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Volumn 49, Issue 1-3, 2011, Pages 87-96

microRNAs at the regulatory frontier: An investigation into how microRNAs impact the development and effector functions of CD4 T cells

Author keywords

Autoimmunity; Cancer immunity; Immunoregulation; microRNA; T cells

Indexed keywords

MICRORNA; MICRORNA 17-92; MICRORNA 181A; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

EID: 79952703781     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12026-010-8196-4     Document Type: Review
Times cited : (20)

References (76)
  • 2
    • 0034093737 scopus 로고    scopus 로고
    • Signal transduction by the TCR for antigen
    • DOI 10.1016/S0952-7915(00)00083-2
    • Kane LP, Lin J, Weiss A. Signal transduction by the TCR for antigen. Curr Opin Immunol. 2000;12:242-9. (Pubitemid 30240532)
    • (2000) Current Opinion in Immunology , vol.12 , Issue.3 , pp. 242-249
    • Kane, L.P.1    Lin, J.2    Weiss, A.3
  • 4
    • 0036221481 scopus 로고    scopus 로고
    • Signal transduction mediated by the T cell antigen receptor: The role of adapter proteins
    • Samelson, L.E.: Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins. Annu Rev Immunol 2002; 20: 371-394.
    • (2002) Annu Rev Immunol , vol.20 , pp. 371-394
    • Samelson, L.E.1
  • 5
    • 58149083028 scopus 로고    scopus 로고
    • Scaffold proteins and immune-cell signalling
    • Shaw AS, Filbert EL. Scaffold proteins and immune-cell signalling. Nat Rev Immunol. 2009;9:47-56.
    • (2009) Nat Rev Immunol , vol.9 , pp. 47-56
    • Shaw, A.S.1    Filbert, E.L.2
  • 6
    • 77953629046 scopus 로고    scopus 로고
    • Regulation of mRNA translation and stability by microRNAs
    • Fabian MR, Sonenberg N, Filipowicz W. Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem. 2010;79:351-79.
    • (2010) Annu Rev Biochem , vol.79 , pp. 351-379
    • Fabian, M.R.1    Sonenberg, N.2    Filipowicz, W.3
  • 7
    • 0346727524 scopus 로고    scopus 로고
    • MicroRNAs Modulate Hematopoietic Lineage Differentiation
    • DOI 10.1126/science.1091903
    • Chen CZ, Li L, Lodish HF, Bartel DP. microRNAs modulate hematopoietic lineage differentiation. Science. 2004;303:83-6. (Pubitemid 38055775)
    • (2004) Science , vol.303 , Issue.5654 , pp. 83-86
    • Chen, C.-Z.1    Li, L.2    Lodish, H.F.3    Bartel, D.P.4
  • 8
    • 33947721625 scopus 로고    scopus 로고
    • miR-181a Is an Intrinsic Modulator of T Cell Sensitivity and Selection
    • Li QJ, et al. miR-181a Is an Intrinsic Modulator of T Cell Sensitivity and Selection. Cell. 2007;129:147-61.
    • (2007) Cell , vol.129 , pp. 147-161
    • Li, Q.J.1
  • 9
    • 47849125676 scopus 로고    scopus 로고
    • MicroRNAs: New regulators of immune cell development and function
    • DOI 10.1038/ni.f.209, PII NI.F.209
    • Baltimore D, Boldin MP, O'Connell RM, Rao DS, Taganov KD. microRNAs: new regulators of immune cell development and function. Nat Immunol. 2008;9:839-45. (Pubitemid 352038302)
    • (2008) Nature Immunology , vol.9 , Issue.8 , pp. 839-845
    • Baltimore, D.1    Boldin, M.P.2    O'Connell, R.M.3    Rao, D.S.4    Taganov, K.D.5
  • 10
    • 0028589333 scopus 로고
    • Kinetics of T-cell receptor binding to peptide/I-Ek complexes: Correlation of the dissociation rate with T-cell responsiveness
    • Matsui K, Boniface JJ, Steffner P, Reay PA, Davis MM. Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness. Proc Natl Acad Sci USA. 1994;91:12862-6.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 12862-12866
    • Matsui, K.1    Boniface, J.J.2    Steffner, P.3    Reay, P.A.4    Davis, M.M.5
  • 12
    • 0037331525 scopus 로고    scopus 로고
    • Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation
    • DOI 10.1016/S1074-7613(03)00019-0
    • Holler PD, Kranz DM. Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation. Immunity. 2003;18:255-64. (Pubitemid 36263000)
    • (2003) Immunity , vol.18 , Issue.2 , pp. 255-264
    • Holler, P.D.1    Kranz, D.M.2
  • 13
    • 1242270594 scopus 로고    scopus 로고
    • T cell receptors: Affinities, cross-reactivities, and a conformer model
    • DOI 10.1016/j.molimm.2003.11.013
    • Holler PD, Kranz DM. T cell receptors: affinities, cross-reactivities, and a conformer model. Mol Immunol. 2004;40:1027-31. (Pubitemid 38221182)
    • (2004) Molecular Immunology , vol.40 , Issue.14-15 , pp. 1027-1031
    • Holler, P.D.1    Kranz, D.M.2
  • 14
    • 0026434554 scopus 로고
    • Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand
    • Evavold BD, Allen PM. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science. 1991;252:1308-10. (Pubitemid 21917045)
    • (1991) Science , vol.252 , Issue.5010 , pp. 1308-1310
    • Evavold, B.D.1    Allen, P.M.2
  • 16
    • 15044358353 scopus 로고    scopus 로고
    • Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity
    • DOI 10.1038/nature03391
    • Krogsgaard M, et al. Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity. Nature. 2005;434:238-43. (Pubitemid 40388057)
    • (2005) Nature , vol.434 , Issue.7030 , pp. 238-243
    • Krogsgaard, M.1    Li, Q.-J.2    Sumen, C.3    Huppa, J.B.4    Huse, M.5    Davis, M.M.6
  • 17
    • 0025761241 scopus 로고
    • Lower receptor avidity required for thymic clonal deletion than for effector T-cell function
    • Pircher H, Rohrer UH, Moskophidis D, Zinkernagel RM, Hengartner H. Lower receptor avidity required for thymic clonal deletion than for effector T-cell function. Nature. 1991;351:482-5. (Pubitemid 21896624)
    • (1991) Nature , vol.351 , Issue.6326 , pp. 482-485
    • Pircher, H.1    Rohrer, U.H.2    Moskophidis, D.3    Zinkernagel, R.M.4    Hengartner, H.5
  • 19
    • 0033103008 scopus 로고    scopus 로고
    • Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire
    • Lucas B, Stefanova I, Yasutomo K, Dautigny N, Germain RN. Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire. Immunity. 1999;10:367-76. (Pubitemid 29165291)
    • (1999) Immunity , vol.10 , Issue.3 , pp. 367-376
    • Lucas, B.1    Stefanova, I.2    Yasutomo, K.3    Dautigny, N.4    Germain, R.N.5
  • 20
    • 0032055547 scopus 로고    scopus 로고
    • -) to TCR/CD8 signaling in response to antigen
    • Curtsinger JM, Lins DC, Mescher MF. CD8+ memory T cells (CD44high, Ly-6C+) are more sensitive than naive cells to (CD44low, Ly-6C-) to TCR/CD8 signaling in response to antigen. J Immunol. 1998;160:3236-43. (Pubitemid 28164712)
    • (1998) Journal of Immunology , vol.160 , Issue.7 , pp. 3236-3243
    • Curtsinger, J.M.1    Lins, D.C.2    Mescher, M.F.3
  • 22
    • 12344273653 scopus 로고    scopus 로고
    • An antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II-restricted T cells in the absence of CD4
    • DOI 10.1084/jem.20041574
    • Kao H, Allen PM. An antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II-restricted T cells in the absence of CD4. J Exp Med. 2005;201:149-58. (Pubitemid 40130092)
    • (2005) Journal of Experimental Medicine , vol.201 , Issue.1 , pp. 149-158
    • Kao, H.1    Allen, P.M.2
  • 23
    • 0037167816 scopus 로고    scopus 로고
    • Direct observation of ligand recognition by T cells
    • DOI 10.1038/nature01076
    • Irvine DJ, Purbhoo MA, Krogsgaard M, Davis MM. Direct observation of ligand recognition by T cells. Nature. 2002;419:845-9. (Pubitemid 35238571)
    • (2002) Nature , vol.419 , Issue.6909 , pp. 845-849
    • Irvine, D.J.1    Purbhoo, M.A.2    Krogsgaard, M.3    Davis, M.M.4
  • 24
    • 4444298148 scopus 로고    scopus 로고
    • CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse
    • Li QJ, et al. CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse. Nat Immunol. 2004;5:791-9.
    • (2004) Nat Immunol , vol.5 , pp. 791-799
    • Li, Q.J.1
  • 25
    • 2442651482 scopus 로고    scopus 로고
    • T cell killing does not require the formation of a stable mature immunological synapse
    • DOI 10.1038/ni1058
    • Purbhoo MA, Irvine DJ, Huppa JB, Davis MM. T cell killing does not require the formation of a stable mature immunological synapse. Nat Immunol. 2004;5:524-30. (Pubitemid 38660465)
    • (2004) Nature Immunology , vol.5 , Issue.5 , pp. 524-530
    • Purbhoo, M.A.1    Irvine, D.J.2    Huppa, J.B.3    Davis, M.M.4
  • 26
    • 55349122507 scopus 로고    scopus 로고
    • Low ligand requirement for deletion and lack of synapses in positive selection enforce the gauntlet of thymic T cell maturation
    • Ebert PJ, Ehrlich LI, Davis MM. Low ligand requirement for deletion and lack of synapses in positive selection enforce the gauntlet of thymic T cell maturation. Immunity. 2008;29:734-45.
    • (2008) Immunity , vol.29 , pp. 734-745
    • Ebert, P.J.1    Ehrlich, L.I.2    Davis, M.M.3
  • 27
    • 0029066263 scopus 로고
    • A role for CD5 in TCR-mediated signal transduction and thymocyte selection
    • Tarakhovsky A, et al. A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science. 1995;269:535-7.
    • (1995) Science , vol.269 , pp. 535-537
    • Tarakhovsky, A.1
  • 28
    • 0142149044 scopus 로고    scopus 로고
    • Thymocyte Sensitivity and Supramolecular Activation Cluster Formation Are Developmentally Regulated: A Partial Role for Sialylation
    • Starr TK, Daniels MA, Lucido MM, Jameson SC, Hogquist KA. Thymocyte sensitivity and supramolecular activation cluster formation are developmentally regulated: a partial role for sialylation. J Immunol. 2003;171:4512-20. (Pubitemid 37310566)
    • (2003) Journal of Immunology , vol.171 , Issue.9 , pp. 4512-4520
    • Starr, T.K.1    Daniels, M.A.2    Lucido, M.M.3    Jameson, S.C.4    Hogquist, K.A.5
  • 29
    • 77949962019 scopus 로고    scopus 로고
    • CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development
    • Zikherman J, et al. CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development. Immunity. 2010;32:342-54.
    • (2010) Immunity , vol.32 , pp. 342-354
    • Zikherman, J.1
  • 31
    • 64249119896 scopus 로고    scopus 로고
    • PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background
    • Zikherman J, et al. PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background. J Immunol. 2009;182:4093-106.
    • (2009) J Immunol , vol.182 , pp. 4093-4106
    • Zikherman, J.1
  • 32
    • 58749088416 scopus 로고    scopus 로고
    • SIT and TRIM determine T cell fate in the thymus
    • Koelsch U, Schraven B, Simeoni L. SIT and TRIM determine T cell fate in the thymus. J Immunol. 2008;181:5930-9.
    • (2008) J Immunol , vol.181 , pp. 5930-5939
    • Koelsch, U.1    Schraven, B.2    Simeoni, L.3
  • 33
    • 0036380174 scopus 로고    scopus 로고
    • MAP kinase phosphatases
    • REVIEWS3009
    • Theodosiou, A. & Ashworth, A.: MAP kinase phosphatases. Genome Biol 2002; 3: REVIEWS3009.
    • (2002) Genome Biol , vol.3
    • Theodosiou, A.1    Ashworth, A.2
  • 34
    • 70350435670 scopus 로고    scopus 로고
    • An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a
    • Ebert, P.J., Jiang, S., Xie, J., Li, Q.J. & Davis, M.M.: An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a. Nat Immunol 2009.
    • (2009) Nat Immunol
    • Ebert, P.J.1    Jiang, S.2    Xie, J.3    Li, Q.J.4    Davis, M.M.5
  • 35
    • 56349133372 scopus 로고    scopus 로고
    • Pre-miRNA loop nucleotides control the distinct activities of mir-181a-1, mir-181c in early T cell development
    • Liu G, Min H, Yue S, Chen CZ. Pre-miRNA loop nucleotides control the distinct activities of mir-181a-1, mir-181c in early T cell development. PLoS One. 2008;3:e3592.
    • (2008) PLoS One , vol.3
    • Liu, G.1    Min, H.2    Yue, S.3    Chen, C.Z.4
  • 38
    • 25844526684 scopus 로고    scopus 로고
    • Central tolerance: Learning self-control in the thymus
    • DOI 10.1038/nri1707
    • Hogquist KA, Baldwin TA, Jameson SC. Central tolerance: learning self-control in the thymus. Nat Rev Immunol. 2005;5:772-82. (Pubitemid 41400851)
    • (2005) Nature Reviews Immunology , vol.5 , Issue.10 , pp. 772-782
    • Hogquist, K.A.1    Baldwin, T.A.2    Jameson, S.C.3
  • 41
    • 34447098797 scopus 로고    scopus 로고
    • Multistep pathogenesis of autoimmune disease
    • Goodnow, C.C.: Multistep pathogenesis of autoimmune disease. Cell 2007; 130: 25-35.
    • (2007) Cell , vol.130 , pp. 25-35
    • Goodnow, C.C.1
  • 43
    • 0034680105 scopus 로고    scopus 로고
    • Progression of autoimmune diabetes driven by avidity maturation of a T-cell population
    • Amrani A, et al. Progression of autoimmune diabetes driven by avidity maturation of a T-cell population. Nature. 2000;406:739-42.
    • (2000) Nature , vol.406 , pp. 739-742
    • Amrani, A.1
  • 44
    • 0033118739 scopus 로고    scopus 로고
    • A kinetic basis for T cell receptor repertoire selection during an immune response
    • DOI 10.1016/S1074-7613(00)80048-5
    • Savage PA, Boniface JJ, Davis MM. A kinetic basis for T cell receptor repertoire selection during an immune response. Immunity. 1999;10:485-92. (Pubitemid 29205484)
    • (1999) Immunity , vol.10 , Issue.4 , pp. 485-492
    • Savage, P.A.1    Boniface, J.J.2    Davis, M.M.3
  • 45
    • 0035876930 scopus 로고    scopus 로고
    • The frequency of high avidity T cells determines the hierarchy of determinant spreading
    • Tian J, Gregori S, Adorini L, Kaufman DL. The frequency of high avidity T cells determines the hierarchy of determinant spreading. J Immunol. 2001;166:7144-50. (Pubitemid 32525585)
    • (2001) Journal of Immunology , vol.166 , Issue.12 , pp. 7144-7150
    • Tian, J.1    Gregori, S.2    Adorini, L.3    Kaufman, D.L.4
  • 46
    • 34247849183 scopus 로고    scopus 로고
    • Effector and memory CTL differentiation
    • DOI 10.1146/annurev.immunol.25.022106.141548
    • Williams MA, Bevan MJ. Effector and memory CTL differentiation. Annu Rev Immunol. 2007;25:171-92. (Pubitemid 46697906)
    • (2007) Annual Review of Immunology , vol.25 , pp. 171-192
    • Williams, M.A.1    Bevan, M.J.2
  • 47
    • 65249100690 scopus 로고    scopus 로고
    • Generation and maintenance of memory CD4(+) T Cells
    • van Leeuwen EM, Sprent J, Surh CD. Generation and maintenance of memory CD4(+) T Cells. Curr Opin Immunol. 2009;21:167-72.
    • (2009) Curr Opin Immunol , vol.21 , pp. 167-172
    • Van Leeuwen, E.M.1    Sprent, J.2    Surh, C.D.3
  • 48
    • 77952313777 scopus 로고    scopus 로고
    • Differentiation of effector CD4 T cell populations (*)
    • Zhu J, Yamane H, Paul WE. Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol. 2010;28:445-89.
    • (2010) Annu Rev Immunol , vol.28 , pp. 445-489
    • Zhu, J.1    Yamane, H.2    Paul, W.E.3
  • 49
    • 75649108622 scopus 로고    scopus 로고
    • An emerging player in the adaptive immune response: MicroRNA-146a is a modulator of IL-2 expression and activation-induced cell death in T lymphocytes
    • Curtale G, et al. An emerging player in the adaptive immune response: microRNA-146a is a modulator of IL-2 expression and activation-induced cell death in T lymphocytes. Blood. 2010;115:265-73.
    • (2010) Blood , vol.115 , pp. 265-273
    • Curtale, G.1
  • 50
    • 77956632634 scopus 로고    scopus 로고
    • Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses
    • Lu LF, et al. Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell. 2010;142:914-29.
    • (2010) Cell , vol.142 , pp. 914-929
    • Lu, L.F.1
  • 51
    • 77956511013 scopus 로고    scopus 로고
    • MicroRNA-146a expresses in interleukin-17 producing T cells in rheumatoid arthritis patients
    • Niimoto T, et al. microRNA-146a expresses in interleukin-17 producing T cells in rheumatoid arthritis patients. BMC Musculoskelet Disord. 2010;11:209.
    • (2010) BMC Musculoskelet Disord , vol.11 , pp. 209
    • Niimoto, T.1
  • 53
    • 77955298958 scopus 로고    scopus 로고
    • Selected microRNAs define cell fate determination of murine central memory CD8 T cells
    • Almanza G, et al. Selected microRNAs define cell fate determination of murine central memory CD8 T cells. PLoS One. 2010;5:e11243.
    • (2010) PLoS One , vol.5
    • Almanza, G.1
  • 55
    • 34247594818 scopus 로고    scopus 로고
    • Regulation of the germinal center response by microRNA-155
    • Thai TH, et al. Regulation of the germinal center response by microRNA-155. Science. 2007;316:604-8.
    • (2007) Science , vol.316 , pp. 604-608
    • Thai, T.H.1
  • 56
    • 33847242598 scopus 로고    scopus 로고
    • Foxp3 occupancy and regulation of key target genes during T-cell stimulation
    • Marson A, et al. Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature. 2007;445:931-5.
    • (2007) Nature , vol.445 , pp. 931-935
    • Marson, A.1
  • 57
    • 33847220736 scopus 로고    scopus 로고
    • Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells
    • Zheng Y, et al. Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. Nature. 2007;445:936-40.
    • (2007) Nature , vol.445 , pp. 936-940
    • Zheng, Y.1
  • 58
    • 58149268107 scopus 로고    scopus 로고
    • Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein
    • Lu LF, et al. Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity. 2009;30:80-91.
    • (2009) Immunity , vol.30 , pp. 80-91
    • Lu, L.F.1
  • 59
    • 64849100152 scopus 로고    scopus 로고
    • Cutting edge: The Foxp3 target miR-155 contributes to the development of regulatory T cells
    • Kohlhaas S, et al. Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells. J Immunol. 2009;182:2578-82.
    • (2009) J Immunol , vol.182 , pp. 2578-2582
    • Kohlhaas, S.1
  • 60
    • 2342450524 scopus 로고    scopus 로고
    • Molecular evolution of a microRNA cluster
    • DOI 10.1016/j.jmb.2004.03.065, PII S0022283604003833
    • Tanzer A, Stadler PF. Molecular evolution of a microRNA cluster. J Mol Biol. 2004;339:327-35. (Pubitemid 38596952)
    • (2004) Journal of Molecular Biology , vol.339 , Issue.2 , pp. 327-335
    • Tanzer, A.1    Stadler, P.F.2
  • 61
    • 2342449399 scopus 로고    scopus 로고
    • Identification and Characterization of a Novel Gene, C13orf25, as a Target for 13q31-q32 Amplification in Malignant Lymphoma
    • DOI 10.1158/0008-5472.CAN-03-3773
    • Ota A, et al. EIdentification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma. Cancer Res. 2004;64:3087-95. (Pubitemid 38581408)
    • (2004) Cancer Research , vol.64 , Issue.9 , pp. 3087-3095
    • Ota, A.1    Tagawa, H.2    Karnan, S.3    Tsuzuki, S.4    Karpas, A.5    Kira, S.6    Yoshida, Y.7    Seto, M.8
  • 65
    • 77954721060 scopus 로고    scopus 로고
    • Regulatory T cells in tumor immunity
    • Nishikawa H, Sakaguchi S. Regulatory T cells in tumor immunity. Int J Cancer. 2010;127:759-67.
    • (2010) Int J Cancer , vol.127 , pp. 759-767
    • Nishikawa, H.1    Sakaguchi, S.2
  • 66
    • 77954382780 scopus 로고    scopus 로고
    • Mir-17-92, a cluster of miRNAs in the midst of the cancer network
    • Olive V, Jiang I, He L. Mir-17-92, a cluster of miRNAs in the midst of the cancer network. Int J Biochem Cell Biol. 2010;42:1348-54.
    • (2010) Int J Biochem Cell Biol , vol.42 , pp. 1348-1354
    • Olive, V.1    Jiang, I.2    He, L.3
  • 67
    • 70349463161 scopus 로고    scopus 로고
    • The estrogen receptor-alpha-induced microRNA signature regulates itself and its transcriptional response
    • Castellano L, et al. The estrogen receptor-alpha-induced microRNA signature regulates itself and its transcriptional response. Proc Natl Acad Sci USA. 2009;106:15732-7.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 15732-15737
    • Castellano, L.1
  • 68
    • 71849111080 scopus 로고    scopus 로고
    • Alterations in microRNA expression in stress-induced cellular senescence
    • Li G, Luna C, Qiu J, Epstein DL, Gonzalez P. Alterations in microRNA expression in stress-induced cellular senescence. Mech Ageing Dev. 2009;130:731-41.
    • (2009) Mech Ageing Dev , vol.130 , pp. 731-741
    • Li, G.1    Luna, C.2    Qiu, J.3    Epstein, D.L.4    Gonzalez, P.5
  • 69
    • 70349220767 scopus 로고    scopus 로고
    • Repression of the miR-17-92 cluster by p53 has an important function in hypoxia-induced apoptosis
    • Yan HL, et al. Repression of the miR-17-92 cluster by p53 has an important function in hypoxia-induced apoptosis. EMBO J. 2009;28:2719-32.
    • (2009) EMBO J , vol.28 , pp. 2719-2732
    • Yan, H.L.1
  • 70
    • 77954257796 scopus 로고    scopus 로고
    • Secreted monocytic miR-150 enhances targeted endothelial cell migration
    • Zhang Y, et al. Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol Cell. 2010;39:133-44.
    • (2010) Mol Cell , vol.39 , pp. 133-144
    • Zhang, Y.1
  • 71
    • 49949116902 scopus 로고    scopus 로고
    • The impact of microRNAs on protein output
    • Baek, D. et al.: The impact of microRNAs on protein output. Nature 2008.
    • (2008) Nature
    • Baek, D.1
  • 72
    • 49949117302 scopus 로고    scopus 로고
    • Widespread changes in protein synthesis induced by microRNAs
    • Selbach, M. et al.: Widespread changes in protein synthesis induced by microRNAs. Nature 2008.
    • (2008) Nature
    • Selbach, M.1
  • 73
    • 67749132423 scopus 로고    scopus 로고
    • Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps
    • Chi SW, Zang JB, Mele A, Darnell RB. Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps. Nature. 2009;460:479-86.
    • (2009) Nature , vol.460 , pp. 479-486
    • Chi, S.W.1    Zang, J.B.2    Mele, A.3    Darnell, R.B.4
  • 74
    • 28444469246 scopus 로고    scopus 로고
    • Silencing of microRNAs in vivo with 'antagomirs'
    • Krutzfeldt J, et al. Silencing of microRNAs in vivo with 'antagomirs'. Nature. 2005;438:685-9.
    • (2005) Nature , vol.438 , pp. 685-689
    • Krutzfeldt, J.1
  • 75
    • 57749168828 scopus 로고    scopus 로고
    • MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
    • Thum, T. et al.: MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 2008.
    • (2008) Nature
    • Thum, T.1
  • 76
    • 66449136951 scopus 로고    scopus 로고
    • Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model
    • Kota J, et al. Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell. 2009;137:1005-17.
    • (2009) Cell , vol.137 , pp. 1005-1017
    • Kota, J.1


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