
Neuraxon Inc. 3,5-Substituted indole compounds having NOS and norepinephrine reuptake inhibitory activity. WO2009062318
-
Neuraxon, Inc. 3,5-Substituted indole compounds having NOS and norepinephrine reuptake inhibitory activity. WO2009062318; 2009
-
(2009)
-
-
-
49
-
-
79952958931
-
-
Neuraxon Inc. Indole compounds and methods for treating visceral pain. WO2009062319
-
Neuraxon, Inc. Indole compounds and methods for treating visceral pain. WO2009062319; 2009
-
(2009)
-
-
-
50
-
-
0028245391
-
Nitric oxide synthase assays
-
• This paper discusses in-depth the procedure for measuring NOS activity utilizing the hemoglobin capture assay
-
Hevel JM, Marletta MA. Nitric oxide synthase assays. Methods Enzymol 1994;133:250-8 • This paper discusses in-depth the procedure for measuring NOS activity utilizing the hemoglobin capture assay
-
(1994)
Methods Enzymol
, vol.133
, pp. 250-258
-
-
Hevel, J.M.1
Marletta, M.A.2
-
51
-
-
79952925419
-
-
Neuraxon Inc. Substituted benzimidazole compounds with dual NOS inhibitory activity and mu-opoid agonist activity. WO2007017764
-
Neuraxon, Inc. Substituted benzimidazole compounds with dual NOS inhibitory activity and mu-opoid agonist activity. WO2007017764; 2007
-
(2007)
-
-
-
52
-
-
79952973187
-
-
Neuraxon Inc. Quinolone and tetrahydroquinolone and related compounds having NOS inhibitory activity. US20080234237
-
Neuraxon, Inc. Quinolone and tetrahydroquinolone and related compounds having NOS inhibitory activity. US20080234237; 2008
-
(2008)
-
-
-
53
-
-
79952912780
-
-
Neuraxon Inc. Benzoxazines benzothiazines and related compounds having NOS inhibitory activity. WO2010000073
-
Neuraxon, Inc. Benzoxazines, benzothiazines, and related compounds having NOS inhibitory activity. WO2010000073; 2010
-
(2010)
-
-
-
54
-
-
79952961409
-
-
Northwestern University. Heteroaromatic selective inhibitors of neuronal nitric oxide synthase. WO20050107369
-
Northwestern University. Heteroaromatic selective inhibitors of neuronal nitric oxide synthase. WO20050107369; 2005
-
(2005)
-
-
-
55
-
-
79952905273
-
-
Northwestern University. Heteroaromatic selective inhibitors of neuronal nitric oxide synthase. WO2005026111
-
Northwestern University. Heteroaromatic selective inhibitors of neuronal nitric oxide synthase. WO2005026111; 2005
-
(2005)
-
-
-
56
-
-
79952928949
-
-
NOS inhibitors for the treatment of motor deficit disorders. WO2008036294; 2008
-
(2008)
-
-
-
57
-
-
79952956513
-
-
North Western University. Potent and highly selective heteroaromatic inhibitors of neuronal nitric oxide synthase. US20080108814, • This article describes the synthesis and nNOS inhibition of the most potent and selective nNOS inhibitor reported to date
-
North Western University. Potent and highly selective heteroaromatic inhibitors of neuronal nitric oxide synthase. US20080108814; 2008 • This article describes the synthesis and nNOS inhibition of the most potent and selective nNOS inhibitor reported to date
-
(2008)
-
-
-
58
-
-
61449263657
-
Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping
-
•• This study shows the establishment of a new fragment-based de novo design strategy called fragment hopping. Using this approach, pyrrolidinomethyl aminopyridines were designed and synthesized, which showed nanomolar nNOS inhibitory potency and > 1000-fold nNOS selectivity over eNOS
-
Ji H, Li H, Martasek P, et al. Discovery of Highly Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase by Fragment Hopping. J Med Chem 2009;52:779-97 •• This study shows the establishment of a new fragment-based de novo design strategy called fragment hopping. Using this approach, pyrrolidinomethyl aminopyridines were designed and synthesized, which showed nanomolar nNOS inhibitory potency and > 1000-fold nNOS selectivity over eNOS
-
(2009)
J Med Chem
, vol.52
, pp. 779-797
-
-
Ji, H.1
Li, H.2
Martasek, P.3
-
59
-
-
62149098014
-
Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability
-
Lawton GR, Ranaivo HR, Chic LK, et al. Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability. Bioorg Med Chem 2009;17:2371-80
-
(2009)
Bioorg Med Chem
, vol.17
, pp. 2371-2380
-
-
Lawton, G.R.1
Ranaivo, H.R.2
Chic, L.K.3
-
60
-
-
72249117759
-
Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability
-
Xue F, Fang J, Lewis WW, et al. Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability. Bioorg Med Chem 2010;20:544-57
-
(2010)
Bioorg Med Chem
, vol.20
, pp. 544-557
-
-
Xue, F.1
Fang, J.2
Lewis, W.W.3
-
61
-
-
79952941675
-
-
Northwestern University. Potent and selective neuronal nitric oxide synthase inhibitors with improved membrane permeability. US201001902320
-
Northwestern University. Potent and selective neuronal nitric oxide synthase inhibitors with improved membrane permeability. US201001902320; 2010
-
(2010)
-
-
-
62
-
-
79952942104
-
-
Northwestern University. Aminopyridine dimer compounds compositions and related methods for neuronal nitric oxide synthase inhibition. US20100203613
-
Northwestern University. Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition. US20100203613; 2010
-
(2010)
-
-
-
63
-
-
0033549862
-
N(ω)-nitroarginine-containing dipeptide amides. Potent and highly selective inhibitors of neuronal nitric oxide synthase
-
DOI 10.1021/jm990111c
-
Haung H, Martasek P, Roman LJ, et al. N-nitroarginine-containing dipeptide amides. Potent and highly selective inhibitors of neuronal nitric oxide synthase. J Med Chem 1999;42:3147-53 (Pubitemid 29384050)
-
(1999)
Journal of Medicinal Chemistry
, vol.42
, Issue.16
, pp. 3147-3153
-
-
Huang, H.1
Martasek, P.2
Roman, L.J.3
Masters, B.S.S.4
Silverman, R.B.5
-
64
-
-
79952970456
-
-
Northwestern University. Selective neuronal nitric oxide synthase inhibitors. US20030119751
-
Northwestern University. Selective neuronal nitric oxide synthase inhibitors. US20030119751; 2003
-
(2003)
-
-
-
65
-
-
79952934775
-
-
Northwestern University. NOS inhibitors for treatment of motor deficit disorders. WO2008036294
-
Northwestern University. NOS inhibitors for treatment of motor deficit disorders. WO2008036294; 2008
-
(2008)
-
-
-
66
-
-
79952946639
-
-
Northwestern University. Selective neuronal nitric oxide synthase inhibitors. US7470815
-
Northwestern University. Selective neuronal nitric oxide synthase inhibitors. US7470815: 2008
-
(2008)
-
-
-
67
-
-
0035797359
-
Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoalkyl] aminopentyl)-N′-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase
-
DOI 10.1021/jm0101491
-
Hah JM, Roman LJ, Martasek P, et al. Reduced amide bond isosteric peptidomimetics. (4S)-N-(4-Amino-5- [aminoalkyl]aminopentyl)-N'- nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase. J Med Chem 2001;44:2667-70 (Pubitemid 32852155)
-
(2001)
Journal of Medicinal Chemistry
, vol.44
, Issue.16
, pp. 2667-2670
-
-
Hah, J.-M.1
Roman, L.J.2
Martasek, P.3
Silverman, R.B.4
-
68
-
-
0344088452
-
Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase
-
DOI 10.1021/jm0202932
-
Hah JM, Martasek P, Roman LJ, et al. Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase. J Med Chem 2003;46:1661-9 • This study reports reduced amide bond pseudo dipeptide analogs with a high degree of lipophilicity and high potency for nNOS as well as high selectivity of nNOS over endothelial NOS and inducible NOS (Pubitemid 36444219)
-
(2003)
Journal of Medicinal Chemistry
, vol.46
, Issue.9
, pp. 1661-1669
-
-
Hah, J.-M.1
Martasek, P.2
Roman, L.J.3
Silverman, R.B.4
-
69
-
-
0028128416
-
NO at work
-
DOI 10.1016/0092-8674(94)90267-4
-
Schmidt HH, Walter U. NO at work. Cell 1994;78:919-25 (Pubitemid 24292320)
-
(1994)
Cell
, vol.78
, Issue.6
, pp. 919-925
-
-
Schmidt, H.H.H.W.1
Walter, U.2
-
70
-
-
0032928083
-
Nitric oxide in septic shock
-
Titheradge MA. Nitric oxide in septic shock. Biochim Biophys Acta 1991;1411:437-55
-
(1991)
Biochim Biophys Acta
, vol.1411
, pp. 437-455
-
-
Titheradge, M.A.1
-
71
-
-
0032948112
-
Inhibition of nitric oxide synthase as a potential therapeutic target
-
DOI 10.1146/annurev.pharmtox.39.1.191
-
Hobbs AJ, Higgs A, Moncada S. Inhibition of nitric oxide synthase as a potential therapeutic target. Annu Rev Pharmacol Toxicol 1999;39:191-220 (Pubitemid 29222557)
-
(1999)
Annual Review of Pharmacology and Toxicology
, vol.39
, pp. 191-220
-
-
Hobbs, A.J.1
Higgs, A.2
Moncada, S.3
-
72
-
-
0041519221
-
Inhibitors of the NOS enzymes: A patent review
-
Mete A, Connolly S. Inhibitors of the NOS enzymes: A patent review. IDrugs 2003;6:57-65 •• A previous patent review of NOS inhibitors up to 2003 (Pubitemid 46780290)
-
(2003)
IDrugs
, vol.6
, Issue.1
, pp. 57-65
-
-
Mete, A.1
Connolly, S.2
-
73
-
-
0028863627
-
Molecular mechanisms and therapeutic strategies related to nitric oxide
-
Moncada S, Higgs EA. Molecular mechanisms and therapeutic strategies related to nitric oxide. FASEB J 1995;9:1319-30
-
(1995)
FASEB J
, vol.9
, pp. 1319-1330
-
-
Moncada, S.1
Higgs, E.A.2
-
74
-
-
0031040613
-
1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo
-
DOI 10.1074/jbc.272.8.4959
-
Garvey EP, Oplinger JA, Furfine ES, et al. 1400W is a slow, tight binding and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem 1997;272:4959-63 (Pubitemid 27090046)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.8
, pp. 4959-4963
-
-
Garvey, E.P.1
Oplinger, J.A.2
Furfine, E.S.3
Kiff, R.J.4
Laszlo, F.5
Whittle, B.J.R.6
Knowles, R.G.7
-
75
-
-
0034689418
-
Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine
-
DOI 10.1016/S0960-894X(00)00055-X, PII S0960894X0000055X
-
Young RJ, Beams RM, Carter K, et al. Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine. Bioorg Med Chem Lett 2000;10:597-600 (Pubitemid 30162468)
-
(2000)
Bioorganic and Medicinal Chemistry Letters
, vol.10
, Issue.6
, pp. 597-600
-
-
Young, R.J.1
Beams, R.M.2
Carter, K.3
Clark, H.A.R.4
Coe, D.M.5
Chambers, C.L.6
Davies, P.I.7
Dawson, J.8
Drysdale, M.J.9
Franzman, K.W.10
French, C.11
Hodgson, S.T.12
Hodson, H.F.13
Kleanthous, S.14
Rider, P.15
Sanders, D.16
Sawyer, D.A.17
Scott, K.J.18
Shearer, B.G.19
Stocker, R.20
Smith, S.21
Tackley, M.C.22
Knowles, R.G.23
more..
-
76
-
-
21244458471
-
GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivo
-
DOI 10.1038/sj.bjp.0706168
-
Alderton WK, Angell AD, Craig C, et al. GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivo. Br J Pharmacol 2005;145:301-12 • This study showed that the effects of GW274150 and GW273629 in vivo were consistent with high selectivity for iNOS, as these inhibitors were of low potency against nNOS in the rat cerebellum and did not cause significant effects on blood pressure in mice. Both compounds show a high oral bioavailability (> 90%) in rats and mice (Pubitemid 40896075)
-
(2005)
British Journal of Pharmacology
, vol.145
, Issue.3
, pp. 301-312
-
-
Alderton, W.K.1
Angell, A.D.R.2
Craig, C.3
Dawson, J.4
Garvey, E.5
Moncada, S.6
Monkhouse, J.7
Rees, D.8
Russell, L.J.9
Russell, R.J.10
Schwartz, S.11
Waslidge, N.12
Knowles, R.G.13
-
77
-
-
0035938426
-
3,4-dihydro-1-isoquinolinamines: A novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency
-
DOI 10.1016/S0960-894X(01)00119-6, PII S0960894X01001196
-
Beaton H, Hamley P, Nicholls DJ, et al. 3,4-Dihydro-1-isoquinolinamines: A novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency. Bioorg Med Chem Lett 2001;11:1023-6 (Pubitemid 32319972)
-
(2001)
Bioorganic and Medicinal Chemistry Letters
, vol.11
, Issue.8
, pp. 1023-1026
-
-
Beaton, H.1
Hamley, P.2
Nicholls, D.J.3
Tinker, A.C.4
Wallace, A.V.5
-
78
-
-
0037435062
-
1,2-Dihydro-4-quinazolinamines: Potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo
-
DOI 10.1021/jm0255926
-
Tinker AC, Beaton HG, Boughton-Smith N, et al. 1,2-Dihydro-4- quinazolinamines: Potent, highly selective inhibitors of inducible nitric oxide synthase which show anti-inflammatory activity in vivo. J Med Chem 2003;46:913-16 (Pubitemid 36423137)
-
(2003)
Journal of Medicinal Chemistry
, vol.46
, Issue.6
, pp. 913-916
-
-
Tinker, A.C.1
Beaton, H.G.2
Boughton-Smith, N.3
Cook, T.R.4
Cooper, S.L.5
Fraser-Rae, L.6
Hallam, K.7
Hamley, P.8
McInally, T.9
Nicholls, D.J.10
Pimm, A.D.11
Wallace, A.V.12
-
79
-
-
0035076467
-
ONO1714, a new inducible nitric oxide synthase inhibitor, attenuates sepsis-induced diaphragmatic dysfunction in hamsters
-
Nishina K, Mikawa K, Kodoma S, et al. ONO1714, a new inducible nitric oxide synthase inhibitor, attenuates sepsis-induced diaphragmatic dysfunction in hamsters. Anesth Analg 2001;92:959-66 (Pubitemid 32239142)
-
(2001)
Anesthesia and Analgesia
, vol.92
, Issue.4
, pp. 959-966
-
-
Nishina, K.1
Mikawa, K.2
Kodama, S.-I.3
Obara, H.4
-
80
-
-
0038604348
-
A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics
-
Hansel RT, Kharitonov SA, Donnelly LE, et al. A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics. FASEB J 2003;16:1298-300
-
(2003)
FASEB J
, vol.16
, pp. 1298-1300
-
-
Hansel, R.T.1
Kharitonov, S.A.2
Donnelly, L.E.3
-
81
-
-
0037334020
-
Pharmacological interference with dimerization of human neuronal nitric-oxide synthase expressed in adenovirus-infected DLD-1 cells
-
DOI 10.1124/mol.63.3.682
-
Habisch HJ, Gorren AC, Liang H, et al. Pharmacological interference with dimerization of human neuronal nitric-oxide synthase expressed in adenovirus-infected DLD-1 cells. Mol Pharmacol 2003;63:682-9 (Pubitemid 36297341)
-
(2003)
Molecular Pharmacology
, vol.63
, Issue.3
, pp. 682-689
-
-
Habisch, H.-J.1
Gorren, A.C.F.2
Liang, H.3
Venema, R.C.4
Parkinson, J.F.5
Schmidt, K.6
Mayer, B.7
-
82
-
-
79952979499
-
-
Altana Pharma AG. Imidazo(4,5-B) pyridine-derivatives as inducible NO-synthase inhibitors. WO2005030768
-
Altana Pharma AG. Imidazo(4,5-B) pyridine-derivatives as inducible NO-synthase inhibitors. WO2005030768; 2005
-
(2005)
-
-
-
83
-
-
79952948800
-
-
Altana Pharma AG. Imidazopyridine-derivatives as inducible NO-synthase inhibitors. WO2005030770
-
Altana Pharma AG. Imidazopyridine-derivatives as inducible NO-synthase inhibitors. WO2005030770; 2005
-
(2005)
-
-
-
84
-
-
79952966761
-
-
Altana Pharma AG. Imidazolyl-substituted azabenzophenone compounds. WO2007039578
-
Altana Pharma AG. Imidazolyl-substituted azabenzophenone compounds. WO2007039578; 2007
-
(2007)
-
-
-
85
-
-
79952949621
-
-
Altana Pharma AG. Imidazole-substituted benzophenone compounds. WO2007039580
-
Altana Pharma AG. Imidazole-substituted benzophenone compounds. WO2007039580; 2007
-
(2007)
-
-
-
86
-
-
79952927673
-
-
Altana Pharma AG. Imidazolyl-substituted diazabenzophenone compounds. WO2007039581
-
Altana Pharma AG. Imidazolyl-substituted diazabenzophenone compounds. WO2007039581; 2007
-
(2007)
-
-
-
87
-
-
79952917108
-
-
Altana Pharma AG. Oxazolo[4,5-B] pyridine compounds as nitric oxide synthase inhibitors. WO2007045622
-
Altana Pharma AG. Oxazolo[4,5-B] pyridine compounds as nitric oxide synthase inhibitors. WO2007045622; 2007
-
(2007)
-
-
-
88
-
-
79952933969
-
-
Altana Pharma AG. Imidazopyridine-derivatives as inducible NO-synthase inhibitors. WO2005030769
-
Altana Pharma AG. Imidazopyridine-derivatives as inducible NO-synthase inhibitors. WO2005030769; 2005
-
(2005)
-
-
-
89
-
-
79952974144
-
-
Altana Pharma AG. Imidazopyridine-derivatives as inducible NO-synthase inhibitors. WO2005030771
-
Altana Pharma AG. Imidazopyridine-derivatives as inducible NO-synthase inhibitors. WO2005030771; 2005
-
(2005)
-
-
-
90
-
-
79952958214
-
-
Altana Pharma AG. Alkoxypyridine-derivatives. US7138399
-
Altana Pharma AG. Alkoxypyridine-derivatives. US7138399; 2006
-
(2006)
-
-
-
91
-
-
79952950436
-
-
Altana Pharma AG. Imidazopyridine-derivatives as inducible NO-synthase inhibitors. US20090036482
-
Altana Pharma AG. Imidazopyridine-derivatives as inducible NO-synthase inhibitors. US20090036482; 2009
-
(2009)
-
-
-
92
-
-
79952977749
-
-
Altana Pharma AG. Aminopyridine-derivatives. US7781453
-
Altana Pharma AG. Aminopyridine-derivatives. US7781453; 2010
-
(2010)
-
-
-
93
-
-
79952932748
-
-
Aventis Pharmaceuticals, Inc. Coumarins as iNOS inhibitors. WO2005026143
-
Aventis Pharmaceuticals, Inc. Coumarins as iNOS inhibitors. WO2005026143; 2005
-
(2005)
-
-
-
94
-
-
79952976706
-
-
Aventis Pharmaceutical, Inc. Coumarins as iNOS inhibitors. US7538233
-
Aventis Pharmaceutical, Inc. Coumarins as iNOS inhibitors. US7538233; 2009
-
(2009)
-
-
-
95
-
-
0025191219
-
Isolation of nitric oxide synthase, a calmodulin-requiring enzyme
-
Bredt DS, Snyder SH. Isolation of nitric oxide synthase, a calmodulin-requiring enzyme. Proc Natl Acad Sci 1990;87:682-5
-
(1990)
Proc Natl Acad Sci
, vol.87
, pp. 682-685
-
-
Bredt, D.S.1
Snyder, S.H.2
-
96
-
-
79952933620
-
-
Nycomed GMBH. Aminoazepine derivatives as highly efficient inhibitors of the inducible nitric oxide synthase. WO2008031788
-
Nycomed GMBH. Aminoazepine derivatives as highly efficient inhibitors of the inducible nitric oxide synthase. WO2008031788; 2008
-
(2008)
-
-
-
97
-
-
79952975436
-
-
Nycomed GMBH. Imidazopyridine derivatives useful as iNOS inhibitors. US7790710
-
Nycomed GMBH. Imidazopyridine derivatives useful as iNOS inhibitors. US7790710; 2010
-
(2010)
-
-
-
98
-
-
79952960184
-
-
Schering. N-heterocyclic derivatives as NOS inhibitors. US20060094725
-
Schering. N-heterocyclic derivatives as NOS inhibitors. US20060094725; 2006
-
(2006)
-
-
-
99
-
-
79952933159
-
-
Schering. 1-(Pyridazin-3-yl)-imidazole derivatives as inhibitors of nitric oxide synthase (NOS). US7202263
-
Schering. 1-(Pyridazin-3-yl)-imidazole derivatives as inhibitors of nitric oxide synthase (NOS). US7202263; 2007
-
(2007)
-
-
-
100
-
-
79952941662
-
-
Berlex Laboratories, Inc. N-Heterocyclic derivatives as NOS inhibitors. WO0114371
-
Berlex Laboratories, Inc. N-Heterocyclic derivatives as NOS inhibitors. WO0114371; 2003
-
(2003)
-
-
-
101
-
-
79952964417
-
-
Berlex Laboratories, Inc. N-Heterocyclic derivatives as NOS inhibitors. WO0114371
-
Berlex Laboratories, Inc. N-Heterocyclic derivatives as NOS inhibitors. WO0114371; 2005
-
(2005)
-
-
-
102
-
-
79952947477
-
-
Berlex Laboratories, Inc. N-Heterocyclic derivatives as NOS inhibitors. US6841674
-
Berlex Laboratories, Inc. N-Heterocyclic derivatives as NOS inhibitors. US6841674; 2005
-
(2005)
-
-
-
103
-
-
46149129367
-
Fluorometric determination of nitrite
-
Damiani P, Burini G. Fluorometric determination of nitrite. Talanta 1986;33:649-52
-
(1986)
Talanta
, vol.33
, pp. 649-652
-
-
Damiani, P.1
Burini, G.2
-
104
-
-
79952938598
-
-
Seoul national university foundation. Pharmaceutical composition, health food composition and iNOS inhibitors, containing theopederin derivatives. WO2008072937
-
Seoul national university foundation. Pharmaceutical composition, health food composition and iNOS inhibitors, containing theopederin derivatives. WO2008072937; 2007
-
(2007)
-
-
-
105
-
-
79952951719
-
-
Pharmacia Corp. Amidino compounds useful as nitric oxide synthase inhibitors. US6914158
-
Pharmacia Corp. Amidino compounds useful as nitric oxide synthase inhibitors. US6914158; 2004
-
(2004)
-
-
-
106
-
-
79952905686
-
-
Pharmacia Corp. 2-Amino-2-alkyl- 4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors. US20050256199
-
Pharmacia Corp. 2-Amino-2-alkyl- 4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors. US20050256199; 2005
-
(2005)
-
-
-
107
-
-
79952968362
-
-
Pharmacia Corp. Combination therapy with inhibitors of inducible nitric oxide and alkylating agents. WO2005025620
-
Pharmacia Corp. Combination therapy with inhibitors of inducible nitric oxide and alkylating agents. WO2005025620; 2005
-
(2005)
-
-
-
108
-
-
79952954875
-
-
Pharmacia Corp. Amidino compounds useful as nitric oxide synthase inhibitors. US7196118
-
Pharmacia Corp. Amidino compounds useful as nitric oxide synthase inhibitors. US7196118; 2007
-
(2007)
-
-
-
109
-
-
79952916247
-
-
Pharmacia Corp. 2-Amino-2-alkyl-5 heptenoic and heptynoic acid derivatives. WO2007203823
-
Pharmacia Corp. 2-Amino-2-alkyl-5 heptenoic and heptynoic acid derivatives. WO2007203823; 2007
-
(2007)
-
-
-
110
-
-
79952916254
-
-
Erba Carlo Spa. New aryl- and heteroarylathenylene derivatives and process for their preparation. WO1991013055
-
Erba Carlo Spa. New aryl- and heteroarylathenylene derivatives and process for their preparation. WO1991013055; 1991
-
(1991)
-
-
-
111
-
-
79952920856
-
-
Searle & CO; Currie Mark G. Amidino derivatives useful as nitric oxide synthase inhibitors. WO1995025717
-
Searle & CO; Currie Mark G. Amidino derivatives useful as nitric oxide synthase inhibitors. WO1995025717; 1995
-
(1995)
-
-
-
112
-
-
0033504035
-
Fluorometric nitrate analysis using 2,3-diaminonaphthalene: An improvement of the method
-
Carre MC, Mahieuxe JC, Andre JC, et al. Fluorometric nitrate analysis using 2,3-diaminonaphthalene: An improvement of the method. Analusis 1999;27:835-8
-
(1999)
Analusis
, vol.27
, pp. 835-838
-
-
Carre, M.C.1
Mahieuxe, J.C.2
Andre, J.C.3
-
113
-
-
79952962295
-
-
Kalypsys Incorporation. Inducible nitric oxide synthase dimerization inhibitors. US20060116515
-
Kalypsys Incorporation. Inducible nitric oxide synthase dimerization inhibitors. US20060116515; 2006
-
(2006)
-
-
-
114
-
-
79952924276
-
-
Kalypsys Incorporation. Inducible nitric oxide synthase dimerization inhibitors. US2006060424
-
Kalypsys Incorporation. Inducible nitric oxide synthase dimerization inhibitors. US2006060424; 2006
-
(2006)
-
-
-
115
-
-
79952958921
-
-
Kalypsys Incorporation. Salts of inducible nitric oxide synthase dimerization inhibitors. US20070197609
-
Kalypsys Incorporation. Salts of inducible nitric oxide synthase dimerization inhibitors. US20070197609; 2007
-
(2007)
-
-
-
116
-
-
79952903026
-
-
Kalypsys Incorporation. Imidazole derivatives as nitric oxide synthase dimerization inhibitor. WO2007062410
-
Kalypsys Incorporation. Imidazole derivatives as nitric oxide synthase dimerization inhibitor. WO2007062410; 2007
-
(2007)
-
-
-
117
-
-
79952954006
-
-
Kalypsys Incorporation. Methods of preparing 2-imidazol-1-yl-4-methyl-6- pyrrolidin-2-yl-pyrimidine and 4-(1- alkylpyrrolodin-2-yl)-2-(1H-imidazol-1- yl)-6methylpyrimidine derivatives. US20080293942
-
Kalypsys Incorporation. Methods of preparing 2-imidazol-1-yl-4-methyl-6- pyrrolidin-2-yl-pyrimidine and 4-(1- alkylpyrrolodin-2-yl)-2-(1H-imidazol-1- yl)-6methylpyrimidine derivatives. US20080293942; 2008
-
(2008)
-
-
-
118
-
-
79952937326
-
-
Kalypsys Incorporation. Quinolones useful as inducible nitric oxide synthase inhibitors. WO2007117778
-
Kalypsys Incorporation. Quinolones useful as inducible nitric oxide synthase inhibitors. WO2007117778; 2007
-
(2007)
-
-
-
119
-
-
79952927682
-
-
Kalypsys Incorporation. Isoquinolines useful as inducible nitric oxide synthase inhibitors. WO2008103615
-
Kalypsys Incorporation. Isoquinolines useful as inducible nitric oxide synthase inhibitors. WO2008103615; 2008
-
(2008)
-
-
-
120
-
-
79952947908
-
-
Kalypsys Incorporation. Topical pharmaceutical formulation comprising an iNOS inhibitor for the treatment of disease. WO2008086176
-
Kalypsys Incorporation. Topical pharmaceutical formulation comprising an iNOS inhibitor for the treatment of disease. WO2008086176; 2008
-
(2008)
-
-
-
121
-
-
79952979959
-
-
Kalypsys Incorporation. 4-[heterocyclylmethyl]- 8-fluoro-quinolin-2-ones useful as nitric oxide synthase inhibitors. WO2009029625
-
Kalypsys Incorporation. 4-[heterocyclylmethyl]- 8-fluoro-quinolin-2-ones useful as nitric oxide synthase inhibitors. WO2009029625; 2009
-
(2009)
-
-
-
122
-
-
79952939040
-
-
Kalypsys Incorporation. Diarylamine-substituted quinolones useful as inducible nitric oxide synthase inhibitors. WO2009029617
-
Kalypsys Incorporation. Diarylamine-substituted quinolones useful as inducible nitric oxide synthase inhibitors. WO2009029617; 2009
-
(2009)
-
-
-
123
-
-
79952947920
-
-
Kalypsys Incorporation. Heterobicyclic-substituted quinolones useful as nitric oxide synthase inhibitors. WO2009029595
-
Kalypsys Incorporation. Heterobicyclic-substituted quinolones useful as nitric oxide synthase inhibitors. WO2009029595; 2009
-
(2009)
-
-
-
124
-
-
0031889021
-
Evidence that inducible nitric oxide synthase is involved in LPS-induced plasma leakage in rat skin through the activation of nuclear factor-κB
-
DOI 10.1038/sj.bjp.0701730
-
Luvone T, D'Acquisto F, Van Osselaer N, et al. Evidence that inducible nitric oxide synthase is involved in LPS-induced plasma leakage in rat skin through the activation of nuclear factor-kappaB. Br J Pharmacol 1998;123:1325-30 • This study indicated that LPS-induced plasma leakage in rat skin is modulated by NO mainly produced by the inducible isoform of NOS. Furthermore, the suppression of plasma leakage by PDTC, an inhibitor of NF-kB activation, is correlated to the inhibition of iNOS protein expression (Pubitemid 28143131)
-
(1998)
British Journal of Pharmacology
, vol.123
, Issue.7
, pp. 1325-1330
-
-
Iuvone, T.1
D'Acquisto, F.2
Van Osselaer, N.3
Di Rosa, M.4
Carnuccio, R.5
Herman, A.G.6
-
125
-
-
79952960185
-
-
Kalypsys Incorporation. Treatment of inflammation and related disorders by activation of the unfolded protein response. WO2007084868
-
Kalypsys Incorporation. Treatment of inflammation and related disorders by activation of the unfolded protein response. WO2007084868; 2007
-
(2007)
-
-
-
126
-
-
79952903901
-
-
Kalypsys Incorporation. Novel 2-oxo-1,2,3,4-tetrahydropyrimidines, bicyclic pyrimidine diones and imidazolidine-2,4-diones useful as inducible nitric oxide synthase inhibitors. WO2007101213
-
Kalypsys Incorporation. Novel 2-oxo-1,2,3,4-tetrahydropyrimidines, bicyclic pyrimidine diones and imidazolidine-2,4-diones useful as inducible nitric oxide synthase inhibitors. WO2007101213; 2007
-
(2007)
-
-
-
127
-
-
79952952728
-
-
Pfizer Inc. S-[2[(1-Iminoethyl)amino] ethyl]-2-methyl-L-cysteine maleate hydrochloride crystalline salt. US7767850
-
Pfizer, Inc. S-[2[(1-Iminoethyl)amino] ethyl]-2-methyl-L-cysteine maleate hydrochloride crystalline salt. US7767850; 2010
-
(2010)
-
-
-
128
-
-
79952921385
-
-
Pharmacia Corporation. Amidino compounds and salts thereof useful as nitric oxide synthase inhibitors. US6403830
-
Pharmacia Corporation. Amidino compounds and salts thereof useful as nitric oxide synthase inhibitors. US6403830; 2002
-
(2002)
-
-
-
129
-
-
79952974622
-
-
AstraZeneca. Anti-inflammatory 3-Aryl-3-thiazolyl-alkylamines. WO2004041794
-
AstraZeneca. Anti-inflammatory 3-Aryl-3-thiazolyl-alkylamines. WO2004041794; 2004
-
(2004)
-
-
-
130
-
-
79952946228
-
-
AstraZeneca. Novel compounds. WO2004009580
-
AstraZeneca. Novel compounds. WO2004009580; 2004
-
(2004)
-
-
-
131
-
-
79952929357
-
-
AstraZeneca. Heteroarylheteroallkylamine derivatives and their use as inhibitors of nitric oxide synthase. WO03011831
-
AstraZeneca. Heteroarylheteroallkylamine derivatives and their use as inhibitors of nitric oxide synthase. WO03011831; 2004
-
(2004)
-
-
-
132
-
-
79952933963
-
-
AstraZeneca. Arylheteroalkylamine derivatives and their use as inhibitors of nitric oxide synthase. WO03011210
-
AstraZeneca. Arylheteroalkylamine derivatives and their use as inhibitors of nitric oxide synthase. WO03011210; 2005
-
(2005)
-
-
-
133
-
-
79952936021
-
-
AstraZeneca. Compounds for the inhibition of nitric oxide synthase. US7276528
-
AstraZeneca. Compounds for the inhibition of nitric oxide synthase. US7276528; 2007
-
(2007)
-
-
-
134
-
-
79952940376
-
-
AstraZeneca. Substituted thiophene compounds. US7329686
-
AstraZeneca. Substituted thiophene compounds. US7329686; 2008
-
(2008)
-
-
-
135
-
-
0026565840
-
Induced RAW 264.7 macrophages express soluble and particulate nitric oxide synthase: Inhibition by transforming growth factor-beta
-
Forstermann U, Schmidt HHHW, Kohlhaas KL, et al. Induced RAW 264.7 macrophages express soluble and particulate nitric oxide synthase: Inhibition by transforming growth factor-beta. Eur J Pharm 1992;225:161-5
-
(1992)
Eur J Pharm
, vol.225
, pp. 161-165
-
-
Forstermann, U.1
Schmidt, H.H.H.W.2
Kohlhaas, K.L.3
-
136
-
-
0036912721
-
Nitric oxide as a unique signaling molecule in the vascular system: A historical overview
-
Ignarro LJ. Nitric oxide as a unique signaling molecule in the vascular system: A historical overview. J Physiol Pharmacol 2002;53:503-14 • This review discusses novel NO donor drugs for clinical use for the treatment of essential hypertension, stroke, coronary artery disease, vascular complications of diabetes, impotency and other disorders involving the vascular system (Pubitemid 36014797)
-
(2002)
Journal of Physiology and Pharmacology
, vol.53
, Issue.4 I
, pp. 503-514
-
-
Ignarro, L.J.1
-
137
-
-
0037324283
-
Endothelial dysfunction: A marker of atherosclerotic risk
-
DOI 10.1161/01.ATV.0000051384.43104.FC
-
Bonetti PO, Lerman LO, Lerman A. Endothelial dysfunction: A marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol 2003;23:168-75 (Pubitemid 36231924)
-
(2003)
Arteriosclerosis, Thrombosis, and Vascular Biology
, vol.23
, Issue.2
, pp. 168-175
-
-
Bonetti, P.O.1
Lerman, L.O.2
Lerman, A.3
-
138
-
-
0035960677
-
Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease
-
Heitzer T, Schlinzig T, Krohn K, et al. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 2001;104:2673-8 (Pubitemid 33108132)
-
(2001)
Circulation
, vol.104
, Issue.22
, pp. 2673-2678
-
-
Heitzer, T.1
Schlinzig, T.2
Krohn, K.3
Meinertz, T.4
Munzel, T.5
-
139
-
-
0034634281
-
Endothelial dysfunction in cardiovascular diseases: The role of oxidant stress
-
Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: The role of oxidant stress. Circ Res 2000;87:840-4
-
(2000)
Circ Res
, vol.87
, pp. 840-844
-
-
Cai, H.1
Harrison, D.G.2
-
140
-
-
57749085681
-
Multifunctional drugs as neurotherapeutics
-
• A review of the design and progress made on multifunctional drugs and why this approach may have merit in designing therapeutics for neurodegenerative disorders
-
Van der Schyf CJ, Youdim MB. Multifunctional drugs as neurotherapeutics. Neurotherapeutics 2009;6:1-201 • A review of the design and progress made on multifunctional drugs and why this approach may have merit in designing therapeutics for neurodegenerative disorders
-
(2009)
Neurotherapeutics
, vol.6
, pp. 1-201
-
-
Van Der Schyf, C.J.1
Youdim, M.B.2
-
141
-
-
65249163408
-
Design of selective neuronal nitric oxide synthase inhibitors for the prevention and treatment of neurodegenerative diseases
-
•• This study describes that the cis and trans isomers of a series of amino pyrrolidinomethyl 2-aminopyridine derivatives had different binding conformations in the NOS active site, revealing some critical structural requirements for ligand binding
-
Silverman RB. Design of selective neuronal nitric oxide synthase inhibitors for the prevention and treatment of neurodegenerative diseases. Acc Chem Res 2009;42(3):439-51 •• This study describes that the cis and trans isomers of a series of amino pyrrolidinomethyl 2-aminopyridine derivatives had different binding conformations in the NOS active site, revealing some critical structural requirements for ligand binding.
-
(2009)
Acc Chem Res
, vol.42
, Issue.3
, pp. 439-451
-
-
Silverman, R.B.1
|