Neuronal death and oxidative stress in the developing brain

Antioxidants and Redox Signaling

Volumn 14, Issue 8, 2011, Pages 1535-1550

  Ikonomidou, Chrysanthy ^a   Kaindl, Angela M ^b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ANTICONVULSIVE AGENT; FREE RADICAL; SEDATIVE AGENT;

AGE DETERMINATION; BRAIN DAMAGE; BRAIN DEVELOPMENT; BRAIN GROWTH; BRAIN NERVE CELL; CELL DEATH; ENERGY RESOURCE; HUMAN; HYPEROXIA; HYPOXIA; ISCHEMIA; METABOLIC PARAMETERS; MITOCHONDRION; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; OXYGEN TOXICITY; PATHOGENESIS; PERINATAL ASPHYXIA; PREMATURITY; PRIORITY JOURNAL; REVIEW; TRAUMATIC BRAIN INJURY;

ANIMALS; BRAIN; CELL DEATH; FREE RADICAL SCAVENGERS; HUMANS; NEURONS; OXIDATIVE STRESS;

EID: 79952854710     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2010.3581     Document Type: Review

References (201)

1. Adelson PD, Kochanek PM. Head injury in children. J Child Neurol 13: 2-15, 1998. (Pubitemid 28136228)
2. Amin S, Chen SY, Collipp PJ, Castro-Magana M, Maddaiah VT, and Klein SW. Selenium in premature infants. Nutr Metab 24: 331-340, 1980. (Pubitemid 11237329)
3. Appelberg KS, Hovda DA, and Prins ML. The effects of a ketogenic diet on behavioral outcome after controlled cortical impact injury in the juvenile and adult rat. J Neurotrauma 26: 497-506, 2009.
4. Asimiadou S, Bittigau P, Felderhoff-Mueser U, Manthey D, Sifringer M, Pesditschek S, Dzietko M, Kaindl AM, Pytel M, Studniarczyk D, Mozrzymas JW, and Ikonomidou C. Protection with estradiol in developmental models of apoptotic neurodegeneration. Ann Neurol 58: 266-276, 2005. (Pubitemid 41098884)
5. Aspberg A and Tottmar O. Development of antioxidant enzymes in rat brain and in reaggregation culture of fetal brain cells. Brain Res Dev Brain Res 66: 55-58, 1992.
6. Barr HM and Streissguth AP. Identifying maternal selfreported alcohol use associated with fetal alcohol spectrum disorders. Alcohol Clin Exp Res 25: 283-287, 2001. (Pubitemid 32167446)
7. Ben-Ari Y, Gaiarsa JL, Tyzio R, and Khazipov R. GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations. Physiol Rev 87: 1215-1284, 2007. (Pubitemid 350041471)
8. Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, and Gaiarsa JL. GABAA, NMDA and AMPA receptors: a developmentally regulated "menage a trois." Trends Neurosci 20: 523-529, 1997. (Pubitemid 27459658)
9. Bhave G, Karim F, Carlton SM, and Gereau RWT. Peripheral group I metabotropic glutamate receptors modulate nociception in mice. Nat Neurosci 4: 417-423, 2001. (Pubitemid 32260119)
10. Bittigau P and Ikonomidou C. Glutamate in neurologic diseases. J Child Neurol 12:471-485, 1997. (Pubitemid 28087362)
11. Bittigau P, Pohl D, Sifringer M, Shimizu H, Ikeda M, Ishimaru M, Stadthaus D, Fuhr S, Dikranian K, Olney JW, and Ikonomidou C. Modeling pediatric head trauma: mechanisms of degeneration and potential strategies for neuroprotection. Res Neurol Neurosci 13: 11-23, 1998. (Pubitemid 28526917)
12. Bittigau P, Sifringer M, Felderhoff-Mueser U, Hansen HH, and Ikonomidou C. Neuropathological and biochemical features of traumatic injury in the developing brain. Neurotox Res 5: 475-490, 2003.
13. Bittigau P, Sifringer M, Felderhoff-Mueser U, and Ikonomidou C. Apoptotic neurodegeneration in the context of traumatic injury to the developing brain. Exp Toxicol Pathol 56: 83-89, 2004. (Pubitemid 39486850)
14. Bittigau P, Sifringer M, Genz K, Reith E, Pospischil D, Govindarajalu S, Dzietko M, Pesditschek S, Mai I, Dikranian K, Olney JW, and Ikonomidou C. Antiepileptic drugs and apoptotic neurodegeneration in the developing brain. Proc Natl Acad Sci USA 99: 15089-15094, 2002. (Pubitemid 35334614)
15. Bittigau P, Sifringer M, Pohl D, Stadthaus D, Ishimaru M, Shimizu H, Ikeda M, Lang D, Speer A, Olney JW, Ikonomidou C, et al. Apoptotic neurodegeneration following trauma is markedly enhanced in the immature brain. Ann Neurol 45: 724-735, 1999. (Pubitemid 29260749)
16. Blomgren K and Hagberg H. Free radicals, mitochondria, and hypoxia-ischemia in the developing brain. Free Radic Biol Med 40: 388-397, 2006. (Pubitemid 43139674)
17. Blomgren K, Leist M, and Groc L. Pathological apoptosis in the developing brain. Apoptosis 12: 993-1010, 2007. (Pubitemid 46653298)
18. Booth RF, Patel TB, and Clark JB. The development of enzymes of energy metabolism in the brain of a precocial (guinea pig) and non-precocial (rat) species. J Neurochem 34: 17-25, 1980. (Pubitemid 10172674)
19. Borowsky IW and Collins RC. Metabolic anatomy of brain: a comparison of regional capillary density, glucose metabolism, and enzyme activities. J Comp Neurol 288: 401-413, 1989. (Pubitemid 19247617)
20. Bouslama M, Renaud J, Olivier P, Fontaine RH, Matrot B, Gressens P, and Gallego J. Melatonin prevents learning disorders in brain-lesioned newborn mice. Neuroscience 150: 712-719, 2007. (Pubitemid 350214500)
21. Brion LP, Bell EF, and Raghuveer TS. Vitamin E supplementation for prevention of morbidity and mortality in preterm infants. Cochrane Database Syst Rev CD003665, 2003.
22. Bruns J Jr and Hauser WA. The epidemiology of traumatic brain injury: a review. Epilepsia 44(suppl 10): 2-10, 2003. (Pubitemid 37280386)
23. Bulte DP, Chiarelli PA, Wise RG, and Jezzard P. Cerebral perfusion response to hyperoxia. J Cereb Blood Flow Metab 27: 69-75, 2007. (Pubitemid 46006585)
24. Buonocore G, Perrone S, and Bracci R. Free radicals and brain damage in the newborn. Biol Neonate 79: 180-186, 2001. (Pubitemid 32247083)
25. Chu J, Tong M, and de la Monte SM. Chronic ethanol exposure causes mitochondrial dysfunction and oxidative stress in immature central nervous system neurons. Acta Neuropathol 113: 659-673, 2007. (Pubitemid 46863902)
26. Conti F. Localization of NMDA receptors in the cerebral cortex: a schematic overview. Braz J Med Biol Res 30: 555-560, 1997. (Pubitemid 127521173)
27. Cooper PA, Rothberg AD, Pettifor JM, Bolton KD, and Devenhuis S. Growth and biochemical response of premature infants fed pooled preterm milk or special formula. J Pediatr Gastroenterol Nutr 3: 749-754, 1984. (Pubitemid 14011397)
28. Cotman CW, Monaghan DT, and Ganong AH. Excitatory amino acid neurotransmission: NMDA receptors and Hebb-type synaptic plasticity. Annu Rev Neurosci 11: 61-80, 1988. (Pubitemid 18081033)
29. Cremer JE, Braun LD, and Oldendorf WH. Changes during development in transport processes of the blood-brain barrier. Biochim Biophys Acta 448: 633-637, 1976.
30. Dahl DR and Samson FE Jr. Metabolism of rat brain mitochondria during postnatal development. Am J Physiol 196: 470-472, 1959.
31. Danysz W and Parsons CG. Glycine and N-methyl-Daspartate receptors: physiological significance and possible therapeutic applications. Pharmacol Rev 50: 597-664, 1998. (Pubitemid 29028813)
32. Darlow BA, Buss H, McGill F, Fletcher L, Graham P, and Winterbourn CC. Vitamin C supplementation in very preterm infants: a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed 90: F117-F122, 2005. (Pubitemid 40333079)
33. Deputy S. Shaking-impact syndrome of infancy. Semin Pediatr Neurol 10: 112-119, 2003. (Pubitemid 37222278)
34. Dickerson JW and Dobbing J. Some peculiarities of cerebellar growth in pigs. Proc R Soc Med 59: 1088, 1966.
35. Dikranian K, Ishimaru MJ, Tenkova T, Labruyere J, Qin YQ, Ikonomidou C, and Olney JW. Apoptosis in the in vivo mammalian forebrain. Neurobiol Dis 8: 359-379, 2001. (Pubitemid 32566129)
36. Ditelberg JS, Sheldon RA, Epstein CJ, and Ferriero DM. Brain injury after perinatal hypoxia-ischemia is exacerbated in copper=zinc superoxide dismutase transgenic mice. Pediatr Res 39: 204-208, 1996. (Pubitemid 26039540)
37. Dobbing J and Sands J. Growth and development of the brain and spinal cord of the guinea pig. Brain Res 17: 115-123, 1970.
38. Dobbing J and Sands J. Comparative aspects of the brain growth spurt. Early Hum Dev 3: 79-83, 1979. (Pubitemid 9141710)
39. Dobbing J and Sands J. Quantitative growth and development of human brain. Arch Dis Child 48: 757-767, 1973.
40. Dobbing J and Sands J. Timing of neuroblast multiplication in developing human brain. Nature 226: 639-640, 1970.
41. Dobbing J and Sands J. Vulnerability of developing brain not explained by cell number=cell size hypothesis. Early Hum Dev 5: 227-231, 1981. (Pubitemid 11044252)
42. Dong J, Sulik KK, and Chen SY. Nrf2-mediated transcriptional induction of antioxidant response in mouse embryos exposed to ethanol in vivo: implications for the prevention of fetal alcohol spectrum disorders. Antioxid Redox Signal 10: 2023-2033, 2008.
43. Dreiem A, Gertz CC, and Seegal RF. The effects of methylmercury on mitochondrial function and reactive oxygen species formation in rat striatal synaptosomes are agedependent. Toxicol Sci 87: 156-162, 2005. (Pubitemid 41222667)
44. Dwyer DS, Vannucci SJ, and Simpson IA. Expression, regulation, and functional role of glucose transporters (GLUTs) in brain. Int Rev Neurobiol 51: 159-188, 2002.
45. Emond D, Lachance C, Gagnon J, and Bard H. Arterial partial pressure of oxygen required to achieve 90% saturation of hemoglobin in very low birth weight newborns. Pediatrics 91: 602-604, 1993. (Pubitemid 23065407)
46. Erecinska M, Cherian S, and Silver IA. Energy metabolism in mammalian brain during development. Prog Neurobiol 73: 397-445, 2004. (Pubitemid 39099270)
47. Ewing-Cobbs L, Kramer L, Prasad M, Canales DN, Louis PT, Fletcher JM, Vollero H, Landry SH, and Cheung K. Neuroimaging, physical, and developmental findings after inflicted and noninflicted traumatic brain injury in young children. Pediatrics 102: 300-307, 1998. (Pubitemid 28354993)
48. Felderhoff-Mueser U, Bittigau P, Sifringer M, Jarosz B, Korobowicz E, Mahler L, Piening T, Moysich A, Grune T, Thor F, and Ikonomidou C. Oxygen causes cell death in the developing brain. Neurobiol Dis 17: 273-282, 2004. (Pubitemid 39345782)
49. Felderhoff-Mueser U, and Ikonomidou C. Mechanisms of neurodegeneration after paediatric brain injury. Curr Opin Neurol 13: 141-145, 2000.
50. Felderhoff-Mueser U, Sifringer M, Pesditschek S, Kuckuck H, Moysich A, Bittigau P, and Ikonomidou C. Pathways leading to apoptotic neurodegeneration following trauma to the developing rat brain. Neurobiol Dis 11: 231-245, 2002. (Pubitemid 36135688)
51. Felderhoff-Mueser U, Sifringer M, Polley O, Dzietko M, Leineweber B, Mahler L, Baier M, Bittigau P, Obladen M, Ikonomidou C, and Buehrer C. Caspase-1-processed interleukins in hyperoxia-induced cell death in the developing brain. Ann Neurol 57: 50-59, 2005. (Pubitemid 40053315)
52. Ferguson S, Mouzon B, Kayihan G, Wood M, Poon F, Doore S, Mathura V, Humphrey J, O'Steen B, Hayes R, Roses A, Mullan M, and Crawford F. Apolipoprotein E genotype and oxidative stress response to traumatic brain injury. Neuroscience 168: 811-900, 2010.
53. Fiskum G, Murphy AN, and Beal MF. Mitochondria in neurodegeneration: acute ischemia and chronic neurodegenerative diseases. J Cereb Blood Flow Metab 19: 351-369, 1999. (Pubitemid 30161223)
54. Frank L. Antioxidants, nutrition, and bronchopulmonary dysplasia. Clin Perinatol 19: 541-562, 1992.
55. Frank L and Sosenko IR. Failure of premature rabbits to increase antioxidant enzymes during hyperoxic exposure: increased susceptibility to pulmonary oxygen toxicity compared with term rabbits. Pediatr Res 29: 292-296, 1991.
56. Fujimura M, Morita-Fujimura Y, Noshita N, Sugawara T, Kawase M, and Chan PH. The cytosolic antioxidant copper=zinc-superoxide dismutase prevents the early release of mitochondrial cytochrome c in ischemic brain after transient focal cerebral ischemia in mice. J Neurosci 20: 2817-2824, 2000. (Pubitemid 30220306)
57. Fullerton HJ, Ditelberg JS, Chen SF, Sarco DP, Chan PH, Epstein CJ, and Ferriero DM. Copper=zinc superoxide dismutase transgenic brain accumulates hydrogen peroxide after perinatal hypoxia ischemia. Ann Neurol 44: 357-364, 1998. (Pubitemid 28421440)
58. Gerstner B, Buhrer C, Rheinlander C, Polley O, Schuller A, Berns M, Obladen M, and Felderhoff-Mueser U. Maturationdependent oligodendrocyte apoptosis caused by hyperoxia. J Neurosci Res 84: 306-315, 2006. (Pubitemid 44126283)
59. Gerstner B, DeSilva TM, Genz K, Armstrong A, Brehmer F, Neve RL, Felderhoff-Mueser U, Volpe JJ, and Rosenberg PA. Hyperoxia causes maturation-dependent cell death in the developing white matter. J Neurosci 28: 1236-1245, 2008. (Pubitemid 351186357)
60. Gerstner B, Sifringer M, Dzietko M, Schuller A, Lee J, Simons S, Obladen M, Volpe JJ, Rosenberg PA, and Felderhoff- Mueser U. Estradiol attenuates hyperoxia-induced cell death in the developing white matter. Ann Neurol 61: 562-573, 2007. (Pubitemid 47068138)
61. Gitto E, Reiter RJ, Cordaro SP, La Rosa M, Chiurazzi P, Trimarchi G, Gitto P, Calabro MP, and Barberi I. Oxidative and inflammatory parameters in respiratory distress syndrome of preterm newborns: beneficial effects of melatonin. Am J Perinatol 21: 209-216, 2004. (Pubitemid 38691520)
62. Gitto E, Romeo C, Reiter RJ, Impellizzeri P, Pesce S, Basile M, Antonuccio P, Trimarchi G, Gentile C, and Barberi I. Melatonin reduces oxidative stress in surgical neonates. J Pediatr Surg 39: 184-189, 2004. (Pubitemid 38146434)
63. Goldstein M. Traumatic brain injury: a silent epidemic. Ann Neurol 27: 327, 1990. (Pubitemid 20122385)
64. Gonzalez-Burgos I, Letechipia-Vallejo G, Lopez-Loeza E, Morali G, and Cervantes M. Long-term study of dendritic spines from hippocampal CA1 pyramidal cells, after neuroprotective melatonin treatment following global cerebral ischemia in rats. Neurosci Lett 423: 162-166, 2007. (Pubitemid 47259587)
65. Gregson NA and Williams PL. A comparative study of brain and liver mitochondria from new-born and adult rats. J Neurochem 16: 617-626, 1969.
66. Grisel JJ and Chen WJ. Antioxidant pretreatment does not ameliorate alcohol-induced Purkinje cell loss in the developing rat cerebellum. Alcohol Clin Exp Res 29: 1223-1229, 2005. (Pubitemid 41060438)
67. Gucuyener K, Atalay Y, Aral YZ, Hasanoglu A, Turkyilmaz C, and Biberoglu G. Excitatory amino acids and taurine levels in cerebrospinal fluid of hypoxic ischemic encephalopathy in newborn. Clin Neurol Neurosurg 101: 171-174, 1999. (Pubitemid 29447581)
68. Guertin F, Roy CC, Lepage G, Yousef I, and Tuchweber B. Liver membrane composition after short-term parenteral nutrition with and without taurine in guinea pigs: the effect to taurine. Proc Soc Exp Biol Med 203: 418-423, 1993. (Pubitemid 23246355)
69. Gunn AJ. Cerebral hypothermia for prevention of brain injury following perinatal asphyxia. Curr Opin Pediatr 12: 111-115, 2000. (Pubitemid 30165569)
70. Haberny KA, Paule MG, Scallet AC, Sistare FD, Lester DS, Hanig JP, and Slikker W Jr. Ontogeny of the N-methyl-Daspartate (NMDA) receptor system and susceptibility to neurotoxicity. Toxicol Sci 68: 9-17, 2002. (Pubitemid 34785224)
71. Hansen HH, Briem T, Dzietko M, Sifringer M, Voss A, Rzeski W, Zdzisinska B, Thor F, Heumann R, Stepulak A, and Ikonomidou C. Mechanisms leading to disseminated apoptosis following NMDA receptor blockade in the developing rat brain. Neurobiol Dis 16: 440-453, 2004. (Pubitemid 38757324)
72. Hawkins RA, Williamson DH, and Krebs HA. Ketone-body utilization by adult and suckling rat brain in vivo. Biochem J 122: 13-18, 1971.
73. Hawley CA, Ward AB, Magnay AR, and Long J. Children's brain injury: a postal follow-up of 525 children from one health region in the UK. Brain Inj 16: 969-985, 2002. (Pubitemid 35331088)
74. Heaton MB, Paiva M, Madorsky I, and Shaw G. Ethanol effects on neonatal rat cortex: comparative analyses of neurotrophic factors, apoptosis-related proteins, and oxidative processes during vulnerable and resistant periods. Brain Res Dev Brain Res 145: 249-262, 2003. (Pubitemid 37357134)
75. Henderson GI, Devi BG, Perez A, and Schenker S. In utero ethanol exposure elicits oxidative stress in the rat fetus. Alcohol Clin Exp Res 19: 714-720, 1995.
76. Herlenius E and Lagercrantz H. Development of neurotransmitter systems during critical periods. Exp Neurol 190 suppl 1: S8-S21, 2004. (Pubitemid 39451785)
77. Husson I, Mesples B, Bac P, Vamecq J, Evrard P, and Gressens P. Melatoninergic neuroprotection of the murine periventricular white matter against neonatal excitotoxic challenge. Ann Neurol 51: 82-92, 2002. (Pubitemid 34027980)
78. Huston RK, Jelen BJ, and Vidgoff J. Selenium supplementation in low-birthweight premature infants: relationship to trace metals and antioxidant enzymes. J Parenter Enteral Nutr 15: 556-559, 1991.
79. Huttenlocher PR and Dabholkar AS. Regional differences in synaptogenesis in human cerebral cortex. J Comp Neurol 387: 167-178, 1997. (Pubitemid 27430343)
80. Ikonomidou C, Bittigau P, Ishimaru MJ, Wozniak DF, Koch C, Genz K, Price MT, Stefovska V, Horster F, Tenkova T, and Olney JW. Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome. Science 287: 1056-1060, 2000. (Pubitemid 30094364)
81. Ikonomidou C, Bosch F, Miksa M, Bittigau P, Vockler J, Dikranian K, Tenkova TI, Stefovska V, Turski L, and Olney JW. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science 283: 70-74, 1999. (Pubitemid 29044848)
82. Ikonomidou C, Mosinger JL, and Olney JW. Hypothermia enhances protective effect of MK-801 against hypoxic= ischemic brain damage in infant rats. Brain Res 487: 184-187, 1989. (Pubitemid 19135182)
83. Ikonomidou C, Price MT, Mosinger JL, Frierdich G, Labruyere J, Salles KS, and Olney JW. Hypobaric-ischemic conditions produce glutamate-like cytopathology in infant rat brain. J Neurosci 9: 1693-1700, 1989. (Pubitemid 19146264)
84. Ikonomidou C, Qin Y, Labruyere J, Kirby C, and Olney JW. Prevention of trauma-induced neurodegeneration in infant rat brain. Pediatr Res 39: 1020-1027, 1996. (Pubitemid 26000145)
85. Ikonomidou C and Turski L. Antiepileptic drugs and brain development. Epilepsy Res 88: 11-22, 2010.
86. Ishimaru MJ, Ikonomidou C, Tenkova TI, Der TC, Dikranian K, Sesma MA, and Olney JW. Distinguishing excitotoxic from apoptotic neurodegeneration in the developing rat brain. J Comp Neurol 408: 461-476, 1999. (Pubitemid 29211175)
87. Jevtovic-Todorovic V, Hartman RE, Izumi Y, Benshoff ND, Dikranian K, Zorumski CF, Olney JW, andWozniak DF. Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. J Neurosci 23: 876-882, 2003. (Pubitemid 36206178)
88. Juurlink BH and Paterson PG. Review of oxidative stress in brain and spinal cord injury: suggestions for pharmacological and nutritional management strategies. J Spinal Cord Med 21: 309-334, 1998. (Pubitemid 128731776)
89. KaindlAM, Sifringer M, Koppelstaetter A, Genz K, Loeber R, Boerner C, Stuwe J, Klose J, and Felderhoff-Mueser U. Erythropoietin protects the developing brain from hyperoxiainduced cell death and proteome changes. Ann Neurol 64: 523-534, 2008.
90. Kaindl AM, Sifringer M, Zabel C, Nebrich G, Wacker MA, Felderhoff-Mueser U, Endesfelder S, von der Hagen M, Stefovska V, Klose J, and Ikonomidou C. Acute and longterm proteome changes induced by oxidative stress in the developing brain. Cell Death Differ 13: 1097-1109, 2006. (Pubitemid 43905591)
91. Kaindl AM SM, Zabel C, Lehnert R, Stefovska V, Klose J, and Ikonomidou C. Subacute proteome changes following traumatic injury of the developing brain: implications for a dysregulation of neuronal migration and neurite arborization. Proteomics Clin Appl 1: 640-649, 2007.
92. Kay HH, Tsoi S, Grindle K, and Magness RR. Markers of oxidative stress in placental villi exposed to ethanol. J Soc Gynecol Invest 13: 118-121, 2006. (Pubitemid 43155844)
93. Keenan HT, Runyan DK, Marshall SW, Nocera MA, Merten DF, and Sinal SH. A population-based study of inflicted traumatic brain injury in young children. JAMA 290: 621-626, 2003. (Pubitemid 37430482)
94. Keller JN, Kindy MS, Holtsberg FW, St Clair DK, Yen HC, Germeyer A, Steiner SM, Bruce-Keller AJ, Hutchins JB, and Mattson MP. Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction. J Neurosci 18: 687-697, 1998. (Pubitemid 28041905)
95. Kelly FJ, Rodgers W, Handel J, Smith S, and Hall MA. Time course of vitamin E repletion in the premature infant. Br J Nutr 63: 631-638, 1990. (Pubitemid 20201467)
96. Kew JN and Kemp JA. Ionotropic and metabotropic glutamate receptor structure and pharmacology. Psychopharmacology (Berl) 179: 4-29, 2005. (Pubitemid 40576690)
97. Kim GW, Kondo T, Noshita N, and Chan PH. Manganese superoxide dismutase deficiency exacerbates cerebral infarction after focal cerebral ischemia=reperfusion in mice: implications for the production and role of superoxide radicals. Stroke 33: 809-815, 2002. (Pubitemid 34207703)
98. Kobayashi T, Kuroda S, Tada M, Houkin K, Iwasaki Y, and Abe H. Calcium-induced mitochondrial swelling and cytochrome c release in the brain: its biochemical characteristics and implication in ischemic neuronal injury. Brain Res 960: 62-70, 2003. (Pubitemid 36044563)
99. Kochanek PM, Clark RS, Ruppel RA, Adelson PD, Bell MJ, Whalen MJ, Robertson CL, Satchell MA, Seidberg NA, and Marion DW. Biochemical, cellular, and molecular mechanisms in the evolution of secondary damage after severe traumatic brain injury in infants and children: lessons learned from the bedside. Pediatr Crit Care Med 1: 4-19, 2000.
100. Koskiniemi M, Kyykka T, Nybo T, and Jarho L. Long-term outcome after severe brain injury in preschoolers is worse than expected. Arch Pediatr Adolesc Med 149: 249-254, 1995.
101. Kumar A, Mittal R, Khanna HD, and Basu S. Free radical injury and blood-brain barrier permeability in hypoxic-ischemic encephalopathy. Pediatrics 122: 722-727, 2008.
102. Land JM, Booth RF, Berger R, and Clark JB. Development of mitochondrial energy metabolism in rat brain. Biochem J 164: 339-348, 1977. (Pubitemid 8105670)
103. Leong SF and Clark JB. Regional development of glutamate dehydrogenase in the rat brain. J Neurochem 43: 106-111, 1984. (Pubitemid 14083322)
104. Leong SF and Clark JB. Regional enzyme development in rat brain: enzymes associated with glucose utilization. Biochem J 218: 131-138, 1984. (Pubitemid 14190927)
105. Leong SF and Clark JB. Regional enzyme development in rat brain: enzymes of energy metabolism. Biochem J 218: 139-145, 1984. (Pubitemid 14190928)
106. Lindeman JH, van Zoeren-Grobben D, Schrijver J, Speek AJ, Poorthuis BJ, and Berger HM. The total free radical trapping ability of cord blood plasma in preterm and term babies. Pediatr Res 26: 20-24, 1989.
107. Lipton SA. NMDA receptor activity regulates transcription of antioxidant pathways. Nat Neurosci 11: 381-382, 2009. (Pubitemid 351441871)
108. Lizasoain I, Weiner CP, Knowles RG, and Moncada S. The ontogeny of cerebral and cerebellar nitric oxide synthase in the guinea pig and rat. Pediatr Res 39: 779-783, 1996. (Pubitemid 26130016)
109. Lockitch G, Jacobson B, Quigley G, Dison P, and Pendray M. Selenium deficiency in low birth weight neonates: an unrecognized problem. J Pediatr 114: 865-870, 1989. (Pubitemid 19122990)
110. Maalouf M, Sullivan PG, Davis L, Kim DY, and Rho JM. Ketones inhibit mitochondrial production of reactive oxygen species production following glutamate excitotoxicity by increasing NADH oxidation. Neuroscience 145: 256-264, 2007. (Pubitemid 46227735)
111. Mahoney WJ, D'Souza BJ, Haller JA, Rogers MC, Epstein MH, and Freeman JM. Long-term outcome of children with severe head trauma and prolonged coma. Pediatrics 71: 756-762, 1983. (Pubitemid 13081707)
112. Mammis A, McIntosh TK, and Maniker AH. Erythropoietin as a neuroprotective agent in traumatic brain injury. Surg Neurol 71: 527-531, 2009.
113. Marin-Padilla M. Prenatal and early postnatal ontogenesis of the human motor cortex: a Golgi study, II: the basketpyramidal system. Brain Res 23: 185-191, 1970.
114. Marin-Padilla M. Prenatal and early postnatal ontogenesis of the human motor cortex: a Golgi study, I: the sequential development of the cortical layers. Brain Res 23: 167-183, 1970.
115. Marino MD, Aksenov MY, and Kelly SJ. Vitamin E protects against alcohol-induced cell loss and oxidative stress in the neonatal rat hippocampus. Int J Dev Neurosci 22: 363-377, 2004. (Pubitemid 39233544)
116. Massagli TL, Fann JR, Burington BE, Jaffe KM, Katon WJ, and Thompson RS. Psychiatric illness after mild traumatic brain injury in children. Arch Phys Med Rehabil 85: 1428-1434, 2004. (Pubitemid 39221080)
117. Matsumoto S, Friberg H, Ferrand-Drake M, and Wieloch T. Blockade of the mitochondrial permeability transition pore diminishes infarct size in the rat after transient middle cerebral artery occlusion. J Cereb Blood Flow Metab 19: 736-741, 1999. (Pubitemid 30159798)
118. McDonald JW and Johnston MV. Physiological and pathophysiological roles of excitatory amino acids during central nervous system development. Brain Res Brain Res Rev 15: 41-70, 1990. (Pubitemid 20158154)
119. McDonald JW, Johnston MV, and Young AB. Differential ontogenic development of three receptors comprising the NMDA receptor=channel complex in the rat hippocampus. Exp Neurol 110: 237-247, 1990.
120. McElroy MC, Postle AD, and Kelly FJ. Catalase, superoxide dismutase and glutathione peroxidase activities of lung and liver during human development. Biochim Biophys Acta 1117: 153-158, 1992.
121. McKinlay A, Dalrymple-Alford JC, Horwood LJ, and Fergusson DM. Long term psychosocial outcomes after mild head injury in early childhood. J Neurol Neurosurg Psychiatry 73: 281-288, 2002.
122. McLean C and Ferriero D. Mechanisms of hypoxic-ischemic injury in the term infant. Semin Perinatol 28: 425-432, 2004. (Pubitemid 40037569)
123. Mesenge C, Margaill I, Verrecchia C, Allix M, Boulu RG, and Plotkine M. Protective effect of melatonin in a model of traumatic brain injury in mice. J Pineal Res 25: 41-46, 1998. (Pubitemid 28319915)
124. Mitchell JJ, Paiva M, and Heaton MB. Vitamin E and betacarotene protect against ethanol combined with ischemia in an embryonic rat hippocampal culture model of fetal alcohol syndrome. Neurosci Lett 263: 189-192, 1999. (Pubitemid 29158960)
125. Morita-Fujimura Y, Fujimura M, Yoshimoto T, and Chan PH. Superoxide during reperfusion contributes to caspase-8 expression and apoptosis after transient focal stroke. Stroke 32: 2356-2361, 2001. (Pubitemid 32958557)
126. Murakami K, Kondo T, Kawase M, Li Y, Sato S, Chen SF, and Chan PH. Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency. J Neurosci 18: 205-213, 1998. (Pubitemid 28046782)
127. Nasser M, Javaheri H, Fedorowicz Z, and Noorani Z. Carnitine supplementation for inborn errors of metabolism. Cochrane Database Syst Rev CD006659, 2009.
128. Nazarewicz RR, Ziolkowski W, Vaccaro PS, and Ghafourifar P. Effect of short-term ketogenic diet on redox status of human blood. Rejuven Res 10: 435-440, 2007.
129. Nedergaard M, Gjedde A, and Diemer NH. Hyperglycaemia protects against neuronal injury around experimental brain infarcts. Neurol Res 9: 241-244, 1987. (Pubitemid 18066102)
130. Nehlig A, Boyet S, and Pereira de Vasconcelos A. Autoradiographic measurement of local cerebral betahydroxybutyrate uptake in the rat during postnatal development. Neuroscience 40: 871-878, 1991.
131. Nehlig A, Lehr PR, and Gayet J. Glucose and amino acid metabolism in chick telencephalon slices: changes with incubation conditions and animals' development. Neurochem Res 12: 641-649, 1987. (Pubitemid 17095782)
132. Olney JW, Young C, Wozniak DF, Jevtovic-Todorovic V, and Ikonomidou C. Do pediatric drugs cause developing neurons to commit suicide? Trends Pharmacol Sci 25: 135-139, 2004. (Pubitemid 38264503)
133. Ozdemir D, Uysal N, Gonenc S, Acikgoz O, Sonmez A, Topcu A, Ozdemir N, Duman M, Semin I, and Ozkan H. Effect of melatonin on brain oxidative damage induced by traumatic brain injury in immature rats. Physiol Res 54: 631-637, 2005. (Pubitemid 43161729)
134. Paintlia MK, Paintlia AS, Barbosa E, Singh I, and Singh AK. N-acetylcysteine prevents endotoxin-induced degeneration of oligodendrocyte progenitors and hypomyelination in developing rat brain. J Neurosci Res 78: 347-361, 2004. (Pubitemid 39488259)
135. Papadia S, Soriano FX, Leveille F, Martel MA, Dakin KA, Hansen HH, Kaindl A, Sifringer M, Fowler J, Stefovska V, McKenzie G, Craigon M, Corriveau R, Ghazal P, Horsburgh K, Yankner BA, Wyllie DJ, Ikonomidou C, and Hardingham GE. Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses. Nat Neurosci 11: 476-487, 2008. (Pubitemid 351441886)
136. Piantadosi CA and Zhang J. Mitochondrial generation of reactive oxygen species after brain ischemia in the rat. Stroke 27: 327-331, 1996.
137. Poeggeler B, Saarela S, Reiter RJ, Tan DX, Chen LD, Manchester LC, and Barlow-Walden LR. Melatonin: a highly potent endogenous radical scavenger and electron donor: new aspects of the oxidation chemistry of this indole accessed in vitro. Ann N Y Acad Sci 738: 419-420, 1994.
138. Poggi SH, Goodwin KM, Hill JM, Brenneman DE, Tendi E, Schninelli S, and Spong CY. Differential expression of c-fos in a mouse model of fetal alcohol syndrome. Am J Obstet Gynecol 189: 786-789, 2003. (Pubitemid 37194106)
139. Pohl D, Bittigau P, Ishimaru MJ, Stadthaus D, Hubner C, Olney JW, Turski L, and Ikonomidou C. N-Methyl-Daspartate antagonists and apoptotic cell death triggered by head trauma in developing rat brain. Proc Natl Acad Sci USA 96: 2508-2513, 1999. (Pubitemid 29117946)
140. Poliakov GI. Some results of research into the development of the neuronal structure of the cortical ends of the analyzers in man. J Comp Neurol 117: 197-212, 1961.
141. Potts MB, Koh SE, Whetstone WD, Walker BA, Yoneyama T, Claus CP, Manvelyan HM, and Noble-Haeusslein LJ. Traumatic injury to the immature brain: inflammation, oxidative injury, and iron-mediated damage as potential therapeutic targets. NeuroRx 3: 143-153, 2006. (Pubitemid 44061703)
142. Prins ML, Fujima LS, and Hovda DA. Age-dependent reduction of cortical contusion volume by ketones after traumatic brain injury. J Neurosci Res 82: 413-420, 2005. (Pubitemid 41552492)
143. Pu Y, Li QF, Zeng CM, Gao J, Qi J, Luo DX, Mahankali S, Fox PT, and Gao JH. Increased detectability of alpha brain glutamate=glutamine in neonatal hypoxic-ischemic encephalopathy. Am J Neuroradiol 21: 203-212, 2000. (Pubitemid 30225854)
144. Puka-Sundvall M, Gilland E, and Hagberg H. Cerebral hypoxia-ischemia in immature rats: involvement of mitochondrial permeability transition? Dev Neurosci 23: 192-197, 2001. (Pubitemid 34701671)
145. Pulsinelli WA, Waldman S, Rawlinson D, and Plum F. Moderate hyperglycemia augments ischemic brain damage: a neuropathologic study in the rat. Neurology 32: 1239-1246, 1982.
146. Pun PB, Lu J, and Moochhala S. Involvement of ROS in BBB dysfunction. Free Radic Res 43: 348-364, 2009.
147. Puyal J, Grassi S, Dieni C, Frondaroli A, Dememes D, Raymond J, and Pettorossi VE. Developmental shift from long-term depression to long-term potentiation in the rat medial vestibular nuclei: role of group I metabotropic glutamate receptors. J Physiol 553: 427-443, 2003. (Pubitemid 37527546)
148. Pysh JJ. Mitochondrial changes in rat inferior colliculus during postnatal development: an electron microscopic study. Brain Res 18: 325-342, 1970.
149. Rho JM, Kim DW, Robbins CA, Anderson GD, and Schwartzkroin PA. Age-dependent differences in flurothyl seizure sensitivity in mice treated with a ketogenic diet. Epilepsy Res 37: 233-240, 1999. (Pubitemid 29476521)
150. Rice JE 3rd, Vannucci RC, and Brierley JB. The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann Neurol 9: 131-141, 1981. (Pubitemid 11191192)
151. Rossi S, Stocchetti N, Longhi L, Balestreri M, Spagnoli D, Zanier ER, and Bellinzona G. Brain oxygen tension, oxygen supply, and oxygen consumption during arterial hyperoxia in a model of progressive cerebral ischemia. J Neurotrauma 18: 163-174, 2001. (Pubitemid 32173424)
152. Samson FE Jr, Balfour WM, and Jacobs RJ. Mitochondrial changes in developing rat brain. Am J Physiol 199: 693-696, 1960.
153. Shah RS, Rajalakshmi R, Bhatt RV, Hazra MN, Patel BC, Swamy NB, and Patel TV. Vitamin E status of the newborn in relation to gestational age, birth weight and maternal vitamin E status. Br J Nutr 58: 191-198, 1987. (Pubitemid 18020749)
154. Sheng M. The postsynaptic NMDA-receptor: PSD-95 signaling complex in excitatory synapses of the brain. J Cell Sci 114: 251, 2001.
155. Shi Y and Ethell IM. Integrins control dendritic spine plasticity in hippocampal neurons through NMDA recep- tor and Ca2\+=calmodulin-dependent protein kinase IImediated actin reorganization. J Neurosci 26: 1813-1822, 2006.
156. Sifringer M, Genz K, Brait D, Brehmer F, Lober R, Weichelt U, Kaindl AM, Gerstner B, and Felderhoff-Mueser U. Erythropoietin attenuates hyperoxia-induced cell death by modulation of inflammatory mediators and matrix metalloproteinases. Dev Neurosci 31: 394-402, 2009.
157. Sjostedt S and Rooth G. Low oxygen tension in the management of newborn infants. Arch Dis Child 32: 397-400, 1957.
158. Skeberdis VA, Chevaleyre V, Lau CG, Goldberg JH, Pettit DL, Suadicani SO, Lin Y, Bennett MV, Yuste R, Castillo PE, and Zukin RS. Protein kinase A regulates calcium permeability of NMDA receptors. Nat Neurosci 9: 501-510, 2006.
159. Soghier LM and Brion LP. Cysteine, cystine or Nacetylcysteine supplementation in parenterally fed neonates. Cochrane Database Syst Rev CD004869, 2006.
160. Sola A, Rogido MR, and Deulofeut R. Oxygen as a neonatal health hazard: call for detente in clinical practice. Acta Paediatr 96: 801-812, 2007. (Pubitemid 46846899)
161. Sosenko IR and Frank L. Guinea pig lung development: antioxidant enzymes and premature survival in high O2. Am J Physiol 252: 693-698, 1987.
162. Sosenko IR and Frank L. Thyroid hormone depresses antioxidant enzyme maturation in fetal rat lung. Am J Physiol 253: 592-598, 1987.
163. Sosin DM, Sniezek JE, and Waxweiler RJ. Trends in death associated with traumatic brain injury, 1979 through 1992: success and failure. JAMA 273: 1778-1780, 1995.
164. Sugawara T, Noshita N, Lewen A, Gasche Y, Ferrand- Drake M, Fujimura M, Morita-Fujimura Y, and Chan PH. Overexpression of copper=zinc superoxide dismutase in transgenic rats protects vulnerable neurons against ischemic damage by blocking the mitochondrial pathway of caspase activation. J Neurosci 22: 209-217, 2002. (Pubitemid 34036536)
165. Sullivan JL and Newton RB. Serum antioxidant activity in neonates. Arch Dis Child 63: 748-750, 1988.
166. Tang Q, Gandhoke R, Burritt A, Hruby VJ, Porreca F, and Lai J. High-affinity interaction of (des-Tyrosyl)dynorphin A(2-17) with NMDA receptors. J Pharmacol Exp Ther 291: 760-765, 1999. (Pubitemid 29503550)
167. Thakker JC, Splaingard M, Zhu J, Babel K, Bresnahan J, Havens PL. Survival and functional outcome of children requiring endotracheal intubation during therapy for severe traumatic brain injury. Crit Care Med 25: 1396-1401, 1997. (Pubitemid 27347307)
168. The International Liaison Committee on Resuscitation (ILCOR). Consensus on science with treatment recommendations for pediatric and neonatal patients: pediatric basic and advanced life support. Pediatrics 117: 955-977, 2006.
169. Then SM, Mazlan M, Mat Top G, and Wan Ngah WZ. Is vitamin E toxic to neuron cells? Cell Mol Neurobiol 29: 485-496, 2009.
170. Thurman D and Guerrero J. Trends in hospitalization associated with traumatic brain injury. JAMA 282: 954-957, 1999. (Pubitemid 29420314)
171. Towfighi J, Mauger D, Vannucci RC, and Vannucci SJ. In- fluence of age on the cerebral lesions in an immature rat model of cerebral hypoxia-ischemia: a light microscopic study. Brain Res Dev Brain Res 100: 149-160, 1997. (Pubitemid 27286387)
172. Tubman TR, Halliday HL, and McMaster D. Glutathione peroxidase and selenium levels in the preterm infant. Biol Neonate 58: 305-310, 1990.
173. Turrens JF. Mitochondrial formation of reactive oxygen species. J Physiol 552: 335-344, 2003. (Pubitemid 37321833)
174. Tutunculer F, Eskiocak S, Basaran UN, Ekuklu G, Ayvaz S, and Vatansever U. The protective role of melatonin in experimental hypoxic brain damage. Pediatr Int 47: 434-439, 2005. (Pubitemid 41169579)
175. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, and Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39: 44-84, 2007. (Pubitemid 44566469)
176. van Zoeren-Grobben D, Lindeman JH, Houdkamp E, Brand R, Schrijver J, and Berger HM. Postnatal changes in plasma chain-breaking antioxidants in healthy preterm infants fed formula and=or human milk. Am J Clin Nutr 60: 900-906, 1994. (Pubitemid 24377272)
177. Vannucci RC. Mechanisms of perinatal hypoxic-ischemic brain damage. Semin Perinatol 17: 330-337, 1993. (Pubitemid 23321462)
178. Vannucci RC and Perlman JM. Interventions for perinatal hypoxic-ischemic encephalopathy. Pediatrics 100: 1004-1014, 1997. (Pubitemid 27516489)
179. Vannucci RC and Vannucci SJ. A model of perinatal hypoxic-ischemic brain damage. Ann N Y Acad Sci 835: 234-249, 1997. (Pubitemid 28046111)
180. Vannucci RC, Vasta F, and Vannucci SJ. Cerebral metabolic responses of hyperglycemic immature rats to hypoxiaischemia. Pediatr Res 21: 524-529, 1987. (Pubitemid 17076180)
181. Vannucci SJ and Simpson IA. Developmental switch in brain nutrient transporter expression in the rat. Am J Physiol Endocrinol Metab 285: 127-134, 2003.
182. Vieira HL, Belzacq AS, Haouzi D, Bernassola F, Cohen I, Jacotot E, Ferri KF, El Hamel C, Bartle LM, Melino G, Brenner C, Goldmacher V, and Kroemer G. The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal. Oncogene 20: 4305-4316, 2001. (Pubitemid 32726872)
183. Volpe JJ. Perinatal brain injury: from pathogenesis to neuroprotection. Ment Retard Dev Disabil Res Rev 7: 56-64, 2001. (Pubitemid 32206303)
184. Wang C, McInnis J, West JB, Bao J, Anastasio N, Guidry JA, Ye Y, Salvemini D, and Johnson KM. Blockade of phencyclidine- induced cortical apoptosis and deficits in prepulse inhibition by M40403, a superoxide dismutase mimetic. J Pharmacol Exp Ther 304: 266-271, 2003. (Pubitemid 36008937)
185. Wang C, Sadovova N, Patterson TA, Zou X, Fu X, Hanig JP, Paule MG, Ali SF, Zhang X, and Slikker W Jr. Protective effects of 7-nitroindazole on ketamine-induced neurotoxicity in rat forebrain culture. Neurotoxicology 29: 613-620, 2008.
186. Wang X, Svedin P, Nie C, Lapatto R, Zhu C, Gustavsson M, Sandberg M, Karlsson JO, Romero R, Hagberg H, and Mallard C. N-acetylcysteine reduces lipopolysaccharidesensitized hypoxic-ischemic brain injury. Ann Neurol 61: 263-271, 2007. (Pubitemid 46557350)
187. Weinberger B, Watorek K, Strauss R, Witz G, Hiatt M, and Hegyi T. Association of lipid peroxidation with hepatocellular injury in preterm infants. Crit Care 6: 521-525, 2002. (Pubitemid 35414584)
188. Wong-Riley MT. Cytochrome oxidase: an endogenous metabolic marker for neuronal activity. Trends Neurosci 12: 94-101, 1989. (Pubitemid 19067056)
189. Woolsey TA, Rovainen CM, Cox SB, Henegar MH, Liang GE, Liu D, Moskalenko YE, Sui J, and Wei L. Neuronal units linked to microvascular modules in cerebral cortex: response elements for imaging the brain. Cereb Cortex 6: 647-660, 1996. (Pubitemid 26337836)
190. Xiong Y, Peterson PL,and Lee CP. Effect of N-acetylcysteine on mitochondrial function following traumatic brain injury in rats. J Neurotrauma 16: 1067-1082, 1999.
191. Yager JY and Thornhill JA. The effect of age on susceptibility to hypoxic-ischemic brain damage. Neurosci Biobehav Rev 21: 167-174, 1997. (Pubitemid 27102561)
192. Yang G, Chan PH, Chen J, Carlson E, Chen SF, Weinstein P, Epstein CJ, and Kamii H. Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia. Stroke 25: 165-170, 1994.
193. Yi JH, Hoover R, McIntosh TK, and Hazell AS. Early, transient increase in complexin I and complexin II in the cerebral cortex following traumatic brain injury is attenuated by N-acetylcysteine. J Neurotrauma 23: 86-96, 2006. (Pubitemid 43191089)
194. Yis U, Kurul SH, Kumral A, Cilaker S, Tugyan K, Genc S, and Yilmaz O. Hyperoxic exposure leads to cell death in the developing brain. Brain Dev 30: 556-562, 2008.
195. Yis U, Kurul SH, Kumral A, Tugyan K, Cilaker S, Yilmaz O, Genc S, and Genc K. Effect of erythropoietin on oxygeninduced brain injury in the newborn rat. Neurosci Lett 448: 45-49, 2008.
196. Yon JH, Carter LB, Reiter RJ, and Jevtovic-Todorovic V. Melatonin reduces the severity of anesthesia-induced apoptotic neurodegeneration in the developing rat brain. Neurobiol Dis 21:522-530, 2006. (Pubitemid 43277535)
197. Yoshimoto T and Siesjo BK. Posttreatment with the immunosuppressant cyclosporin A in transient focal ischemia. Brain Res 839: 283-291, 1999. (Pubitemid 29416814)
198. Yusa T, Beckman JS, Crapo JD, and Freeman BA. Hyperoxia increases H2O2 production by brain in vivo. J Appl Physiol 63: 348-358, 1987.
199. Ziegler DR, Ribeiro LC, Hagenn M, Siqueira IR, Araujo E, Torres IL, Gottfried C, Netto CA, and Goncalves CA. Ketogenic diet increases glutathione peroxidase activity in rat hippocampus. Neurochem Res 28: 1793-1797, 2003. (Pubitemid 37444674)
200. Zou X, Patterson TA, Divine RL, Sadovova N, Zhang X, Hanig JP, Paule MG, Slikker W Jr, and Wang C. Prolonged exposure to ketamine increases neurodegeneration in the developing monkey brain. Int J Dev Neurosci 27: 727-731, 2009.
201. Zou X, Sadovova N, Patterson TA, Divine RL, Hotchkiss CE, Ali SF, Hanig JP, Paule MG, Slikker W Jr, and Wang C. The effects of L-carnitine on the combination of, inhalation anesthetic-induced developmental, neuronal apoptosis in the rat frontal cortex. Neuroscience 151: 1053-1065, 2008.