Nitric oxide v. Therapeutic potential of nitric oxide donors and inhibitors

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 276, Issue 6 39-6, 1999, Pages

  Muscará, Marcelo N ^a   Wallace, John L ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

Inflammation; Inflammatory bowel disease; Ischemia reperfusion; Ulcer

Indexed keywords

NITRIC OXIDE; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; PEROXYNITRITE;

ARTICLE; DIGESTIVE SYSTEM INJURY; ENTERITIS; GASTROINTESTINAL MUCOSA; GASTROINTESTINAL TOXICITY; HUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SHOCK; ULCEROGENESIS;

EID: 0033063534     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1999.276.6.g1313     Document Type: Article

References (26)

1. Beckman, J. S., T. W. Beckman, J. Chen, P.A. Marshall, and B.A. Freeman. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. USA 87: 1620-1624, 1990.
2. Beckman, J. S., Y. Z. Ye, P. G. Anderson, J. Chen, M. A. Accavitti, M. M. Tarpey, and C. R. White. Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry. Biol. Chem. Hoppe-Seyler 375: 81-88, 1994.
3. Eiserich, J. P., M. Hristova, C. E. Cross, A. D. Jones, B. A. Freeman, B. Halliwell, and A. Van der Vliet. Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils. Nature 391: 393-397, 1998.
4. Elliott, S. N., W. McKnight, G. Cirino, and J. L. Wallace. A nitric oxide-releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in rats. Gastroenterology 109: 524-530, 1995.
5. Fricker, S. P., E. Slade, N. A. Powell, O. J. Vaughan, G. R. Henderson, B. A. Murrer, I. L. Megson, S. K. Bisland, and F. W. Flitney. Ruthenium complexes as nitric oxide scavengers: a potential therapeutic approach to nitric oxide-mediated diseases. Br. J. Pharmacol. 122: 1441-1449, 1997.
6. Fujihara, C. K., D. M. A. C. Malheiros, J. L. Donato, A. Poli, G. De Nucci, and R. Zatz. Nitroflurbiprofen, a new nonsteroidal anti-inflammatory, ameliorates structural injury in the remnant kidney. Am. J. Physiol. 274 (Renal Physiol. 43): F573-F579, 1998.
7. Kamisaki, Y., K. Wada, K. Bian, B. Balabanli, K. Davis, E. Martin, F. Behbod, Y. C. Lee, and F. Murad. An activity in rat tissues that modifies nitrotyrosine-containing proteins. Proc. Natl. Acad. Sci. USA 95: 11584-11589, 1998.
8. Kimura, H., R. Hokari, S. Miura, T. Shigematsu, M. Hirokawa, Y. Akiba, I. Kurose, H. Higuchi, H. Fujimori, Y. Tsuzuki, H. Serizawa, and H. Ishii. Increased expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in colonic mucosa of patients with active ulcerative colitis. Gut 42: 180-187, 1998.
9. Kubes, P., and J. L. Wallace. Nitric oxide as a mediator of gastrointestinal mucosal injury - say it ain't so. Med. Inflamm. 4: 397-405, 1995.
10. Lund, J. N., and J. H. Scholefield. Glyceryl trinitrate is an effective treatment for anal fissure. Dis. Colon Rectum 40: 468-470, 1997.
11. MacNaughton, W. K., G. Cirino, and J. L. Wallace. Endothelium-derived relaxing factor (nitric oxide) has protective actions in the stomach. Life Sci. 45: 1869-1876, 1989.
12. Maeda, H., T. Akaike, M. Yoshida, and M. Suga. Multiple functions of nitric oxide in pathophysiology and microbiology: analysis by a new nitric oxide scavenger. J. Leukoc. Biol. 56: 588-592, 1994.
13. McCafferty, D. M., J. S. Mudgett, M. G. Swain, and P. Kubes. Inducible nitric oxide synthase plays a critical role in resolving intestinal inflammation. Gastroenterology 112: 1022-1027, 1997.
14. Miller, M. J. S., and M. B. Grisham. Nitric oxide as a mediator of inflammation? You had better believe it! Med. Inflamm. 4: 387-396, 1995.
15. Miller, M. J. S., J. H. Thompson, X. J. Zhang, H. Sadowska-Krowicka, J. L. Kakkis, U. K. Munshi, M. Sandoval, J. L. Rossi, S. Eloby-Childress, J. S. Beckman, Y. Z. Ye, C. P. Rodi, P. T. Manning, M. G. Currie, and D. A. Clark. Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis. Gastroenterology 109: 1475-1483, 1995.
16. Payne, D., and P. Kubes. Nitric oxide donors reduce the rise in reperfusion-induced intestinal mucosal permeability. Am. J. Physiol. 265 (Gastrointest. Liver Physiol. 28): G189-G195, 1993.
17. Ribbons, K. A., M. G. Currie, J. R. Connor, P. T. Manning, P. C. Allen, P. Didier, M. S. Rattevree, D. A. Clark, and M. J. Miller. The effect of inhibitors of inducible nitric oxide synthase on chronic colitis in the rhesus monkey. J. Pharmacol. Exp. Ther. 280: 1008-1115, 1997.
18. Saavedra, J. E., T. R. Billiar, D. L. Williams, Y. M. Kim, S. C. Watkins, and L. K. Keefer. Targeting nitric oxide (NO) delivery in vivo. Design of a liver-selective NO donor prodrug that blocks tumor necrosis factor-α-induced apoptosis and toxicity in the liver. J. Med. Chem. 40: 1947-1955, 1997.
19. Sandoval, M., X. Liu, E. E. Mannick, D. A. Clark, and M. J. Miller. Peroxynitrite-induced apoptosis in human intestinal epithelial cells is attenuated by mesalamine. Gastroenterology 113: 1480-1488, 1997.
20. Southan, G. J., and C. Szabo. Selective pharmacological inhibition of distinct nitric oxide synthase isoforms. Biochem. Pharmacol. 51: 383-394, 1996.
21. Southey, A., S. Tanaka, T. Murakami, H. Miyoshi, T. Ishizuka, M. Sugiura, K. Kawashima, and T. Sugita. Pathophysiological role of nitric oxide in experimental colitis. Int. J. Immunopharmacol. 19: 669-676, 1997.
22. Wallace, J. L. Cooperative modulation of gastrointestinal mucosal defence by prostaglandins and nitric oxide. Clin. Invest. Med. 19: 346-351, 1996.
23. Wallace, J. L. Nonsteroidal anti-inflammatory drugs and gastroenteropathy: the second hundred years. Gastroenterology 112: 1000-1016, 1997.
24. Wallace, J. L., S. N. Elliott, P. Del Soldato, W. McKnight, F. Sannicolo, and G. Cirino. Gastrointestinal sparing anti-inflammatory drugs: the development of nitric oxide-releasing NSAIDs. Drug Dev. Res. 42: 144-149, 1998.
25. Wallace, J. L., B. Reuter, C. Cicala, W. McKnight, M. B. Grisham, and G. Cirino. Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat. Gastroenterology 107: 173-179, 1994.
26. Zingarelli, B., S. Cuzzocrea, C. Szabo, and A. L. Salzman. Mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, reduces trinitrobenzene sulfonic acid-induced colonic damage in rats. J. Pharmacol. Exp. Ther. 287: 1048-1055, 1998.