Antioxidant Pretreatment does not ameliorate alcohol-induced Purkinje cell loss in the developing rat cerebellum

Alcoholism: Clinical and Experimental Research

Volumn 29, Issue 7, 2005, Pages 1223-1229

  Grisel, Jedidiah J ^a   Chen, Wei Jung A ^a  

^a TEXAS A M COLLEGE OF MEDICINE   (United States)

Author keywords

Brain; Ethanol; Melatonin; Oxidative Stress; U83836E (lazaroid)

Indexed keywords

2 [[4 [2,6 BIS(1 PYRROLIDINYL) 4 PYRIMIDINYL] 1 PIPERAZINYL]METHYL] 3,4 DIHYDRO 2,5,7,8 TETRAMETHYL 2H 1 BENZOPYRAN 6 OL; ALCOHOL; ANTIOXIDANT; MELATONIN;

ALCOHOL BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; BRAIN PROTECTION; BRAIN SIZE; CELL COUNT; CELL DENSITY; CEREBELLUM VERMIS; CONTROLLED STUDY; DRUG MECHANISM; FETAL ALCOHOL SYNDROME; MICROCEPHALY; NEUROTOXICITY; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PERINATAL DEVELOPMENT; PRIORITY JOURNAL; PURKINJE CELL; RAT;

AGE FACTORS; ANIMALS; ANTIOXIDANTS; CEREBELLUM; CHROMANS; ETHANOL; FEMALE; FETAL ALCOHOL SYNDROME; MELATONIN; OXIDATIVE STRESS; PIPERAZINES; PREGNANCY; PREMEDICATION; PURKINJE CELLS; RATS;

EID: 23044509541     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ALC.0000171932.13148.CF     Document Type: Article

References (53)

1. Bandyopadhyay D, Ghosh G, Bandyopadhyay A, Reiter RJ (2004) Melatonin protects against piroxicam-induced gastric ulceration. J Pineal Res 36:195-203.
2. Bonthius DJ, Bonthius NE, Napper RMA, West JR (1992) Early postnatal alcohol exposure acutely and permanently reduces the number of granule cells and mitral cells in the rat olfactory bulb: a stereological study. J Comp Neurol 324:557-566.
3. Bonthius DJ, West JR (1990) Alcohol-induced neuronal loss in developing rats: increased brain damage with binge exposure. Alcohol Clin Exp Res 14:107-118.
4. Cano MJ, Ayala A, Murillo ML, Carreras O (2001) Protective effect of folic acid against oxidative stress produced in 21-day postpartum rats by maternal-ethanol chronic consumption during pregnancy and lactation period. Free Radic Res 34:1-8.
5. Chaudhuri JD (2000) Alcohol and the developing fetus-a review. Med Sci Monitor 6:1031-1041.
6. Chen WJA, Berryhill EC, West JR (2001) Zinc supplementation does not attenuate alcohol-induced cerebellar Purkinje cell loss during the brain growth spurt period. Alcohol Clin Exp Res 25:600-605.
7. Chen WJA, Maier SE, Parnell SE, West JR (2003) Alcohol and developing brain: neuroanatomical studies. Alcohol Res Health 27:174-180.
8. Chen WJA, Maier SE, West JR. (1996) Toxic effects of ethanol on the fetal brain, in Pharmacological Effects of Ethanol on the Nervous System (Deitrich RA, Erwin VG, eds), pp 343-361. Boca Raton, FL, CRC Press.
9. Cohen-Kerem R, Koren G (2003) Antioxidants and fetal protection against ethanol teratogenicity, I: review of the experimental data and implications to humans. Neurotoxicol Teratol 25:1-9.
10. Diaz J (1991) Experimental rearing of rat pups using chronic gastric fistulas, in Developmental Psychobiology: New Methods and Changing Concepts (Shair HN, Barr GA, Hofer MA, eds), pp 272-284, New York, Oxford University Press.
11. Edwards RB, Manzanna E, Chen WJ (2002) Melatonin (an antioxidant) does not ameliorate alcohol-induced Purkinje cell loss in the developing cerebellum. Alcohol Clin Exp Res 26:1003-1009.
12. Giese H, Mertsch K, Ingolf BE (1995) Effect of MK-801 and U83836E on a porcine brain capillary endothelial cell barrier during hypoxia. Neurosci Lett 191:169-172.
13. Goodlett CR, Horn KH (2001) Mechanisms of alcohol-induced damage to the developing nervous system. Alcohol Res Health 25:175-184.
14. Gundersen HJG, Bendsten TF, Korbo L, Marcussen N, Moller A, Nielsen K, Nyengaard JR, Pakkenberg B, Sorsensen FB, Vesterby A, West MJ (1988) Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS 96:379-394.
15. Hall ED, Pazara KE, Braughler JM, Linseman KL, Jacobsen EJ. (1990) Nonsteroidal lazaroid U78517F in models of focal and global ischemia. Stroke 21(suppl III):III-83-III-87.
16. Heaton MB, Mitchell JJ, Paiva M (2000) Amelioration of ethanol-induced neurotoxicity in the neonatal rat central nervous system by antioxidant therapy. Alcohol Clin Exp Res 24:512-518.
17. Heaton MB, Paiva M, Madorsky I, Shaw G (2003) Ethanol effects on neonatal rat cortex: comparative analyses of neurotrophic factors, apoptosis-related proteins, and oxidative processes during vulnerable and resistant periods. Brain Res Dev Brain Res 145:249-262.
18. Jones KL, Smith DW (1973) Recognition of the fetal alcohol syndrome in early infancy. Lancet 2:999-1001.
19. Klintsova AY, Scamra C, Hoffman M, Napper RM, Goodlett CR, Greenough WT (2002) Therapeutic effects of complex motor training on motor performance deficits induced by neonatal binge-like alcohol exposure in rats, II: a quantitative stereological study of synaptic plasticity in female rat cerebellum. Brain Res 937:83-93.
20. Lai YL, Wu HD, Chen CF (1998) Antioxidants attenuate chronic hypoxic pulmonary hypertension. J Cardiovasc Pharmacol 32:714-720.
21. Light KE, Belcher SM, Pierce DR (2002) Time course and manner of Purkinje neuron death following a single ethanol exposure on postnatal day 4 in the developing rat. Neuroscience 114:327-337.
22. Lucca E, Angeretti N, Forloni G (1997) Influence of cell culture conditions on the protective effect of antioxidants against beta-amyloid toxicity: studies with lazaroids. Brain Res 764:293-298.
23. Maier SE, Miller JA, Blackwell JM, West JR (1999) Fetal alcohol exposure and temporal vulnerability: regional differences in cell loss as a function of the timing of binge-like alcohol exposure during brain development. Alcohol Clin Exp Res 23:726-734.
24. Maier SE, West JR (2001) Regional differences in cell loss associated with binge like alcohol exposure during the first two trimesters equivalent in the rat. Alcohol 23:49-57.
25. Mertsch K, Grune T, Kunnstmann S, Wienser B, Ladhoff AM, Siems WG, Haseloff RF (1998) Protective effects of WR2721 and U83836E on lipid peroxidation in endothelial cells during hypoxia/reoxygenation. Biochem Pharmacol 56:945-954.
26. Mitchell JJ, Paiva M, Heaton MB (1999a) The antioxidants vitamin E and beta-carotene protect against ethanol-induced neurotoxicity in embryonic rat hippocampal cultures. Alcohol 17:163-168.
27. Mitchell JJ, Paiva M, Heaton MB (1999b) Vitamin E and beta-carotene protect against ethanol combined with ischemia in an embryonic rat hippocampal culture model of fetal alcohol syndrome. Neurosci Lett 263:189-192.
28. Moreland N, La Grange L, Montoya R (2002) Impact of in utero exposures to EtOH on corpus callosum development and paw preference in rats: protective effects of silymarin. BMC Complement Altern Med 11:10.
29. Napper RMA, West JR (1995) Permanent neuronal cell loss in the cerebellum of rats exposed to continuous low blood alcohol levels during the brain growth spurt: a stereological investigation. J Comp Neurol 362:283-292.
30. Olney JW, Ishimaru J, Bittigau P, Ikonomidou C (2000) Ethanol-induced apoptotic neurodegeneration in the developing brain. Apoptosis 5:515-521.
31. Penton Z (1985) Headspace measurement of ethanol in blood by gas chromatography with a modified auto sampler. Clin Chem 31:439-441.
32. Ramachandran V, Perez A, Chen J, Senthill D, Schenker S, Henderson GI (2001) In utero ethanol exposure causes mitochondrial dysfunction, which can result in apoptotic cell death in fetal brain: a potential role for 4-hydroxynonenal. Alcohol Clin Exp Res 25:862-871.
33. Ramachandran V, Watts LT, Shivani KM, Chen J, Schenker S, Henderson G (2003) Ethanol-induced oxidative stress precedes mitochondrially mediated apoptotic death of cultured fetal cortical neurons. J Neurosci 74:577-588.
34. Reiter RJ, Acuna-Castroviejo D, Tan DX, Burkhardt S (2001) Free radical-mediated molecular damage: mechanisms for the protective actions of rnelatonin in the central nervous system. Ann NY Acad Sci 939:200-215.
35. Ricciarelli R, Zingg JM, Azzi A (2001) Vitamin E: protective role of a Janus molecule. FASEB J 15:2314-2325.
36. Roebuck TM, Mattson SN, Riley EP (1999) Prenatal exposure to alcohol: effects on brain structure and neuropsychological functioning, in Alcohol: Effects on Brain and Development (Hannigan JH, Spear LP, Spear NE, Goodlett CR, eds), pp 1-16, Mahwah, NJ, Lawrence Erlbaum Associates Publishers.
37. Sarna JR, Hawkes R (2003) Patterned Purkinje cell death in the cerebellum. Prog Neurobiol 70:473-507.
38. Şener G, Jahovic N, Tosun O, Atasoy BM, Yegen BC (2003a) Melatonin ameliorates ionizing radiation induced oxidative organ damage in rats. Life Sci 74:563-572.
39. Şener G, Paskaloglu K, Toklu H, Kapueu C, Ayanoglu-Dulger G, Kaema A, Sakarean A (2004) Melatonin ameliorates chronic renal failure-induced oxidative organ damage in rats. J Pineal Res 36:232-241.
40. Şener G, Tosun O, Sehirli AO, Kacmaz A, Arbak S, Ersoy Y, Ayanoglu-Dulger G (2003b) Melatonin and N-acetylcysteine have beneficial effects during hepatic ischemia and reperfusion. Life Sci 72:2707-2718.
41. Singh P, Bhargava VK, Garg SK (2002) Effect of melatonin and beta-carotene on indomethacin induced gastric mucosal injury. Indian J Physiol Pharmacol 46:229-234.
42. Sokol RJ, Delaney-Black V, Nordstrom B (2003) Fetal alcohol spectrum disorder. JAMA 290:2996-2999.
43. Spong CY, Abebe DT, Gozes I, Brenneman DE, Hill JM (2001) Prevention of fetal demise and growth restriction in a mouse model of fetal alcohol syndrome. Pharmacol Exp Ther 297:774-779.
44. Stratton K, Howe C, Battaglia F (1996) Fetal Alcohol Syndrome: Diagnosis, Epidemiology, Prevention, and Treatment. Washington, DC, National Academy Press.
45. Stull ND, Polan DP, Iacovitti L (2002) Antioxidant compounds protect dopamine neurons from death due to oxidative stress in vitro. Brain Res 931:181-185.
46. Tran TD, Jackson HD, Horn KH, Goodlett CR (2005) Vitamin E does not protect against neonatal ethanol-induced cerebellar damage or deficits in eyeblink classical conditioning in rats. Alcohol Clin Exp Res 29:117-129.
47. Wang X, Mori T, Sumii T, Lo EH (2002) Hemoglobin-induced cytotoxicity in rat cerebral cortical neurons: caspase activation and oxidative stress. Stroke 33:1882-1888.
48. West JR, Chen WJA, Pantazis NJ (1994) Fetal alcohol syndrome: the vulnerability of the developing brain and possible mechanisms of damage. Metab Brain Dis 9:291-322.
49. West JR, Parnell SE, Chen WJ, Cudd TA (2001) Alcohol-mediated Purkinje cell loss in the absence of hypoxemia during the third trimester in an ovine model system. Alcohol Clin Exp Res 25:1051-1057.
50. Widdowson PS, Gyte A, Upton R, Foster J, Coutts CT, Wyatt I. (1997) Calpain activation and not oxidative damage mediates L-2-chloropropionic acid-induced cerebellar granule cell Necrosis Toxicol Appl Pharmacol 142:248-255.
51. Yamamoto H, Mohanan PV (2002) Melatonin attenuates brain mitochondria DNA damage induced by potassium cyanide in vivo and in vitro. Technology 179:29-36.
52. Yoshida M, Fukuda A, Hara M, Terada A, Kitanaka Y, Owada S (2003) Melatonin prevents the increase in hydroxyl radical-spin trap adduct formation caused by the addition of cisplatin in vitro. Life Sci 72:1773-1780.
53. Yoshioka T, Iwamoto N, Ito K (1996) An application of electron paramagnetic resonance to evaluate nitric oxide and its quenchers. J Am Soc Nephrol 7:961-965.