Benzo[c]phenanthridine alkaloids exhibit strong anti-proliferative activity in malignant melanoma cells regardless of their p53 status

Journal of Dermatological Science

Volumn 62, Issue 1, 2011, Pages 22-35

  Hammerová, Jindřiška ^a   Uldrijan, Stjepan ^a   Táborská, Eva ^a   Slaninová, Iva ^a  

^a MASARYK UNIVERSITY   (Czech Republic)

Author keywords

Apoptosis; Benzo c phenanthridine alkaloids; DNA damage; Melanoma; P53

Indexed keywords

BENZO[C]PHENANTHRIDINE DERIVATIVE; CAMPTOTHECIN; CASPASE 3; CHELERYTHRINE; CHELIDONINE; CHELILUTINE; DNA; DOXORUBICIN; HISTONE H2AX; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL XL; PROTEIN MCL 1; PROTEIN P53; SANGUILUTINE; SANGUINARINE; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DNA DAMAGE; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG RESPONSE; HUMAN; HUMAN CELL; IC 50; MELANOMA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION; WILD TYPE;

ALKALOIDS; AMINO ACID CHLOROMETHYL KETONES; APOPTOSIS; BENZOPHENANTHRIDINES; CASPASES; CELL PROLIFERATION; CELL SURVIVAL; DNA; DNA DAMAGE; GENES, P53; HUMANS; MELANOMA; MODELS, BIOLOGICAL; MODELS, CHEMICAL; SKIN NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 79952705778     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2011.01.006     Document Type: Article

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