Evidence that inducible nitric oxide synthase is involved in LPS-induced plasma leakage in rat skin through the activation of nuclear factor-κB

British Journal of Pharmacology

Volumn 123, Issue 7, 1998, Pages 1325-1330

  Iuvone, Teresa ^a,c   D'Acquisto, Fulvio ^a   Van Osselaer, Nancy ^b   Di Rosa, Massimo ^a   Carnuccio, Rosa ^a   Herman, Arnold G ^b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF ANTWERP   (Belgium)

^c Dept of Experimental Pharmacology ^*  (Italy)

Author keywords

iNOS; L NAME; LPS induced plasma leakage; Nitric oxide; Nuclear factor B

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PYRROLIDINE DITHIOCARBAMATE; SERUM ALBUMIN; THIOUREA DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; EXTRAVASATION; IMMUNOBLOTTING; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SKIN BLOOD FLOW;

ANIMALS; CAPILLARY PERMEABILITY; ENZYME INDUCTION; ENZYME INHIBITORS; LIPOPOLYSACCHARIDES; MALE; NF-KAPPA B; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PYRROLIDINES; RATS; RATS, WISTAR; SKIN; THIOCARBAMATES;

EID: 0031889021     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701730     Document Type: Article

References (33)

1. ADCOCK, I.M., BROWN, C.R., KWON, O. & BARNES, P.J. (1994). Oxidative stress induces NF-κB DNA binding and inducible NOS mRNA in human epithelial cells. Biochem. Biophys. Res. Commun., 199, 1518-1524.
2. BAEUERLE, P.A. & HENKEL, T. (1994). Function and activation of NF-κB in the immune system. Ann. Rev. Immunol., 12, 141-179.
3. BLACKWELL, T.S., BLACKWELL, T.R., HOLDEN, E.P., CHRISTMAN, B.W. & CHRISTMAN, J.W. (1996). In vivo antioxidant treatment suppresses nuclear factor-κB activation and neutrophilic lung inflammation. J. Immunol., 157, 1630-1637.
4. G-nitro-L-arginine methyl ester to the rat on inhibition of nitric oxide-mediated responses. Br. J. Pharmacol., 114, 1673-1679.
5. ESSANI, N.A., MCGUIRE, G.M., MANNING, A.M. & JAESCHKE, H. (1996). Endotoxin-induced activation of nuclear transcription factor κB and expression of E-selectin messenger RNA in hepatocytes, Kupffer cells, and endothelial cells in vivo. J. Immunol., 156, 2956-2963.
6. FUJII, E., IRIE, K., OGAWA, A., OHBA, K. & MURAKI, T. (1996). Role of nitric oxide and prostaglandins in lipopolysaccharide-induced increase in vascular permeability in mouse skin. Eur. J. Pharmacol., 297, 257-263.
7. G-nitro-L-arginine methyl ester in conscious, Long Evans rats. Br. J. Pharmacol., 101, 625-631.
8. GRIMM, S. & BAEUERLE, P.A. (1993). The inducible transcription factor NF-κB: structure-function relationship of its protein subunits. Biochem. J., 290, 297-308.
9. IALENTI, A., IANARO, A., MONCADA, S. & DI ROSA, M. (1992). Modulation of acute inflammation by endogenous nitric oxide. Eur. J. Pharmacol., 24, 177-182.
10. ISSEKUTZ, A.C. & BHIMJI, S. (1982). Role for endotoxin in the leukocyte infiltration accompaying Escherichia Coli inflammation. Infect. Immunol., 36, 558-566.
11. IUVONE, T., VAN OSSELAER, N., D'ACQUISTO, F., CARNUCCIO, R. & HERMAN, A.G. (1997). Differential effect of L-NAME and S-methylisothiourea on leukocyte emigration in carrageenin-soaked sponge implants in rat. Br. J. Pharmacol., 121, 1637-1644.
12. KIELIAN, T.L. & BLECHA, F. (1995). CD14 and other recognition molecules for lipopolysaccharide: a review. Immunopharmacology, 29, 187-205.
13. KNOWLES, R.G. & MONCADA, S. (1994). Nitric oxide synthase in mammals. Biochem. J., 298, 249-258.
14. KOPANIAK, M.M., ISSEKUTZ, A.C. & MOVAT, H.Z. (1980). Kinetics of acute inflammation induced by E. Coli in rabbits: quantitation of blood flow, enhanced vascular permeability, hemorrage and leukocyte accumulation. Am. J. Pathol., 98, 485-498.
15. KUBES, P., SUZUKI, M & GRANGER, D.N. (1991). Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc. Natl. Acad. Sci. U.S.A., 88, 4651-4655.
16. LASZLO, F., WHITTLE, B.J.R., EVANS, S.M. & MONCADA, S. (1995). Association of microvascular leakage with induction of nitric oxide synthase: effects of nitric oxide synthase inhibitors in various organs. Eur. J. Pharmacol., 283, 47-53.
17. LEE, S.H., SOYOLA, E., CHANMUGARN, P., HART, S., SUN, W., ZHONG, H., LIOU, S., SIMMONS, D., & HWANG, D. (1992). Selective expression of mitogen inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J. Biol. Chem., 267, 25934-25939.
18. MISKO, T.P., MOORE, W.M., KASTEN, T.P., NICKOLS, G.A., CORBETT, J.A., TILTON, R.G., MCDANIEL, M.L., WILLIAMSON, J.R. & CURRIE, M.G. (1993). Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. Eur. J. Pharmacol., 233, 119-125.
19. MONCADA. S., PALMER, R.M.J. & HIGGS, E.A. (1991). Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol. Rev., 43, 109-142.
20. MULSCH, A., SCHRAY-UTZ, B., MORDVINTCEV, P.I., HAUSCHILDT, S. & BUSSE, R. (1993). Diethyldithiocarbamate inhibits induction of macrophage NO synthase. FEBS Lett., 321, 215-218.
21. REES, D.D., PALMER, R.M.J., SCHULZ, R., HUDSON, H.F. & MONCADA, S. (1990). Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br. J. Pharmacol., 101, 746-752.
22. SALVEMINI, D., WANG, Z-Q., BOURDON, D.M., STERN, M.K., CURRIE, MG. & MANNING, P.T. (1996). Evidence of peroxynitrite involvement in the carrageenin-induced rat paw edema. Eur. J. Pharmacol., 303, 217-220.
23. SCHRECK, R., MEIER, B., MANNEL, D.N., DROGE, W. & BAEUERLE, P.A. (1992). Dithiocarbammates as potent inhibitors of nuclear factor kappa B activation in intact cells. J. Exp. Med., 175, 1181-1194.
24. SCHRECK, R., RIEBER, P. & BAEUERLE, P.A. (1991). The role of hydrogen peroxide and Superoxide as messengers in the activation of transcription factor NF-κB. EMBO J., 10, 2247-2258.
25. SCHREIBER, E., MATTHIAS, P., MULLER, M.M. & SHAFFNER, W. (1989). Rapid detection of octamer binding proteins with 'miniextracts' prepared from a smaller number of cells. Nucl. Acids Res., 17, 6419.
26. SOUTHAN, G.J., SZABO, C. & THIEMERMANN, C. (1995). Isothioureas: potent inhibitors of nitric oxide with variable isoform selectivity. Br. J. Pharmacol., 114, 510-516.
27. SZABO, C., SOUTHAN, G.J. & THIEMERMANN, C. (1994). Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase. Proc. Natl. Acad. Sci. U.S.A., 91, 12472-12476.
28. TOMLINSON, A., APPELTON, I., MOORE, A.R., GILROY, D.W., WILLIS, D., MITCHELL, J. & WILLOUGHBY, D.A. (1994). Cyclooxygenase and nitric oxide synthase isoforms in rat carrageenin-induced pleurisy. Br. J. Pharmacol., 113, 693-698.
29. 2 and the vascular changes of inflammation. Br. J. Pharmacol., 65, 517-524.
30. WRIGHT, C.E., REES, D.D. & MONCADA, S. (1992). Protective and pathological roles of nitric oxide in endotoxic shock. Cardivasc. Res., 26, 48-57.
31. WU, C.C., CHEN, S.J., SZABO, C., THIEMERMANN, C. & VANE, J.R. (1995). Aminoguanidine attenuates the delayed circulatory failure and improves survival in rodent models of endotoxic shock. Br. J. Pharmacol., 114, 1666-1672.
32. WULCZYN, F.G., KRAPPMANN, D. & SCHEIDEREIT, C. (1996). The NF-κB/Rel and IκB gene families: mediators of immune response and inflammation. J. Mol. Med., 74, 749-769.
33. XIE, Q., KASHIWABARA, Y. & NATHAN, C. (1994). Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase. J. Biol. Chem., 269, 4705-4708.