ONO1714, a new inducible nitric oxide synthase inhibitor, attenuates sepsis-induced diaphragmatic dysfunction in hamsters

Anesthesia and Analgesia

Volumn 92, Issue 4, 2001, Pages 959-966

  Nishina, Kahoru ^a   Mikawa, Katsuya ^a   Kodama, Shun Ichi ^a   Obara, Hidefumi ^a  

^a KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

7 CHLORO 3 IMINO 5 METHYL 2 AZABICYCLO[4.1.0]HEPTANE; MALONALDEHYDE; NITRATE; NITRIC OXIDE SYNTHASE INHIBITOR; NITRITE; PEROXYNITRITE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIAPHRAGM PARALYSIS; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG SELECTIVITY; ENDURANCE; FATIGUE; LIPID PEROXIDATION; MUSCLE CONTRACTILITY; NONHUMAN; PRIORITY JOURNAL; SEPSIS; SYRIAN HAMSTER;

EID: 0035076467     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-200104000-00031     Document Type: Article

References (25)

1. Mechanisms of disease: Are oxygen-derived free radicals involved in diaphragmatic dysfunction?
2. Peritonitis causes diaphragm weakness in rats
3. Induction of diaphragmatic nitric oxide synthase after endotoxin administration in rats: Role on diaphragmatic contractile dysfunction
4. Endotoxin-induced skeletal muscle contractile dysfunction: Contribution of nitric oxide synthases
5. Peroxynitrite induces contractile dysfunction and lipid peroxidation in the diaphragm
6. Endogenous peroxynitrite mediates mitochondrial dysfunction in rat diaphragm during endotoxemia
7. Endotoxin-induced skeletal muscle contractile dysfunction: Contribution of nitric oxide synthases
8. Diaphragm sarcolemmal injury is induced by sepsis and alleviated by nitric oxide synthase inhibition
9. A potent inhibitor of inducible nitric oxide synthase, ONO-1714, a cyclic amidine derivative
10. Sepsis and septic shock - A review of laboratory models and a proposal
11. A new chromatogenic endotoxin specific assay using recombined limulus coagulation enzymes and its clinical application
12. Analysis of nitrate, nitrite, and 15N nitrate in biological fluids
13. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
14. Determination of malondialdehyde precursor in tissues by thiobarbituric acid test
15. Dynamic properties of mammalian skeletal muscles
16. Expression of nitric oxide synthases and GTP cyclohydrolase I in the ventilatory and limb muscles during endotoxemia
17. Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide
18. Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly
19. Redox signaling: Nitrosylation and related target interactions of nitric oxide
20. Peroxynitrite causes energy depletion and increases permeability via activation of poly (ADP-ribose) synthetase in pulmonary epithelial cells
21. DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite
22. Lipopolysaccharide-induced diaphragmatic contractile dysfunction in mice lacking the inducible nitric oxide synthase
23. Peroxynitrite formed by simultaneous nitric oxide and superoxide generation causes cyclosporin-A-sensitive mitochondrial calcium efflux and depolarisation
24. The diaphragm as a muscle: Mechanisms underlying fatigue
25. Respiratory muscle energetics during endotoxic shock in dogs