A decisive role of mitochondria in defining rate and intensity of apoptosis induction by different alkaloids

Toxicology Letters

Volumn 177, Issue 3, 2008, Pages 168-181

  Kaminskyy, Vitaliy ^a   Kulachkovskyy, Oleksandr ^b   Stoika, Rostyslav ^a,b  

^a INSTITUTE OF CELL BIOLOGY   (Ukraine)

^b IVAN FRANKO NATIONAL UNIVERSITY OF LVIV   (Ukraine)

Author keywords

Apoptosis; Caspases; Chelerythrine; Chelidonine; Mitochondria; Sanguinarine

Indexed keywords

ACETYLCYSTEINE; ALKALOID; CASPASE 3; CASPASE 8; CASPASE 9; CELL DNA; CELL ENZYME; CHELERYTHRINE; CHELIDONINE; CYTOCHROME C; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; SANGUINARINE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL ORGANELLE; CELL STRUCTURE; CONTROLLED STUDY; CYTOSOL; DNA DAMAGE; DNA FRAGMENTATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME RELEASE; HUMAN; HUMAN CELL; LEUKEMIA CELL; MITOCHONDRIAL RESPIRATION; PRIORITY JOURNAL; TREATMENT DURATION;

ACETYLCYSTEINE; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BENZOPHENANTHRIDINES; CELLS, CULTURED; CHELIDONIUM; CYCLOSPORINE; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; ISOQUINOLINES; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES;

EID: 40849146903     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2008.01.009     Document Type: Article

References (54)

1. Adhami V.M., Aziz M.H., Mukhtar H., and Ahmad N. Activation of prodeath Bcl-family proteins and mitochondrial apoptosis pathway by sanguinarine in immortalized human HaCaT keratinocytes. Clin. Cancer. Res. 9 (2003) 3176-3182
2. Adhami V.M., Aziz M.H., Reagan-Shaw S.R., Nihal M., Mukhtar H., and Ahmad N. Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery. Mol. Cancer. Ther. 3 (2004) 933-940
3. Ahmad N., Gupta S., Husain M.M., Heiskanen K.M., and Mukhtar H. Differential antiproliferative and apoptotic response of sanguinarine for cancer cells versus normal cells. Clin. Cancer Res. 6 (2000) 1524-1528
4. Ahsan H., Reagan-Shaw S., Breur J., and Ahmad N. Sanguinarine induces apoptosis of human pancreatic carcinoma AsPC-1 and BxPC-3 cells via modulations in Bcl-2 family proteins. Cancer Lett. 249 (2006) 198-208
5. Andre N., Braguer D., Brasseur G., Gonçalves A., Lemesle-Meunier D., Guise S., Jordan M.A., and Briand C. Paclitaxel induces release of cytochrome c from mitochondria isolated from human neuroblastoma cells. Cancer Res. 60 (2000) 5349-5353
6. Barreto M.C., Pinto R.E., Arrabaca J.D., and Pavao M.L. Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids. Toxicol. Lett. 146 (2003) 37-47
7. Cai J., and Jones D. Superoxide in apoptosis. Mitochondrial generation triggered by cytochrome c loss. J. Biol. Chem. 273 (1998) 11401-11404
8. Carter B.Z., Kornblau S.M., Tsao T., Wang R.Y., Schober W.D., Milella M., Sung H.G., Reed J.C., and Andreeff M. Caspase-independent cell death in AML: caspase inhibition in vitro with pan-caspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis. Blood 102 (2003) 4179-4186
9. Chan S.L., Lee M.C., Tan K.O., Yang L.K., et al. Identification of chelerythrine as inhibitor of Bcl-XL function. J. Biol. Chem. 278 (2003) 20453-20456
10. Chang M.C., Chan C.P., Wang Y.J., Lee P.H., Chen L.I., Tsai Y.L., Lin B.R., Wang Y.L., and Jeng J.H. Induction of necrosis and apoptosis to KB cancer cells by sanguinarine is associated with reactive oxygen species production and mitochondrial membrane depolarization. Toxicol. Appl. Pharmacol. 218 (2007) 143-151
11. Chmura S.J., Dolan M.E., Cha A., Mauceri H.J., Kufe D.W., and Weichselbaum R.R. In vitro and in vivo activity of protein kinase c inhibitor chelerythrine chloride induces tumor cell toxicity and growth delay in vivo. Clin. Cancer Res. 6 (2000) 737-742
12. Colombo M.R., and Bosisio E. Pharmacological activities of Chelidonium majus L. (Papaveraceae). Pharmacol. Res. 33 (1996) 127-134
13. Cordes N., Plasswilm L., Bamberg M., and Rodemann H. Ukrain, an alkaloid thiophosphoric acid derivative of Chelidonium majus L. protects human fibroblasts but not human tumour cells in vitro against ionizing radiation. Int. J. Radiat. Biol. 78 (2002) 17-27
14. Debiton E., Madelmont J.C., Legault J., and Barthomeu C. Sanguinarine-induced apoptosis is associated with early and severe cellular glutathione depletion. Cancer Chemother. Pharmacol. 51 (2003) 474-482
15. Deng X., Gao F., Flagg T., Anderson J., and May W.S. Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 153-158
16. Friesen C., Herr I., Krammer P.H., and Debatin K.M. Involvement of the CD95 (APO-1/Fas) receptor/ligand system in drug-induced apoptosis in leukemia cells. Nat. Med. 2 (1996) 574-577
17. Gong J., Traganos F., and Darzynkiewicz Z. A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry. Anal. Biochem. 218 (1994) 314-316
18. Gonzalvez F., and Gottlieb E. Cardiolipin: setting the beat of apoptosis. Apoptosis 12 (2007) 877-885
19. Green D.R., and Reed J.C. Mitochondria and apoptosis. Science 281 (1998) 1309-1312
20. Gulston M., de Lara C., Jenner T., Davis E., and O'Neill P. Processing of clustered DNA damage generates additional double-strand breaks in mammalian cells post-irradiation. Nucleic Acids Res. 32 (2004) 1602-1609
21. Habermehl D., Kammerer B., Handrick R., Eldh T., Gruber C., Cordes N., Daniel P.T., Plasswilm L., Bamberg M., Belka C., and Jendrossek V. Proapoptotic activity of Ukrain is based on Chelidonium majus L. alkaloids and mediated via a mitochondrial death pathway. BMC Cancer 6 (2006) 14
22. Hampton M., and Orrenius S. Redox regulation of apoptotic cell death in the immune system. Toxicol. Lett. 102-103 (1998) 355-358
23. Heaton P.R., Ransley R., Charlton C.J., Mann S.J., Stevenson J., Smith B.H., Rawlings J.M., and Harper E.J. Application of single-cell gel electrophoresis (comet) assay for assessing levels of DNA damage in canine and feline leukocytes. J. Nutr. 132 (2002) 1598S-1603S
24. Hohenwarter O., Strutzenberger K., and Katinger H. Selective inhibition of in vitro cell growth by the anti-tumour drug Ukrain. Drugs Exp. Clin. Res. 18 (1992) 1-4
25. Hussain A.R., Al-Jomah N.A., Siraj A.K., Manogaran P., Al-Hussein K., Abubaker J., Platanias L.C., Al-Kuraya K.S., and Uddin S. Sanguinarine-dependent induction of apoptosis in primary effusion lymphoma cells. Cancer Res. 67 (2007) 3888-3897
26. Johnson L., Walsh M., Bockus B., and Chen L. Monitoring of relative mitochondrial membrane potential in living cells by fluorescence microscopy. J. Cell Biol. 88 (1981) 526-535
27. Kamins'kyi V.O., Kryv'iak N.V., Lutsyk M.D., and Stoika R.S. Effect of alkaloids from celandine on calcium accumulation and oxidative phosphorylation in mitochondria depending on their DNA intercalating properties. Ukr. Biokhim. Zh. 78 (2006) 73-78 (in Ukrainian)
28. Kaminskyy V.O., Lootsik M.D., and Stoika R.S. Cytotoxic activity of various greater celandine alkaloids correlates with their DNA intercalating properties and ability to induce breaks in DNA of NK/Ly murine lymphoma cells. Central Eur. J. Biol. 1 (2006) 2-15
29. Kemeny-Beke A., Aradi J., Damjanovich J., Beck Z., Facsko A., Berta A., and Bodnar A. Apoptotic response of uveal melanoma cells upon treatment with chelidonine, sanguinarine and chelerythrine. Cancer Lett. 237 (2006) 67-75
30. Lin S.S., Bassik M.C., Suh H., Nishino M., Arroyo J.D., Hahn W.C., Korsmeyer S.J., and Roberts T.M. PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum. J. Biol. Chem. 281 (2006) 23003-230012
31. Milanesi E., Costantini P., Gambalunga A., Colonna R., Petronilli V., Cabrelle A., Semenzato G., Cesura A.M., Pinard E., and Bernardi P. The mitochondrial effects of small organic ligands of Bcl-2. J. Biol. Chem. 281 (2006) 10066-10072
32. Orrenius S., Gogvadze V., and Zhivotovsky B. Mitochondrial oxidative stress: implications for cell death. Annu. Rev. Pharmacol. Toxicol. 47 (2007) 143-183
33. Ott M., Zhivotovsky B., and Orrenius S. Role of cardiolipin in cytochrome c release from mitochondria. Cell Death Differ. 14 (2007) 1243-1247
34. Panzer A., Joubert A.M., Bianchi P.C., Hamel E., and Seegers J.C. The effects of chelidonine on tubulin polymerisation, cell cycle progression and selected signal transmission pathways. Eur. J. Cell Biol. 80 (2001) 111-118
35. Park S.J., Wu C.H., Gordon J.D., Zhong X., Emami A., and Safa A.R. Taxol induces caspase-10-dependent apoptosis. J. Biol. Chem. 279 (2004) 51057-51067
36. Peterson G.L. A simplification of the protein assay of Lowry et al. which is more generally applicable. Anal. Biochem. 83 (1977) 346-356
37. Platzbecker U., Ward J.L., and Deeg H.J. Chelerythrin activates caspase-8, downregulates FLIP long and short, and overcomes resistance to tumour necrosis factor-related apoptosis-inducing ligand in KG1a cells. Br. J. Haematol. 122 (2003) 489-497
38. Reynolds E.S. The use of lead citrate at high pH as an electronopaque stain in electron microscopy. J. Cell. Biol. 17 (1963) 208-212
39. Rodriguez-Nieto S., and Zhivotovsky B. Role of alterations in the apoptotic machinery in sensitivity of cancer cells to treatment. Curr. Pharm. Des. 12 (2006) 4411-4425
40. Roublevskaia I., Haake A., Ludlow J., and Polevoda B. Induced apoptosis in human prostate cancer cell line LNCaP by Ukrain. Drugs Exp. Clin. Res. 26 (2000) 141-147
41. Roublevskaia I., Polevoda B., Ludlow J., and Haake A. Induced G2/M arrest and apoptosis in human epidermoid carcinoma cell lines by semisynthetic drug Ukrain. Anticancer Res. 20 (2000) 3163-3167
42. Skulachev V.P. Bioenergetic aspects of apoptosis, necrosis and mitoptosis. Apoptosis 11 (2006) 473-485
43. Stoetzer O., Pogrebniak A., Pelka-Fleicher R., Hasmann M., Hiddemann W., and Nuessler V. Modulation of apoptosis by mitochondrial uncouples: apoptosis-delaying features despite intrinsic cytotoxicity. Biochem. Pharmacol. 63 (2002) 471-483
44. Tsujimoto Y., and Shimizu S. Role of the mitochondrial membrane permeability transition in cell death. Apoptosis 12 (2007) 835-840
45. Wajant H. The Fas signaling pathway: more than a paradigm. Science 296 (2002) 1635-1636
46. Wang L.G., Liu X.M., Kreis W., and Budman R.D. The effect of antimicrotubule agents on signal transduction pathways of apoptosis: a review. Cancer Chemother. Pharmacol. 44 (1999) 355-361
47. Waring P., and Beaver J. Cyclosporin A rescues thymocytes from apoptosis induced by very low concentrations of thapsigargin: effects on mitochondrial function. Exp. Cell. Res. 227 (1996) 264-276
48. Waterhouse N.J., Goldstein J.C., von Ahsen O., Schuler M., Newmeyer D.D., and Green D.R. Cytochrome c maintains mitochondrial transmembrane potential and ATP generation after outer mitochondrial membrane permeabilization during the apoptotic process. J. Cell Biol. 153 (1998) 319-328
49. Weerasinghe P., Hallock S., Tang S.C., and Liepins A. Sanguinarine induces bimodal cell death in K562 but not in high Bcl-2-expressing JM1 cells. Pathol. Res. Pract. 197 (2001) 717-726
50. Wolff J., and Knipling L. Antimicrotubule properties of benzophenanthridine alkaloids. Biochemistry 32 (1993) 13334-13339
51. Yamamoto K., Ichijo H., and Korsmeyer S.J. Bcl-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G2/M. Mol. Cell Biol. 19 (1999) 8469-8478
52. Yamamoto S., Seta K., Morisco C., Vatner S.F., and Sadoshima J. Chelerythrine rapidly induces apoptosis through generation of reactive oxygen species in cardiac myocytes. J. Mol. Cell Cardiol. 33 (2001) 1829-1848
53. Yu R., Mandlekar S., Tan T.H., and Kong A.N. Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C. J. Biol. Chem. 275 (2000) 9612-9619
54. Zhang Y.H., Bhunia A., Wan K.F., Lee M.C., Chan S.L., Yu V.C.K., and Mok Y.K. Chelerythrine and sanguinarine dock at distinct sites on Bcl-XL that are not the classic BH3 binding cleft. J. Mol. Biol. 364 (2006) 536-549