Induction of necrosis and apoptosis to KB cancer cells by sanguinarine is associated with reactive oxygen species production and mitochondrial membrane depolarization

Toxicology and Applied Pharmacology

Volumn 218, Issue 2, 2007, Pages 143-151

  Chang, Mei Chi ^a   Chan, Chiu Po ^b   Wang, Ying Jan ^c   Lee, Po Hsuen ^a   Chen, Lin I ^d   Tsai, Yi Ling ^d   Lin, Bor Ru ^d   Wang, Yin Lin ^c   Jeng, Jiiang Huei ^d  

^a CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Anticarcinogenic; Apoptosis; Cytotoxicity; Mitochondrial membrane potential; Necrosis; Reactive oxygen species; Sanguinarine

Indexed keywords

ACETYLCYSTEINE; CATALASE; COLLAGEN; DIMETHYLTHIOUREA; DNA FRAGMENT; FIBRONECTIN; LIPOCORTIN 5; PROPIDIUM IODIDE; REACTIVE OXYGEN METABOLITE; RHODAMINE; SANGUINARINE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CELL ADHESION; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL DEATH; CHELLIDONIUM MAJUS; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; FLOW CYTOMETRY; FLUORESCENCE; HUMAN; HUMAN CELL; MEDICINAL PLANT; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE; SANGUINARIA; SANGUINARIA CANADENSIS;

ACETYLCYSTEINE; ALKALOIDS; ANNEXIN A5; ANTICARCINOGENIC AGENTS; ANTIOXIDANTS; APOPTOSIS; BENZOPHENANTHRIDINES; CATALASE; CELL ADHESION; CELL CYCLE; CELL PROLIFERATION; COLLAGEN; DNA FRAGMENTATION; FIBRONECTINS; FLOW CYTOMETRY; HUMANS; ISOQUINOLINES; KB CELLS; MEMBRANE POTENTIALS; MITOCHONDRIAL MEMBRANES; NECROSIS; REACTIVE OXYGEN SPECIES; THIOUREA; TUMOR STEM CELL ASSAY;

SANGUINARIA CANADENSIS;

EID: 33846626446     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2006.10.025     Document Type: Article

References (40)

1. Adhami V.M., Aziz M.H., Mukhtar H., and Ahmad N. Activation of prodeath Bcl-2 family proteins and mitochondrial apoptosis pathway by sanguinarine in immortalized human HaCaT keratinocytes. Clin. Cancer Res. 9 (2003) 3176-3182
2. Ahmad N., Gupta M., Husain M.M., Heiskanen K.M., and Mukhtar H. Differential antiproliferative and apoptotic response sanguinarine for cancer cells versus normal cells. Clin. Cancer Res. 6 (2000) 1524-1528
3. Babich H., Zuckerbraun H.L., Barber I.B., and Babich S.B. Cytotoxicity of sanguinarine chloride to cultured human cells from oral tissue. Pharmacol. Toxicol. 78 (1996) 397-403
4. Banerjee B.D., Seth V., Koner B.C., Ahmed R.S., Sharma M., Grover S.S., Rautals R.S., Avasthi R., and Pasha S.T. Evaluation of oxidative stress in some cases of argimone poisoning during a recent outbreak of epidemic dropsy India. Int. J. Environ. Health Res. 10 (2000) 341-346
5. Chakraborti T., Das S., Mondal M., Roychoudhury S., and Chakraborti S. Oxidant, mitochondria and calcium: an overview. Cell. Signal 11 (1999) 77-85
6. Chang M.C., Ho Y.S., Lee P.H., Chan C.P., Lee J.J., Hahn L.J., Wang Y.J., and Jeng J.H. Areca nut extract and arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB epithelial cells: association of glutathione, reactive oxygen species and mitochondrial membrane potential. Carcinogenesis 22 (2001) 1527-1535
7. Chang M.C., Uang B.J., Wu H.L., Lee J.J., Hahn L.J., and Jeng J.H. Inducing the cell cycle arrest and apoptosis of oral KB carcinoma cells by hydroxychavicol: roles of glutathione and reactive oxygen species. Br. J. Pharmacol. 135 (2002) 619-630
8. Chang M.C., Wu H.L., Lee J.J., Lee P.H., Chang H.H., Hahn L.J., Lin B.R., Chen Y.J., and Jeng J.H. The induction of prostaglandin E2 production, interleukin-6 production, cell cycle arrest and cytotoxicity in primary oral keratinocytes and KB cancer cells by areca ut ingredients is differentially regulated by MEK/ERK activation. J. Biol. chem. 279 (2004) 50676-50683
9. Charron T., Nili N., and Strauss B.H. The cell cycle: a critical therapeutic target to prevent vascular proliferative disease. Can. J. Cardiol. 22 suppl B (2006) 41B-55B
10. Chaturvedi M.M., Kumar A., Darnay B.G., Chainy G.B.N., Agaarwal S., and Aggarwal B.B. Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-kB activation, IkBα phosphorylation, and degradation. J. Biol. Chem. 272 (1997) 30129-30134
11. Collins J.A., Schandl C.A., Young K.K., Vesely J., and Willingham M.C. Major DNA fragmentation is a late event in apoptosis. J. Histochem. Cytochem. 45 (1997) 923-934
12. Debiton E., Madelmont J.C., legault J., and Barthomeuf C. Sanguinarine-induced apoptosis is associated with a nearly and severe cellular glutathione depletion. Cancer Chemother. Pharmacol. 51 (2003) 474-482
13. Ding Z., Tang S.C., Weerasinghe P., Yang X., Peter A., and Liepins A. The alkaloid sanguinarin is effective against multidrug resistance in human cervical cells via bimodal cell death. Biochem. Pharmacol. 63 (2002) 1415-1421
14. Francos V.H., Brusick D.J., Johnson E.M., Maibach H.I., Munro I., Squire R.A., and Weil C.S. Safety of sauguinaria extract as used in commercial toothpaste and oral rinse products. J. Can. Dent. Assoc. 56 (1990) 41-47 (Suppl.)
15. Godowski K.C., Wolff E.D., Thompson D.M., Housley C.J., Polson A.M., Dunn R.L., Duke S.P., Stoller N.H., and Southard G.L. Whole mouth microbiota effects following subgingival delivery of sanguinarum. J. Periodontol. 66 (1995) 870-877
16. Heath-Engel H.M., and Shore G.C. Mitochondrial membrane dynamic, cristae remodeling and apoptosis. Biochim. Biophys. Acta. 1763 (2006) 549-560
17. Hu C.M., Cheng H.W., Cheng Y.W., and Kan J.J. Mechanisms underlying the induction of vasorelaxation in rat thoracic aorta by sanguinarine. Jpn. J. Pharmacol. 85 (2001) 47-53
18. Jeng J.H., Ho Y.S., Chan C.P., Wang Y.J., Hahn L.J., Lei D., Hsu C.C., and Chang M.C. Areca nut extract up-regulates prostaglandin production, cyclooxygenase-2 mRNA and protein expression of human oral keratinocytes. Carcinogenesis 21 (2000) 1365-1370
19. Jeng J.H., Wang Y.J., Chiang B.L., Lee P.H., Chan C.P., Ho Y.S., Wang T.M., Lee J.J., Hahn L.J., and Chang M.C. Roles of keratinocyte inflammation in oral cancer: regulating the prostaglandin E2, interleukin-6 and TNF-alpha production of oral epithelial cells by areca nut extract and arecoline. Carcinogenesis 24 (2003) 1301-1315
20. Jeng J.H., Wang Y.J., Chang W.H., Wu H.L., Li C.H., Yang B.J., Kang J.J., Lee J.J., Hahn L.J., Lin B.R., and Chang M.C. Reactive oxygen species are crucial for hydroxychavicol toxicity toward KB epithelial cells. Cell. Mol. Life Sci. 61 (2004) 83-96
21. Jeng, J.H., Wu, H.L., Lin, B.R., Lan, W.H., Chang, H.H., Ho, Y.S., Lee, P.H., Wang, Y.J., Wang, J.S., Chen, Y.J., Chang, M.C., in press. Antiplatelet effect of sanguinarine is correlated to calcium mobilization, thromboxane and cAMP production. Atherosclerosis.
22. Kim R., Emi M., Tanabe K., Murakami S., Uchida Y., and Arihiro K. Regulation and interplay of apoptotic and non-apoptotic cell death. J. Pathol. 208 (2006) 319-326
23. Laconi E., Pani P., and Farber E. The resistance phenotype in the development and treatment of cancer. Lancet Oncol. 1 (2000) 235-241
24. Laster L.L., and Lobene R.P. New perspectives on sanguinarine clinicals: individual toothpaste and oral rinse testing. J. Can. Dent. Assoc. 56 (1990) 19-23 (suppl)
25. Lee P.H., Chang M.C., Chang W.H., Wang T.M., Wang Y.J., Hahn L.J., Ho Y.S., Lin C.Y., and Jeng J.H. Prolonged exposure to arecoline arrested human KB epithelial cell growth: regulatory mechanisms of cell cycle and apoptosis. Toxicology 220 (2006) 81-89
26. Mahady G.B., and Beecher C.W.W. Quercetin-induced benzo-phenanthridine alkaloid production in suspension cell cultures of Sanguinaria canadensis. Planta Med. 60 (1994) 553-557
27. Mascarenhas A.K., Allen C.M., and Loudon J. The association between Viadent use and oral leukoplakia. Epidemiology 12 (2001) 741-743
28. Melnikova V.O., and Ananthaswamy H.N. Cellular and molecular events leading to the development of skin cancer. Mutat. Res. 571 (2005) 91-106
29. Parsons L.G., Thomas L.G., Southard G.L., Woodall I.R., and Jones B.J.B. Effect of sanguinaria extract on established plaque and gingivitis when supragingivally delivered as a manual rinse or under pressure in an oral irrigator. J. Clin. Periodontol. 14 (1987) 381-385
30. Renvoize C., Biola A., Pallardy M., and Beard J. Apoptosis: identification of dying cells. Cell Biol. Toxicol. 14 (1998) 111-120
31. Slaninova I., Taborska E., Bochorakova H., and Slanina J. Interaction of benzo(c)phenanthridine and protobrine alkaloids with animal and yeast cells. Cell Biol. Toxicol. 17 (2001) 51-63
32. Trump B.F., and Berezesky I.K. Calcium-mediated cell injury and cell death. FASEB J. 9 (1995) 219-228
33. Van Zandwijk N. N-acetylcysteine (NAC) and glutathione (GSH): antioxidant and chemopreventive properties, with special reference to lung cancer. J. Cell. Biochem. 22 (1995) 24-32 (Suppl.)
34. Vavreckova C., Gawlik I., and Muller K. Benzophenanthridine alkaloids of Chelidonium majus: I. Inhibition of 5- and 12-lipoxygenase by a non-redox mechanism. Planta Med. 62 (1996) 397-401
35. Vermes I., Haanen C., Steffens-Nakken H., and Reutelingsperger C. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled Annexin V. Immunol. Methods 184 (1995) 39-51
36. Vrba J., Hrbac J., Ulricjova J., and Modriansky M. Sanguinarine is a potent inhibitor of oxidative burst in DMSO-differentiated HL-60 cells by a non-redox mechanism. Chem.-Biol. Interact. 147 (2004) 35-47
37. Walterova D., Ulrichova J., Valka I., Vicar J., Vavreckova C., Taborska E., Harjrader R.J., Meyer D.L., Cerna H., and Simanek V. Benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine: biological activities and dental care applications. Acta Univ. Palacki. Olomuc. Fac. Med. 139 (1995) 7-16
38. Weerasinghe P., Hallock S., and Liepins A. Bax, Bcl-2, and NF-κB expression in sanguinarine induced bimodal cell death. Exp. Mol. Pathol. 71 (2001) 89-98
39. Wolf K., and Friedl P. Molecular mechanisms of cancer cell invasion and plasticity. Br. J. Dermatol. 154 Suppl. 1 (2006) 11-15
40. Wyllie A.H. Apoptosis: an overview. Br. Med. Bull. 53 (1997) 451-465