Sanguinarine-induced apoptosis is associated with an early and severe cellular glutathione depletion

Cancer Chemotherapy and Pharmacology

Volumn 51, Issue 6, 2003, Pages 474-482

  Debiton, Eric ^a   Madelmont, Jean Claude ^a   Legault, Jean ^a   Barthomeuf, Chantal ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ DU QUÉBEC À MONTRÉAL   (Canada)

Author keywords

Anticancer candidate; Apoptosis; Caspases Glutathione depletion; ROS production; Sanguinarine

Indexed keywords

ACETYLCYSTEINE; ALKALOID DERIVATIVE; ANTINEOPLASTIC AGENT; BENZOPHENANTHRIDINE DERIVATIVE; CASPASE 3; CASPASE 7; DITHIOTHREITOL; DNA FRAGMENT; GLUTATHIONE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; SANGUINARINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DNA DETERMINATION; DRUG MECHANISM; DRUG SPECIFICITY; ENZYME ACTIVATION; ENZYME DEGRADATION; FLUOROMETRY; GROWTH INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL;

EID: 0037713603     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-003-0609-9     Document Type: Article

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